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1.发明申请Gaming machine environment having controlled audio and visual media presentation 有权游戏机环境具有受控的音视频媒体呈现公开(公告)号：US20060009285A1
公开(公告)日：2006-01-12
申请号：US11222709
申请日：2005-09-09
申请人： Eric Pryzby , Richard Schwartz
发明人： Eric Pryzby , Richard Schwartz
IPC分类号： A63F13/00
CPC分类号： G07F17/32 , G07F17/3227
摘要： A gaming machine system comprises a plurality of multimedia output devices, including audio, visual, and/or tactile devices strategically mounted around a casino. The multimedia devices may be used to present celebratory sights, sounds, and/or other sensations throughout the casino when a player achieves a winning outcome. The celebratory sights, sounds, and/or other sensations increase the overall level of stimuli in the casino, thereby helping to create a celebratory atmosphere. In some embodiments, the celebratory multimedia stimuli are communicated to certain gaming machines in the casino based on a triggering event that occurred at a remote gaming machine. The gaming machines may be the same type and/or brand, or they may be different types and/or brands such that the same celebratory stimuli are used to promote multiple types and/or brands of gaming machines. The celebratory stimuli may also be customized specifically for a gaming machine, a player(s), or a casino.
摘要翻译： 游戏机系统包括多个多媒体输出设备，包括围绕娱乐场策略地安装的音频，视觉和/或触觉设备。 当玩家获得胜利结果时，多媒体设备可用于在整个赌场呈现庆祝的景点，声音和/或其他感觉。 庆祝的景点，声音和/或其他感觉增加了赌场的整体刺激水平，从而有助于创造一个庆祝的气氛。 在一些实施例中，基于在远程游戏机上发生的触发事件，将庆祝的多媒体刺激传送到娱乐场中的某些游戏机。 游戏机可以是相同的类型和/或品牌，或者它们可以是不同类型和/或品牌，使得相同的庆祝刺激被用于促进游戏机的多种类型和/或品牌。 庆祝的刺激也可以专门为游戏机，玩家或娱乐场定制。
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2.发明授权MDCK cell lines supporting viral growth to high titers and bioreactor process using the same 有权支持病毒生长至高滴度的MDCK细胞系和使用其的生物反应器过程公开(公告)号：US08846032B2
公开(公告)日：2014-09-30
申请号：US13595897
申请日：2012-08-27
申请人： Jonathan Liu , Richard Schwartz , Mark Thompson , Luis Maranga , Mridul Ghosh , Ajit Subramanian , Simon Sheng-Tsiung Hsu
发明人： Jonathan Liu , Richard Schwartz , Mark Thompson , Luis Maranga , Mridul Ghosh , Ajit Subramanian , Simon Sheng-Tsiung Hsu
CPC分类号： C12N7/00 , C12N2760/16151 , C12N2760/16152 , C12N2760/16251 , C12N2760/16252
摘要： The present invention relates to novel MDCK cells which can be to grow viruses, e.g., influenza viruses, in cell culture to higher titer than previously possible. The MDCK cells can be adapted to serum-free culture medium. The present invention further relates to cell culture compositions comprising the MDCK cells and cultivation methods for growing the MDCK cells. The present invention further relates to methods for producing influenza viruses in cell culture using the MDCK cells of the invention.
摘要翻译： 本发明涉及可以在细胞培养中将病毒（例如流感病毒）生长至比先前可能更高滴度的新型MDCK细胞。 MDCK细胞可适应于无血清培养基。 本发明还涉及包含MDCK细胞的细胞培养组合物和用于培养MDCK细胞的培养方法。 本发明还涉及使用本发明的MDCK细胞在细胞培养中生产流感病毒的方法。
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公开(公告)号：US08748174B2
公开(公告)日：2014-06-10
申请号：US13355252
申请日：2012-01-20
CPC分类号： C12N7/00 , C12N5/0037 , C12N5/0043 , C12N2500/36 , C12N2500/76 , C12N2500/90 , C12N2501/11 , C12N2501/395 , C12N2510/02 , C12N2760/16151 , C12N2760/16161 , C12N2760/16251 , C12N2760/16261
摘要： The present invention provides novel MDCK-derived adherent non-tumorigenic cell lines that can be grown in the presence or absence of serum. The cell lines of the present invention are useful for the production of vaccine material (e.g., viruses). More specifically, the cell lines of the present invention are useful for the production of influenza viruses in general and ca/ts influenza viruses in particular. The invention further provides methods and media formulations for the adaptation and cultivation of MDCK cells such that they remain non-tumorigenic. Additionally, the present invention provides methods for the production of vaccine material (e.g., influenza virus) in the novel cell lines of the invention.
摘要翻译： 本发明提供可在血清存在或不存在的情况下生长的新型MDCK衍生的粘附性非致瘤细胞系。 本发明的细胞系可用于生产疫苗材料（例如病毒）。 更具体地说，本发明的细胞系通常用于生产流感病毒，尤其是流感病毒。 本发明还提供了用于适应和培养MDCK细胞的方法和培养基制剂，使得它们保持非致瘤性。 此外，本发明提供了在本发明的新型细胞系中生产疫苗材料（例如流感病毒）的方法。
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公开(公告)号：US08336541B2
公开(公告)日：2012-12-25
申请号：US12592406
申请日：2009-11-24
IPC分类号： A61M11/00
CPC分类号： A61M16/0488 , A61B1/267 , A61M16/0418 , A61M16/0434
摘要： An endotracheal intubation device 10 is disclosed. The endotracheal intubation device 10 includes a stylet 100, an elongate rod 300 mounted within the stylet 100 and adapted to deform/curve the stylet 100 as well as an endotracheal tube 400 mounted thereto by contacting an inner wall of the endotracheal tube 400 via a slot 130 through which the rod 300 bows outwardly, and a handle 200 mounted to the stylet 100 and adapted to actuate the elongate rod 300 to deform/curve the stylet 100. The endotracheal intubation device 10 can be used on a patient by a medical professional to access the patient's trachea by inserting the endotracheal tube 400 into the patient. Upon insertion, the handle 200 is actuated to deform the stylet 100.
摘要翻译： 公开了一种气管内插管装置10。 气管内插管装置10包括探针装置100，安装在探针100内的细长杆300，并且适于使探针管100变形/弯曲，以及通过气管插管400的内壁经由插槽 130，杆300通过其向外弯曲;以及手柄200，其安装到探针100上并且适于致动细长杆300以使管心针100变形/弯曲。气管插管装置10可由医疗专业人员在患者身上使用 通过将气管插管400插入患者来进入病人的气管。 在插入时，手柄200被致动以使探针100变形。
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公开(公告)号：US20120115206A1
公开(公告)日：2012-05-10
申请号：US13355252
申请日：2012-01-20
CPC分类号： C12N7/00 , C12N5/0037 , C12N5/0043 , C12N2500/36 , C12N2500/76 , C12N2500/90 , C12N2501/11 , C12N2501/395 , C12N2510/02 , C12N2760/16151 , C12N2760/16161 , C12N2760/16251 , C12N2760/16261
摘要： The present invention provides novel MDCK-derived adherent non-tumorigenic cell lines that can be grown in the presence or absence of serum. The cell lines of the present invention are useful for the production of vaccine material (e.g., viruses). More specifically, the cell lines of the present invention are useful for the production of influenza viruses in general and ca/ts influenza viruses in particular. The invention further provides methods and media formulations for the adaptation and cultivation of MDCK cells such that they remain non-tumorigenic. Additionally, the present invention provides methods for the production of vaccine material (e.g., influenza virus) in the novel cell lines of the invention.
摘要翻译： 本发明提供可在血清存在或不存在的情况下生长的新型MDCK衍生的粘附性非致瘤细胞系。 本发明的细胞系可用于生产疫苗材料（例如病毒）。 更具体地说，本发明的细胞系通常用于生产流感病毒，尤其是流感病毒。 本发明还提供了用于适应和培养MDCK细胞的方法和培养基制剂，使得它们保持非致瘤性。 此外，本发明提供了在本发明的新型细胞系中生产疫苗材料（例如流感病毒）的方法。
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公开(公告)号：US20110196204A1
公开(公告)日：2011-08-11
申请号：US12931746
申请日：2011-02-09
申请人： Harsha Setty , Richard Schwartz , John Schwartz
发明人： Harsha Setty , Richard Schwartz , John Schwartz
CPC分类号： A61M16/04 , A61B1/00052 , A61B1/00154 , A61B1/0052 , A61B1/0056 , A61B1/0058 , A61B1/018 , A61B1/267 , A61M16/0418 , A61M16/0431 , A61M16/0488 , A61M2205/502
摘要： The disclosure generally relates to an endotracheal intubation device 100 including a channel element 120 that defines a first channel 122 and additional retaining structure that defines a second channel 140. The device 100 is reversibly movable between a first relaxed position A (e.g., a generally extended or straight position) and a second curved position B (e.g., an articulated, generally non-linear position) with an articulating means 160. An endotracheal tube 200 can be inserted into the second channel 140, and the intubation device 100 then can be used to intubate a patient P according to a disclosed intubation method.
摘要翻译： 本公开内容通常涉及气管插管装置100，其包括限定第一通道122的通道元件120和限定第二通道140的附加保持结构。装置100可在第一松弛位置A（例如，大体上延伸 或直线位置）和第二弯曲位置B（例如，铰接的，大致非线性位置）具有关节运动装置160.气管插管200可插入第二通道140中，然后可以使用插管装置100 根据所公开的插管方法插管患者P。
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公开(公告)号：US20110137127A1
公开(公告)日：2011-06-09
申请号：US12928126
申请日：2010-12-03
申请人： John Schwartz , Richard Schwartz , Harsha Setty
发明人： John Schwartz , Richard Schwartz , Harsha Setty
IPC分类号： A61B1/267
CPC分类号： A61B1/267 , A61B1/00052 , A61B1/05 , A61B1/2673
摘要： A system and method are disclosed for using a laryngoscope blade with a camera and an endotracheal intubation device with a camera to enable simultaneous viewing of images from the two cameras on a display means such as an LCD display screen. The system enables accurate insertion and placement of an endotracheal tube in a patient with less risk to the patient.
摘要翻译： 公开了一种用于使用具有照相机的喉镜刀片和具有照相机的气管插管装置的系统和方法，以能够在诸如LCD显示屏的显示装置上同时观看来自两个照相机的图像。 该系统能够将患者的气管插管精确插入和放置在病人身上，风险较小。
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公开(公告)号：US20110120458A1
公开(公告)日：2011-05-26
申请号：US12592406
申请日：2009-11-24
CPC分类号： A61M16/0488 , A61B1/267 , A61M16/0418 , A61M16/0434
摘要： An endotracheal intubation device 10 is disclosed. The endotracheal intubation device 10 includes a stylet 100, an elongate rod 300 mounted within the stylet 100 and adapted to deform/curve the stylet 100 as well as an endotracheal tube 400 mounted thereto by contacting an inner wall of the endotracheal tube 400 via a slot 130 through which the rod 300 bows outwardly, and a handle 200 mounted to the stylet 100 and adapted to actuate the elongate rod 300 to deform/curve the stylet 100. The endotracheal intubation device 10 can be used on a patient by a medical professional to access the patient's trachea by inserting the endotracheal tube 400 into the patient. Upon insertion, the handle 200 is actuated to deform the stylet 100.
摘要翻译： 公开了一种气管内插管装置10。 气管内插管装置10包括探针装置100，安装在探针100内的细长杆300，并且适于使探针管100变形/弯曲，以及通过气管插管400的内壁经由插槽 130，杆300通过其向外弯曲;以及手柄200，其安装到探针100上并且适于致动细长杆300以使管心针100变形/弯曲。气管插管装置10可由医疗专业人员在患者身上使用 通过将气管插管400插入患者来进入病人的气管。 在插入时，手柄200被致动以使探针100变形。
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公开(公告)号：US07658708B2
公开(公告)日：2010-02-09
申请号：US11230392
申请日：2005-09-20
申请人： John Schwartz , Richard Schwartz
发明人： John Schwartz , Richard Schwartz
CPC分类号： A61B1/267 , A61B1/00032 , A61M16/0418 , A61M16/0488
摘要： An endotracheal intubation device having a curvable portion and internal optics or a viewing device which facilitate the insertion of an endotracheal tube into a patient. The device has a handle and a trigger. When the trigger is squeezed the curvable portion curves in a controlled manner from a fully straight configuration.
摘要翻译： 一种气管内插管装置，其具有可弯曲部分和内部光学器件，或观察装置，其便于将气管插管插入患者体内。 该设备具有句柄和触发器。 当触发器被挤压时，可弯曲部分以完全直的构型以受控的方式弯曲。
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10.外观设计公开(公告)号：USD603958S1
公开(公告)日：2009-11-10
申请号：US29312314
申请日：2008-10-14
申请人： John Schwartz , Richard Schwartz , Harsha Setty
设计人： John Schwartz , Richard Schwartz , Harsha Setty
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