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    Antimicrobial medicotechnical product, process for its production and use
    1.
    发明申请
    Antimicrobial medicotechnical product, process for its production and use 有权
    抗菌药物产品，其生产和使用过程

    公开(公告)号：US20080292675A1

    公开(公告)日：2008-11-27

    申请号：US12073560

    申请日：2008-03-06

    申请人： Erich Edermatt ,  Ingo Berndt ,  Joerg Tiller ,  Chau Hon Ho

    发明人： Erich Edermatt ,  Ingo Berndt ,  Joerg Tiller ,  Chau Hon Ho

    IPC分类号： A01N25/26 ,  A61K9/16 ,  A01P15/00 ,  A61K38/02

    CPC分类号： A61L29/16 ,  A61L15/46 ,  A61L17/005 ,  A61L17/10 ,  A61L29/085 ,  A61L2300/102 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/624 ,  A61L2400/12 ,  C08L77/04

    摘要： The invention relates to a medicotechnical product having an antimicrobial finish consisting of a complex material of metal nanoparticles and macromolecules, the macromolecules being at least partially formed from amphiphilically modified polyamino acids which contain amino acid units, which aside from the functional groups bonded in the peptide bond contain at least one further functional group and at least some of these groups are modified with substances bearing hydrophobic radicals via covalent bonds. The hydrophobic radicals are bonded by addition of substances bearing epoxy groups to the at least one further functional group and/or via at least one amino group of an amino acid unit bearing at least one amino group as a further functional group with maintenance of an amino function on the polyamino acids. The invention furthermore relates to the production of the complex material and of the medicotechnical product.

    摘要翻译： 本发明涉及具有由金属纳米颗粒和大分子的复合材料组成的抗微生物整理剂的药物产品，所述大分子至少部分地由包含氨基酸单元的两亲改性的聚氨基酸形成，除了与肽键合的官能团 键含有至少一个另外的官能团，并且这些基团中的至少一些通过共价键与具有疏水基团的物质一起被修饰。 通过向至少一个另外的官能团和/或经由具有至少一个氨基的氨基酸单元的至少一个氨基作为另外的官能团加入带有环氧基团的物质来结合疏水基团，维持氨基 对聚氨基酸起作用。 本发明还涉及复合材料和医药产品的生产。

    Antimicrobial medicotechnical product, process for its production and use
    2.
    发明授权
    Antimicrobial medicotechnical product, process for its production and use 有权
    抗菌药物产品，其生产和使用过程

    公开(公告)号：US08105619B2

    公开(公告)日：2012-01-31

    申请号：US12073560

    申请日：2008-03-06

    申请人： Erich Odermatt ,  Ingo Berndt ,  Joerg Tiller ,  Chau Hon Ho

    发明人： Erich Odermatt ,  Ingo Berndt ,  Joerg Tiller ,  Chau Hon Ho

    IPC分类号： A61K47/00 ,  A01N25/00

    CPC分类号： A61L29/16 ,  A61L15/46 ,  A61L17/005 ,  A61L17/10 ,  A61L29/085 ,  A61L2300/102 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/624 ,  A61L2400/12 ,  C08L77/04

    摘要： The invention relates to a medicotechnical product having an antimicrobial finish consisting of a complex material of metal nanoparticles and macromolecules, the macromolecules being at least partially formed from amphiphilically modified polyamino acids which contain amino acid units, which aside from the functional groups bonded in the peptide bond contain at least one further functional group and at least some of these groups are modified with substances bearing hydrophobic radicals via covalent bonds. The hydrophobic radicals are bonded by addition of substances bearing epoxy groups to the at least one further functional group and/or via at least one amino group of an amino acid unit bearing at least one amino group as a further functional group with maintenance of an amino function on the polyamino acids. The invention furthermore relates to the production of the complex material and of the medicotechnical product.

    摘要翻译： 本发明涉及具有由金属纳米颗粒和大分子的复合材料组成的抗微生物整理剂的药物产品，所述大分子至少部分地由包含氨基酸单元的两亲改性的聚氨基酸形成，除了与肽键合的官能团 键含有至少一个另外的官能团，并且这些基团中的至少一些通过共价键与具有疏水基团的物质一起被修饰。 通过向至少一个另外的官能团和/或经由具有至少一个氨基的氨基酸单元的至少一个氨基作为另外的官能团加入带有环氧基团的物质来结合疏水基团，维持氨基 对聚氨基酸起作用。 本发明还涉及复合材料和医药产品的生产。

    Antimicrobial polymeric surfaces
    4.
    发明申请
    Antimicrobial polymeric surfaces 审中-公开
    抗微生物聚合物表面

    公开(公告)号：US20050249695A1

    公开(公告)日：2005-11-10

    申请号：US11107412

    申请日：2005-04-14

    申请人： Joerg Tiller ,  Chun-Jen Liao ,  Kim Lewis ,  Alexander Klibanov

    发明人： Joerg Tiller ,  Chun-Jen Liao ,  Kim Lewis ,  Alexander Klibanov

    IPC分类号： A01N43/40 ,  A61L27/34 ,  A61L27/50 ,  A61K31/785

    CPC分类号： A61L27/50 ,  A01N43/40 ,  A61L27/34 ,  A01N25/34 ,  A01N25/10 ,  A01N2300/00 ,  C08L33/14

    摘要： Bactericidal compositions are disclosed that comprise a polymeric compound immobilized on a material. Medical devices are also disclosed which comprise such a bactericidal composition. Methods are disclosed for covalently derivatizing the surfaces of common materials with an antibacterial polycation, e.g., poly(vinyl-N-pyridinium bromide); the first step of the methods involves coating the surface with a nanolayer of silica. Various commercial synthetic polymers derivatized in this manner are bactericidal, i.e., they kill on contact up to 99% of deposited Gram-positive and Gram-negative bacteria, whether deposited through air or water.

    摘要翻译： 公开了包含固定在材料上的聚合物的杀菌组合物。 还公开了包含这种杀菌组合物的医疗装置。 公开了用抗菌聚阳离子共价衍生普通材料的表面的方法，例如聚（乙烯基-N-吡啶鎓溴化物）; 该方法的第一步包括用纳米二氧化硅涂覆表面。 以这种方式衍生的各种商业合成聚合物是杀菌剂的，即它们在接触高达99％的沉积的革兰氏阳性和革兰氏阴性细菌时杀死，无论是通过空气还是水沉积。