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1.发明授权Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis 有权显示内皮细胞特异性的启动子及其用于调节血管发生的方法公开(公告)号：US08835398B2
公开(公告)日：2014-09-16
申请号：US13549355
申请日：2012-07-13
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , A61K48/0008 , A61K48/0058 , C07K14/475 , C07K14/49 , C07K14/503 , C07K14/515 , C07K14/52 , C07K14/57536 , C07K14/70578 , C07K2319/70 , C12N15/85 , C12N2710/10343 , C12N2800/108 , C12N2830/002 , C12N2830/008 , C12N2830/15 , C12N2830/30 , C12N2830/85 , C12N2840/20 , C12N2840/203
摘要： Isolated polynucleotide sequences exhibiting endothelial cell specific promoter activity, novel cis regulatory elements and methods of use thereof enabling treatment of diseases characterized by aberrant neovascularization or cell growth are disclosed.
摘要翻译： 公开了显示内皮细胞特异性启动子活性的分离的多核苷酸序列，新的顺式调节元件及其使用方法，其能够治疗以异常新生血管形成或细胞生长为特征的疾病。
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2.发明申请Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis 审中-公开显示内皮细胞特异性的启动子及其用于调节血管发生的方法公开(公告)号：US20100081193A1
公开(公告)日：2010-04-01
申请号：US12591252
申请日：2009-11-13
IPC分类号： C07H21/04
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , A61K48/0008 , A61K48/0058 , C07K14/475 , C07K14/49 , C07K14/503 , C07K14/515 , C07K14/52 , C07K14/57536 , C07K14/70578 , C07K2319/70 , C12N15/85 , C12N2710/10343 , C12N2800/108 , C12N2830/002 , C12N2830/008 , C12N2830/15 , C12N2830/30 , C12N2830/85 , C12N2840/20 , C12N2840/203
摘要： Isolated polynucleotide sequences exhibiting endothelial cell specific promoter activity, novel cis regulatory elements and methods of use thereof enabling treatment of diseases characterized by aberrant neovascularization or cell growth are disclosed.
摘要翻译： 公开了显示内皮细胞特异性启动子活性的分离的多核苷酸序列，新的顺式调节元件及其使用方法，其能够治疗以异常新生血管形成或细胞生长为特征的疾病。
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3.发明申请PROMOTERS EXHIBITING ENDOTHELIAL CELL SPECIFICITY AND METHODS OF USING SAME FOR REGULATION OF ANGIOGENESIS 审中-公开展示内皮细胞特异性及其使用方法用于调节血管生成公开(公告)号：US20110207985A1
公开(公告)日：2011-08-25
申请号：US13098512
申请日：2011-05-02
IPC分类号： A61N5/00
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , A61K48/0008 , A61K48/0058 , C07K14/475 , C07K14/49 , C07K14/503 , C07K14/515 , C07K14/52 , C07K14/57536 , C07K14/70578 , C07K2319/70 , C12N15/85 , C12N2710/10343 , C12N2800/108 , C12N2830/002 , C12N2830/008 , C12N2830/15 , C12N2830/30 , C12N2830/85 , C12N2840/20 , C12N2840/203
摘要： Isolated polynucleotide sequences exhibiting endothelial cell specific promoter activity, novel cis regulatory elements and methods of use thereof enabling treatment of diseases characterized by aberrant neovascularization or cell growth are disclosed.
摘要翻译： 公开了显示内皮细胞特异性启动子活性的分离的多核苷酸序列，新的顺式调节元件及其使用方法，其能够治疗以异常新生血管形成或细胞生长为特征的疾病。
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4.发明授权Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis 有权显示内皮细胞特异性的启动子及其用于调节血管发生的方法公开(公告)号：US08206743B2
公开(公告)日：2012-06-26
申请号：US13018447
申请日：2011-02-01
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , A61K48/0008 , A61K48/0058 , C07K14/475 , C07K14/49 , C07K14/503 , C07K14/515 , C07K14/52 , C07K14/57536 , C07K14/70578 , C07K2319/70 , C12N15/85 , C12N2710/10343 , C12N2800/108 , C12N2830/002 , C12N2830/008 , C12N2830/15 , C12N2830/30 , C12N2830/85 , C12N2840/20 , C12N2840/203
摘要： Isolated polynucleotide sequences exhibiting endothelial cell specific promoter activity, novel cis regulatory elements and methods of use thereof enabling treatment of diseases characterized by aberrant neovascularization or cell growth are disclosed.
摘要翻译： 公开了显示内皮细胞特异性启动子活性的分离的多核苷酸序列，新的顺式调节元件及其使用方法，其能够治疗以异常新生血管形成或细胞生长为特征的疾病。
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5.发明授权Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis 有权显示内皮细胞特异性的启动子及其用于调节血管发生的方法公开(公告)号：US08039261B2
公开(公告)日：2011-10-18
申请号：US11359513
申请日：2006-02-23
CPC分类号： A61K38/1858 , A01K2267/0331 , A01K2267/0393 , A61K31/198 , A61K31/573 , A61K38/1866 , A61K48/00 , A61K48/0058 , A61K48/0066 , C12N15/85 , C12N15/86 , C12N2710/10343 , C12N2830/002 , C12N2830/008 , C12N2840/203
摘要： Isolated polynucleotide sequences exhibiting endothelial cell specific promoter activity, novel cis regulatory elements and methods of use thereof enabling treatment of diseases characterized by aberrant neovascularization or cell growth are disclosed.
摘要翻译： 公开了显示内皮细胞特异性启动子活性的分离的多核苷酸序列，新的顺式调节元件及其使用方法，其能够治疗以异常新生血管形成或细胞生长为特征的疾病。
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公开(公告)号：US09567605B2
公开(公告)日：2017-02-14
申请号：US13520457
申请日：2011-01-05
申请人： Yael Cohen , Naamit Sher , Erez Feige , Livnat Bangio , Eyal Breitbart
发明人： Yael Cohen , Naamit Sher , Erez Feige , Livnat Bangio , Eyal Breitbart
IPC分类号： A01N63/00 , C12N15/00 , C12N7/01 , C12N15/86 , A61K48/00 , C07H21/04 , C07K14/705 , C07K14/715 , A61K38/17 , C12N15/87
CPC分类号： C12N15/86 , A61K38/177 , A61K48/005 , A61K48/0058 , A61K48/0083 , C07K14/70578 , C07K14/7151 , C07K2319/00 , C12N15/87 , C12N2799/022 , C12N2830/008 , C12N2830/85
摘要： Anti-angiogenic adenovirus vectors, and therapeutic use thereof are provided, and more particularly, but not exclusively, clinical protocols for treatment of solid tumors in patients with an Ad5-PPE-1-3X-fas-chimera adenovirus vector.
摘要翻译： 本发明提供了抗血管生成腺病毒载体及其治疗用途，更具体地但非唯一地，用于在Ad5-PPE-1-3X-嵌合体腺病毒载体的患者中治疗实体瘤的临床方案。
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公开(公告)号：US20130209450A1
公开(公告)日：2013-08-15
申请号：US13520452
申请日：2011-01-05
申请人： Yael Cohen , Livnat Bangio , Andrew J. Brenner , Eyal Breitbart
发明人： Yael Cohen , Livnat Bangio , Andrew J. Brenner , Eyal Breitbart
IPC分类号： A61K38/17 , A61K39/395 , A61N5/10 , A61K48/00
CPC分类号： A61K38/177 , A61K38/162 , A61K39/39558 , A61K48/005 , A61K2039/5258 , A61N5/1001 , A61N5/1077 , A61N2005/1087 , C07K14/70578 , C12N2799/022 , Y02E60/36
摘要： Methods of treating a malignant glioma in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a viral vector comprising: (i) a first polynucleotide sequence encoding a Fas-chimera (Fas-c), said first polynucleotide sequence comprising SEQ ID NOs: 2 and 3; and (ii) a second polynucleotide sequence encoding an endothelial cell-specific promoter or a periendothelial cell-specific promoter.
摘要翻译： 公开了治疗受试者的恶性胶质瘤的方法。 所述方法包括向受试者施用治疗有效量的病毒载体，其包含：（i）编码Fas嵌合体（Fas-c）的第一多核苷酸序列，所述第一多核苷酸序列包含SEQ ID NO：2和3; 和（ii）编码内皮细胞特异性启动子或周外皮细胞特异性启动子的第二多核苷酸序列。
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公开(公告)号：US08071740B2
公开(公告)日：2011-12-06
申请号：US10988487
申请日：2004-11-14
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , A61K48/0008 , A61K48/0058 , C07K14/475 , C07K14/49 , C07K14/503 , C07K14/515 , C07K14/52 , C07K14/57536 , C07K14/70578 , C07K2319/70 , C12N15/85 , C12N2710/10343 , C12N2800/108 , C12N2830/002 , C12N2830/008 , C12N2830/15 , C12N2830/30 , C12N2830/85 , C12N2840/20 , C12N2840/203
摘要： Isolated polynucleotide sequences exhibiting endothelial cell specific promoter activity, novel cis regulatory elements and methods of use thereof enabling treatment of diseases characterized by aberrant neovascularization or cell growth are disclosed.
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9.发明申请Methods of Producing Adenovirus Vectors and Viral Preparations Generated Thereby 审中-公开产生腺病毒载体和病毒制剂的方法公开(公告)号：US20130052165A1
公开(公告)日：2013-02-28
申请号：US13521691
申请日：2011-01-12
申请人： Livnat Bangio , Naamit Sher , Eyal Breitbart
发明人： Livnat Bangio , Naamit Sher , Eyal Breitbart
CPC分类号： C12N15/87 , C07K2319/00 , C12N7/00 , C12N2710/10343 , C12N2710/10352 , C12N2830/008
摘要： The present invention, in some embodiments thereof, relates to methods of producing adenoviruses such as pro- and anti-angiogenic adenovirus vectors and preparations generated thereby. Particularly, in some embodiments, the viral vectors comprise a heterologous pro- or anti-angiogenic gene under the transcriptional control of the murine pre-proendothelin promoter (e.g. PPE-1-3X), for targeted expression of in angiogenic endothelium.
摘要翻译： 本发明在其一些实施方案中涉及产生腺病毒的方法，例如促血管生成腺病毒载体和抗血管生成腺病毒载体以及由此产生的制剂。 特别地，在一些实施方案中，病毒载体在鼠前期内皮素启动子（例如PPE-1-3X）的转录控制下包含用于靶向表达血管生成内皮的异源原或抗血管生成基因。
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10.发明申请Promoters Exhibiting Endothelial Cell Specificity and Methods of Using Same for Regulation of Angiogenesis 有权展示内皮细胞特异性的启动子和使用它们调节血管生成的方法公开(公告)号：US20130011367A1
公开(公告)日：2013-01-10
申请号：US13549355
申请日：2012-07-13
IPC分类号： A61K31/7088 , A61P35/00 , A61P9/00 , C12N15/85
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , A61K48/0008 , A61K48/0058 , C07K14/475 , C07K14/49 , C07K14/503 , C07K14/515 , C07K14/52 , C07K14/57536 , C07K14/70578 , C07K2319/70 , C12N15/85 , C12N2710/10343 , C12N2800/108 , C12N2830/002 , C12N2830/008 , C12N2830/15 , C12N2830/30 , C12N2830/85 , C12N2840/20 , C12N2840/203
摘要： Isolated polynucleotide sequences exhibiting endothelial cell specific promoter activity, novel cis regulatory elements and methods of use thereof enabling treatment of diseases characterized by aberrant neovascularization or cell growth are disclosed.
摘要翻译： 公开了显示内皮细胞特异性启动子活性的分离的多核苷酸序列，新的顺式调节元件及其使用方法，其能够治疗以异常新生血管形成或细胞生长为特征的疾病。
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