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    Bioactive agent release coating and controlled humidity method
    1.
    发明申请
    Bioactive agent release coating and controlled humidity method 有权
    生物活性剂释放涂层和受控湿度法

    公开(公告)号：US20070248637A1

    公开(公告)日：2007-10-25

    申请号：US11207380

    申请日：2005-08-19

    申请人： Ralph A. Chappa ,  Robert W. Hergenrother ,  Aron B. Anderson ,  Linh V. Tran ,  Laurie R. Lawin ,  Ronald F. Ofstead

    发明人： Ralph A. Chappa ,  Robert W. Hergenrother ,  Aron B. Anderson ,  Linh V. Tran ,  Laurie R. Lawin ,  Ronald F. Ofstead

    IPC分类号： A61F2/02 ,  B05D3/00

    CPC分类号： A61L31/16 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/602 ,  A61L2300/606

    摘要： A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).

    摘要翻译： 一种或多种制剂形式的涂料组合物，以及在受控湿度条件下施用这种组合物的方法，用于涂覆装置表面以控制和/或提高其在水性体系中释放生物活性剂的能力。 涂层组合物特别适用于在其递送和/或使用过程中经历显着弯曲和/或膨胀的医疗装置，例如支架和导管。 组合物包括与第一聚合物组分如（甲基）丙烯酸聚烷基酯，（甲基）丙烯酸聚芳酯，（甲基）丙烯酸聚烷基酯或（甲基）丙烯酰基烷基酯）和第二聚合物组分如聚（乙烯 - 共 - 乙酸乙烯酯）。

    Bioactive agent release coating and controlled humidity method
    2.
    发明授权
    Bioactive agent release coating and controlled humidity method 有权
    生物活性剂释放涂层和受控湿度法

    公开(公告)号：US07833548B2

    公开(公告)日：2010-11-16

    申请号：US11207380

    申请日：2005-08-19

    申请人： Ralph A. Chappa ,  Robert W. Hergenrother ,  Aron B. Anderson ,  Linh V. Tran ,  Laurie R. Lawin ,  Ronald F. Ofstead

    发明人： Ralph A. Chappa ,  Robert W. Hergenrother ,  Aron B. Anderson ,  Linh V. Tran ,  Laurie R. Lawin ,  Ronald F. Ofstead

    IPC分类号： A61K9/14

    CPC分类号： A61L31/16 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/602 ,  A61L2300/606

    摘要： A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).

    摘要翻译： 一种或多种制剂形式的涂料组合物，以及在受控湿度条件下施用这种组合物的方法，用于涂覆装置表面以控制和/或提高其在水性体系中释放生物活性剂的能力。 涂料组合物特别适用于在其递送和/或使用过程中经历显着弯曲和/或膨胀的医疗装置，例如支架和导管。 组合物包括与第一聚合物组分如（甲基）丙烯酸聚烷基酯，（甲基）丙烯酸聚芳酯，（甲基）丙烯酸聚烷基酯或（甲基）丙烯酰基烷基酯）和第二聚合物组分如聚（乙烯 - 共 - 乙酸乙烯酯）。

    BIOACTIVE AGENT RELEASE COATING AND CONTROLLED HUMIDITY METHOD
    4.
    发明申请
    BIOACTIVE AGENT RELEASE COATING AND CONTROLLED HUMIDITY METHOD 审中-公开
    生物试剂释放涂层和控制湿度法

    公开(公告)号：US20110054417A1

    公开(公告)日：2011-03-03

    申请号：US12941132

    申请日：2010-11-08

    申请人： Ralph A. Chappa ,  Robert W. Hergenrother ,  Aron B. Anderson ,  Linh V. Tran ,  Laurie R. Lawin ,  Ronald F. Ofstead

    发明人： Ralph A. Chappa ,  Robert W. Hergenrother ,  Aron B. Anderson ,  Linh V. Tran ,  Laurie R. Lawin ,  Ronald F. Ofstead

    IPC分类号： A61L29/14 ,  B05D7/00

    CPC分类号： A61L31/16 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/602 ,  A61L2300/606

    摘要： A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).

    摘要翻译： 一种或多种制剂形式的涂料组合物，以及在受控湿度条件下施用这种组合物的方法，用于涂覆装置表面以控制和/或提高其在水性体系中释放生物活性剂的能力。 涂层组合物特别适用于在其递送和/或使用过程中经历显着弯曲和/或膨胀的医疗装置，例如支架和导管。 组合物包括与第一聚合物组分如（甲基）丙烯酸聚烷基酯，（甲基）丙烯酸聚芳酯，（甲基）丙烯酸聚烷基酯或（甲基）丙烯酰基烷基酯）和第二聚合物组分如聚（乙烯 - 共 - 乙酸乙烯酯）。

    Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility
    6.
    发明授权
    Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility 失效
    用于控制活性剂释放或血液相容性的装置，制品，涂层和方法

    公开(公告)号：US08663673B2

    公开(公告)日：2014-03-04

    申请号：US11493346

    申请日：2006-07-26

    申请人： Timothy M. Kloke ,  Robert W. Hergenrother ,  Laurie R. Lawin

    发明人： Timothy M. Kloke ,  Robert W. Hergenrother ,  Laurie R. Lawin

    IPC分类号： A61F13/00

    CPC分类号： C09D133/14 ,  A61K31/785 ,  A61L15/44 ,  A61L27/34 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L33/064 ,  A61L2300/80 ,  C08L33/26

    摘要： The present invention relates to devices, articles, coatings, and methods for controlled active agent release and/or for providing a hemocompatible surface. More specifically, the present invention relates to copolymer compositions and devices, articles, and methods regarding the same for controlled active agent release. In an embodiment, the present invention includes a copolymer composition. The copolymer composition can include a copolymer and an active agent. In an embodiment, the copolymer includes an effective portion of a monomeric unit including a polar moiety. The active agent can be polar. The active agent can be charged. The active agent can be non-polar. In an embodiment, the copolymer composition includes a random copolymer. In an embodiment, the random copolymer includes butyl methacrylate-co-acrylamido-methyl-propane sulfonate copolymer, which can provide reduced platelet adhesion.

    摘要翻译： 本发明涉及用于控制的活性剂释放和/或用于提供血液相容性表面的装置，制品，涂层和方法。 更具体地说，本发明涉及与受控活性剂释放相同的共聚物组合物和装置，制品和方法。 在一个实施方案中，本发明包括共聚物组合物。 共聚物组合物可以包括共聚物和活性剂。 在一个实施方案中，共聚物包括包含极性部分的单体单元的有效部分。 活性剂可以是极性的。 活性剂可以充电。 活性剂可以是非极性的。 在一个实施方案中，共聚物组合物包括无规共聚物。 在一个实施方案中，无规共聚物包括可提供降低的血小板粘附的甲基丙烯酸丁酯 - 共 - 丙烯酰氨基 - 甲基 - 丙烷磺酸共聚物。

    Combination degradable and non-degradable matrices for active agent delivery
    10.
    发明授权
    Combination degradable and non-degradable matrices for active agent delivery 有权
    用于活性剂递送的组合可降解和不可降解的基质

    公开(公告)号：US08968782B2

    公开(公告)日：2015-03-03

    申请号：US11770316

    申请日：2007-06-28

    申请人： Ralph A. Chappa ,  Robert W. Hergenrother ,  Paula Bushendorf ,  Joram Slager

    发明人： Ralph A. Chappa ,  Robert W. Hergenrother ,  Paula Bushendorf ,  Joram Slager

    IPC分类号： A61K47/30 ,  A61K38/02 ,  A61K9/00 ,  A61K39/395 ,  A61K45/00 ,  A61L27/58 ,  A61L27/48 ,  A61L27/54 ,  C08L23/08 ,  C08L33/08 ,  C08L71/02

    CPC分类号： A61L27/58 ,  A61L27/48 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/256 ,  A61L2300/604 ,  C08L23/0853 ,  C08L23/0869 ,  C08L33/08 ,  C08L71/02 ,  C08L2201/06 ,  C08L2666/22

    摘要： The present invention relates to relates to combination degradable and non-degradable matrices and related methods. In an embodiment, the invention includes an active agent delivery matrix including a degradable polymer network, a non-degradable polymer network, the non-degradable polymer network interspersed within the degradable polymer network, and an active agent. In an embodiment, the invention includes an active agent elution control matrix including a degradable polymer; and a non-degradable polymer interspersed with the degradable polymer. In an embodiment, the invention includes a method of making an active agent delivery matrix including mixing a degradable polymer with a first solvent to form a degradable polymer solution; mixing a non-degradable polymer with a second solvent to form a non-degradable polymer solution; and simultaneously depositing the degradable polymer solution and the non-degradable polymer solution onto a substrate.

    摘要翻译： 本发明涉及可降解和不可降解的基质和相关方法。 在一个实施方案中，本发明包括活性剂递送基质，其包括可降解聚合物网络，不可降解聚合物网络，散布在可降解聚合物网络内的不可降解聚合物网络和活性剂。 在一个实施方案中，本发明包括包含可降解聚合物的活性剂洗脱控制基质; 和散布有可降解聚合物的不可降解聚合物。 在一个实施方案中，本发明包括制备活性剂递送基质的方法，包括将可降解聚合物与第一溶剂混合以形成可降解聚合物溶液; 将不可降解的聚合物与第二溶剂混合以形成不可降解的聚合物溶液; 同时将可降解聚合物溶液和不可降解聚合物溶液沉积在基材上。