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    Antimicrobial medicotechnical product, process for its production and use
    8.
    发明授权
    Antimicrobial medicotechnical product, process for its production and use 有权
    抗菌药物产品，其生产和使用过程

    公开(公告)号：US08105619B2

    公开(公告)日：2012-01-31

    申请号：US12073560

    申请日：2008-03-06

    申请人： Erich Odermatt ,  Ingo Berndt ,  Joerg Tiller ,  Chau Hon Ho

    发明人： Erich Odermatt ,  Ingo Berndt ,  Joerg Tiller ,  Chau Hon Ho

    IPC分类号： A61K47/00 ,  A01N25/00

    CPC分类号： A61L29/16 ,  A61L15/46 ,  A61L17/005 ,  A61L17/10 ,  A61L29/085 ,  A61L2300/102 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/624 ,  A61L2400/12 ,  C08L77/04

    摘要： The invention relates to a medicotechnical product having an antimicrobial finish consisting of a complex material of metal nanoparticles and macromolecules, the macromolecules being at least partially formed from amphiphilically modified polyamino acids which contain amino acid units, which aside from the functional groups bonded in the peptide bond contain at least one further functional group and at least some of these groups are modified with substances bearing hydrophobic radicals via covalent bonds. The hydrophobic radicals are bonded by addition of substances bearing epoxy groups to the at least one further functional group and/or via at least one amino group of an amino acid unit bearing at least one amino group as a further functional group with maintenance of an amino function on the polyamino acids. The invention furthermore relates to the production of the complex material and of the medicotechnical product.

    摘要翻译： 本发明涉及具有由金属纳米颗粒和大分子的复合材料组成的抗微生物整理剂的药物产品，所述大分子至少部分地由包含氨基酸单元的两亲改性的聚氨基酸形成，除了与肽键合的官能团 键含有至少一个另外的官能团，并且这些基团中的至少一些通过共价键与具有疏水基团的物质一起被修饰。 通过向至少一个另外的官能团和/或经由具有至少一个氨基的氨基酸单元的至少一个氨基作为另外的官能团加入带有环氧基团的物质来结合疏水基团，维持氨基 对聚氨基酸起作用。 本发明还涉及复合材料和医药产品的生产。