公开(公告)号：US20180179562A1

公开(公告)日：2018-06-28

申请号：US15898369

申请日：2018-02-16

Applicant: AJINOMOTO CO., INC. ,  EVOLVA SA

Inventor： Markus Schwab ,  Maud Babau ,  David Fischer ,  Anaelle Hatsch ,  Sabina de Andrade Pereira Tavares ,  Curt Aime Friis Nielsen ,  Jens Klein ,  Corina Daniela Wirdnam

IPC: C12P13/00 ,  C12P1/02 ,  C12N1/16 ,  C12N9/12 ,  C12P7/64

CPC classification number: C12P13/001 ,  C07C215/10 ,  C07F9/09 ,  C12N1/16 ,  C12N9/12 ,  C12N9/1205 ,  C12P1/02 ,  C12P7/6481 ,  C12Y207/01091 ,  C12Y207/11001

Abstract: A method for producing an objective substance such as phytosphingosine and sphinganine using yeast is provided. An objective substance is produced by cultivating yeast having an ability to produce the objective substance and modified so that the expression and/or activities of proteins encoded by LCB4 and CKA2 genes are reduced in a culture medium, and collecting the objective substance from cells of the yeast and/or the culture medium.

公开(公告)号：US20180179563A1

公开(公告)日：2018-06-28

申请号：US15898358

申请日：2018-02-16

Applicant: AJINOMOTO CO., INC. ,  EVOLVA SA

Inventor： Markus Schwab ,  Corina Daniela Wirdnam ,  Thomas Oestergaard Tange ,  Maud Babau ,  Anaelle Hatsch ,  Fanny Delegrange ,  David Fischer ,  Sabina de Andrade Pereira Tavares

IPC: C12P13/02 ,  C12P13/00

CPC classification number: C12P13/02 ,  C12N2500/05 ,  C12N2500/30 ,  C12P13/001 ,  C12Y101/01102 ,  C12Y114/13169 ,  C12Y114/18 ,  C12Y203/01 ,  C12Y203/01024 ,  C12Y203/0105 ,  C12Y203/01199 ,  C12Y204/0108 ,  C12Y207/01091 ,  C12Y207/11001 ,  C12Y305/01023 ,  C12Y403/01017

Abstract: A method for producing an objective substance such as sphingoid bases and sphingolipids using yeast is provided. An objective substance is produced by cultivating yeast having an ability to produce the objective substance in a culture medium containing an additive that is able to associate with, bind to, solubilize, and/or capture the objective substance, and collecting the objective substance from cells of the yeast and/or the culture medium.

公开(公告)号：US11155841B2

公开(公告)日：2021-10-26

申请号：US15898358

申请日：2018-02-16

Applicant: AJINOMOTO CO., INC. ,  EVOLVA SA

Inventor： Markus Schwab ,  Corina Daniela Wirdnam ,  Thomas Oestergaard Tange ,  Maud Babau ,  Anaelle Hatsch ,  Fanny Delegrange ,  David Fischer ,  Sabina de Andrade Pereira Tavares

IPC: C12P13/00 ,  C12P13/02

Abstract: A method for producing an objective substance such as sphingoid bases and sphingolipids using yeast is provided. An objective substance is produced by cultivating yeast having an ability to produce the objective substance in a culture medium containing an additive that is able to associate with, bind to, solubilize, and/or capture the objective substance, and collecting the objective substance from cells of the yeast and/or the culture medium.

公开(公告)号：US20180371513A1

公开(公告)日：2018-12-27

申请号：US15761654

申请日：2016-09-21

Applicant: Evolva SA

Inventor： Michael Naesby ,  Zina Zokouri ,  David Fischer ,  Michael Eichenberger ,  Anders Hansson

IPC: C12P17/06

Abstract: Methods for producing anthocyanin by expression in a microorganism are disclosed including culturing of the microorganism under anthocyanin producing conditions, wherein the microorganism has an operative metabolic pathway including at least one heterologous enzyme activity, the pathway producing anthocyanin from simple sugars or other simple carbon sources.

公开(公告)号：US11111511B2

公开(公告)日：2021-09-07

申请号：US15898369

申请日：2018-02-16

Applicant: AJINOMOTO CO., INC. ,  EVOLVA SA

Inventor： Markus Schwab ,  Maud Babau ,  David Fischer ,  Anaelle Hatsch ,  Sabina de Andrade Pereira Tavares ,  Curt Aime Friis Nielsen ,  Jens Klein ,  Corina Daniela Wirdnam

IPC: C12P13/00 ,  C12N9/12 ,  C12N1/16 ,  C12P1/02 ,  C12P7/64 ,  C07C215/10 ,  C07F9/09

Abstract: A method for producing an objective substance such as phytosphingosine and sphinganine using yeast is provided. An objective substance is produced by cultivating yeast having an ability to produce the objective substance and modified so that the expression and/or activities of proteins encoded by LCB4 and CKA2 genes are reduced in a culture medium, and collecting the objective substance from cells of the yeast and/or the culture medium.