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公开(公告)号:US5453354A
公开(公告)日:1995-09-26
申请号:US108000
申请日:1993-08-18
申请人: Eva Akerlof , Ake Pousette
发明人: Eva Akerlof , Ake Pousette
IPC分类号: A61K38/00 , A61K35/16 , A61K38/16 , A61K39/395 , A61P13/02 , A61P15/00 , C07K1/16 , C07K1/22 , C07K14/00 , C07K14/435 , C07K14/47 , C07K14/52 , C07K14/76 , C07K14/765 , C07K14/775 , C07K16/00 , C07K16/06 , C07K16/18 , C07K16/24 , C07K16/42 , C07K19/00 , G01N33/577 , A01N1/02
CPC分类号: C07K16/42 , C07K14/4705 , C07K14/765 , C07K14/775 , C07K16/06 , C07K16/18 , A61K38/00
摘要: The present invention relates to a macromolecule of proteinaceous nature which activates sperm motility, a process for the preparation thereof by purification of the macromolecule from extracellular fluids, pharmaceutical preparations containing the macromolecule and antibodies directed against determinants specific to the macromolecule and the use thereof as a method to assay the potential fertility of sperm.
摘要翻译: 本发明涉及一种蛋白质性质的大分子,其活化精子活力,其通过从细胞外液中纯化大分子而制备的方法,含有大分子的药物制剂和针对大分子特异性决定簇的抗体及其作为 测定精子潜力的方法。
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公开(公告)号:US5304464A
公开(公告)日:1994-04-19
申请号:US777277
申请日:1991-11-27
申请人: Eva Akerlof , Ake Pousette
发明人: Eva Akerlof , Ake Pousette
IPC分类号: A61K38/00 , A61K35/16 , A61K38/16 , A61K39/395 , A61P13/02 , A61P15/00 , C07K1/16 , C07K1/22 , C07K14/00 , C07K14/435 , C07K14/47 , C07K14/52 , C07K14/76 , C07K14/765 , C07K14/775 , C07K16/00 , C07K16/06 , C07K16/18 , C07K16/24 , C07K16/42 , C07K19/00 , G01N33/577 , A01N1/02 , A61K37/10
CPC分类号: C07K16/42 , C07K14/4705 , C07K14/765 , C07K14/775 , C07K16/06 , C07K16/18 , A61K38/00
摘要: The present invention relates to a macromolecule of proteinaceous nature which activates sperm motility, a process for the preparation thereof by purification of the macromolecule from extracellular fluids, pharmaceutical preparations containing the macromolecule and antibodies directed against determinants specific to the macromolecule and the use thereof as a method to assay the potential fertility of sperm.
摘要翻译: PCT No.PCT / SE90 / 00213 Sec。 371日期1991年11月27日 102(e)日期1991年11月27日PCT 1990年4月2日PCT PCT。 出版物WO90 / 12032 1990年10月18日的日期。本发明涉及一种活化精子活力的蛋白质性质的大分子,其通过从细胞外液中纯化大分子而制备的方法,含有大分子的药物制剂和针对特异性的决定簇的抗体 大分子及其用途作为测定精子潜在生殖力的方法。
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3.
公开(公告)号:US20050143357A1
公开(公告)日:2005-06-30
申请号:US10505665
申请日:2003-02-25
申请人: Ake Pousette , Gunnar Norstedt , Jacob Pang
发明人: Ake Pousette , Gunnar Norstedt , Jacob Pang
IPC分类号: A61K31/59 , A61K38/17 , A61K45/06 , A61P13/08 , G01N33/50 , G01N33/574 , C12Q1/68 , C07H21/04 , C07K14/72
CPC分类号: G01N33/57434 , A61K31/59 , A61K38/1709 , A61K45/06 , G01N33/5011 , A61K2300/00
摘要: A method for selecting a compound or a composition of matter for treatment of hyperproliferative disorders of the prostate in a mammal by administering the compound or the composition to a mammal (in vivo) or to a prostate cell culture (in vitro) and assessing the effect of the compound or the composition on the content of the transcription and/or translation product of a gene under the influence of at least one regulatory region of Vitamin D upregulated protein 1 (VDUP-1) gene and optionally assessing the effect of the compound or the composition on the content of apoptosis signalling kinase (ASK-1) and/or thioredoxin, in the prostate cells of said mammal or in the cells of the prostate cell culture. A substance for use in the treatment of hyperproliferative disorders of the prostate selected by the above method, a pharmaceutical composition comprising said substance, a method of treatment by of a hyperproliferative disorder of the prostate. A gene encoding VDUP-1 or a functional equivalent thereof for use as a medicament and a vector capable of expressing VDUP-1. A method of diagnosis of a hyperproliferative disorder of the prostate in a mammal by assessing the content of the transcription and/or translation products of at least one of the genes encoding ezrin, thioredoxin, peroxiredoxin 5, cyclin-dependent kinase 4, growth response protein CL6, defender against cell death 1, CD24, osteoactivin, vitamin D-upregulated protein 1, placental growth factor gene 1+2, Gata-4, duffy blood antigen, interferon-inducible 17-kDa membrane protein, 14-3-3 protein, CD9 antigen (p24), Ste-20 related kinase, ephrin type A receptor 5 precursor, programmed cell death factor 4 and DNA-methyltransferase 3a, in cells obtained from the prostate of said mammal. A kit for use in a method of diagnosis of a hyperproliferative disorder of the prostate in a mammal.
摘要翻译: 一种用于通过将哺乳动物(体内)或前列腺细胞培养物(体外)施用该化合物或组合物或在体外给予前列腺细胞培养物(体外)来选择用于治疗哺乳动物过度增生性疾病的物质的化合物或组合物的方法, 的化合物或组合物在维生素D上调蛋白1(VDUP-1)基因的至少一个调节区域的影响下的基因的转录和/或翻译产物的含量,并任选地评估化合物的作用或 在所述哺乳动物的前列腺细胞或前列腺细胞培养物的细胞中的凋亡信号激酶(ASK-1)和/或硫氧还蛋白的含量的组成。 用于治疗通过上述方法选择的前列腺增生性疾病的物质,包含所述物质的药物组合物,通过前列腺过度增生性病症治疗的方法。 编码VDUP-1或其功能等同物的基因用作药物和能够表达VDUP-1的载体。 通过评估编码ezrin,硫氧还蛋白,过氧氧化还原酶5,细胞周期蛋白依赖性激酶4,生长反应蛋白质的至少一种基因的转录和/或翻译产物的含量来诊断哺乳动物中前列腺过度增生性疾病的方法 CL6,抗细胞死亡防御1,CD24,骨诱导因子,维生素D上调蛋白1,胎盘生长因子基因1 + 2,Gata-4,duffy血液抗原,干扰素诱导型17-kDa膜蛋白,14-3-3蛋白 ,CD9抗原(p24),Ste-20相关激酶,ephrin A型受体5前体,程序性细胞死亡因子4和DNA-甲基转移酶3a在从所述哺乳动物前列腺获得的细胞中。 用于诊断哺乳动物前列腺过度增生性疾病的方法的试剂盒。
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