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公开(公告)号：US08133168B2
公开(公告)日：2012-03-13
申请号：US12066997
申请日：2006-09-01
申请人： Eric Monnet , E. Christopher Orton , Susan P. James , Kyle Garrett Ordway , John Ordway, legal representative
IPC分类号： A61N1/362
CPC分类号： A61F2/2481 , A61F2/2442
摘要： A dynamic device for reducing functional mitral regurgitation is described. The device is disposed externally to the heart and effectively acts as a splint for reducing further dilation of the heart in patients diagnosed with cardiomyopathy, and for reducing tethering of the papillary muscle on the mitral valve. The device does not require cardiopulmonary bypass for its installation since it is attached to the outside of the left ventricle, thereby reducing surgical risk, and is not exposed to the patient's blood once installed, thereby reducing the risk of thromboembolic disease.
摘要翻译： 描述了用于减少功能性二尖瓣反流的动态装置。 该装置设置在心脏外部，并有效地用作夹板，以减少诊断为心肌病的患者心脏的进一步扩张，并减少二尖瓣上乳头肌的束缚。 该装置不需要用于其安装的体外循环，因为其连接到左心室的外部，从而降低手术风险，并且一旦安装就不会暴露于患者的血液，从而降低血栓栓塞性疾病的风险。
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公开(公告)号：US20090287037A1
公开(公告)日：2009-11-19
申请号：US12066997
申请日：2006-09-01
IPC分类号： A61N1/375
CPC分类号： A61F2/2481 , A61F2/2442
摘要： A dynamic device for reducing functional mitral regurgitation is described. The device is disposed externally to the heart and effectively acts as a splint for reducing further dilation of the heart in patients diagnosed with cardiomyopathy, and for reducing tethering of the papillary muscle on the mitral valve. The device does not require cardiopulmonary bypass for its installation since it is attached to the outside of the left ventricle, thereby reducing surgical risk, and is not exposed to the patient's blood once installed, thereby reducing the risk of thromboembolic disease.
摘要翻译： 描述了用于减少功能性二尖瓣反流的动态装置。 该装置设置在心脏外部，并有效地用作夹板，以减少诊断为心肌病的患者心脏的进一步扩张，并减少二尖瓣上乳头肌的束缚。 该装置不需要用于其安装的体外循环，因为其连接到左心室的外部，从而降低手术风险，并且一旦安装就不会暴露于患者的血液，从而降低血栓栓塞性疾病的风险。
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3.发明授权Apparatus and methods for mitigating impairments due to central auditory nervous system binaural phase-time asynchrony 失效用于减轻由于中枢神经系统双相相位时间异步引起的损伤的装置和方法公开(公告)号：US07929711B2
公开(公告)日：2011-04-19
申请号：US11443859
申请日：2006-05-31
IPC分类号： H04R25/00
摘要： Pathological binaural phase time delay (PBTD) asynchrony is measured at a variety of frequencies and speech stimuli to develop a BPTD profile for a subject. A corrective device (600, 1000) is designed to apply clinical PBTD to compensate for the subject's pathological BPTD. An electronic device (500) is used to measure the subject's ability to comprehend words at a variety of relative time delays between ears to estimate the ideal overall relative time delay. The optimal relative phase shift at a variety of frequencies is also measured. An electronic device (600) may be used to correct the pathological BPTD by delaying sound in different frequency bands differently to the target ear, according to the BPTD profile, or a passive filtered earplug (1000) may be used to correct smaller amounts of BPTD.
摘要翻译： 在各种频率和言语刺激下测量病理性双相时间延迟（PBTD）异步，以开发受试者的BPTD分布。 矫正装置（600,1000）被设计为应用临床PBTD来补偿受试者的病理BPTD。 电子设备（500）用于测量受试者在耳朵之间的各种相对时间延迟上理解单词的能力，以估计理想的整体相对时间延迟。 还测量了各种频率下的最佳相对相移。 可以使用电子设备（600）来根据BPTD简档来延迟与目标耳朵不同的不同频带的声音来校正病理BPTD，或者可以使用无源滤波耳塞（1000）来校正较小量的BPTD 。
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4.发明申请Outer layer material having entanglement of hydrophobic polymer host blended with a maleated hydrophobic polymer co-host, and hydrophilic polymer guest 有权具有与马来酸化疏水性聚合物共主体共混的疏水性聚合物主体的缠结的外层材料和亲水性聚合物客体公开(公告)号：US20080318022A1
公开(公告)日：2008-12-25
申请号：US12148598
申请日：2008-04-21
CPC分类号： C08J3/246 , A61L31/048 , C08B37/00 , C08B37/0072 , C08J9/42 , C08J2323/06 , C08J2405/08 , C08L5/08 , Y10T428/249953 , C08L2666/02 , C08L101/00 , C08L2666/26
摘要： An outer layer material having an entanglement comprising an intermingling of cloaked hydrophilic guest and a hydrophobic polymer host, wherein molecules of the guest have been crosslinked with each other. Under certain circumstances, using complexes of the guest may be desirable or even necessary. Prior to intermingling with the guest, a host blend may be produced to include a physical blend of a hydrophobic polymer host and a maleated hydrophobic co-host (preferably, an anhydride functionalized hydrophobic polymer, whereby the polymer so functionalized, is the same as that selected for the host). The intermingling of the guest and host, or host-co-host blend, includes a physical tangling, whether it also comprises crosslinking by primary bonding (e.g., chemical/covalent bonding) there-between. Also a method of producing an outer layer material having such an entanglement, including the steps of: temporarily cloaking at least a portion of the hydrophilic groups of the guest; intermingling at least a portion of the cloaked groups with a porous polymeric structure by diffusing the guest with cloaked groups into at least a portion of the structure's pores; within the pores, crosslinking at least a portion of the molecules of the guest with the guest; and removing the cloaking. Cloaking may be performed by silylation or acylation. Intermingling may be performed by producing a mixture of guest and host, or host blend, (whether in solution, powdered, granular, etc., form); next, a crosslinking of the guest with itself is performed; then, the mixture is molded into the outer layer with or without additional crosslinking of the host to the host.
摘要翻译： 具有缠结的外层材料，其包含掩蔽的亲水性客体和疏水性聚合物主体的混合物，其中客体的分子彼此交联。 在某些情况下，使用客人的复合物可能是理想的或甚至是必需的。 在与客体混合之前，可以制备主体共混物以包括疏水性聚合物主体和马来酸化疏水性共主体的物理共混物（优选为酸酐官能化的疏水性聚合物，由此使官能化的聚合物与之相同） 为主机选择）。 客体和宿主或宿主 - 共同宿主混合物的混合包括物理缠结，不管其是否还包括通过其间的初次键合（例如，化学/共价键合）的交联。 还有一种制造具有这种缠结的外层材料的方法，包括以下步骤：暂时掩蔽客体的至少一部分亲水基团; 通过将具有掩蔽基团的客体扩散到结构的孔的至少一部分中来将具有多孔聚合物结构的至少一部分掩蔽组混合; 在孔内，与客体交联客体的至少一部分分子; 并去除隐形。 掩蔽可以通过甲硅烷基化或酰化进行。 混合可以通过生产客体和主体或主体混合物的混合物（无论是溶液，粉末状，颗粒状等）形式进行; 接下来，进行客人与其自身的交联; 然后，将该混合物模塑到外层中，该主体与主体有或没有额外的交联。
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5.发明授权公开(公告)号：US08524886B2
公开(公告)日：2013-09-03
申请号：US12705753
申请日：2010-02-15
申请人： Susan P. James , Min Zhang , Guy Beauregard
发明人： Susan P. James , Min Zhang , Guy Beauregard
CPC分类号： C08J9/42 , B05D5/00 , B29C67/24 , C08B37/00 , C08B37/0072 , C08L5/08 , C08L101/00 , Y10T428/249953 , Y10T428/31504 , Y10T428/31855 , Y10T428/31971 , C08L2666/02 , C08L2666/26
摘要： An outer layer having an entanglement comprising an intermingling of cloaked hydrophilic guest and a hydrophobic polymer host, wherein molecules of the guest have been crosslinked with each other. Under certain circumstances, using complexes of the guest may be desirable or even necessary. The intermingling of the guest and host includes a physical tangling, whether it also comprises crosslinking by primary bonding (e.g., chemical/covalent bonding) there-between. Also a method of producing an outer layer having such an entanglement, including the steps of: temporarily cloaking at least a portion of the hydrophilic groups of the guest; intermingling at least a portion of the cloaked groups with a porous polymeric structure by diffusing the guest with cloaked groups into at least a portion of the structure's pores; within the pores, crosslinking at least a portion of the molecules of the guest with the guest; and removing the cloaking. Cloaking may be performed by silylation or acylation. Intermingling may be performed by producing a mixture of guest and host (whether in solution, powdered, granular, etc., form); next, a crosslinking of the guest with itself is performed; then, the mixture is molded into the outer layer.
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6.发明申请POLYMERIC MATERIALS INCLUDING A GLYCOSAMINOGLYCAN NETWORKED WITH A POLYOLEFIN-CONTAINING POLYMER 审中-公开包含含聚烯丙基聚合物的糖蛋白聚糖的聚合物公开(公告)号：US20120264852A1
公开(公告)日：2012-10-18
申请号：US13503900
申请日：2010-10-29
IPC分类号： C08G63/91 , C08L5/10 , C08L5/00 , C08L89/00 , C08L1/02 , C08K3/10 , C08K3/32 , C08L5/08 , C08L101/00 , B82Y5/00
CPC分类号： C08F251/00 , A61K31/726 , A61K31/727 , A61K31/728 , A61K31/737 , A61K47/36 , A61L15/60 , A61L27/18 , C08J3/075 , C08J2351/02 , C08L51/02 , C08L51/003
摘要： The present invention relates to polymeric materials including a glycosaminoglycan networked with a polyolefin-containing polymer. The present invention also relates to hydrogels containing the polymeric materials. The present invention further relates to methods of synthesizing the polymeric materials and hydrogels of the present invention.
摘要翻译： 本发明涉及包含与含聚烯烃的聚合物网络化的糖胺聚糖的聚合物材料。 本发明还涉及含有聚合物材料的水凝胶。 本发明还涉及合成本发明的聚合物材料和水凝胶的方法。
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7.发明授权Outer layer having entanglement of hydrophobic polymer host and hydrophilic polymer guest 有权外层具有疏水聚合物主体和亲水聚合物客体的缠结公开(公告)号：US07662954B2
公开(公告)日：2010-02-16
申请号：US10283760
申请日：2002-10-29
申请人： Susan P. James , Min Zhang , Guy Beauregard
发明人： Susan P. James , Min Zhang , Guy Beauregard
CPC分类号： C08J9/42 , B05D5/00 , B29C67/24 , C08B37/00 , C08B37/0072 , C08L5/08 , C08L101/00 , Y10T428/249953 , Y10T428/31504 , Y10T428/31855 , Y10T428/31971 , C08L2666/02 , C08L2666/26
摘要： An outer layer having an entanglement comprising an intermingling of cloaked hydrophilic guest and a hydrophobic polymer host, wherein molecules of the guest have been crosslinked with each other. Under certain circumstances, using complexes of the guest may be desirable or even necessary. The intermingling of the guest and host includes a physical tangling, whether it also comprises crosslinking by primary bonding (e.g., chemical/covalent bonding) there-between. Also a method of producing an outer layer having such an entanglement, including the steps of: temporarily cloaking at least a portion of the hydrophilic groups of the guest; intermingling at least a portion of the cloaked groups with a porous polymeric structure by diffusing the guest with cloaked groups into at least a portion of the structure's pores; within the pores, crosslinking at least a portion of the molecules of the guest with the guest; and removing the cloaking. Cloaking may be performed by silylation or acylation. Intermingling may be performed by producing a mixture of guest and host (whether in solution, powdered, granular, etc., form); next, a crosslinking of the guest with itself is performed; then, the mixture is molded into the outer layer.
摘要翻译： 具有缠结的外层，其包含掩蔽的亲水客体和疏水性聚合物主体的混合物，其中客体的分子彼此交联。 在某些情况下，使用客人的复合物可能是理想的或甚至是必需的。 客人和主持人的混合包括物理缠结，无论其是否还包括通过其间的初次键合（例如，化学/共价键合）的交联。 还有一种制造具有这种缠结的外层的方法，包括以下步骤：暂时隐藏客人的至少一部分亲水基团; 通过将具有掩蔽基团的客体扩散到结构的孔的至少一部分中来将具有多孔聚合物结构的至少一部分掩蔽组混合; 在孔内，与客体交联客体的至少一部分分子; 并去除隐形。 掩蔽可以通过甲硅烷基化或酰化进行。 混合可以通过生产客体和主机的混合物（无论是溶液，粉末，颗粒等）形式进行; 接下来，进行客人与其自身的交联; 然后将混合物模塑成外层。
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8.发明申请COPOLYMER SYNTHESIZED FROM A MODIFIED GLYCOSAMINOGLYCAN (GAG) AND AN ANHYDRIDE FUNCTIONALIZED HYDROPHOBIC POLYMER 审中-公开由改性的甘氨酰胺（GAG）和无水官能化的疏水性聚合物合成的共聚物公开(公告)号：US20130197160A1
公开(公告)日：2013-08-01
申请号：US12596583
申请日：2008-04-18
IPC分类号： C08F255/02
CPC分类号： C08F255/02 , C08B37/0063 , C08B37/0072 , C08G81/02
摘要： A new copolymer synthesized from a glycosaminoglycan (GAG) such as hyaluronan/hyaluronic acid (HA), chondroitin sulfates, derma tan sulfates, keratan sulfates, heparan sulfate, and heparin, and an anhydride functionalized hydrophobic polymer, i.e., any polyolefin which has been ‘functionalized’ (grafted onto the backbone or incorporated into the backbone) with anhydride functional groups, such as maleic anhydride-graft-polyethylene, (or, maleated polyethylene), maleic anhydride-graft-polystyrene, maleic anhydride-graft-polypropylene, etc. The functionalized polyolefin may be a polyolefin backbone to which the anhydride functional groups have been grafted, or otherwise incorporated with the backbone. Also, a unique synthesis technique combines a modified GAG with a graft polyolefin, resulting in a unique copolymer with its constituents by-and-large covalently bound to each other.
摘要翻译： 由糖胺聚糖（GAG）如透明质酸/透明质酸（HA），硫酸软骨素，硫酸皮肤素，硫酸角质素，硫酸乙酰肝素和肝素合成的新共聚物，以及酸酐官能化的疏水性聚合物，即任何已经被 马来酸酐接枝聚乙烯（或马来酸化聚乙烯），马来酸酐接枝 - 聚苯乙烯，马来酸酐 - 接枝 - 聚丙烯等的酸酐官能团“官能化”（接枝到骨架上或并入骨架中） 官能化聚烯烃可以是聚酐主链，酸酐官能团已经被接枝或以其它方式与主链结合。 此外，独特的合成技术将改性的GAG与接枝聚烯烃结合在一起，形成独特的共聚物，其组成物彼此共价结合。
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9.发明授权Apparatus and methods for mitigating impairments due to central auditory nervous system binaural phase-time asynchrony 有权用于减轻由于中枢神经系统双相相位时间异步引起的损伤的装置和方法公开(公告)号：US07120258B1
公开(公告)日：2006-10-10
申请号：US10110035
申请日：2000-10-05
IPC分类号： H04R29/00
摘要： Pathological binaural phase time delay (BPTD) asynchrony is measured at a variety of frequencies and to speech stimuli to develop a BPTD profile for a subject. Then a corrective device (600, 1000) is designed to apply clinical BPTD to compensate for the subject's pathological BPTD. An electronic device (500) is used to measure the subject's ability to comprehend words at a variety of relative time delays between ears to estimate the ideal overall relative time delay. The optimal relative phase shift at a variety of frequencies is also measured. An electronic device (600) may be used to correct the pathological BPTD by delaying sound in different frequency bands differently to the target ear, according to the BPTD profile, or a passive filtered earplug (1000) may be used to correct smaller amounts of BPTD.
摘要翻译： 在各种频率和言语刺激下测量病理性双耳时间延迟（BPTD）异步，以开发受试者的BPTD分布。 然后，设计了一种矫正装置（600,1000）来应用临床BPTD来补偿受试者的病理性BPTD。 电子设备（500）用于测量受试者在耳朵之间的各种相对时间延迟上理解单词的能力，以估计理想的整体相对时间延迟。 还测量了各种频率下的最佳相对相移。 可以使用电子设备（600）来根据BPTD简档来延迟与目标耳朵不同的不同频带的声音来校正病理BPTD，或者可以使用无源滤波耳塞（1000）来校正较小量的BPTD 。
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10.发明授权Outer layer material having entanglement of hydrophobic polymer hostblended with a maleated hydrophobic polymer co-host, and hydrophilic polymer guest 有权外层材料具有与马来酸化疏水性聚合物共主体共混的疏水性聚合物和亲水性聚合物客体的缠结公开(公告)号：US08524884B2
公开(公告)日：2013-09-03
申请号：US12148598
申请日：2008-04-21
CPC分类号： C08J3/246 , A61L31/048 , C08B37/00 , C08B37/0072 , C08J9/42 , C08J2323/06 , C08J2405/08 , C08L5/08 , Y10T428/249953 , C08L2666/02 , C08L101/00 , C08L2666/26
摘要： An outer layer material having an entanglement comprising an intermingling of cloaked hydrophilic guest and a hydrophobic polymer host, wherein molecules of the guest have been crosslinked with each other. Under certain circumstances, using complexes of the guest may be desirable or even necessary. Prior to intermingling with the guest, a host blend may be produced to include a physical blend of a hydrophobic polymer host and a maleated hydrophobic co-host (preferably, an anhydride functionalized hydrophobic polymer, whereby the polymer so functionalized, is the same as that selected for the host). The intermingling of the guest and host, or host-co-host blend, includes a physical tangling, whether it also comprises crosslinking by primary bonding (e.g., chemical/covalent bonding) there-between. Also a method of producing an outer layer material having such an entanglement, including the steps of: temporarily cloaking at least a portion of the hydrophilic groups of the guest; intermingling at least a portion of the cloaked groups with a porous polymeric structure by diffusing the guest with cloaked groups into at least a portion of the structure's pores; within the pores, crosslinking at least a portion of the molecules of the guest with the guest; and removing the cloaking. Cloaking may be performed by silylation or acylation. Intermingling may be performed by producing a mixture of guest and host, or host blend, (whether in solution, powdered, granular, etc., form); next, a crosslinking of the guest with itself is performed; then, the mixture is molded into the outer layer with or without additional crosslinking of the host to the host.
摘要翻译： 具有缠结的外层材料，其包含掩蔽的亲水性客体和疏水性聚合物主体的混合物，其中客体的分子彼此交联。 在某些情况下，使用客人的复合物可能是理想的或甚至是必需的。 在与客体混合之前，可以制备主体共混物以包括疏水性聚合物主体和马来酸化疏水性共主体的物理共混物（优选为酸酐官能化的疏水性聚合物，由此使官能化的聚合物与之相同） 为主机选择）。 客体和宿主或宿主 - 共同宿主混合物的混合包括物理缠结，不管其是否还包括通过其间的初次键合（例如，化学/共价键合）的交联。 还有一种制造具有这种缠结的外层材料的方法，包括以下步骤：暂时掩蔽客体的至少一部分亲水基团; 通过将具有掩蔽基团的客体扩散到结构的孔的至少一部分中来将具有多孔聚合物结构的至少一部分掩蔽组混合; 在孔内，与客体交联客体的至少一部分分子; 并去除隐形。 掩蔽可以通过甲硅烷基化或酰化进行。 混合可以通过生产客体和主体或主体混合物的混合物（无论是溶液，粉末状，颗粒状等）形式进行; 接下来，进行客人与其自身的交联; 然后，将该混合物模塑到外层中，该主体与主体有或没有额外的交联。
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