-
公开(公告)号：US20070142414A1
公开(公告)日：2007-06-21
申请号：US11303114
申请日：2005-12-16
IPC分类号： A61K31/506 , A61K31/4745 , C07D471/02
CPC分类号： C07D471/04
摘要： Compounds represented by formula (I) wherein A, R1, R2, R3, R4, R5, and R6 are as defined in the specification, pharmaceutical compositions thereof, and methods of use thereof.
摘要翻译： 由式（I）表示的化合物，其中A，R 1，R 2，R 3，R 4， R 5和R 6如本说明书中所定义，其药物组合物及其使用方法。
-
公开(公告)号：US08673893B2
公开(公告)日：2014-03-18
申请号：US13611679
申请日：2012-09-12
申请人： Andrea Lombardi Borgia , Maria Menichincheri , Paolo Orsini , Achille Panzeri , Ettore Perrone , Ermes Vanotti , Marcella Nesi , Chiara Marchionni
发明人： Andrea Lombardi Borgia , Maria Menichincheri , Paolo Orsini , Achille Panzeri , Ettore Perrone , Ermes Vanotti , Marcella Nesi , Chiara Marchionni
IPC分类号： A61K31/415 , A61K31/535 , A61K31/445
CPC分类号： C07D405/14 , A61K31/496 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12
摘要： Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer.
摘要翻译： 公开了本说明书中定义的式（I）的取代的吲唑衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
-
公开(公告)号：US20100292207A1
公开(公告)日：2010-11-18
申请号：US12668745
申请日：2008-07-08
申请人： Andrea Lombardi Borgia , Maria Menichincheri , Paolo Orsini , Achille Panzeri , Ettore Perrone , Ermes Vanotti , Marcella Nesi , Chiara Marchionni
发明人： Andrea Lombardi Borgia , Maria Menichincheri , Paolo Orsini , Achille Panzeri , Ettore Perrone , Ermes Vanotti , Marcella Nesi , Chiara Marchionni
IPC分类号： A61K31/416 , C07D403/12 , C07D231/56 , C07D405/14 , C07D405/12 , C07D413/14 , C07D403/14 , C07D413/12 , A61K31/497 , A61K31/5513 , A61K31/454 , A61K31/5377 , A61P35/00 , A61P29/00 , A61P27/02 , A61P17/06 , A61P35/04 , A61P9/00 , A61P11/00
CPC分类号： C07D405/14 , A61K31/496 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12
摘要： Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer.
摘要翻译： 公开了本说明书中定义的式（I）的取代的吲唑衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
-
公开(公告)号：US07279575B2
公开(公告)日：2007-10-09
申请号：US10912319
申请日：2004-08-05
申请人： Ermes Vanotti , Roberto D'Alessio , Marcellino Tibolla , Mario Varasi , Alessia Montagnoli , Corrado Santocanale , Paolo Orsini , Antonio Pillan
发明人： Ermes Vanotti , Roberto D'Alessio , Marcellino Tibolla , Mario Varasi , Alessia Montagnoli , Corrado Santocanale , Paolo Orsini , Antonio Pillan
IPC分类号： C07D239/02 , A01N43/54 , A61K31/505
CPC分类号： C07D471/04 , A61K31/506 , A61K31/513 , A61K31/52 , A61K41/00 , A61K45/06 , A61K2300/00
摘要： Pyrimidylpyrrole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
摘要翻译： 公开了式（I）的嘧啶基吡咯衍生物及其药学上可接受的盐，如本说明书中定义的制备方法和包含它们的药物组合物; 本发明的化合物在治疗中可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
-
公开(公告)号：US20050043323A1
公开(公告)日：2005-02-24
申请号：US10912319
申请日：2004-08-05
申请人： Ermes Vanotti , Roberto D'Alessio , Marcellino Tibolla , Mario Varasi , Alessia Montagnoli , Corrado Santocanale , Paolo Orsini , Antonio Pillan
发明人： Ermes Vanotti , Roberto D'Alessio , Marcellino Tibolla , Mario Varasi , Alessia Montagnoli , Corrado Santocanale , Paolo Orsini , Antonio Pillan
IPC分类号： A61K31/506 , A61K31/513 , A61K31/52 , A61K41/00 , A61K45/06 , C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , A61K31/506 , A61K31/513 , A61K31/52 , A61K41/00 , A61K45/06 , A61K2300/00
摘要： Pyrimidylpyrrole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
摘要翻译： 公开了本说明书中定义的式（I）的嘧啶基吡咯衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物在治疗中可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
-
公开(公告)号：US07618982B2
公开(公告)日：2009-11-17
申请号：US11311386
申请日：2005-12-19
申请人： Ermes Vanotti , Barbara Forte , Katia Martina , Maria Menichincheri , Alessandra Cirla , Paolo Orsini
发明人： Ermes Vanotti , Barbara Forte , Katia Martina , Maria Menichincheri , Alessandra Cirla , Paolo Orsini
IPC分类号： C07D471/02
CPC分类号： C07D471/04
摘要： Compounds represented by formula (I) wherein A, R1, R2, R3, R4, R5 and R6 are as defined in the specification or a pharmaceutically acceptable salt or solvate thereof, compositions thereof, and methods of use thereof.
摘要翻译： 由式（I）表示的其中A，R 1，R 2，R 3，R 4，R 5和R 6如说明书中所定义的化合物或其药学上可接受的盐或溶剂化物，其组合物及其使用方法。
-
公开(公告)号：US20070142415A1
公开(公告)日：2007-06-21
申请号：US11311386
申请日：2005-12-19
申请人： Ermes Vanotti , Barbara Forte , Katia Martina , Maria Menichincheri , Alessandra Cirla , Paolo Orsini
发明人： Ermes Vanotti , Barbara Forte , Katia Martina , Maria Menichincheri , Alessandra Cirla , Paolo Orsini
IPC分类号： A61K31/506 , A61K31/4745 , C07D471/02
CPC分类号： C07D471/04
摘要： Compounds represented by formula (I) wherein A, R1, R2, R3, R4, R5 and R6 are as defined in the specification or a pharmaceutically acceptable salt or solvate thereof, compositions thereof, and methods of use thereof.
摘要翻译： 由式（I）表示的化合物，其中A，R 1，R 2，R 3，R 4， R 5和R 6如说明书或其药学上可接受的盐或溶剂化物，其组合物及其使用方法中所定义。
-
公开(公告)号：US08299057B2
公开(公告)日：2012-10-30
申请号：US12668745
申请日：2008-07-08
申请人： Andrea Lombardi Borgia , Maria Menichincheri , Paolo Orsini , Achille Panzeri , Ettore Perrone , Ermes Vanotti , Marcella Nesi , Chiara Marchionni
发明人： Andrea Lombardi Borgia , Maria Menichincheri , Paolo Orsini , Achille Panzeri , Ettore Perrone , Ermes Vanotti , Marcella Nesi , Chiara Marchionni
IPC分类号： A61K31/035 , A61K31/55 , A61K31/535 , A61K31/497 , A61K31/445 , A61K31/415 , C07D413/10 , C07D231/56 , C07D243/08
CPC分类号： C07D405/14 , A61K31/496 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12
摘要： Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer.
摘要翻译： 公开了本说明书中定义的式（I）的取代的吲唑衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
-
公开(公告)号：US20140045846A1
公开(公告)日：2014-02-13
申请号：US14061100
申请日：2013-10-23
申请人： Gianluca Mariano Enrico Papeo , Jay Aaron Bertrand , Giovanni Cervi , Barbara Forte , Rosita Lupi , Alessia Montagnoli , Alessandra Scolaro , Fabio Zuccotto , Paolo Orsini , Helena Posteri
发明人： Gianluca Mariano Enrico Papeo , Jay Aaron Bertrand , Giovanni Cervi , Barbara Forte , Rosita Lupi , Alessia Montagnoli , Alessandra Scolaro , Fabio Zuccotto , Paolo Orsini , Helena Posteri
IPC分类号： C07D217/24 , C07D401/12
CPC分类号： C07D217/24 , C07D221/18 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , Y10T436/145555
摘要： There are provided substituted isoquinolin-1(2H)-one derivatives which selectively inhibit the activity of poly (ADP-ribose) polymerase PARP-1 with respect to poly (ADP-ribose) polymerase PARP-2. The compounds of the present invention are therefore useful in treating diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds. A screening method for the identification of compounds capable of binding several PARP proteins, as well the probes used in such method, are further objects of the invention.
摘要翻译： 提供了选择性地抑制聚（ADP-核糖）聚合酶PARP-1相对于聚（ADP-核糖）聚合酶PARP-2的活性的取代的异喹啉-1（2H） - 酮衍生物。 因此，本发明的化合物可用于治疗诸如癌症，心血管疾病，中枢神经系统损伤和不同形式的炎症的疾病。 本发明还提供了制备这些化合物的方法，包含这些化合物的药物组合物，以及利用包含这些化合物的药物组合物治疗疾病的方法。 用于鉴定能够结合若干PARP蛋白的化合物的筛选方法以及在该方法中使用的探针是本发明的另外的目的。
-
10.发明申请3-0X0-2,3-DIHYDRO-1H-ISOINDOLE-4-CARBOXAMIDES WITH SELECTIVE PARP-1 INHIBITION 有权具有选择性PARP-1抑制剂的3-0X0-2,3-二氢-1H-吲哚-4-羧酸酰胺公开(公告)号：US20120245143A1
公开(公告)日：2012-09-27
申请号：US13383611
申请日：2010-07-06
申请人： Gianluca Mariano Enrico Papeo , Alina Anatolievna Busel , Elena Casale , Alexander Khvat , Mikhail Yurievitch Krasavin , Paolo Orsini , Helena Posteri , Alessandra Scolaro
发明人： Gianluca Mariano Enrico Papeo , Alina Anatolievna Busel , Elena Casale , Alexander Khvat , Mikhail Yurievitch Krasavin , Paolo Orsini , Helena Posteri , Alessandra Scolaro
IPC分类号： A61K31/454 , C07D413/10 , A61K31/5377 , C07D401/10 , C07D403/10 , A61K31/496 , C07D401/14 , A61K31/4545 , C07D417/14 , C07D405/14 , C07D413/14 , A61K31/4035 , C07D403/04 , C07D409/14 , A61P35/00 , C07D401/04
CPC分类号： C07D209/46 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： There are provided substituted 3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide derivatives (I) which selectively inhibit the activity of poly (ADP-ribose) polymerase PARP-1 with respect to poly (ADP-ribose) polymerase PARP-2. The compounds of this invention are therefore useful in treating diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.
摘要翻译： 提供取代的3-氧代-2,3-二氢-1H-异吲哚-4-甲酰胺衍生物（I），其选择性地抑制聚（ADP-核糖）聚合酶PARP-1相对于聚（ADP-核糖）的活性， 聚合酶PARP-2。 因此，本发明的化合物可用于治疗诸如癌症，心血管疾病，中枢神经系统损伤和不同形式的炎症的疾病。 本发明还提供了制备这些化合物的方法，包含这些化合物的药物组合物，以及利用包含这些化合物的药物组合物治疗疾病的方法。
-
-
-
-
-
-
-
-
-
搜索结果
32 条记录 (耗时 0.029 秒)
