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    Mevinic acid derivatives useful as antihypercholesterolemic agents and method for preparing same
    1.
    发明授权
    Mevinic acid derivatives useful as antihypercholesterolemic agents and method for preparing same 失效
    可用作抗高胆固醇血症药的米维酸衍生物及其制备方法

    公开(公告)号：US5166364A

    公开(公告)日：1992-11-24

    申请号：US765806

    申请日：1991-09-26

    申请人： Jeffrey O. Saunders ,  Eric M. Gordon

    发明人： Jeffrey O. Saunders ,  Eric M. Gordon

    IPC分类号： C07C59/11 ,  C07D309/30 ,  C07F7/18

    CPC分类号： C07F7/1856 ,  C07C59/11 ,  C07D309/30

    摘要： Mevinic acid derivatives are provided which are 6-hydroxy-8-(2,2-dimethyl-1-oxybutoxy- 2-methyl)-substituted-decahydronaphthalene esters and have the structure ##STR1## wherein Z is ##STR2## wherein R is alkali metal such as Na, or H or lower alkyl, and are HMG CoA reductase inhibitors and thus are useful as antihypercholesterolemic agents and in treating atherosclerosis, and also as antifungal agents.In addition, a method for preparing the above-mevinic acid derivatives is also provided.

    摘要翻译： 提供了6-羟基-8-（2,2-二甲基-1-氧丁氧基-2-甲基） - 取代十氢萘酯的维甲酸衍生物，其结构为：其中R为碱 金属如Na或H或低级烷基，并且是HMG CoA还原酶抑制剂，因此可用作抗高胆固醇血症药物和治疗动脉粥样硬化，并且还可用作抗真菌剂。 此外，还提供了制备上述维甲酸衍生物的方法。

    Phenyl hydroxamic acids including a hetero-containing substituent
    2.
    发明授权
    Phenyl hydroxamic acids including a hetero-containing substituent 失效
    苯基异羟肟酸，包括含杂原子的取代基

    公开(公告)号：US4906667A

    公开(公告)日：1990-03-06

    申请号：US203527

    申请日：1988-05-23

    申请人： Ravi K. Varma ,  Eric M. Gordon ,  Martin F. Haslanger

    发明人： Ravi K. Varma ,  Eric M. Gordon ,  Martin F. Haslanger

    IPC分类号： C07C259/10

    CPC分类号： C07C259/10 ,  C07C2101/04 ,  C07C2101/08 ,  C07C2101/14

    摘要： Phenyl hydroxamic acids are disclosed having the general formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein X is NR, oxygen, sulfur, ##STR2## or a single bond, and Y is NR, oxygen, sulfur, ##STR3## or a single bond, where R can be hydrogen or lower alkyl, g can be 1 or 2, and with the proviso that at least one of X and Y is other than a single bond; Z is aryl, aralkyl or cycloalkyl; R.sub.1 is hydrogen, substituted or unsubstituted lower alkyl, cycloalkyl, lower alkenyl or aryl; R.sub.2 is hydrogen, lower alkyl, aroyl or acyl; m is 0 to 4 carbon atoms; and, n is 0 to 4 carbon atoms further providing that if one of X or Y is oxygen, the other of X or Y must be oxygen and further that when X and Y are oxygen Z cannot be aralalkyl.These new compounds have been found to be inhibitors or arachidonic acid 5-lipoxygenase and are therefore useful as antiallergy agents and antipsoriatics.

    摘要翻译： 公开了具有通式为“IMAGE”或其药学上可接受的盐的苯基异羟肟酸，其中X是NR，氧，硫，或单键，Y是NR，氧，硫， 单键，其中R可以是氢或低级烷基，g可以是1或2，条件是X和Y中的至少一个不是单键; Z是芳基，芳烷基或环烷基; R 1是氢，取代或未取代的低级烷基，环烷基，低级烯基或芳基; R2是氢，低级烷基，芳酰基或酰基; m为0〜4个碳原子; 并且n为0至4个碳原子，条件是如果X或Y中的一个为氧，X或Y中的另一个必须为氧，此外，当X和Y为氧时，Z不能为芳烷基。 已经发现这些新化合物是抑制剂或花生四烯酸5-脂氧合酶，因此可用作抗过敏剂和抗牛皮癣剂。