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1.发明授权Absorbable polymeric blend compositions based on copolymers prepared from mono- and di-functional polymerization initiators, processing methods, and medical devices therefrom 有权基于由单功能和二官能聚合引发剂，加工方法和医疗装置制备的共聚物的可吸收聚合共混物组合物公开(公告)号：US09259514B2
公开(公告)日：2016-02-16
申请号：US14571371
申请日：2014-12-16
Applicant: Ethicon, Inc.
Inventor： Sasa Andjelic , Dennis D. Jamiolkowski , Brian M. Kelly , Christopher DeFelice , Daniel Steiger
IPC: C08G63/91 , A61L31/04 , A61L31/14 , A61L27/18 , A61L29/06 , A61L31/06 , A61L17/12 , C08L67/04 , A61B17/064 , C08G65/32 , A61B17/00
CPC classification number: A61L31/041 , A61B17/064 , A61B17/0642 , A61B2017/00004 , A61B2017/00889 , A61B2017/00893 , A61L17/12 , A61L27/18 , A61L29/06 , A61L31/06 , A61L31/148 , C08G63/664 , C08L67/04 , C08L2205/025 , C08L2205/03
Abstract: Novel absorbable polymeric blends made from components wherein at least one of the components is synthesized using mixtures of mono- and di-functional initiators are disclosed. The blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide and a second component that is either poly(p-dioxanone) homopolymer, or a poly(p-dioxanone-co-glycolide) copolymer. The novel polymeric blends provide medical devices having dimensional stability. Also disclosed are novel absorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.
Abstract translation: 公开了由组分制成的新型可吸收聚合物共混物，其中使用单官能和二官能引发剂的混合物合成至少一种组分。 共混物具有第一组分，其是聚丙交酯聚合物或丙交酯和乙交酯的共聚物，第二组分是聚（对二恶烷酮）均聚物或聚（对 - 二恶烷酮 - 共 - 乙交酯）共聚物。 新型聚合物共混物提供具有尺寸稳定性的医疗装置。 还公开了由这些新型聚合物共混物制成的新型可吸收医疗器件以及新颖的制造方法。
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公开(公告)号：US09173979B2
公开(公告)日：2015-11-03
申请号：US14084932
申请日：2013-11-20
Applicant: Ethicon, Inc.
Inventor： Brian M. Kelly , Dennis D. Jamiolkowski , Christopher DeFelice
IPC: A61K47/34 , A61F2/00 , A61F2/82 , A61B17/00 , A61B17/04 , A61B17/08 , A61B17/64 , A61B17/84 , A61B17/86 , C08L67/00 , A61L31/04 , A61B17/064 , C08L67/04 , A61L31/14 , A61L31/16
CPC classification number: C08L67/04 , A61B17/0401 , A61B17/064 , A61B2017/00004 , A61B2017/00526 , A61B2017/0647 , A61L31/041 , A61L31/148 , A61L31/16 , A61L2300/404 , A61L2300/442 , C08L2205/025 , C08L2666/18
Abstract: Novel bioabsorbable polymeric blends are disclosed. The blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide and a second component that is poly(p-dioxanone) polymer. The novel polymeric blends provide medical devices having dimensional stability. Also disclosed are novel bioabsorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.
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3.发明申请BIOABSORBABLE POLYMERIC COMPOSITIONS, PROCESSING METHODS, AND MEDICAL DEVICES THEREFROM 审中-公开生物可降解聚合物组合物，加工方法及其医疗器械公开(公告)号：US20140073705A1
公开(公告)日：2014-03-13
申请号：US14084932
申请日：2013-11-20
Applicant: Ethicon, Inc.
Inventor： Brian M. Kelly , Dennis D. Jamiolkowski , Christopher DeFelice
CPC classification number: C08L67/04 , A61B17/0401 , A61B17/064 , A61B2017/00004 , A61B2017/00526 , A61B2017/0647 , A61L31/041 , A61L31/148 , A61L31/16 , A61L2300/404 , A61L2300/442 , C08L2205/025 , C08L2666/18
Abstract: Novel bioabsorbable polymeric blends are disclosed. The blends have a first component that is a polylactide polymers or a copolymer of lactide and glycolide and a second component that is poly(p-dioxanone) polymer. The novel polymeric blends provide medical devices having dimensional stability. Also disclosed are novel bioabsorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.
Abstract translation: 公开了新的生物可吸收聚合物共混物。 共混物具有第一组分，其是聚丙交酯聚合物或丙交酯和乙交酯的共聚物，第二组分是聚（对二恶烷酮）聚合物。 新型聚合物共混物提供具有尺寸稳定性的医疗装置。 还公开了由这些新型聚合物共混物制成的新颖的生物可吸收的医疗装置，以及新颖的制造方法。
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公开(公告)号：US11596709B2
公开(公告)日：2023-03-07
申请号：US17349535
申请日：2021-06-16
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Christopher DeFelice , Sasa Andjelic , Brian M. Kelly , Marc Wisnudel , Daniel Steiger , Gaoyuan Gavin Chen
Abstract: Novel surgical sutures and novel medical devices made from novel semi-crystalline, glycolide-rich A-B-A triblock copolymers of glycolide and lactide, wherein said B-segment is a fully amorphous random copolymer of glycolide and lactide, for long term medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, meshes and other medical devices, especially for patients with compromised healing. The novel sutures have improved properties and improved breaking strength retention, while still substantially absorbing within about a 120-day period post-implantation.
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5.发明申请公开(公告)号：US20200165380A1
公开(公告)日：2020-05-28
申请号：US16202454
申请日：2018-11-28
Applicant: Ethicon, Inc.
Inventor： Sasa Andjelic , Brian M. Kelly , Marc Wisnudel
Abstract: The present invention is directed methods of making absorbable poly(p-dioxanone) pellets by melt polymerization of p-dioxanone conducted in a single reactor with a temperature regulator by charging a melt reactor with a mixture of p-dioxanone (PDO) monomer, initiator, catalyst, and optionally a dye; melt polymerizing the mixture in the melt reactor with sufficient agitation of the mixture to allow complete mixing of the monomer and for sufficient time to form a PDO polymer product having an unreacted PDO monomer content of at least 65 mole percent; placing the PDO polymer product under a vacuum to remove at least portion of unreacted PDO; discharging the PDO polymer product from the melt reactor directly into an in-line, underwater pelletizer to produce undried PDO pellets, collecting the undried PDO pellets, and storing the collected PDO pellets in the freezer or a vacuum chamber prior to drying.
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Patent Agency Ranking
公开(公告)号：US10058637B2
公开(公告)日：2018-08-28
申请号：US14548536
申请日：2014-11-20
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Daniel Steiger , Brian M. Kelly , Christopher DeFelice , Sasa Andjelic , Modesto Erneta
IPC: A61L27/26 , A61L27/58 , C08L67/04 , A61L31/04 , A61L31/14 , A61B17/064 , A61L17/10 , A61B17/06 , A61B17/00
CPC classification number: A61L31/041 , A61B17/06166 , A61B17/064 , A61B2017/00004 , A61L17/105 , A61L27/26 , A61L27/58 , A61L31/148 , C08L67/04 , C08L2205/03 , C08L2666/18
Abstract: Novel absorbable polymeric blends are disclosed. The blends have a first absorbable polymer type that is a polylactide polymer or a copolymer of lactide and glycolide and a second absorbable polymer type that is poly(p-dioxanone), wherein the first absorbable polymer type or the second absorbable polymer type or the first absorbable polymer type and the second absorbable polymer type additionally comprise a first polymeric component and a second polymeric component. The first polymeric component has a higher weight average molecular weight than the second polymeric component and at least one of said components is at least partially end-capped by a carboxylic acid. The novel polymeric blends are useful for manufacturing medical devices having dimensional stability, having engineered degradation and breaking strength retention in vivo. Also disclosed are novel absorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.
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公开(公告)号：US20210322624A1
公开(公告)日：2021-10-21
申请号：US17349535
申请日：2021-06-16
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Christopher DeFelice , Sasa Andjelic , Brian M. Kelly , Marc Wisnudel , Daniel Steiger , Gaoyuan Gavin Chen
Abstract: Novel surgical sutures and novel medical devices made from novel semi-crystalline, glycolide-rich A-B-A triblock copolymers of glycolide and lactide, wherein said B-segment is a fully amorphous random copolymer of glycolide and lactide, for long term medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, meshes and other medical devices, especially for patients with compromised healing. The novel sutures have improved properties and improved breaking strength retention, while still substantially absorbing within about a 120-day period post-implantation.
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8.发明授权公开(公告)号：US11028222B2
公开(公告)日：2021-06-08
申请号：US16202454
申请日：2018-11-28
Applicant: Ethicon, Inc.
Inventor： Sasa Andjelic , Brian M. Kelly , Marc Wisnudel
IPC: C08G63/08 , C08G63/89 , C08G63/90 , C08L67/04 , C08G63/66 , C08G63/78 , C08G63/85 , C08J3/12 , C08K5/18 , C08G63/664
Abstract: The present invention is directed methods of making absorbable poly(p-dioxanone) pellets by melt polymerization of p-dioxanone conducted in a single reactor with a temperature regulator by charging a melt reactor with a mixture of p-dioxanone (PDO) monomer, initiator, catalyst, and optionally a dye; melt polymerizing the mixture in the melt reactor with sufficient agitation of the mixture to allow complete mixing of the monomer and for sufficient time to form a PDO polymer product having an unreacted PDO monomer content of at least 65 mole percent; placing the PDO polymer product under a vacuum to remove at least portion of unreacted PDO; discharging the PDO polymer product from the melt reactor directly into an in-line, underwater pelletizer to produce undried PDO pellets, collecting the undried PDO pellets, and storing the collected PDO pellets in the freezer or a vacuum chamber prior to drying.
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9.发明申请公开(公告)号：US20200000958A1
公开(公告)日：2020-01-02
申请号：US16021322
申请日：2018-06-28
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Christopher DeFelice , Sasa Andjelic , Brian M. Kelly , Marc Wisnudel , Daniel Steiger , Gaoyuan Gavin Chen
Abstract: Novel surgical sutures and novel medical devices made from novel semi-crystalline, glycolide-rich A-B-A triblock copolymers of glycolide and lactide, wherein said B-segment is a fully amorphous random copolymer of glycolide and lactide, for long term medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, meshes and other medical devices, especially for patients with compromised healing. The novel sutures have improved properties and improved breaking strength retention, while still substantially absorbing within about a 120-day period post-implantation.
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10.发明申请Bioabsorbable Polymeric Compositions, Processing Methods, and Medical Devices Therefrom 审中-公开生物可吸收聚合物组合物，加工方法和医疗器械公开(公告)号：US20160040008A1
公开(公告)日：2016-02-11
申请号：US14886590
申请日：2015-10-19
Applicant: Ethicon, Inc.
Inventor： Brian M. Kelly , Dennis D. Jamiolkowski , Christopher DeFelice
CPC classification number: C08L67/04 , A61B17/0401 , A61B17/064 , A61B2017/00004 , A61B2017/00526 , A61B2017/0647 , A61L31/041 , A61L31/148 , A61L31/16 , A61L2300/404 , A61L2300/442 , C08L2205/025 , C08L2666/18
Abstract: Novel bioabsorbable polymeric blends are disclosed. The blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide and a second component that is poly(p-dioxanone) polymer. The novel polymeric blends provide medical devices having dimensional stability. Also disclosed are novel bioabsorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.
Abstract translation: 公开了新的生物可吸收聚合物共混物。 共混物具有第一组分，其是聚丙交酯聚合物或丙交酯和乙交酯的共聚物，第二组分是聚（对二恶烷酮）聚合物。 新型聚合物共混物提供具有尺寸稳定性的医疗装置。 还公开了由这些新型聚合物共混物制成的新颖的生物可吸收的医疗装置，以及新颖的制造方法。
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