公开(公告)号：US5880258A

公开(公告)日：1999-03-09

申请号：US909735

申请日：1997-08-12

申请人： Ryo Muramatsu ,  Akiko Sukesada ,  Satoru Misawa ,  Eriko Nukui ,  Koichi Wada ,  Masaharu Nakano ,  Tadanori Morikawa ,  Kyoichi Kobashi

发明人： Ryo Muramatsu ,  Akiko Sukesada ,  Satoru Misawa ,  Eriko Nukui ,  Koichi Wada ,  Masaharu Nakano ,  Tadanori Morikawa ,  Kyoichi Kobashi

IPC分类号： A61K38/00 ,  C07K14/815 ,  C07K14/00

CPC分类号： C07K14/815 ,  A61K38/00

摘要： The present invention relates to hirudin variants having high anti-thrombin and anti-platelet activity, methods for producing them, and anti-coagulants having said variants as active ingredients.Hirudin variants shown in formula (I) having tyrosine residues or having their hydroxyl group sulfated.Methods for producing hirudin variants by sulfating hydroxyl group of said tyrosine residues, and anti-coagulants having hirudin variants shown in formula (I) as active ingredients.Phe-Glu-A-Ile-Pro-D-Tyr(R) Tyr(R) (I)�In the formula, A represents Glu or Pro, R represents Glu, Tyr (R), Glu-Asp or Glu-Tyr(R), and (R) represents the hydroxy group or its sulfated ester (--O--SO.sub.3 H) of tyrosine residue.!

摘要翻译： 本发明涉及具有高抗凝血酶和抗血小板活性的水蛭素变体，其制备方法和具有所述变体作为活性成分的抗凝血剂。 具有酪氨酸残基或其羟基硫酸化的式（I）所示的水蛭素变体。 通过硫酸化所述酪氨酸残基的羟基来生产水蛭变异体的方法和具有式（I）所示的水蛭素变体的抗凝血剂作为活性成分。Phe-Glu-A-Ile-Pro-D-Tyr（R）Tyr ）（I）[式中，A表示Glu或Pro，R表示Glu，Tyr（R），Glu-Asp或Glu-Tyr（R），（R）表示羟基或其硫酸酯 -SO3H）酪氨酸残基。

公开(公告)号：US5767235A

公开(公告)日：1998-06-16

申请号：US367758

申请日：1995-01-03

申请人： Eriko Nukui ,  Koichi Wada ,  Masaharu Nakano ,  Tadanori Morikawa ,  Kyoichi Kobashi ,  Ryo Muramatsu ,  Akiko Sukesada ,  Satoru Misawa

发明人： Eriko Nukui ,  Koichi Wada ,  Masaharu Nakano ,  Tadanori Morikawa ,  Kyoichi Kobashi ,  Ryo Muramatsu ,  Akiko Sukesada ,  Satoru Misawa

IPC分类号： A61K38/00 ,  C07K14/815 ,  A61K38/08

CPC分类号： C07K14/815 ,  A61K38/00

摘要： The present invention relates to hirudin variants having high anti-thrombin and anti-platelet activity, methods for producing them, and anti-coagulants having said variants as active ingredients. Hirudin variants shown in formula (I) having tyrosine residues or having their hydroxyl group sulfated. Methods for producing hirudin variants by sulfating hydroxyl group of said tyrosine residues, and anti-coagulants having hirudin variants shown in formula (I) as active ingredients. Phe-Glu-A-Ile-Pro-B-Tyr(R)-Tyr(R) (I) �In the formula, A represents Glu or Pro, B represents Glu, Tyr (R), Glu-Asp or Glu-Tyr(R), and (R) represents the hydroxy group or its sulfated ester (--O--SO.sub.3 H) of tyrosine residue.!

摘要翻译： 本发明涉及具有高抗凝血酶和抗血小板活性的水蛭素变体，其制备方法和具有所述变体作为活性成分的抗凝血剂。 具有酪氨酸残基或其羟基硫酸化的式（I）所示的水蛭素变体。 通过将所述酪氨酸残基的羟基硫酸化制备水蛭变体的方法和具有式（I）所示水蛭素变体的抗凝血剂作为活性成分。Phe-Glu-A-Ile-Pro-B-Tyr（R）-Tyr R）（I）[式中，A表示Glu或Pro，B表示Glu，Tyr（R），Glu-Asp或Glu-Tyr（R），（R）表示羟基或其硫酸酯（ - O-SO3H）酪氨酸残基。

公开(公告)号：US06228841B1

公开(公告)日：2001-05-08

申请号：US09029604

申请日：1998-04-28

申请人： Shinobu Sakurada ,  Toru Okayama ,  Eriko Nukui ,  Kazuya Hongo ,  Tadashi Ogawa ,  Tomoko Hongo ,  Satoko Takeshima ,  Nobuhiro Take ,  Masaharu Nakano

发明人： Shinobu Sakurada ,  Toru Okayama ,  Eriko Nukui ,  Kazuya Hongo ,  Tadashi Ogawa ,  Tomoko Hongo ,  Satoko Takeshima ,  Nobuhiro Take ,  Masaharu Nakano

IPC分类号： A61K3807

CPC分类号： C07K7/02 ,  A61K38/00 ,  C07K5/0202

摘要： Compounds represented by the following general formula and salts thereof; Y-L-Tyr-Q-NR1—CH(R2)—CO—X, wherein R1 represents hydrogen or C1-6 alkyl; R2 represents optionally substituted benzyl; Q represents D- or L-Arg; Y represents two hydrogen atoms of N-terminal amino group of L-Tyr, or one or two functional groups substituting for the hydrogen atoms, for example, a C1-6 alkyl optionally having amino or carboxy; and X represents N-methyl-&bgr;-alanine and other. The compounds have analgesic effect and can be used for the treatment of cancer pain or the like.

摘要翻译： 由以下通式表示的化合物及其盐; Y-L-Tyr-Q-NR1-CH（R2）-CO-X，其中R1表示氢或C1-6烷基; R2代表任选取代的苄基; Q表示D-或L-Arg; Y代表L-Tyr的N末端氨基的两个氢原子，或一个或两个取代氢原子的官能团，例如任选具有氨基或羧基的C 1-6烷基; X表示N-甲基-β-丙氨酸等。 这些化合物具有镇痛作用，可用于治疗癌症疼痛等。

公开(公告)号：US20110188358A1

公开(公告)日：2011-08-04

申请号：US13122101

申请日：2008-10-03

申请人： Kazuo Takahashi ,  Masaharu Nakano

发明人： Kazuo Takahashi ,  Masaharu Nakano

IPC分类号： G11B7/09

CPC分类号： G11B7/0945 ,  G11B7/08505 ,  G11B2007/0013

摘要： Disclosed herein are an optical recording medium driving device and an additional recording method, which performs tracking servo control for moving an objective lens in a direction orthogonal to a tangential direction of a guide track so that a guide tracking error signal is decreased with respect to a guide track of a guide layer separation type recording medium, detects an additional recording start position subsequent to a recorded track if the recorded track is present in a recording layer of the optical recording medium, generates a tracking correction signal according to the reproduction tracking error signal upon tracking servo control of the recorded track just before the additional recording start position, and corrects tracking servo control according to the tracking correction signal upon additional recording start.

摘要翻译： 本文公开了一种光记录介质驱动装置和附加记录方法，其执行跟踪伺服控制，用于在与导轨的切线方向正交的方向上移动物镜，使得引导跟踪误差信号相对于 引导层分离型记录介质的引导轨迹，如果记录的轨道存在于光记录介质的记录层中，则检测记录轨道之后的附加记录开始位置，根据再现跟踪误差信号产生跟踪校正信号 在附加记录开始位置之前跟踪记录的轨道的伺服控制，并且在附加记录开始时根据跟踪校正信号来校正跟踪伺服控制。

公开(公告)号：US08189433B2

公开(公告)日：2012-05-29

申请号：US13122101

申请日：2008-10-03

申请人： Kazuo Takahashi ,  Masaharu Nakano

发明人： Kazuo Takahashi ,  Masaharu Nakano

IPC分类号： G11B7/004

CPC分类号： G11B7/0945 ,  G11B7/08505 ,  G11B2007/0013

摘要： Disclosed herein are an optical recording medium driving device and an additional recording method, which performs tracking servo control for moving an objective lens in a direction orthogonal to a tangential direction of a guide track so that a guide tracking error signal is decreased with respect to a guide track of a guide layer separation type recording medium, detects an additional recording start position subsequent to a recorded track if the recorded track is present in a recording layer of the optical recording medium, generates a tracking correction signal according to the reproduction tracking error signal upon tracking servo control of the recorded track just before the additional recording start position, and corrects tracking servo control according to the tracking correction signal upon additional recording start.

摘要翻译： 本文公开了一种光记录介质驱动装置和附加记录方法，其执行跟踪伺服控制，用于在与导轨的切线方向正交的方向上移动物镜，使得引导跟踪误差信号相对于 引导层分离型记录介质的引导轨迹，如果记录的轨道存在于光记录介质的记录层中，则检测记录轨道之后的附加记录开始位置，根据再现跟踪误差信号产生跟踪校正信号 在附加记录开始位置之前跟踪记录的轨道的伺服控制，并且在附加记录开始时根据跟踪校正信号来校正跟踪伺服控制。

公开(公告)号：US20120069723A1

公开(公告)日：2012-03-22

申请号：US13265684

申请日：2009-04-24

申请人： Makoto Sato ,  Masakazu Ogasawara ,  Kazuo Takahashi ,  Masaharu Nakano

发明人： Makoto Sato ,  Masakazu Ogasawara ,  Kazuo Takahashi ,  Masaharu Nakano

IPC分类号： G11B7/00

CPC分类号： G11B7/0938 ,  G11B7/0908 ,  G11B7/1356 ,  G11B7/1378 ,  G11B7/139 ,  G11B7/13925 ,  G11B2007/0013

摘要： An optical recording medium drive device including: a combining prism for combining a recording first laser beam emitted from a first light source with a recording second laser beam emitted from the first light source so as to coaxially guide them; an objective lens for condensing the first and second laser beams from the combining prism toward an optical recording medium; a first photodetecting means for detecting reflected light of the first laser beam from a recording layer; a second photodetecting means for detecting reflected light of the second laser beam from a guide layer; a magnification conversion element disposed on an optical path of the second laser beam between a second light source and the combining prism for diffusing or converging the second laser beam incident upon the objective lens; a first focus error generating means for generating a first focus error signal indicating an error between a condensed spot position of the first laser beam and the recording layer based on an output signal of the first photodetecting means; a second focus error generating means for generating a second focus error signal indicating an error between a condensed spot position of the second laser beam and the guide layer based on an output signal of the second photodetecting means; a first focus control means for controlling the objective lens in an optical axis direction thereof in accordance with the first focus error signal; and a second focus control means for controlling a magnitude of the diffusion or convergence of the second laser beam by the magnification conversion element in accordance with the second focus error signal.

摘要翻译： 一种光记录介质驱动装置，包括：组合棱镜，用于将从第一光源发射的记录第一激光束与从第一光源发射的记录第二激光束组合以同轴地引导它们; 用于将来自组合棱镜的第一和第二激光束聚光到光学记录介质的物镜; 用于从记录层检测第一激光束的反射光的第一光检测装置; 用于从引导层检测第二激光束的反射光的第二光电检测装置; 放大转换元件，设置在所述第二激光束的光路上，在第二光源与所述组合棱镜之间，用于使入射到所述物镜上的所述第二激光束扩散或会聚; 第一聚焦误差产生装置，用于基于第一光电检测装置的输出信号产生指示第一激光束的聚光点位置与记录层之间的误差的第一聚焦误差信号; 第二聚焦误差产生装置，用于基于第二光电检测装置的输出信号产生指示第二激光束的聚光点位置与引导层之间的误差的第二聚焦误差信号; 第一聚焦控制装置，用于根据第一聚焦误差信号在其光轴方向上控制物镜; 以及第二焦点控制装置，用于根据第二聚焦误差信号来控制放大转换元件的第二激光束的扩散或会聚的大小。

公开(公告)号：US08111604B2

公开(公告)日：2012-02-07

申请号：US12593036

申请日：2007-03-29

申请人： Masaharu Nakano ,  Masakazu Ogasawara ,  Makoto Sato

发明人： Masaharu Nakano ,  Masakazu Ogasawara ,  Makoto Sato

IPC分类号： G11B7/24

CPC分类号： G11B7/26 ,  G11B7/0045 ,  G11B7/00745 ,  G11B7/0908 ,  G11B7/24038

摘要： A fabrication method of a multilayer optical recording medium having a plurality of recording layers, comprises a step of preparing an optical recording medium having at least one record area; a write-position mark generating step of recording write-position marks in the record area beforehand; a step of preparing an optical system including a common objective lens to focus a data recording beam and a position mark recording beam on different positions in a thickness direction of the record area; a first data writing step of writing data between the write-position marks with following the write-position marks by the data recording beam; a position mark recording step of, in parallel with the first data writing step, recording new write-position marks in the record area by the position mark recording beam; and a second data writing step of writing data between the new write-position marks with following the new write-position marks by the data recording beam.

摘要翻译： 一种具有多个记录层的多层光学记录介质的制造方法，包括制备具有至少一个记录区域的光学记录介质的步骤; 写入位置标记生成步骤，预先在记录区域中记录写入位置标记; 准备包括用于将数据记录光束和位置标记记录光束聚焦在记录区域的厚度方向上的不同位置上的公共物镜的光学系统的步骤; 第一数据写入步骤，在写入位置标记之间通过数据记录光束跟随写入位置标记来写入数据; 位置标记记录步骤，与第一数据写入步骤并行，通过位置标记记录光束在记录区域中记录新的写入位置标记; 以及第二数据写入步骤，用于通过数据记录光束在新的写入位置标记之间写入新的写入位置标记之间的数据。

公开(公告)号：US6051685A

公开(公告)日：2000-04-18

申请号：US145648

申请日：1998-09-02

申请人： Shinobu Sakurada ,  Kimie Murayama ,  Masaharu Nakano ,  Kazuya Hongo ,  Satoko Takeshima ,  Nobuhiro Take

发明人： Shinobu Sakurada ,  Kimie Murayama ,  Masaharu Nakano ,  Kazuya Hongo ,  Satoko Takeshima ,  Nobuhiro Take

IPC分类号： C07K5/087 ,  A61K38/06

CPC分类号： C07K5/0812

摘要： A peptide derivative having analgesic activity represented by the following Formula I: ##STR1## wherein Q represents D-Arg or L-Arg; and X represents for example NR.sup.6 --CHR.sup.7 R.sup.8. Typical compounds include H.sub.2 NC(NH)-Tyr-D-Arg-Phe-NHCH.sub.2 CH.sub.2 COOH and H.sub.2 NC(NH)-Tyr-D-Arg-Phe-NHCH.sub.2 CH.sub.2 CONH.sub.2.

摘要翻译： 具有由下式I表示的止痛活性的肽衍生物：其中Q表示D-Arg或L-Arg; X表示例如NR 6 -CHR 7 R 8。 典型的化合物包括H2NC（NH）-Tyr-D-Arg-Phe-NHCH2CH2COOH和H2NC（NH）-Tyr-D-Arg-Phe-NHCH2CH2CONH2。

公开(公告)号：US20100046349A1

公开(公告)日：2010-02-25

申请号：US12593036

申请日：2007-03-29

申请人： Masaharu Nakano ,  Masakazu Ogasawara ,  Makoto Sato

发明人： Masaharu Nakano ,  Masakazu Ogasawara ,  Makoto Sato

IPC分类号： G11B7/00 ,  G11B7/0045

CPC分类号： G11B7/26 ,  G11B7/0045 ,  G11B7/00745 ,  G11B7/0908 ,  G11B7/24038

摘要： A fabrication method of a multilayer optical recording medium having a plurality of recording layers, comprises a step of preparing an optical recording medium having at least one record area; a write-position mark generating step of recording write-position marks in the record area beforehand; a step of preparing an optical system including a common objective lens to focus a data recording beam and a position mark recording beam on different positions in a thickness direction of the record area; a first data writing step of writing data between the write-position marks with following the write-position marks by the data recording beam; a position mark recording step of, in parallel with the first data writing step, recording new write-position marks in the record area by the position mark recording beam; and a second data writing step of writing data between the new write-position marks with following the new write-position marks by the data recording beam.

摘要翻译： 一种具有多个记录层的多层光学记录介质的制造方法，包括制备具有至少一个记录区域的光学记录介质的步骤; 写入位置标记生成步骤，预先在记录区域中记录写入位置标记; 准备包括用于将数据记录光束和位置标记记录光束聚焦在记录区域的厚度方向上的不同位置上的公共物镜的光学系统的步骤; 第一数据写入步骤，在写入位置标记之间通过数据记录光束跟随写入位置标记来写入数据; 位置标记记录步骤，与第一数据写入步骤并行，通过位置标记记录光束在记录区域中记录新的写入位置标记; 以及第二数据写入步骤，用于通过数据记录光束在新的写入位置标记之间写入新的写入位置标记之间的数据。