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    METHODS AND DEVICES FOR THE TREATMENT OF OCULAR CONDITIONS
    1.
    发明申请
    METHODS AND DEVICES FOR THE TREATMENT OF OCULAR CONDITIONS 失效
    用于治疗眼睛病症的方法和设备

    公开(公告)号：US20110159073A1

    公开(公告)日：2011-06-30

    申请号：US12981038

    申请日：2010-12-29

    申请人： Eugene deJuan ,  Signe E. Varner ,  Laurie R. Lawin

    发明人： Eugene deJuan ,  Signe E. Varner ,  Laurie R. Lawin

    IPC分类号： A61F2/00

    CPC分类号： A61K9/0051 ,  A61F9/0017 ,  A61L27/54 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/43 ,  A61L2300/602 ,  A61L2430/16

    摘要： Featured is a method for instilling one or more bioactive agents into ocular tissue within an eye of a patient for the treatment of an ocular condition, the method comprising concurrently using at least two of the following bioactive agent delivery methods (A)-(C): (A) implanting a sustained release delivery device comprising one or more bioactive agents in a posterior region of the eye so that it delivers the one or more bioactive agents into the vitreous humor of the eye; (B) instilling (e.g., injecting or implanting) one or more bioactive agents subretinally; and (C) instilling (e.g., injecting or delivering by ocular iontophoresis) one or more bioactive agents into the vitreous humor of the eye.

    摘要翻译： 特征是一种将一种或多种生物活性剂滴入患者眼睛内用于治疗眼部病症的眼组织的方法，所述方法包括同时使用至少两种以下生物活性剂递送方法（A） - （C） （A）将包含一种或多种生物活性剂的持续释放递送装置植入眼睛的后部区域，使得其将一种或多种生物活性剂递送至眼睛的玻璃体液中; （B）将一种或多种生物活性剂灌注（例如注射或植入） 和（C）将眼睛离子电渗疗法中的一种或多种生物活性剂灌注（例如，注射或递送）到眼睛的玻璃体液中。

    Methods and devices for the treatment of ocular conditions
    2.
    发明授权
    Methods and devices for the treatment of ocular conditions 失效
    用于治疗眼部病症的方法和装置

    公开(公告)号：US08454582B2

    公开(公告)日：2013-06-04

    申请号：US12981038

    申请日：2010-12-29

    申请人： Eugene deJuan ,  Signe E. Varner ,  Laurie R. Lawin

    发明人： Eugene deJuan ,  Signe E. Varner ,  Laurie R. Lawin

    IPC分类号： A61K9/22 ,  A61M31/00

    CPC分类号： A61K9/0051 ,  A61F9/0017 ,  A61L27/54 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/43 ,  A61L2300/602 ,  A61L2430/16

    摘要： Featured is a method for instilling one or more bioactive agents into ocular tissue within an eye of a patient for the treatment of an ocular condition, the method comprising concurrently using at least two of the following bioactive agent delivery methods (A)-(C): (A) implanting a sustained release delivery device comprising one or more bioactive agents in a posterior region of the eye so that it delivers the one or more bioactive agents into the vitreous humor of the eye; (B) instilling (e.g., injecting or implanting) one or more bioactive agents subretinally; and (C) instilling (e.g., injecting or delivering by ocular iontophoresis) one or more bioactive agents into the vitreous humor of the eye.

    摘要翻译： 特征是一种将一种或多种生物活性剂滴入患者眼睛内用于治疗眼部病症的眼组织的方法，所述方法包括同时使用至少两种以下生物活性剂递送方法（A） - （C） （A）将包含一种或多种生物活性剂的持续释放递送装置植入眼睛的后部区域，使得其将一种或多种生物活性剂递送至眼睛的玻璃体液中; （B）将一种或多种生物活性剂灌注（例如注射或植入） 和（C）将眼睛离子电渗疗法中的一种或多种生物活性剂灌注（例如，注射或递送）到眼睛的玻璃体液中。

    Controlled release bioactive agent delivery device
    3.
    发明授权
    Controlled release bioactive agent delivery device 失效
    控制释放生物活性剂输送装置

    公开(公告)号：US08034369B2

    公开(公告)日：2011-10-11

    申请号：US11225301

    申请日：2005-09-12

    申请人： Aron B. Anderson ,  Laurie R. Lawin ,  Byron C. Shen ,  Eugene de Juan ,  Signe E. Varner ,  Ralph A. Chappa

    发明人： Aron B. Anderson ,  Laurie R. Lawin ,  Byron C. Shen ,  Eugene de Juan ,  Signe E. Varner ,  Ralph A. Chappa

    IPC分类号： A61F2/00

    CPC分类号： A61K31/58 ,  A61F2310/00353 ,  A61K9/0051

    摘要： The invention provides a controlled release bioactive agent delivery device for treatment of an eye that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The first polymer and the second polymer are hydrophobic, and the body member has a length such that, upon placement of the device at an implantation site within a posterior segment of an eye, the device does not enter a central visual field of the eye. The invention also provides methods method of delivering bioactive agent to a posterior region of an eye.

    摘要翻译： 本发明提供一种用于治疗眼睛的控制释放生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中至少一部分 身体构件偏离延伸方向，以及与本体构件的表面接触的聚合物涂覆的组合物，聚合物涂覆的组合物包括第一聚合物，第二聚合物和生物活性剂。 第一聚合物和第二聚合物是疏水性的，并且本体构件具有这样的长度，使得当将该装置放置在眼睛后部的植入部位时，该装置不进入眼睛的中心视野。 本发明还提供了将生物活性剂递送到眼后部区域的方法。

    Controlled release bioactive agent delivery device
    4.
    发明授权
    Controlled release bioactive agent delivery device 失效
    控制释放生物活性剂输送装置

    公开(公告)号：US08021680B2

    公开(公告)日：2011-09-20

    申请号：US10835530

    申请日：2004-04-29

    申请人： Aron B. Anderson ,  Laurie R. Lawin ,  Byron C. Shen ,  Eugene de Juan ,  Signe E. Varner ,  Ralph A. Chappa

    发明人： Aron B. Anderson ,  Laurie R. Lawin ,  Byron C. Shen ,  Eugene de Juan ,  Signe E. Varner ,  Ralph A. Chappa

    IPC分类号： A61F2/00

    CPC分类号： A61K31/58 ,  A61F2310/00353 ,  A61K9/0051

    摘要： The invention provides a controlled release bioactive agent delivery device that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent, wherein the first polymer comprises polyalkyl(meth)acrylate, aromatic poly(meth)acrylate, or a combination of polyalkyl(meth)acrylate and aromatic poly(meth)acrylate, and wherein the second polymer comprises poly(ethylene-co-vinyl acetate). The invention also provides methods of delivering a bioactive agent to a patient in a controlled release manner, as well as methods of making a controlled release bioactive agent delivery device.

    摘要翻译： 本发明提供一种控制释放的生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中，身体构件的至少一部分偏离 所述聚合物涂覆组合物包括第一聚合物，第二聚合物和生物活性剂，其中所述第一聚合物包含（甲基）丙烯酸烷基酯，（甲基）丙烯酸烷基酯，芳族聚（甲基）丙烯酸酯， ）丙烯酸酯或聚（甲基）丙烯酸烷基酯和芳族聚（甲基）丙烯酸酯的组合，其中第二聚合物包括聚（乙烯 - 共 - 乙酸乙烯酯）。 本发明还提供了以受控释放方式将生物活性剂递送到患者的方法，以及制备受控释放的生物活性剂递送装置的方法。

    Controlled release bioactive agent delivery device
    5.
    发明授权
    Controlled release bioactive agent delivery device 失效
    控制释放生物活性剂输送装置

    公开(公告)号：US07976862B2

    公开(公告)日：2011-07-12

    申请号：US11203879

    申请日：2005-08-15

    申请人： Aron B. Anderson ,  Laurie R. Lawin ,  Byron C. Shen ,  Eugene de Juan ,  Signe E. Varner ,  Ralph A. Chappa

    发明人： Aron B. Anderson ,  Laurie R. Lawin ,  Byron C. Shen ,  Eugene de Juan ,  Signe E. Varner ,  Ralph A. Chappa

    IPC分类号： A61F2/00

    CPC分类号： A61K31/58 ,  A61F2310/00353 ,  A61K9/0051

    摘要： The invention provides implantable sustained release bioactive agent delivery devices that include a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension; and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The polymeric coated composition is formulated to provide controlled release of bioactive agent over time when introduced into physiological conditions. Methods of preparing implantable devices configured and formulated to provide controlled release of bioactive agent are also provided.

    摘要翻译： 本发明提供了可植入的缓释生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中，身体构件的至少一部分偏离 延伸方向; 以及与本体构件的表面接触的聚合物涂覆的组合物，所述聚合物涂覆的组合物包含第一聚合物，第二聚合物和生物活性剂。 配制聚合物涂覆的组合物以在引入生理条件时随时间提供生物活性剂的受控释放。 还提供了配制和配制以提供生物活性剂的受控释放的可植入装置的制备方法。

    Controlled release bioactive agent delivery device
    6.
    发明授权
    Controlled release bioactive agent delivery device 失效
    控制释放生物活性剂输送装置

    公开(公告)号：US07824704B2

    公开(公告)日：2010-11-02

    申请号：US11203981

    申请日：2005-08-15

    申请人： Aron B. Anderson ,  Laurie R. Lawin ,  Byron C. Shen ,  Eugene de Juan ,  Signe E. Varner ,  Ralph A. Chappa

    发明人： Aron B. Anderson ,  Laurie R. Lawin ,  Byron C. Shen ,  Eugene de Juan ,  Signe E. Varner ,  Ralph A. Chappa

    IPC分类号： A61F2/00

    CPC分类号： A61K31/58 ,  A61F2310/00353 ,  A61K9/0051

    摘要： The invention provides retrievable devices for sustained delivery of bioactive agent to a site within a patient, the devices including a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension; a cap at the proximal end of the body member; and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent.

    摘要翻译： 本发明提供了用于将生物活性剂持续递送到患者内的部位的可回收装置，所述装置包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中， 身体构件的至少一部分偏离延伸方向; 在主体构件的近端处的帽; 以及与本体构件的表面接触的聚合物涂覆的组合物，所述聚合物涂覆的组合物包含第一聚合物，第二聚合物和生物活性剂。

    Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility
    7.
    发明授权
    Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility 失效
    用于控制活性剂释放或血液相容性的装置，制品，涂层和方法

    公开(公告)号：US08663673B2

    公开(公告)日：2014-03-04

    申请号：US11493346

    申请日：2006-07-26

    申请人： Timothy M. Kloke ,  Robert W. Hergenrother ,  Laurie R. Lawin

    发明人： Timothy M. Kloke ,  Robert W. Hergenrother ,  Laurie R. Lawin

    IPC分类号： A61F13/00

    CPC分类号： C09D133/14 ,  A61K31/785 ,  A61L15/44 ,  A61L27/34 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L33/064 ,  A61L2300/80 ,  C08L33/26

    摘要： The present invention relates to devices, articles, coatings, and methods for controlled active agent release and/or for providing a hemocompatible surface. More specifically, the present invention relates to copolymer compositions and devices, articles, and methods regarding the same for controlled active agent release. In an embodiment, the present invention includes a copolymer composition. The copolymer composition can include a copolymer and an active agent. In an embodiment, the copolymer includes an effective portion of a monomeric unit including a polar moiety. The active agent can be polar. The active agent can be charged. The active agent can be non-polar. In an embodiment, the copolymer composition includes a random copolymer. In an embodiment, the random copolymer includes butyl methacrylate-co-acrylamido-methyl-propane sulfonate copolymer, which can provide reduced platelet adhesion.

    摘要翻译： 本发明涉及用于控制的活性剂释放和/或用于提供血液相容性表面的装置，制品，涂层和方法。 更具体地说，本发明涉及与受控活性剂释放相同的共聚物组合物和装置，制品和方法。 在一个实施方案中，本发明包括共聚物组合物。 共聚物组合物可以包括共聚物和活性剂。 在一个实施方案中，共聚物包括包含极性部分的单体单元的有效部分。 活性剂可以是极性的。 活性剂可以充电。 活性剂可以是非极性的。 在一个实施方案中，共聚物组合物包括无规共聚物。 在一个实施方案中，无规共聚物包括可提供降低的血小板粘附的甲基丙烯酸丁酯 - 共 - 丙烯酰氨基 - 甲基 - 丙烷磺酸共聚物。

    Bioactive agent release coating and controlled humidity method
    8.
    发明申请
    Bioactive agent release coating and controlled humidity method 有权
    生物活性剂释放涂层和受控湿度法

    公开(公告)号：US20070248637A1

    公开(公告)日：2007-10-25

    申请号：US11207380

    申请日：2005-08-19

    申请人： Ralph A. Chappa ,  Robert W. Hergenrother ,  Aron B. Anderson ,  Linh V. Tran ,  Laurie R. Lawin ,  Ronald F. Ofstead

    发明人： Ralph A. Chappa ,  Robert W. Hergenrother ,  Aron B. Anderson ,  Linh V. Tran ,  Laurie R. Lawin ,  Ronald F. Ofstead

    IPC分类号： A61F2/02 ,  B05D3/00

    CPC分类号： A61L31/16 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/602 ,  A61L2300/606

    摘要： A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).

    摘要翻译： 一种或多种制剂形式的涂料组合物，以及在受控湿度条件下施用这种组合物的方法，用于涂覆装置表面以控制和/或提高其在水性体系中释放生物活性剂的能力。 涂层组合物特别适用于在其递送和/或使用过程中经历显着弯曲和/或膨胀的医疗装置，例如支架和导管。 组合物包括与第一聚合物组分如（甲基）丙烯酸聚烷基酯，（甲基）丙烯酸聚芳酯，（甲基）丙烯酸聚烷基酯或（甲基）丙烯酰基烷基酯）和第二聚合物组分如聚（乙烯 - 共 - 乙酸乙烯酯）。