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公开(公告)号:US5010104A
公开(公告)日:1991-04-23
申请号:US372771
申请日:1989-06-29
申请人: Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii
发明人: Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii
IPC分类号: C07C311/16 , C07C323/44 , C07C323/48 , C07C323/49 , C07D313/12 , C07D337/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D495/04
CPC分类号: C07D405/12 , C07C311/16 , C07C323/44 , C07C323/48 , C07C323/49 , C07D313/12 , C07D337/12 , C07D407/12 , C07D409/12 , C07D495/04 , C07C2103/32
摘要: Novel tricyclic compounds having a TXA.sub.2 -antagonizing activity represented by formul (I): ##STR1## which strongly antagonize an action of thromboxane A.sub.2 and are expected to have preventive and therapeutic effects on ischemica diseases, cerebro-vascular diseases, etc.
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公开(公告)号:US4882351A
公开(公告)日:1989-11-21
申请号:US255485
申请日:1988-10-11
申请人: Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii
发明人: Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii
IPC分类号: C07C311/16 , C07C323/44 , C07C323/48 , C07C323/49 , C07D313/12 , C07D337/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D495/04
CPC分类号: C07D405/12 , C07C311/16 , C07C323/44 , C07C323/48 , C07C323/49 , C07D313/12 , C07D337/12 , C07D407/12 , C07D409/12 , C07D495/04 , C07C2103/32
摘要: Novel tricyclic compounds having a TXA.sub.2 -antagonizing activity represented by formula (I): ##STR1## which strongly antagonize an action of thromboxane A.sub.2 and are expected to have preventive and therapeutic effects on ischemica diseases, cerebro-vascular diseases, etc.
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公开(公告)号:US5302602A
公开(公告)日:1994-04-12
申请号:US884208
申请日:1992-05-18
申请人: Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii , Hidee Ishii , Kenji Ohmori
发明人: Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii , Hidee Ishii , Kenji Ohmori
IPC分类号: C07D211/14 , C07D313/12 , C07D333/34 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D471/10 , A61K31/445 , C07D211/22
CPC分类号: C07D405/06 , C07D211/14 , C07D313/12 , C07D333/34 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D471/10
摘要: Novel tricyclic compounds having a TXA.sub.2 antagonizing activity represented by formula (I): ##STR1## possess a potent antagonizing against thromboxane A.sub.2 and also an antiallergic and/or antihistaminic activity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.
摘要翻译: 具有由式(I)表示的TXA2拮抗活性的新型三环化合物:具有对血栓素A2的有效拮抗作用,还具有抗过敏和/或抗组胺活性,并且预期对缺血性疾病具有预防和治疗作用 脑血管疾病等
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公开(公告)号:US5143922A
公开(公告)日:1992-09-01
申请号:US616095
申请日:1990-11-20
申请人: Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii , Hidee Ishii , Kenji Ohmori
发明人: Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii , Hidee Ishii , Kenji Ohmori
IPC分类号: C07D211/14 , C07D313/12 , C07D333/34 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D471/10
CPC分类号: C07D405/06 , C07D211/14 , C07D313/12 , C07D333/34 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D471/10
摘要: Novel tricyclic compounds having a TXA.sub.2 antagonizing activity represented by formula (I): ##STR1## possess a potent antagonizing action against thromboxane A.sub.2 and also an antiallergic and/or antihistaminic acitvity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.
摘要翻译: 具有由式(I)表示的TXA2拮抗活性的新型三环化合物:对抗凝血恶烷A2具有有效的拮抗作用,并且还具有抗过敏和/或抗组胺活性,并且预期对缺血性具有预防和治疗作用 疾病,脑血管疾病等
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公开(公告)号:US5010087A
公开(公告)日:1991-04-23
申请号:US381330
申请日:1989-07-18
申请人: Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii
发明人: Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii
IPC分类号: C07C311/16 , C07C323/44 , C07C323/48 , C07C323/49 , C07D313/12 , C07D337/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D495/04
CPC分类号: C07D405/12 , C07C311/16 , C07C323/44 , C07C323/48 , C07C323/49 , C07D313/12 , C07D337/12 , C07D407/12 , C07D409/12 , C07D495/04 , C07C2103/32
摘要: Novel tricyclic compounds having a TXA.sub.2 -antagonizing activity represented by formula (I): ##STR1## which strongly antagonize an action of thromboxane A.sub.2 and are expected to have preventive and therapeutic effects on ischemica diseases, cerebro-vascular diseases, etc.
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公开(公告)号:US4999363A
公开(公告)日:1991-03-12
申请号:US368242
申请日:1989-06-06
申请人: Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii
发明人: Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii
IPC分类号: A61K31/19 , A61K31/00 , A61K31/41 , A61K31/415 , A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/47 , A61K31/505 , A61P7/02 , A61P9/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07C57/46 , C07C59/13 , C07C63/49 , C07C65/26 , C07C67/00 , C07C229/50 , C07C233/52 , C07C233/81 , C07C235/14 , C07C235/40 , C07C235/54 , C07C235/62 , C07C235/78 , C07C235/82 , C07C235/84 , C07C237/04 , C07C237/24 , C07C237/38 , C07C241/00 , C07C251/20 , C07C317/44 , C07C323/61 , C07D235/06 , C07D313/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04 , C07D491/056 , C07D521/00
CPC分类号: C07D235/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/12 , C07D405/12 , C07D417/12 , C07D471/04 , Y10S514/824 , Y10S514/826
摘要: Novel tricyclic compound represented by formula ##STR1## possess a TXA.sub.2 biosynthesis inhibiting activity and/or a TXA.sub.2 receptor antagonizing activity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.
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公开(公告)号:US5118701A
公开(公告)日:1992-06-02
申请号:US612446
申请日:1990-11-14
申请人: Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii
发明人: Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii
IPC分类号: A61K31/19 , A61K31/00 , A61K31/41 , A61K31/415 , A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/47 , A61K31/505 , A61P7/02 , A61P9/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07C57/46 , C07C59/13 , C07C63/49 , C07C65/26 , C07C67/00 , C07C229/50 , C07C233/52 , C07C233/81 , C07C235/14 , C07C235/40 , C07C235/54 , C07C235/62 , C07C235/78 , C07C235/82 , C07C235/84 , C07C237/04 , C07C237/24 , C07C237/38 , C07C241/00 , C07C251/20 , C07C317/44 , C07C323/61 , C07D235/06 , C07D313/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04 , C07D491/056 , C07D521/00
CPC分类号: C07D235/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/12 , C07D405/12 , C07D417/12 , C07D471/04 , Y10S514/824 , Y10S514/826
摘要: Novel tricyclic compound represented by formula (I): ##STR1## possess a TXA.sub.2 biosynthesis inhibiting activity and/or a TXA.sub.2 receptor antagonizing activity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.
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公开(公告)号:US5302596A
公开(公告)日:1994-04-12
申请号:US980617
申请日:1992-11-23
申请人: Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii
发明人: Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii
IPC分类号: A61K31/19 , A61K31/00 , A61K31/41 , A61K31/415 , A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/47 , A61K31/505 , A61P7/02 , A61P9/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07C57/46 , C07C59/13 , C07C63/49 , C07C65/26 , C07C67/00 , C07C229/50 , C07C233/52 , C07C233/81 , C07C235/14 , C07C235/40 , C07C235/54 , C07C235/62 , C07C235/78 , C07C235/82 , C07C235/84 , C07C237/04 , C07C237/24 , C07C237/38 , C07C241/00 , C07C251/20 , C07C317/44 , C07C323/61 , C07D235/06 , C07D313/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04 , C07D491/056 , C07D521/00 , A61K31/435 , C07D473/00
CPC分类号: C07D235/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/12 , C07D405/12 , C07D417/12 , C07D471/04 , Y10S514/824 , Y10S514/826
摘要: Novel tricyclic compound represented by formula ##STR1## possess a TXA.sub.2 biosynthesis inhibiting activity and/or a TXA.sub.2 receptor antagonizing activity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.
摘要翻译: 由式(I)表示的新型三环化合物具有TXA2生物合成抑制活性和/或TXA2受体拮抗活性,预期对缺血性疾病,脑血管疾病等具有预防和治疗作用。
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公开(公告)号:US5242931A
公开(公告)日:1993-09-07
申请号:US856296
申请日:1992-03-23
申请人: Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii
发明人: Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii
IPC分类号: C07D235/06 , C07D313/12 , C07D405/12 , C07D417/12 , C07D471/04 , C07D521/00
CPC分类号: C07D235/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/12 , C07D405/12 , C07D417/12 , C07D471/04
摘要: Novel Tricyclic compound represented by formula ##STR1## possess a TXA.sub.2 biosynthesis inhibiting act and/or a TXA.sub.2 receptor antagonizing activity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.
摘要翻译: 由式(I)表示的新型三环化合物具有TXA2生物合成抑制作用和/或TXA2受体拮抗活性,预期对缺血性疾病,脑血管疾病等具有预防和治疗作用。
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公开(公告)号:US4994463A
公开(公告)日:1991-02-19
申请号:US281545
申请日:1988-12-08
申请人: Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii , Hidee Ishii , Kenji Ohmori
发明人: Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii , Hidee Ishii , Kenji Ohmori
IPC分类号: C07D211/14 , C07D313/12 , C07D333/34 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D471/10
CPC分类号: C07D405/06 , C07D211/14 , C07D313/12 , C07D333/34 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D471/10
摘要: Novel tricyclic compounds having a TXA.sub.2 antagonizing activity represented by formula (I): ##STR1## possess a potent antagonizing action against thromboxane A.sub.2 and also an antiallergic and/or antihistaminic activity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.
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