公开(公告)号：US08425424B2

公开(公告)日：2013-04-23

申请号：US12620235

申请日：2009-11-17

申请人： Eyal Zadicario ,  Arik Hananel ,  Gilat Schiff ,  Javier Grinfeld

发明人： Eyal Zadicario ,  Arik Hananel ,  Gilat Schiff ,  Javier Grinfeld

IPC分类号： A61B8/00

CPC分类号： A61N7/02 ,  A61B5/0263 ,  A61B90/37 ,  A61N7/022

摘要： The present invention provides procedures and systems that use a closed-loop approach for directing ultrasound energy at a clot while monitoring blood flow and/or liquification of the clot tissue so as to allow automated and/or manual adjustments to various treatment parameters.

摘要翻译： 本发明提供了使用闭环方法在凝块上引导超声能量同时监测凝块组织的血流和/或液化以便允许对各种治疗参数进行自动和/或手动调整的程序和系统。

公开(公告)号：US11857807B2

公开(公告)日：2024-01-02

申请号：US16622050

申请日：2018-06-29

申请人： Yoav Levy ,  Rafi De Picciotto ,  Javier Grinfeld ,  Eyal Zadicario

发明人： Yoav Levy ,  Rafi De Picciotto ,  Javier Grinfeld ,  Eyal Zadicario

IPC分类号： A61M37/00 ,  A61N7/00 ,  A61N5/10 ,  A61B5/00 ,  A61N7/02 ,  A61B34/10 ,  A61B6/12 ,  A61B6/03 ,  A61B6/00

CPC分类号： A61N5/1049 ,  A61B5/489 ,  A61B34/10 ,  A61M37/0092 ,  A61N5/103 ,  A61N5/1039 ,  A61N5/1048 ,  A61N5/1064 ,  A61N7/02 ,  A61B5/4836 ,  A61B6/03 ,  A61B6/12 ,  A61B6/504 ,  A61N2005/1052 ,  A61N2005/1055 ,  A61N2005/1058 ,  A61N2005/1061 ,  A61N2005/1087 ,  A61N2005/1092 ,  A61N2005/1098 ,  A61N2007/0004 ,  A61N2007/0039 ,  A61N2007/0052 ,  A61N2007/0082 ,  A61N2007/027

摘要： Various approaches for computationally generating a protocol for treatment of one or more target BBB regions within a tissue region of interest using a source of focused ultrasound include specifying (i) settings of sonication parameters for applying one or more sequence of sonications to the target BBB region using the source of focused ultrasound and (ii) a characteristic of microbubbles selected to be administered into the target BBB region; electronically simulating treatment in accordance with the protocol at least in part by computationally executing the sequence(s) of sonications and computationally administering the microbubbles having the characteristic; and computationally predicting a tissue disruption effect of the target BBB region resulting from the treatment.

公开(公告)号：US11291866B2

公开(公告)日：2022-04-05

申请号：US15837365

申请日：2017-12-11

申请人： Yoav Levy ,  Eyal Zadicario ,  Shuki Vitek ,  Javier Grinfeld ,  Ohad Silbiger

发明人： Yoav Levy ,  Eyal Zadicario ,  Shuki Vitek ,  Javier Grinfeld ,  Ohad Silbiger

IPC分类号： A61B8/00 ,  A61B8/08 ,  G01S15/89 ,  G01S7/52 ,  A61B5/01 ,  A61B5/055 ,  A61N7/02 ,  A61N7/00 ,  A61B17/22 ,  A61B34/10

摘要： Various approaches to generating and maintaining an ultrasound focus at a target region include configuring a controller to cause transmission of treatment ultrasound pulses from a transducer having multiple transducer elements; cause the transducer to transmit focusing ultrasound pulses to the target region and generate an acoustic reflector therein; measure reflections of the focusing ultrasound pulses from the acoustic reflector; based at least in part on the measured reflections, adjust a parameter value associated with one or more transducer elements so as to maintain and/or improve the ultrasound focus at the target region.

公开(公告)号：US06612988B2

公开(公告)日：2003-09-02

申请号：US09738514

申请日：2000-12-15

申请人： Dov Maor ,  Javier Grinfeld ,  Kullervo Hynynen

发明人： Dov Maor ,  Javier Grinfeld ,  Kullervo Hynynen

IPC分类号： A61B800

CPC分类号： A61N7/02 ,  A61B8/0816 ,  A61B2090/374 ,  A61B2090/376 ,  A61N2007/0095

摘要： The invention provides a method of delivering ultrasound signals. The method includes providing an image of at least a portion of a subject intended to receive ultrasound signals between sources of the ultrasound signals and a desired region of the subject for receiving focused ultrasound signals, identifying, from the image, physical characteristics of different layers of material between the sources and the desired region, and determining at least one of phase corrections and amplitude corrections for the sources depending on respective thicknesses of portions of each of the layers disposed between each source and the desired region.