公开(公告)号：US10301430B2

公开(公告)日：2019-05-28

申请号：US15715414

申请日：2017-09-26

申请人： The United States of America, as represented by the Secretary of the Air Force

发明人： Loon-Seng Tan ,  David Huabin Wang ,  Jeong Jae Wie ,  Timothy J. White

IPC分类号： C08G73/10 ,  C07C323/48 ,  C07C245/08 ,  C08G69/32 ,  C09B35/021 ,  C09B69/10 ,  C09B43/16

摘要： Bis(azo-benzene) diamine monomers and a method of synthesizing the monomers are provided. The bis(azo-benzene) diamine monomers, in combination with amine reactive monomers, form polymers, such as polyimides and copolyimides, having photomechanical and thermomechanical properties.

公开(公告)号：US5608109A

公开(公告)日：1997-03-04

申请号：US350462

申请日：1994-12-07

申请人： Kazuhiro Takagi ,  Tetsuji Ohshima ,  Nobuyoshi Hasegawa ,  Chiaki Katoh ,  Atsushi Kanaoka ,  Hideo Kanno

发明人： Kazuhiro Takagi ,  Tetsuji Ohshima ,  Nobuyoshi Hasegawa ,  Chiaki Katoh ,  Atsushi Kanaoka ,  Hideo Kanno

IPC分类号： A01N47/34 ,  A01N47/38 ,  A01N47/40 ,  C07C11/02 ,  C07C281/14 ,  C07C311/03 ,  C07C311/08 ,  C07C317/28 ,  C07C323/48 ,  C07C323/52 ,  C07C323/56 ,  C07C323/60 ,  C07C327/30 ,  C07C327/58 ,  C07C331/12 ,  C07D239/38 ,  C07D295/185 ,  C07D295/205 ,  C07D295/215 ,  C07D295/26 ,  C07D307/52 ,  C07F9/40 ,  C07C309/64 ,  C07C309/71 ,  C07C309/72

CPC分类号： C07D295/185 ,  A01N47/34 ,  A01N47/38 ,  A01N47/40 ,  C07C281/14 ,  C07C311/03 ,  C07C311/08 ,  C07C317/28 ,  C07C323/48 ,  C07C323/52 ,  C07C323/56 ,  C07C323/60 ,  C07C327/30 ,  C07C327/58 ,  C07C331/12 ,  C07D239/38 ,  C07D295/205 ,  C07D295/215 ,  C07D295/26 ,  C07D307/52 ,  C07F9/4006 ,  C07F9/4056 ,  C07C2101/14

摘要： The present invention relates to a hydrazine derivative represented by the formula (I): ##STR1## (wherein each of Ar.sup.1 and Ar.sup.2 is a substituted or unsubstituted phenyl group, a substituted or unsubstituted heteroaryl group, or the like, R.sup.1 is an alkyl group or the like, and A is a divalent radical having --C.dbd.N--N-- or --CH--NH--N-- as a fundamental skeleton), which is a useful compound as an agricultural and horticultural insecticide.

摘要翻译： 本发明涉及由式（I）表示的肼衍生物：其中Ar1和Ar2各自为取代或未取代的苯基，取代或未取代的杂芳基等，R 1为烷基 A是具有-C = NN-或-CH-NH-N-作为基本骨架的二价基团），其作为农业和园艺杀虫剂是有用的化合物。

公开(公告)号：US5530028A

公开(公告)日：1996-06-25

申请号：US129549

申请日：1993-09-29

申请人： Zev Lidert ,  Dat P. Le ,  Robert E. Hormann ,  Thomas R. Opie

发明人： Zev Lidert ,  Dat P. Le ,  Robert E. Hormann ,  Thomas R. Opie

IPC分类号： A01N37/28 ,  A01N33/00 ,  A01N37/40 ,  A01N43/30 ,  A01N43/32 ,  C07C243/38 ,  C07C251/86 ,  C07C255/24 ,  C07C275/28 ,  C07C311/51 ,  C07C323/48 ,  C07C327/56 ,  C07D207/34 ,  C07D213/54 ,  C07D213/87 ,  C07D241/24 ,  C07D303/38 ,  C07D307/58 ,  C07D307/68 ,  C07D307/79 ,  C07D311/58 ,  C07D317/50 ,  C07D317/68 ,  C07D319/18 ,  C07D321/10 ,  C07D333/38 ,  A01N33/26 ,  C07C243/16

CPC分类号： C07D213/54 ,  A01N37/40 ,  A01N43/30 ,  A01N43/32 ,  C07C243/38 ,  C07C251/86 ,  C07C255/24 ,  C07C275/28 ,  C07C311/51 ,  C07C323/48 ,  C07C327/56 ,  C07D207/34 ,  C07D213/87 ,  C07D241/24 ,  C07D303/38 ,  C07D307/58 ,  C07D307/68 ,  C07D317/68 ,  C07D319/18 ,  C07D333/38 ,  C07C2101/04 ,  C07C2101/14 ,  C07C2101/16 ,  C07C2102/10

摘要： Insecticidal compounds having the formula N-(2-R.sup.a -3-R.sup.b -4-R.sup.h -benzoyl)-N'-(2-R.sup.c -3-R.sup.d -4-R.sup.e -5-R.sup.f -benzoyl)-N'-R.sup.g -hydrazine wherein R.sup.a is a halo or lower alkyl; R.sup. b is lower alkoxy, optionally substituted with halo (preferably fluoro); R.sup.c is selected from hydrogen, halo, lower alkyl, lower alkoxy, lower alkoxy lower alkyl, and nitro; R.sup.d, R.sup.e and R.sup.f are each independently selected from hydrogen, bromo, chloro, fluoro, lower alkyl, lower alkoxy, and lower alkoxy lower alkyl; R.sub.g is a (C.sub.4 -C.sub.6)alkyl; R.sup.h is hydrogen, lower alkoxy, lower alkyl, or when taken together with R.sup.b is methylenedioxy (--OCH.sub.2 O--), 1,2-ethylenedioxy (--OCH.sub.2 CH.sub.2 O--), 1,2-ethyleneoxy (--CH.sub.2 CH.sub.2 O--) or 1,3-propyleneoxy (--CH.sub.2 CH.sub.2 CH.sub.2 O--) wherein an oxo atom is located at the R.sup.b position; and the substituents R.sup.c and R.sup.d, or R.sup.d and R.sup.e, or R.sup.e and R.sup.f when taken together can be methylenedioxy or 1,2-ethylenedioxy as well as compositions comprising an agronomically acceptable carrier and an insecticidally effective amount of such compounds; and methods of using such compounds and compositions.Also, methods for the production of the compounds and their intermediates, which methods comprise either admixing a 3-amino-2-(substituted)-benzoic acid, sodium nitrite and methanol under acidic conditions or admixing a 3,4-fused heterocyclic benzoic acid and an alkyl lithium reagent followed by subsequent reaction with an electrophilic reagent.

摘要翻译： 具有式N-（2-Ra-3-Rb-4-Rh-benzoyl）-N' - （2-Rc-3-Rd-4-Re-5-Rf-benzoyl）-N'-Rg的杀虫化合物 肼，其中R a是卤素或低级烷基; Rb是低级烷氧基，任选被卤素（优选氟）取代; Rc选自氢，卤素，低级烷基，低级烷氧基，低级烷氧基低级烷基和硝基; Rd，Re和Rf各自独立地选自氢，溴，氯，氟，低级烷基，低级烷氧基和低级烷氧基低级烷基; R g是（C 4 -C 6）烷基; 当R 2为氢时，低级烷氧基，低级烷基，或与Rb一起与亚甲二氧基（-OCH 2 O-），1,2-亚乙二氧基（-OCH 2 CH 2 O-），1,2-亚乙基氧基（-CH 2 CH 2 O-） 丙氧基（-CH 2 CH 2 CH 2 O-），其中氧原子位于Rb位; 并且取代基R c和R d，或R d和R Re或Re和R f一起可以是亚甲二氧基或1,2-亚乙二氧基，以及包含农学上可接受的载体和杀虫有效量的这些化合物的组合物; 以及使用这些化合物和组合物的方法。 另外，制备化合物及其中间体的方法，该方法包括在酸性条件下混合3-氨基-2-（取代的） - 苯甲酸，亚硝酸钠和甲醇，或将3,4-稠合的杂环苯甲酸 和烷基锂试剂，随后与亲电试剂反应。

公开(公告)号：US5367093A

公开(公告)日：1994-11-22

申请号：US979095

申请日：1992-11-20

申请人： Mark A. Dekeyser ,  Paul T. McDonald

发明人： Mark A. Dekeyser ,  Paul T. McDonald

IPC分类号： C07D333/38 ,  A01N37/28 ,  A01N37/30 ,  A01N47/02 ,  A01N47/10 ,  A01N47/24 ,  A01N47/34 ,  A01N57/30 ,  A01N57/32 ,  C07C1/20 ,  C07C243/26 ,  C07C243/28 ,  C07C243/30 ,  C07C243/32 ,  C07C243/36 ,  C07C243/38 ,  C07C245/06 ,  C07C281/02 ,  C07C281/06 ,  C07C281/20 ,  C07C311/08 ,  C07C311/49 ,  C07C323/48 ,  C07C327/56 ,  C07C337/02 ,  C07D307/68 ,  C07D307/91 ,  C07F9/24 ,  C07C271/08 ,  A01N37/10

CPC分类号： C07D307/91 ,  A01N37/28 ,  A01N37/30 ,  A01N47/02 ,  A01N47/24 ,  A01N47/34 ,  A01N57/30 ,  C07C243/28 ,  C07C281/02 ,  C07C281/06 ,  C07C311/49 ,  C07C337/02 ,  C07F9/2491 ,  C07C2101/14

摘要： Compounds having the structural formula ##STR1## where X, Y, R and Z are defined in the specification are disclosed. The compounds of this invention are effective for controlling mites, nematodes, rice planthopper, tobacco budworm, and southern corn rootworm. Methods for making these compounds are also set forth.

摘要翻译： 公开了具有结构式为其中X，Y，R和Z在本说明书中定义的结构式（I）的化合物（II）。 本发明的化合物可有效控制螨虫，线虫，稻虱，烟芽夜蛾和南方玉米根虫。 还阐述了制备这些化合物的方法。

公开(公告)号：US5081282A

公开(公告)日：1992-01-14

申请号：US143506

申请日：1988-01-13

申请人： Robert L. Jones ,  Norman H. Wilson

发明人： Robert L. Jones ,  Norman H. Wilson

IPC分类号： A61K31/16 ,  A61K31/18 ,  A61K31/19 ,  A61K31/215 ,  A61K31/27 ,  A61K31/34 ,  A61K31/343 ,  A61K31/42 ,  A61K31/423 ,  A61K31/425 ,  A61K31/428 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/557 ,  A61P7/02 ,  A61P9/08 ,  A61P11/08 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07C33/05 ,  C07C45/30 ,  C07C45/44 ,  C07C47/225 ,  C07C47/47 ,  C07C57/26 ,  C07C59/11 ,  C07C59/147 ,  C07C59/205 ,  C07C59/46 ,  C07C59/74 ,  C07C59/80 ,  C07C62/16 ,  C07C62/22 ,  C07C62/36 ,  C07C62/38 ,  C07C67/00 ,  C07C69/66 ,  C07C69/73 ,  C07C69/732 ,  C07C231/00 ,  C07C235/40 ,  C07C235/82 ,  C07C251/18 ,  C07C251/42 ,  C07C251/54 ,  C07C251/82 ,  C07C251/88 ,  C07C281/06 ,  C07C281/10 ,  C07C313/00 ,  C07C323/47 ,  C07C323/48 ,  C07C323/53 ,  C07C323/55 ,  C07C335/04 ,  C07C401/00 ,  C07C403/00 ,  C07C405/00 ,  C07D213/75 ,  C07D263/58 ,  C07D277/82 ,  C07D307/935 ,  C07D493/08

CPC分类号： C07D493/08 ,  C07C251/72 ,  C07C403/20 ,  C07C405/0041 ,  C07C405/0066 ,  C07C405/0091 ,  C07C45/305 ,  C07C45/44 ,  C07C47/225 ,  C07C47/47 ,  C07C57/26 ,  C07C2101/16

摘要： Bicyclo prostaglandin analogues have been prepared.

公开(公告)号：US4942246A

公开(公告)日：1990-07-17

申请号：US360468

申请日：1989-06-02

申请人： Norio Tanaka ,  Takuya Kakuta ,  Eiichi Oya ,  Masatoshi Baba

发明人： Norio Tanaka ,  Takuya Kakuta ,  Eiichi Oya ,  Masatoshi Baba

IPC分类号： C07D231/20 ,  A01N43/56 ,  B01J27/128 ,  B01J31/28 ,  C07B61/00 ,  C07C17/12 ,  C07C25/13 ,  C07C43/174 ,  C07C63/70 ,  C07C205/12 ,  C07C205/19 ,  C07C205/34 ,  C07C245/20 ,  C07C255/50 ,  C07C255/53 ,  C07C255/54 ,  C07C317/14 ,  C07C317/22 ,  C07C317/32 ,  C07C317/44 ,  C07C317/46 ,  C07C323/09 ,  C07C323/20 ,  C07C323/36 ,  C07C323/48 ,  C07C323/62 ,  C07C323/63 ,  C07C331/12 ,  C07D231/22

CPC分类号： C07D231/22 ,  C07C17/12 ,  C07C201/12 ,  C07C255/50 ,  C07C315/02 ,  C07C315/04 ,  C07C317/14 ,  C07C317/22 ,  C07C317/44 ,  C07C319/14 ,  C07C319/20 ,  C07C323/09 ,  C07C323/20 ,  C07C323/36 ,  C07C323/62 ,  C07C323/63 ,  C07C331/12

摘要： A process for producing a 4-benzoyl-5-hydroxylpyrazole of the formula III: ##STR1## which comprises reacting carbon monoxide and a 5-hydroxypyrazole of the formula II: ##STR2## to a substituted benzene of the formula I: ##STR3## wherein X is a bromine atom, an iodine atom or a diazonium tetrafluoroboron salt group, in the presence of a base and a catalyst of Group VIII of the Periodic Table.

公开(公告)号：US4394387A

公开(公告)日：1983-07-19

申请号：US279918

申请日：1981-07-02

申请人： Leonard G. Copping ,  John C. Kerry ,  Thomas I. Watkins ,  Robert J. Willis ,  Bryan H. Palmer

发明人： Leonard G. Copping ,  John C. Kerry ,  Thomas I. Watkins ,  Robert J. Willis ,  Bryan H. Palmer

IPC分类号： A01N33/26 ,  A01N31/08 ,  A01N37/28 ,  A01N39/04 ,  A01N41/04 ,  A01N41/10 ,  A01N43/08 ,  A01N43/10 ,  A01N47/24 ,  A01N47/34 ,  A01N53/00 ,  A01P7/04 ,  C07C67/00 ,  C07C241/02 ,  C07C301/00 ,  C07C303/28 ,  C07C303/30 ,  C07C309/63 ,  C07C309/65 ,  C07C309/66 ,  C07C309/67 ,  C07C309/73 ,  C07C309/76 ,  C07C311/03 ,  C07C313/00 ,  C07C315/00 ,  C07C315/04 ,  C07C317/32 ,  C07C319/20 ,  C07C323/32 ,  C07C323/48 ,  C07D295/30 ,  C07D307/68 ,  C07D333/38 ,  A01N41/02 ,  A01N43/40 ,  A01N47/10 ,  A01N47/28

CPC分类号： C07D295/30 ,  A01N37/28 ,  A01N39/04 ,  A01N41/04 ,  A01N41/10 ,  A01N43/08 ,  A01N43/10 ,  A01N47/24 ,  A01N47/34 ,  A01N53/00 ,  C07C309/65 ,  C07C309/66 ,  C07C309/67 ,  C07C309/73 ,  C07C311/03 ,  C07C323/32 ,  C07D307/68 ,  C07D333/38 ,  C07C2101/02 ,  C07C2101/04 ,  C07C2101/08

摘要： Novel compounds are described which are substituted benzophenone hydrazones. They have pesticidal activity, especially against insects and acarids, and pesticidal compositions and methods are described. Methods of making the compounds, and novel intermediates, are also described.

公开(公告)号：US4344893A

公开(公告)日：1982-08-17

申请号：US124183

申请日：1980-02-25

申请人： Leonard G. Copping ,  John C. Kerry ,  Thomas I. Watkins ,  Robert J. Willis ,  Bryan H. Palmer

发明人： Leonard G. Copping ,  John C. Kerry ,  Thomas I. Watkins ,  Robert J. Willis ,  Bryan H. Palmer

IPC分类号： A01N33/26 ,  A01N31/08 ,  A01N37/28 ,  A01N39/04 ,  A01N41/04 ,  A01N41/10 ,  A01N43/08 ,  A01N43/10 ,  A01N47/24 ,  A01N47/34 ,  A01N53/00 ,  A01P7/04 ,  C07C67/00 ,  C07C241/02 ,  C07C301/00 ,  C07C303/28 ,  C07C303/30 ,  C07C309/63 ,  C07C309/65 ,  C07C309/66 ,  C07C309/67 ,  C07C309/73 ,  C07C309/76 ,  C07C311/03 ,  C07C313/00 ,  C07C315/00 ,  C07C315/04 ,  C07C317/32 ,  C07C319/20 ,  C07C323/32 ,  C07C323/48 ,  C07D295/30 ,  C07D307/68 ,  C07D333/38 ,  C07C143/68 ,  C07C133/04 ,  C07C133/08 ,  C07C143/74

CPC分类号： C07D295/30 ,  A01N37/28 ,  A01N39/04 ,  A01N41/04 ,  A01N41/10 ,  A01N43/08 ,  A01N43/10 ,  A01N47/24 ,  A01N47/34 ,  A01N53/00 ,  C07C309/65 ,  C07C309/66 ,  C07C309/67 ,  C07C309/73 ,  C07C311/03 ,  C07C323/32 ,  C07D307/68 ,  C07D333/38 ,  C07C2101/02 ,  C07C2101/04 ,  C07C2101/08

摘要： Novel compounds are described which are substituted benzophenone hydrazones. They have pesticidal activity, especially against insects and acarids, and pesticidal compositions and methods are described. Methods of making the compounds, and novel intermediates, are also described.

摘要翻译： 描述了取代的二苯甲酮腙的新型化合物。 它们具有杀虫活性，特别是针对昆虫和螨虫，并描述了杀虫剂组合物和方法。 还描述了制备化合物和新型中间体的方法。

公开(公告)号：US4279911A

公开(公告)日：1981-07-21

申请号：US157203

申请日：1980-06-06

申请人： Michael Martin-Smith ,  Barry J. Price ,  John Bradshaw ,  John W. Clitherow

发明人： Michael Martin-Smith ,  Barry J. Price ,  John Bradshaw ,  John W. Clitherow

IPC分类号： A61K31/34 ,  A61K31/341 ,  A61K31/345 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/495 ,  A61K31/505 ,  A61P1/04 ,  C07C67/00 ,  C07C209/00 ,  C07C209/60 ,  C07C211/29 ,  C07C217/48 ,  C07C261/04 ,  C07C275/32 ,  C07C301/00 ,  C07C303/36 ,  C07C303/40 ,  C07C311/64 ,  C07C313/00 ,  C07C323/29 ,  C07C323/44 ,  C07C323/47 ,  C07C323/48 ,  C07C325/00 ,  C07C335/08 ,  C07D209/48 ,  C07D213/32 ,  C07D295/096 ,  C07D307/28 ,  C07D307/38 ,  C07D307/52 ,  C07D333/20 ,  C07D405/12 ,  C07D409/12 ,  A61K31/44 ,  C07D213/58 ,  C07D307/54

CPC分类号： C07D209/48 ,  C07D213/32 ,  C07D295/096 ,  C07D307/52 ,  C07D333/20 ,  Y10S514/826 ,  Y10S514/887 ,  Y10S514/925 ,  Y10S514/926 ,  Y10S514/927

摘要： The invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts, N-oxides, hydrates and bioprecursors thereof, in which Y represents .dbd.O, .dbd.S, .dbd.CHNO.sub.2 or .dbd.NR.sub.3 where R.sub.3 represents hydrogen, nitro, cyano, lower alkyl, aryl, lower alkylsulphonyl or arylsulphonyl; R.sub.1 and R.sub.2, which may be the same or different, each represent hydrogen lower alkyl, cycloalkyl, lower alkenyl, aralkyl, hydroxy, lower trifluoroalkyl, lower alkyl substituted by hydroxy, lower alkoxy, amine, lower alkylamino or dialkylamino, or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a 5 to 7 membered heterocyclic ring which may contain other heteroatoms or the group ##STR2## where R.sub.4 represents hydrogen or lower alkyl;Q represents a furan or thiophen ring in which incorporation into the rest of the molecule is through bonds at the 2- and 5-positions, or a benzene ring in which incorporation into the rest of the molecule is through bonds at the 1- and 3- or 1- and 4-positions;X represents --CH.sub.2 --, --O-- or --S--;n represents zero, 1 or 2;m represents 2, 3 or 4;Alk represents a straight chain alkylene group of 1 to 3 carbon atoms; (except that n is not zero when X is oxygen and Q is a furan or thiophen ring system);q represents 2, 3 or 4 or can additionally represent zero or 1 when E is a --CH.sub.2 -group;p represents zero, 1 or 2;E represents --CH.sub.2 --, --O-- or --S--; andZ represents a monocyclic 5 or 6 membered carbocyclic or heterocyclic aromatic ring which may be optionally substituted by one or more groups or Z represents the group ##STR3## where Q' represents any of the rings defined for Q; Alk' represents any of the groups defined for Alk; and R.sub.5 and R.sub.6, which may be the same or different, each represent any of the groups defined for R.sub.1 and R.sub.2 ; (except that p is not zero when E is oxygen and Q' or Z is a furan or thiophen ring system).The compounds of formula (I) show pharmacological activity as selective histamine H.sub.2 -antagonists.

公开(公告)号：US4233302A

公开(公告)日：1980-11-11

申请号：US970534

申请日：1978-12-18

申请人： Michael Martin-Smith ,  Barry J. Price ,  John Bradshaw ,  John W. Clitherow

发明人： Michael Martin-Smith ,  Barry J. Price ,  John Bradshaw ,  John W. Clitherow

IPC分类号： A61K31/34 ,  A61K31/341 ,  A61K31/345 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/495 ,  A61K31/505 ,  A61P1/04 ,  C07C67/00 ,  C07C209/00 ,  C07C209/60 ,  C07C211/29 ,  C07C217/48 ,  C07C261/04 ,  C07C275/32 ,  C07C301/00 ,  C07C303/36 ,  C07C303/40 ,  C07C311/64 ,  C07C313/00 ,  C07C323/29 ,  C07C323/44 ,  C07C323/47 ,  C07C323/48 ,  C07C325/00 ,  C07C335/08 ,  C07D209/48 ,  C07D213/32 ,  C07D295/096 ,  C07D307/28 ,  C07D307/38 ,  C07D307/52 ,  C07D333/20 ,  C07D405/12 ,  C07D409/12 ,  A61K31/44 ,  C07D213/58 ,  C07D307/54

CPC分类号： C07D209/48 ,  C07D213/32 ,  C07D295/096 ,  C07D307/52 ,  C07D333/20 ,  Y10S514/826 ,  Y10S514/887 ,  Y10S514/925 ,  Y10S514/926 ,  Y10S514/927

摘要： The invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts, N-oxides, hydrates and bioprecursors thereof, in whichY represents .dbd.O, .dbd.S, .dbd.CHNO.sub.2 or .dbd.NR.sub.3 where R.sub.3 represents hydrogen, nitro, cyano, lower alkyl, aryl, lower alkylsulphonyl or arylsulphonyl;R.sub.1 and R.sub.2, which may be the same or different, each represent hydrogen lower alkyl, cycloalkyl, lower alkenyl, aralkyl, hydroxy, lower trifluoroalkyl, lower alkyl substituted by hydroxy, lower alkoxy, amine, lower alkylamino or dialkylamino, or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a 5 to 7 membered heterocyclic ring which may contain other heteroatoms or the group ##STR2## where R.sub.4 represents hydrogen or lower alkyl; Q represents a furan or thiophen ring in which incorporation into the rest of the molecule is through bonds at the 2- and 5-positions, or a benzene ring in which incorporation into the rest of the molecule is through bonds at the 1- and 3- or 1- and 4-positions;X represents --CH.sub.2, --O-- or --S--;n represents zero, 1 or 2;m represents 2, 3 or 4;Alk represents a straight chain alkylene group of 1 to 3 carbon atoms; (except that n is not zero when X is oxygen and Q is a furan or thiophen ring system)q represents 2, 3 or 4 or can additionally represent zero or 1 when E is a --CH.sub.2 -group;p represents zero, 1 or 2;E represents --CH.sub.2 --, --O-- or --S--; andZ represents a monocyclic 5 or 6 membered carbocyclic or heterocyclic aromatic ring which may be optionally substituted by one or more groups or Z represents the group ##STR3## where Q' represents any of the rings defined for Q; Alk' represents any of the groups defined for Alk; andR.sub.5 and R.sub.6, which may be the same or different, each represent any of the groups defined for R.sub.1 and R.sub.2 ; (except that p is not zero when E is oxygen and Q' or Z is a furan or thiophen ring system).The compounds of formula (I) show pharmacological activity as selective histamine H.sub.2 -antagonists.