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公开(公告)号：US11058792B2
公开(公告)日：2021-07-13
申请号：US16021322
申请日：2018-06-28
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Christopher DeFelice , Sasa Andjelic , Brian M. Kelly , Marc Wisnudel , Daniel Steiger , Gaoyuan Gavin Chen
Abstract: Novel surgical sutures and novel medical devices made from novel semi-crystalline, glycolide-rich A-B-A triblock copolymers of glycolide and lactide, wherein said B-segment is a fully amorphous random copolymer of glycolide and lactide, for long term medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, meshes and other medical devices, especially for patients with compromised healing. The novel sutures have improved properties and improved breaking strength retention, while still substantially absorbing within about a 120-day period post-implantation.
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2.发明申请Absorbable Bimodal Polymeric Blend Compositions, Processing Methods, and Medical Devices 有权可吸收双峰聚合物混合组合物，加工方法和医疗器械公开(公告)号：US20150159011A1
公开(公告)日：2015-06-11
申请号：US14533274
申请日：2014-11-05
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Sasa Andjelic , Brian M. Kelly , Christopher DeFelice
CPC classification number: C08L67/04 , A61B17/06166 , A61B17/064 , A61B2017/00004 , A61B2017/00831 , A61L17/12 , A61L27/18 , A61L29/06 , A61L31/041 , A61L31/06 , A61L31/148 , C08G63/664 , C08L2201/06 , C08L2203/02 , C08L2205/02 , C08L2205/025
Abstract: Novel absorbable polymeric blends having bimodal molecular weight distribution are disclosed. The bimodal blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide having a bimodal molecular weight distribution, and a second component that is a poly(p-dioxanone) polymer of unimodal or bimodal molecular weight distribution. Alternately, the bimodal blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide having a unimodal molecular weight distribution, and a second component that is a poly(p-dioxanone) polymer of bimodal molecular weight distribution. The novel polymeric bimodal molecular weight blends provide medical devices having improved dimensional stability. Also disclosed are novel absorbable medical devices made from these novel bimodal polymer blends, as well as novel methods of manufacture.
Abstract translation: 公开了具有双峰分子量分布的新型可吸收聚合物共混物。 双峰共混物具有第一组分，其是聚丙交酯聚合物或具有双峰分子量分布的丙交酯和乙交酯的共聚物，以及作为单峰或双峰分子量分布的聚（对二恶烷酮）聚合物的第二组分。 或者，双峰共混物具有第一组分，其是具有单峰分子量分布的聚丙交酯聚合物或丙交酯和乙交酯的共聚物，以及作为双峰分子量分布的聚（对二恶烷酮）聚合物的第二组分。 新型聚合双峰分子量共混物提供具有改进的尺寸稳定性的医疗装置。 还公开了由这些新型双峰聚合物共混物制成的新型可吸收医疗装置，以及新颖的制造方法。
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公开(公告)号：US09321917B2
公开(公告)日：2016-04-26
申请号：US14886590
申请日：2015-10-19
Applicant: Ethicon, Inc.
Inventor： Brian M. Kelly , Dennis D. Jamiolkowski , Christopher DeFelice
CPC classification number: C08L67/04 , A61B17/0401 , A61B17/064 , A61B2017/00004 , A61B2017/00526 , A61B2017/0647 , A61L31/041 , A61L31/148 , A61L31/16 , A61L2300/404 , A61L2300/442 , C08L2205/025 , C08L2666/18
Abstract: Novel bioabsorbable polymeric blends are disclosed. The blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide and a second component that is poly(p-dioxanone) polymer. The novel polymeric blends provide medical devices having dimensional stability. Also disclosed are novel bioabsorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.
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4.发明授权Absorbable bimodal polymeric blend compositions, processing methods, and medical devices 有权可吸收的双峰聚合物共混组合物，加工方法和医疗装置公开(公告)号：US09181427B2
公开(公告)日：2015-11-10
申请号：US14533274
申请日：2014-11-05
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Sasa Andjelic , Brian M. Kelly , Christopher DeFelice
IPC: C08G63/91 , C08L67/04 , A61L31/04 , A61L31/14 , A61L27/18 , A61L29/06 , A61L31/06 , A61B17/064 , A61L17/12 , C08G63/664 , C08G65/32
CPC classification number: C08L67/04 , A61B17/06166 , A61B17/064 , A61B2017/00004 , A61B2017/00831 , A61L17/12 , A61L27/18 , A61L29/06 , A61L31/041 , A61L31/06 , A61L31/148 , C08G63/664 , C08L2201/06 , C08L2203/02 , C08L2205/02 , C08L2205/025
Abstract: Novel absorbable polymeric blends having bimodal molecular weight distribution are disclosed. The bimodal blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide having a bimodal molecular weight distribution, and a second component that is a poly(p-dioxanone) polymer of unimodal or bimodal molecular weight distribution. Alternately, the bimodal blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide having a unimodal molecular weight distribution, and a second component that is a poly(p-dioxanone) polymer of bimodal molecular weight distribution. The novel polymeric bimodal molecular weight blends provide medical devices having improved dimensional stability. Also disclosed are novel absorbable medical devices made from these novel bimodal polymer blends, as well as novel methods of manufacture.
Abstract translation: 公开了具有双峰分子量分布的新型可吸收聚合物共混物。 双峰共混物具有第一组分，其是聚丙交酯聚合物或具有双峰分子量分布的丙交酯和乙交酯的共聚物，以及作为单峰或双峰分子量分布的聚（对二恶烷酮）聚合物的第二组分。 或者，双峰共混物具有第一组分，其是具有单峰分子量分布的聚丙交酯聚合物或丙交酯和乙交酯的共聚物，以及作为双峰分子量分布的聚（对二恶烷酮）聚合物的第二组分。 新型聚合双峰分子量共混物提供具有改进的尺寸稳定性的医疗装置。 还公开了由这些新型双峰聚合物共混物制成的新型可吸收医疗装置，以及新颖的制造方法。
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5.发明申请Absorbable Polymeric Blend Compositions with Precisely Controllable Absorption Rates, Processing Methods, and Dimensionally Stable Medical Devices Therefrom 审中-公开可吸收的具有精确控制吸收率的聚合物混合组合物，加工方法和尺寸稳定的医疗器械公开(公告)号：US20150148496A1
公开(公告)日：2015-05-28
申请号：US14548536
申请日：2014-11-20
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Daniel Steiger , Brian M. Kelly , Christopher DeFelice , Sasa Andjelic , Modesto Erneta
CPC classification number: A61L31/041 , A61B17/06166 , A61B17/064 , A61B2017/00004 , A61L17/105 , A61L27/26 , A61L27/58 , A61L31/148 , C08L67/04 , C08L2205/03 , C08L2666/18
Abstract: Novel absorbable polymeric blends are disclosed. The blends have a first absorbable polymer type that is a polylactide polymer or a copolymer of lactide and glycolide and a second absorbable polymer type that is poly(p-dioxanone), wherein the first absorbable polymer type or the second absorbable polymer type or the first absorbable polymer type and the second absorbable polymer type additionally comprise a first polymeric component and a second polymeric component. The first polymeric component has a higher weight average molecular weight than the second polymeric component and at least one of said components is at least partially end-capped by a carboxylic acid. The novel polymeric blends are useful for manufacturing medical devices having dimensional stability, having engineered degradation and breaking strength retention in vivo. Also disclosed are novel absorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.
Abstract translation: 公开了新颖的可吸收聚合物共混物。 共混物具有第一可吸收聚合物类型，其是聚丙交酯聚合物或丙交酯和乙交酯的共聚物，以及聚（对二恶烷酮）的第二可吸收聚合物类型，其中第一可吸收聚合物类型或第二可吸收聚合物类型或第一可吸收聚合物类型 可吸收聚合物类型和第二可吸收聚合物类型另外包含第一聚合物组分和第二聚合物组分。 第一聚合物组分具有比第二聚合物组分更高的重均分子量，并且至少一种所述组分至少部分地被羧酸封端。 新型聚合物共混物可用于制造具有尺寸稳定性，具有工程化降解和体内断裂强度保持性的医疗装置。 还公开了由这些新型聚合物共混物制成的新型可吸收医疗器件以及新颖的制造方法。
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Patent Agency Ranking
公开(公告)号：US11596709B2
公开(公告)日：2023-03-07
申请号：US17349535
申请日：2021-06-16
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Christopher DeFelice , Sasa Andjelic , Brian M. Kelly , Marc Wisnudel , Daniel Steiger , Gaoyuan Gavin Chen
Abstract: Novel surgical sutures and novel medical devices made from novel semi-crystalline, glycolide-rich A-B-A triblock copolymers of glycolide and lactide, wherein said B-segment is a fully amorphous random copolymer of glycolide and lactide, for long term medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, meshes and other medical devices, especially for patients with compromised healing. The novel sutures have improved properties and improved breaking strength retention, while still substantially absorbing within about a 120-day period post-implantation.
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公开(公告)号：US10058637B2
公开(公告)日：2018-08-28
申请号：US14548536
申请日：2014-11-20
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Daniel Steiger , Brian M. Kelly , Christopher DeFelice , Sasa Andjelic , Modesto Erneta
IPC: A61L27/26 , A61L27/58 , C08L67/04 , A61L31/04 , A61L31/14 , A61B17/064 , A61L17/10 , A61B17/06 , A61B17/00
CPC classification number: A61L31/041 , A61B17/06166 , A61B17/064 , A61B2017/00004 , A61L17/105 , A61L27/26 , A61L27/58 , A61L31/148 , C08L67/04 , C08L2205/03 , C08L2666/18
Abstract: Novel absorbable polymeric blends are disclosed. The blends have a first absorbable polymer type that is a polylactide polymer or a copolymer of lactide and glycolide and a second absorbable polymer type that is poly(p-dioxanone), wherein the first absorbable polymer type or the second absorbable polymer type or the first absorbable polymer type and the second absorbable polymer type additionally comprise a first polymeric component and a second polymeric component. The first polymeric component has a higher weight average molecular weight than the second polymeric component and at least one of said components is at least partially end-capped by a carboxylic acid. The novel polymeric blends are useful for manufacturing medical devices having dimensional stability, having engineered degradation and breaking strength retention in vivo. Also disclosed are novel absorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.
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公开(公告)号：US20210322624A1
公开(公告)日：2021-10-21
申请号：US17349535
申请日：2021-06-16
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Christopher DeFelice , Sasa Andjelic , Brian M. Kelly , Marc Wisnudel , Daniel Steiger , Gaoyuan Gavin Chen
Abstract: Novel surgical sutures and novel medical devices made from novel semi-crystalline, glycolide-rich A-B-A triblock copolymers of glycolide and lactide, wherein said B-segment is a fully amorphous random copolymer of glycolide and lactide, for long term medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, meshes and other medical devices, especially for patients with compromised healing. The novel sutures have improved properties and improved breaking strength retention, while still substantially absorbing within about a 120-day period post-implantation.
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9.发明申请公开(公告)号：US20200000958A1
公开(公告)日：2020-01-02
申请号：US16021322
申请日：2018-06-28
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Christopher DeFelice , Sasa Andjelic , Brian M. Kelly , Marc Wisnudel , Daniel Steiger , Gaoyuan Gavin Chen
Abstract: Novel surgical sutures and novel medical devices made from novel semi-crystalline, glycolide-rich A-B-A triblock copolymers of glycolide and lactide, wherein said B-segment is a fully amorphous random copolymer of glycolide and lactide, for long term medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, meshes and other medical devices, especially for patients with compromised healing. The novel sutures have improved properties and improved breaking strength retention, while still substantially absorbing within about a 120-day period post-implantation.
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10.发明申请Bioabsorbable Polymeric Compositions, Processing Methods, and Medical Devices Therefrom 审中-公开生物可吸收聚合物组合物，加工方法和医疗器械公开(公告)号：US20160040008A1
公开(公告)日：2016-02-11
申请号：US14886590
申请日：2015-10-19
Applicant: Ethicon, Inc.
Inventor： Brian M. Kelly , Dennis D. Jamiolkowski , Christopher DeFelice
CPC classification number: C08L67/04 , A61B17/0401 , A61B17/064 , A61B2017/00004 , A61B2017/00526 , A61B2017/0647 , A61L31/041 , A61L31/148 , A61L31/16 , A61L2300/404 , A61L2300/442 , C08L2205/025 , C08L2666/18
Abstract: Novel bioabsorbable polymeric blends are disclosed. The blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide and a second component that is poly(p-dioxanone) polymer. The novel polymeric blends provide medical devices having dimensional stability. Also disclosed are novel bioabsorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.
Abstract translation: 公开了新的生物可吸收聚合物共混物。 共混物具有第一组分，其是聚丙交酯聚合物或丙交酯和乙交酯的共聚物，第二组分是聚（对二恶烷酮）聚合物。 新型聚合物共混物提供具有尺寸稳定性的医疗装置。 还公开了由这些新型聚合物共混物制成的新颖的生物可吸收的医疗装置，以及新颖的制造方法。
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