公开(公告)号：US20180371513A1

公开(公告)日：2018-12-27

申请号：US15761654

申请日：2016-09-21

Applicant: Evolva SA

Inventor： Michael Naesby ,  Zina Zokouri ,  David Fischer ,  Michael Eichenberger ,  Anders Hansson

IPC: C12P17/06

Abstract: Methods for producing anthocyanin by expression in a microorganism are disclosed including culturing of the microorganism under anthocyanin producing conditions, wherein the microorganism has an operative metabolic pathway including at least one heterologous enzyme activity, the pathway producing anthocyanin from simple sugars or other simple carbon sources.

公开(公告)号：US10435730B2

公开(公告)日：2019-10-08

申请号：US15439660

申请日：2017-02-22

Applicant: Evolva SA

Inventor： Jens Houghton-Larsen ,  Paula Hicks ,  Michael Naesby ,  Thomas Tange Ostergaard ,  Jorgen Hansen ,  Michael Mikkelsen Dalgaard ,  Esben Hansen Halkjaer ,  Ernesto Simon ,  Sabina De Andrade Periera Tavares

IPC: C12P19/56 ,  C12N9/10 ,  C12N9/02 ,  C12N1/21 ,  C12N9/88 ,  C12N9/06 ,  C12N9/90 ,  C12N15/81 ,  C12N15/82 ,  C12P19/44 ,  C12N15/63

Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.

公开(公告)号：US20190071474A1

公开(公告)日：2019-03-07

申请号：US16080741

申请日：2017-03-03

Applicant: Evolva SA

Inventor： Esben Halkjaer Hansen ,  Nina Nicoline Rasmussen ,  Michael Naesby ,  Jane Dannow Dyekjaer ,  Simon Carlsen ,  Adam Matthew Takos ,  Nicholas Ohler

IPC: C07K14/415 ,  C12N9/02 ,  C12P27/00

Abstract: The invention relates to recombinant microorganisms and methods for producing gibberellin compounds and gibberellin precursors.

公开(公告)号：US20150344920A1

公开(公告)日：2015-12-03

申请号：US14654291

申请日：2013-12-23

Applicant: Evolva SA

Inventor： Jorgen Hansen ,  Patricia Hoyle ,  Michael Naesby ,  Joseph M. Sheridan ,  Jonathan R. Heal

IPC: C12P17/06 ,  C12P19/44 ,  C12N15/10

CPC classification number: C12P17/06 ,  C12N9/1025 ,  C12N9/1048 ,  C12N15/1079 ,  C12N15/52 ,  C12P19/44 ,  C12Y203/00 ,  C12Y204/00

Abstract: The present disclosure provides methods for identifying anthocyanins with improved stability, color, or hue using a screening method, and producing anthocyanins with improved stability, color, or hue in, for example, host cells comprising one or more heterologous glycosyltransferase nucleic acid molecules and one or more heterologous acyltransferase nucleic acid molecules.

Abstract translation: 本公开提供了使用筛选方法鉴定具有改进的稳定性，颜色或色调的花青素的方法，并且在例如包含一个或多个异源糖基转移酶核酸分子的宿主细胞中产生具有改善的稳定性，颜色或色调的花青素 或更多的异源酰基转移酶核酸分子。

公开(公告)号：US10119154B2

公开(公告)日：2018-11-06

申请号：US14654291

申请日：2013-12-23

Applicant: Evolva SA

Inventor： Jorgen Hansen ,  Patricia Hoyle ,  Michael Naesby ,  Joseph M. Sheridan ,  Jonathan R. Heal

IPC: C12P17/06 ,  C12N15/52 ,  C12N15/10 ,  C12P19/44 ,  C12N9/10

Abstract: The present disclosure provides methods for identifying anthocyanins with improved stability, color, or hue using a screening method, and producing anthocyanins with improved stability, color, or hue in, for example, host cells comprising one or more heterologous glycosyltransferase nucleic acid molecules and one or more heterologous acyltransferase nucleic acid molecules.

公开(公告)号：US20170321238A1

公开(公告)日：2017-11-09

申请号：US15439660

申请日：2017-02-22

Applicant: Evolva SA

Inventor： Jens Houghton-Larsen ,  Paula Hicks ,  Michael Naesby ,  Thomas Tange Ostergaard ,  Jorgen Hansen ,  Michael Mikkelsen Dalgaard ,  Esben Halkjaer Hansen ,  Ernesto Simon ,  Sabina Tavares

IPC: C12P19/56 ,  C12N15/82 ,  C12N15/81 ,  C12N15/63 ,  C12N9/06 ,  C12N9/88 ,  C12N9/10 ,  C12N9/02 ,  C12P19/44 ,  C12N9/90

CPC classification number: C12P19/56 ,  C12N9/0032 ,  C12N9/0071 ,  C12N9/0073 ,  C12N9/1051 ,  C12N9/1085 ,  C12N9/88 ,  C12N9/90 ,  C12N15/63 ,  C12N15/81 ,  C12N15/8243 ,  C12P19/44 ,  Y02P20/52

Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.

公开(公告)号：US20150211036A1

公开(公告)日：2015-07-30

申请号：US14421872

申请日：2013-08-13

Applicant: BASF SE ,  Evolva SA

Inventor： Michael Naesby ,  Christophe Folly ,  Curt Aimé Friis Nielsen ,  Anaelle Hatsch ,  Markus Schwab ,  Oskar Zelder ,  Stefan Haefner ,  Hartwig Schroeder ,  Birgit Hoff ,  Andrea Molt ,  Klaus Ditrich ,  Michael Breuer ,  Holger Hartmann ,  Karsten Koerber

IPC: C12P17/12 ,  C12N9/02 ,  C07D209/90 ,  C12P17/10 ,  C07K16/40 ,  C07D487/06 ,  C12N9/10 ,  C12N9/90

CPC classification number: C12P17/12 ,  C07D209/90 ,  C07D487/06 ,  C07K16/40 ,  C12N9/0004 ,  C12N9/001 ,  C12N9/1007 ,  C12N9/1085 ,  C12N9/90 ,  C12N15/52 ,  C12P17/10 ,  C12P17/182 ,  C12Y205/01

Abstract: Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.

Abstract translation: 用于重组生产角鲨烯型生物碱如环圈子，festuclavine，agroclavine，chanoclavine和chanoclavine醛的微生物和方法，以及多肽，多核苷酸和包含这样的多核苷酸的载体，其可以用于制造棒状的方法 提供生物碱。

公开(公告)号：US20220228185A1

公开(公告)日：2022-07-21

申请号：US17471615

申请日：2021-09-10

Applicant: EVOLVA SA

Inventor： Jens Houghton-Larsen ,  Paula Hicks ,  Michael Naesby ,  Thomas Tange Ostergaard ,  Jorgen Hansen ,  Michael Mikkelsen Dalgaard ,  Esben Hansen Halkjaer ,  Ernesto Simon ,  Sabina De Andrade Periera Tavares

IPC: C12P19/56 ,  C12N9/88 ,  C12N9/06 ,  C12N9/02 ,  C12N9/10 ,  C12N9/90 ,  C12N15/81 ,  C12N15/82 ,  C12P19/44 ,  C12N15/63

Abstract: Recombiant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorgansims, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.

公开(公告)号：US10760062B2

公开(公告)日：2020-09-01

申请号：US15579415

申请日：2016-06-06

Applicant: EVOLVA SA

Inventor： Michael Naesby ,  Ernesto Simón Vecilla ,  Michael Eichenberger ,  Beata Joanna Lehka ,  Walden Emil Bjørn-Yoshimoto ,  Niels Bjerg Jensen

IPC: C12N9/02 ,  C12P7/26 ,  C12P19/44 ,  C12P7/22 ,  C12N9/10 ,  C12N15/81 ,  C12N9/06

Abstract: Provided herein are methods and compositions for producing phenylpropanoid derivatives, such as chalcones and stilbenes, and dihydrophenylpropanoid derivatives, such as dihydrochalcones and dihydrostilbenes, in microorganisms. In particular, the disclosure provides recombinant microorganisms and methods of use thereof for producing phenylpropanoid derivative compounds and dihydrophenylpropanoid derivative compounds.

公开(公告)号：US10190140B2

公开(公告)日：2019-01-29

申请号：US15665674

申请日：2017-08-01

Applicant: Evolva SA

Inventor： Thomas Oestergaard Tange ,  Michael Naesby ,  Christophe Folly ,  Fanny Delegrange ,  Jens Houghton-Larsen ,  Simon Carlsen

IPC: C12N1/16 ,  C12N9/10 ,  C12N9/88 ,  C12P5/00 ,  C12P5/02 ,  C12P7/00 ,  C12P7/04 ,  C12P9/00 ,  C12N15/52 ,  C12N15/63 ,  C12N15/81 ,  C12P15/00 ,  C12P17/10 ,  C12P23/00

Abstract: This invention provides recombinant cells and methods for producing terpenes and terpenoids by increasing production or accumulation or both of isoprenoid precursors thereof.