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    Flexible circuit electrode array
    3.
    发明授权
    Flexible circuit electrode array 有权
    柔性电路电极阵列

    公开(公告)号：US08639344B2

    公开(公告)日：2014-01-28

    申请号：US11413689

    申请日：2006-04-28

    申请人： Robert Jay Greenberg ,  Neil Hamilton Talbot ,  Jordan Matthew Neysmith ,  James Singleton Little ,  Brian V. Mech ,  Mark Humayun ,  Dilek Guven ,  Anne-Marie de Merlier Ripley

    发明人： Robert Jay Greenberg ,  Neil Hamilton Talbot ,  Jordan Matthew Neysmith ,  James Singleton Little ,  Brian V. Mech ,  Mark Humayun ,  Dilek Guven ,  Anne-Marie de Merlier Ripley

    IPC分类号： A61N1/05

    CPC分类号： H05K3/0011 ,  A61N1/0541 ,  A61N1/0543 ,  A61N1/36036 ,  A61N1/36046 ,  Y10T29/49124

    摘要： Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.

    摘要翻译： 聚合物材料可用作神经刺激的电极阵列体。 它们对视网膜刺激特别有用，用于创建人造视觉，人工耳蜗刺激以创建人造听觉或皮质刺激许多目的。 通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。 太小的压力会导致电阻增加以及电场分散。 太大的压力可能会阻止血液流动。 通常的柔性电路制造技术通常需要使柔性电路电极阵列平坦。 由于神经组织几乎从不平坦，平面阵列必然会施加不均匀的压力。 此外，柔性电路聚合物阵列的边缘可以是尖锐的并切割精细的神经组织。 通过将适量的热应用于完整的阵列，可以引起曲线。 对于热塑性聚合物，可以进一步有利的是在多个模具中反复加热柔性电路，每个模具具有减小的半径。 此外，沿着边缘添加材料是有利的。 在柔性电路阵列中提供折叠或扭曲是更有利的。 可以在折叠内部和外部添加附加材料以促进与组织的良好密封。

    Implantable device using ultra-nanocrystalline diamond
    4.
    发明授权
    Implantable device using ultra-nanocrystalline diamond 有权
    使用超微晶钻石的植入式装置

    公开(公告)号：US08630720B2

    公开(公告)日：2014-01-14

    申请号：US13474003

    申请日：2012-05-17

    申请人： Brian V. Mech ,  Robert J. Greenberg

    发明人： Brian V. Mech ,  Robert J. Greenberg

    IPC分类号： A61N1/00

    CPC分类号： C23C16/274 ,  A61K9/0009 ,  A61N1/0543 ,  A61N1/36046 ,  A61N1/375 ,  C23C16/277 ,  C23C16/278 ,  C23C16/279 ,  H01L23/29 ,  H01L23/3107 ,  H01L2924/0002 ,  H01L2924/00

    摘要： An implantable biocompatible electrical device is uniformly covered with a coating approximately one-micron thick of ultra-nanocrystalline diamond, hermetically sealing the electrical device. Selected electrodes are either left uncovered during coating or uncovered by conventional patterning techniques, allowing the electrodes to be exposed to living tissue and fluids. The ultra-nanocrystalline diamond coating may be doped to create electrically conductive electrodes. These approaches eliminate the need for a hermetically sealed lid or cover to protect electrical circuitry, and thus allow the device to be thinner than otherwise possible. The conformal ultra-nanocrystalline diamond coating uniformly covers the device, providing relief from sharp edges and producing a strong, uniformly thick hermetic coating around sharp edges and on high aspect-ratio parts.

    摘要翻译： 植入式生物相容性电气装置均匀地覆盖有大约1微米厚的超微晶金刚石的涂层，气密地密封电气装置。 所选择的电极在涂覆期间未被覆盖或者通过常规图案化技术未被覆盖，允许电极暴露于活组织和流体。 超级纳米晶体金刚石涂层可以被掺杂以产生导电电极。 这些方法消除了对密封的盖或盖的需要以保护电路，并且因此允许该装置比其它可能的更薄。 保形的超纳米晶金刚石涂层均匀地覆盖了该装置，从尖锐的边缘提供浮雕，并在尖锐的边缘和高纵横比的部分上产生强而均匀的厚的密封涂层。

    FLEXIBLE CIRCUIT ELECTRODE ARRAY
    8.
    发明申请
    FLEXIBLE CIRCUIT ELECTRODE ARRAY 审中-公开
    柔性电路阵列

    公开(公告)号：US20080221653A1

    公开(公告)日：2008-09-11

    申请号：US12044830

    申请日：2008-03-07

    申请人： Rajat Agrawal ,  Robert J. Greenberg ,  Mark S. Humayun ,  James Singleton Little ,  Brian V. Mech ,  Jordan Matthew Neysmith ,  Neil Hamilton Talbot ,  Dao Min Zhou

    发明人： Rajat Agrawal ,  Robert J. Greenberg ,  Mark S. Humayun ,  James Singleton Little ,  Brian V. Mech ,  Jordan Matthew Neysmith ,  Neil Hamilton Talbot ,  Dao Min Zhou

    IPC分类号： A61N1/00

    CPC分类号： A61N1/05 ,  A61N1/0541 ,  A61N1/0543 ,  A61N1/36046

    摘要： A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a central opening in the area of the metal traces. A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a soft polymer filling an attachment point. A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a hump to avoid a touching of the flexible electrode array and the optic nerve.

    摘要翻译： 一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 和金属痕迹区域的中心开口。 一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 和填充附着点的软质聚合物。 一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 和一个驼峰以避免触摸柔性电极阵列和视神经。