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1.发明授权公开(公告)号：US08309587B2
公开(公告)日：2012-11-13
申请号：US13419936
申请日：2012-03-14
申请人： Esther Ann Martinborough , Lev Tyler Dewey Fanning , Urvi Jagdishbhai Sheth , Dean Mitchell Wilson , Andreas P. Termin , Timothy Donald Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
发明人： Esther Ann Martinborough , Lev Tyler Dewey Fanning , Urvi Jagdishbhai Sheth , Dean Mitchell Wilson , Andreas P. Termin , Timothy Donald Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
IPC分类号： A01N43/78 , A61K31/425
CPC分类号： C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要： The present invention relates to piperidine and piperazine phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
摘要翻译： 本发明涉及可用作离子通道抑制剂的哌啶和哌嗪苯基磺酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病（包括例如治疗疼痛）的方法。
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公开(公告)号：US20120149742A1
公开(公告)日：2012-06-14
申请号：US13402519
申请日：2012-02-22
申请人： Nicole Hilgraf , Peter Diederik Jan Grootenhuis , Mehdi Numa , Dean Stamos , Corey Anderson , Tara Whitney
发明人： Nicole Hilgraf , Peter Diederik Jan Grootenhuis , Mehdi Numa , Dean Stamos , Corey Anderson , Tara Whitney
IPC分类号： A61K31/427 , A61P29/00 , A61P19/02 , A61P25/06 , A61P25/00 , A61P25/08 , A61P25/28 , A61P25/24 , A61P25/22 , A61P9/06 , A61P25/18 , A61P21/00 , A61P1/00 , A61P13/10 , A61P9/12 , C12N5/071
CPC分类号： C07D417/14
摘要： The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作离子通道抑制剂的杂环衍生物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US08143297B2
公开(公告)日：2012-03-27
申请号：US12913869
申请日：2010-10-28
申请人： Nicole Hilgraf , Peter Diederik Jan Grootenhuis , Mehdi Numa , Dean Stamos , Corey Anderson , Tara Whitney
发明人： Nicole Hilgraf , Peter Diederik Jan Grootenhuis , Mehdi Numa , Dean Stamos , Corey Anderson , Tara Whitney
IPC分类号： A61K31/427 , C12N1/00 , A61P29/00 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/24 , A61P25/22 , A61P19/02 , A61P1/00 , A61P3/10 , A61P31/18 , A61P21/00 , A61P13/00 , A61P13/02
CPC分类号： C07D417/14
摘要： The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作离子通道抑制剂的杂环衍生物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20110082117A1
公开(公告)日：2011-04-07
申请号：US12844047
申请日：2010-07-27
申请人： Esther Martinborough , Lev T.D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
发明人： Esther Martinborough , Lev T.D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
IPC分类号： A61K31/635 , A61K31/454 , A61K31/4178 , A61P29/00 , A61P25/00 , A61P13/00 , A61P17/00
CPC分类号： C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要： The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作离子通道抑制剂的杂环衍生物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20110059965A1
公开(公告)日：2011-03-10
申请号：US12830743
申请日：2010-07-06
申请人： Aarti Sameer Kawatkar , Tara Whitney , Timothy D. Neubert , Nicole Hilgraf , Andreas P. Termin , Esther Martinborough
发明人： Aarti Sameer Kawatkar , Tara Whitney , Timothy D. Neubert , Nicole Hilgraf , Andreas P. Termin , Esther Martinborough
IPC分类号： A61K31/5377 , A61K31/427 , A61K31/433 , A61K31/4725 , A61K31/4709 , A61K31/4439 , A61K31/506 , A61K31/501 , A61K31/454 , A61P29/00 , A61P19/02 , A61P25/06 , A61P3/10 , A61P35/00
CPC分类号： C07D417/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Bicyclic derivatives having formula (I) and a composition thereof are useful as ion channel antagonists:
摘要翻译： 具有式（I）的双环衍生物及其组合物可用作离子通道拮抗剂：
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公开(公告)号：US07812037B2
公开(公告)日：2010-10-12
申请号：US11262509
申请日：2005-10-28
申请人： Wasimul Haque , James Diakur , Vinh Pham , Atiq Rehman , Tara Whitney , Mohammed Omar , Seng Yi , A. Qasim Khan
发明人： Wasimul Haque , James Diakur , Vinh Pham , Atiq Rehman , Tara Whitney , Mohammed Omar , Seng Yi , A. Qasim Khan
IPC分类号： A61K31/4425 , C07D213/65
CPC分类号： C07D213/65 , C07D213/66 , C07D213/74 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/89 , C07D491/04 , C07D498/04
摘要： Compounds with antiplatelet aggregation and anticoagulant characteristics for the treatment of cardiovascular, cerebrovascular, and cardiovascular related diseases and symptoms, are described. The methods are directed to administering pharmaceutical compositions comprising aryl sulfonic pyridoxine and/or substituted pyridoxine analogs.
摘要翻译： 描述了用于治疗心血管，脑血管和心血管相关疾病和症状的具有抗血小板聚集和抗凝血特征的化合物。 该方法涉及给予包含芳基磺酸吡哆醇和/或取代的吡哆醛类似物的药物组合物。
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公开(公告)号：US20090131440A1
公开(公告)日：2009-05-21
申请号：US12269108
申请日：2008-11-12
申请人： Dean Stamos , Esther Martinborough , Nicole Zimmermann , Timothy Neubert , Mehdi Michel Djamel Numa , Tara Whitney , Aarti Sameer Kawatkar
发明人： Dean Stamos , Esther Martinborough , Nicole Zimmermann , Timothy Neubert , Mehdi Michel Djamel Numa , Tara Whitney , Aarti Sameer Kawatkar
IPC分类号： A61K31/5377 , C07D417/14 , A61K31/454 , A61P25/00
CPC分类号： C07D417/14
摘要： The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：US20060094761A1
公开(公告)日：2006-05-04
申请号：US11262509
申请日：2005-10-28
申请人： Wasimul Haque , James Diakur , Vinh Pham , Atiq Rehman , Tara Whitney , Mohammed Omar , Seng Yi , A. Khan
发明人： Wasimul Haque , James Diakur , Vinh Pham , Atiq Rehman , Tara Whitney , Mohammed Omar , Seng Yi , A. Khan
IPC分类号： C07D401/02 , C07D213/63 , A61K31/444 , A61K31/44
CPC分类号： C07D213/65 , C07D213/66 , C07D213/74 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/89 , C07D491/04 , C07D498/04
摘要： Compounds with antiplatelet aggregation and anticoagulant characteristics for the treatment of cardiovascular, cerebrovascular, and cardiovascular related diseases and symptoms, are described. The methods are directed to administering pharmaceutical compositions comprising aryl sulfonic pyridoxine and/or substituted pyridoxine analogs.
摘要翻译： 描述了用于治疗心血管，脑血管和心血管相关疾病和症状的具有抗血小板聚集和抗凝血特征的化合物。 该方法涉及给予包含芳基磺酸吡哆醇和/或取代的吡哆醛类似物的药物组合物。
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公开(公告)号：US08883766B2
公开(公告)日：2014-11-11
申请号：US13457855
申请日：2012-04-27
申请人： Esther Martinborough , Tim Neubert , Tara Whitney , Danielle Lehsten , Tara Hampton , Nicole Zimmermann , Andreas P. Termin
发明人： Esther Martinborough , Tim Neubert , Tara Whitney , Danielle Lehsten , Tara Hampton , Nicole Zimmermann , Andreas P. Termin
IPC分类号： A61K31/63 , A61K31/655 , C07D209/42 , C07D215/06 , C07D405/12 , C07D209/08 , C07D401/06 , C07D401/04 , C07D215/233 , C07D317/60 , C07C311/51 , C07C311/53
CPC分类号： C07D209/08 , C07C311/51 , C07C311/53 , C07C2602/08 , C07D209/42 , C07D215/06 , C07D215/233 , C07D317/60 , C07D401/04 , C07D401/06 , C07D405/12
摘要： In general, the invention relates to compounds useful as ion channel modulators. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are useful as inhibitors of voltage-gated sodium channels.
摘要翻译： 通常，本发明涉及可用作离子通道调节剂的化合物。 现在已经发现，本发明的化合物及其药学上可接受的组合物可用作电压门控钠通道的抑制剂。
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公开(公告)号：US20120178713A1
公开(公告)日：2012-07-12
申请号：US13419936
申请日：2012-03-14
申请人： Esther Martinborough , Lev T.D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
发明人： Esther Martinborough , Lev T.D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
IPC分类号： A61K31/496 , C07D403/12 , A61K31/506 , C07D417/14 , A61K31/501 , A61K31/454 , C07D471/04 , A61K31/437 , A61K31/427 , C07F7/02 , A61K31/695 , C07D413/14 , A61K31/5377 , A61P35/00 , A61P19/02 , A61P25/06 , A61P25/08 , A61P25/28 , A61P25/22 , A61P25/24 , A61P1/00 , A61P13/02 , C07D417/12
CPC分类号： C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要： The present invention relates to phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
摘要翻译： 本发明涉及可用作离子通道抑制剂的苯基磺酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病（包括例如治疗疼痛）的方法。
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