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公开(公告)号：US07408027B1
公开(公告)日：2008-08-05
申请号：US09640737
申请日：2000-08-17
申请人： Eva-Maria Mandelkow , Eckhard Mandelkow , Birgit Lichtenberg-Kraag , Jacek Biernat , Gerard Drewes , Barbara Steiner
发明人： Eva-Maria Mandelkow , Eckhard Mandelkow , Birgit Lichtenberg-Kraag , Jacek Biernat , Gerard Drewes , Barbara Steiner
IPC分类号： A61K38/04 , A61K39/395 , C07K16/00 , C12N5/16 , C12N5/06
CPC分类号： C07K14/4711 , A61K38/00 , A61K39/00 , C07K16/18 , C07K16/40 , C12N9/12 , C12N9/1205 , C12N9/16 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： The invention relates to epitopes of the tau protein which are specifically occurring in a phosphorylated state in tau protein from Alzheimer paired helical filaments, to protein kinases which are responsible for the phosphorylation of the amino acids of the tau protein giving rise to said epitopes, and to antibodies specific for said epitopes. The invention further relates to pharmaceutical compositions for the treatment or prevention of Alzheimer's disease, to diagnostic compositions and methods for the detection of Alzheimer's disease and to the use of said epitopes for the generation of antibodies specifically detecting Alzheimer tau protein. Additionally, the invention relates to methods for testing drugs effective in dissolving Alzheimer paired helical filaments or preventing the formation thereof.
摘要翻译： 本发明涉及tau蛋白的表位，其特异性地以来自阿尔茨海默成对螺旋丝的tau蛋白的磷酸化状态发生，导致引起所述表位的tau蛋白的氨基酸的磷酸化的蛋白激酶，以及 对于所述表位特异性的抗体。 本发明还涉及用于治疗或预防阿尔茨海默氏病的药物组合物，用于检测阿尔茨海默氏病的诊断组合物和方法，以及所述表位用于产生特异性检测阿尔茨海默氏病蛋白质的抗体的用途。 此外，本发明涉及用于测试有效地溶解阿尔茨海默氏成对的螺旋丝或抑制其形成的药物的方法。
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2.发明授权公开(公告)号：US06200768B1
公开(公告)日：2001-03-13
申请号：US08244603
申请日：1994-11-28
申请人： Eva-Maria Mandelkow , Eckhard Mandelkow , Birgit Lichtenberg-Kraag , Jacek Biernat , Gerard Drewes , Barbara Steiner
发明人： Eva-Maria Mandelkow , Eckhard Mandelkow , Birgit Lichtenberg-Kraag , Jacek Biernat , Gerard Drewes , Barbara Steiner
IPC分类号： C12Q148
CPC分类号： C12N9/1205 , A61K38/00 , A61K39/00 , C07K14/4711 , C07K16/18 , C07K16/40 , C12N9/12 , C12N9/16 , G01N33/6896 , G01N2333/4709 , G01N2800/2821 , Y10S435/961 , Y10S436/811
摘要： The invention relates to epitopes of the protein which are specifically occurring in a phosphorylated state in tau protein from Alzheimer paired helical filaments, to protein kinases which are responsible for the phosphorylation of the amino acids of the tau protein giving rise to said epitopes, and to antibodies specific for said epitopes. The invention further relates to pharmaceutical compositions for the treatment or prevention of Alzheimer's disease, to diagnostic compositions and methods for the detection of Alzheimer's disease and to the use of said epitopes for the generation of antibodies specifically detecting Alzheimer tau protein. Additionally, the invention relates to methods for testing drugs effective in dissolving Alzheimer paired helical filaments or preventing the formation thereof.
摘要翻译： 本发明涉及在阿尔茨海默成对螺旋丝中的tau蛋白中特异性发生磷酸化状态的蛋白质的表位，以及导致产生所述表位的tau蛋白的氨基酸的磷酸化的蛋白激酶，以及 对所述表位特异的抗体。 本发明还涉及用于治疗或预防阿尔茨海默氏病的药物组合物，用于检测阿尔茨海默氏病的诊断组合物和方法，以及所述表位用于产生特异性检测阿尔茨海默氏病蛋白质的抗体的用途。 此外，本发明涉及用于测试有效地溶解阿尔茨海默氏成对的螺旋丝或抑制其形成的药物的方法。
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公开(公告)号：US07176290B2
公开(公告)日：2007-02-13
申请号：US10066810
申请日：2002-02-04
申请人： Eva-Marie Mandelkow , Eckhard Mandelkow , Birgit Lichtenberg-Kraag , Jacek Biernat , Gerard Drewes , Barbara Steiner
发明人： Eva-Marie Mandelkow , Eckhard Mandelkow , Birgit Lichtenberg-Kraag , Jacek Biernat , Gerard Drewes , Barbara Steiner
CPC分类号： C07K14/4711 , A61K38/00 , A61K39/00 , C07K16/18 , C07K16/40 , C12N9/12 , C12N9/1205 , C12N9/16 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： The present invention relates to phosphorylated tau protein epitopes associated with Alzheimer's disease, to protein kinases responsible for tau protein epitope phosphorylation, and to antibodies specific for the tau epitopes. Additionally, the present invention relates to pharmaceutical compositions, methods for detection, and methods of testing drugs effective in dissolving paired helical filaments associated with Alzheimer's disease.
摘要翻译： 本发明涉及与阿尔茨海默病相关的磷酸化tau蛋白表位，负责tau蛋白表位磷酸化的蛋白激酶以及对tau表位特异的抗体。 另外，本发明涉及药物组合物，检测方法和测试有效地溶解与阿尔茨海默氏病有关的配对螺旋丝的药物的方法。
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公开(公告)号：US20090162336A1
公开(公告)日：2009-06-25
申请号：US12185319
申请日：2008-08-04
申请人： Eva-Marie Mandelkow , Eckhard Mandelkow , Birgit Lichtenberg-Kraag , Jacek Biernat , Gerard Drewes , Barbara Steiner
发明人： Eva-Marie Mandelkow , Eckhard Mandelkow , Birgit Lichtenberg-Kraag , Jacek Biernat , Gerard Drewes , Barbara Steiner
CPC分类号： C12N9/1205 , A61K38/00 , A61K39/00 , C07K14/4711 , C07K16/18 , C07K16/40 , C12N9/12 , C12N9/16 , G01N33/6896 , G01N2333/4709 , G01N2800/2821 , Y10S435/961 , Y10S436/811
摘要： The invention relates to epitopes of the tau protein which are specifically occurring in a phosphorylated state in tau protein from Alzheimer paired helical filaments, to protein kinases which are responsible for the phosphorylation of the amino acids of the tau protein giving rise to said epitopes, and to antibodies specific for said epitopes. The invention further relates to pharmaceutical compositions for the treatment or prevention of Alzheimer's disease, to diagnostic compositions and methods for the detection of Alzheimer's disease and to the use of said epitopes for the generation of antibodies specifically detecting Alzheimer tau protein. Additionally, the invention relates to methods for testing drugs effective in dissolving Alzheimer paired helical filaments or preventing the formation thereof.
摘要翻译： 本发明涉及tau蛋白的表位，其特异性地以来自阿尔茨海默成对螺旋丝的tau蛋白的磷酸化状态发生，导致引起所述表位的tau蛋白的氨基酸的磷酸化的蛋白激酶，以及 对于所述表位特异性的抗体。 本发明还涉及用于治疗或预防阿尔茨海默氏病的药物组合物，用于检测阿尔茨海默氏病的诊断组合物和方法，以及所述表位用于产生特异性检测阿尔茨海默氏病蛋白质的抗体的用途。 此外，本发明涉及用于测试有效地溶解阿尔茨海默氏成对的螺旋丝或抑制其形成的药物的方法。
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公开(公告)号：US20100151064A1
公开(公告)日：2010-06-17
申请号：US12513480
申请日：2007-11-05
申请人： Eckhard Mandelkow , Eva-Maria Mandelkow , Markus Pickhardt , Jacek Biernat , David George Lloyd , Boris Schmidt , Gregor Larbig
发明人： Eckhard Mandelkow , Eva-Maria Mandelkow , Markus Pickhardt , Jacek Biernat , David George Lloyd , Boris Schmidt , Gregor Larbig
IPC分类号： A61K36/16 , A61K31/55 , A61K31/444 , A61K31/435 , A61K31/445 , A61K31/4439 , A61K31/428 , C07D417/12 , A61P25/28 , A61P25/16 , A61P27/02 , A61P25/14 , A61P25/00 , A61K31/4433
CPC分类号： C07D417/12 , C07D277/50 , C07D417/04
摘要： Described are compounds having a thiazolhydrazide scaffold, pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing at least one of these compounds together with pharmaceutically acceptable carrier, excipient and/or diluents. Said thiazolhydrazide compounds can be used for prophylaxis and/or treatment of neurodegenerative diseases and conditions.
摘要翻译： 描述了具有噻唑酰肼支架的化合物，这些化合物的药学上可接受的盐和包含这些化合物中的至少一种以及药学上可接受的载体，赋形剂和/或稀释剂的药物组合物。 所述噻唑酰肼化合物可用于预防和/或治疗神经变性疾病和病症。
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公开(公告)号：US08410152B2
公开(公告)日：2013-04-02
申请号：US12513480
申请日：2007-11-05
申请人： Eckhard Mandelkow , Eva-Maria Mandelkow , Markus Pickhardt , Jacek Biernat , David George Lloyd , Boris Schmidt , Gregor Larbig
发明人： Eckhard Mandelkow , Eva-Maria Mandelkow , Markus Pickhardt , Jacek Biernat , David George Lloyd , Boris Schmidt , Gregor Larbig
IPC分类号： A01N43/78 , A61K31/425
CPC分类号： C07D417/12 , C07D277/50 , C07D417/04
摘要： Described are compounds having a thiazolhydrazide scaffold, pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing at least one of these compounds together with pharmaceutically acceptable carrier, excipient and/or diluents. Said thiazolhydrazide compounds can be used for prophylaxis and/or treatment of neurodegenerative diseases and conditions.
摘要翻译： 描述了具有噻唑酰肼支架的化合物，这些化合物的药学上可接受的盐和包含这些化合物中的至少一种以及药学上可接受的载体，赋形剂和/或稀释剂的药物组合物。 所述噻唑酰肼化合物可用于预防和/或治疗神经变性疾病和病症。
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公开(公告)号：US20060223812A1
公开(公告)日：2006-10-05
申请号：US11351884
申请日：2006-02-10
IPC分类号： A61K31/497 , A61K31/506
CPC分类号： A61K31/497 , A61K31/506
摘要： The present invention relates to the use of compounds capable of inhibiting protein aggregate formation and capable of depolymerising protein aggregates for the preparation of a pharmiaceutical composition for treating neurodegenerative conditions such as Alzheimer disease.
摘要翻译： 本发明涉及能够抑制蛋白质聚集体形成并能够解聚蛋白质聚集体用于制备用于治疗神经变性疾病如阿尔茨海默病的药物组合物的化合物的用途。
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公开(公告)号：US06579691B1
公开(公告)日：2003-06-17
申请号：US08817832
申请日：1997-09-09
IPC分类号： C12N912
CPC分类号： C12N9/1205 , A61K38/00 , C07K14/4711
摘要： The present invention relates to a DNA sequence encoding a neuronal protein kinase (NPK) which phosphorylates tau proteins as well as other microtubule associated proteins (MAPs) in positions crucial for the binding to microtubules. The invention further relates to Serine or Theorine residues and epitopes comprising said residues phosphorylated by said NMK on said MAPs, to antibodies specifically binding to said protein kinase, pharmaceutical compositions comprising inhibitors to said protein kinase, in particular for the treatment of Alzheimer's disease and cancer, to diagnostic kits and to in vitro diagnostic methods for the detection of Alzheimer's disease and cancer.
摘要翻译： 本发明涉及编码神经元蛋白激酶（NPK）的DNA序列，其在与微管结合至关重要的位置磷酸化tau蛋白以及其它微管相关蛋白（MAP）。 本发明还涉及包含所述NMK在所述MAP上磷酸化的所述残基的丝氨酸或Theorine残基和与所述蛋白激酶特异性结合的抗体的药物组合物，所述药物组合物包含所述蛋白激酶的抑制剂，特别是用于治疗阿尔茨海默氏病和癌症 ，诊断试剂盒和用于检测阿尔茨海默病和癌症的体外诊断方法。
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公开(公告)号：US07485712B2
公开(公告)日：2009-02-03
申请号：US10440435
申请日：2003-05-16
CPC分类号： C12N9/1205 , A61K38/00 , C07K14/4711
摘要： The present invention relates to a DNA sequence encoding a novel neuronal protein kinase (NPK) which phosphorylates tau proteins as well as other microtubule associated proteins (MAPs) in positions crucial for the binding to microtubules. The invention further relates to Serine or Theorine residues and epitopes comprising said residues phosphorylated by said NPK on said MAPs, to antibodies specifically binding to said protein kinase, pharmaceutical compositions comprising inhibitors to said protein kinase, in particular for the treatment of Alzheimer's disease and cancer, to diagnostic kits and to in vitro diagnostic methods for the detection of Alzheimer's disease and cancer.
摘要翻译： 本发明涉及编码新型神经元蛋白激酶（NPK）的DNA序列，其在与微管结合至关重要的位置磷酸化tau蛋白以及其它微管相关蛋白（MAP）。 本发明进一步涉及丝氨酸或Theorine残基和表位，其包含由所述MAP上的所述NPK磷酸化的所述残基，特异性结合所述蛋白激酶的抗体，包含所述蛋白激酶抑制剂的药物组合物，特别是用于治疗阿尔茨海默氏病和癌症 ，诊断试剂盒和用于检测阿尔茨海默病和癌症的体外诊断方法。
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