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公开(公告)号：US11857807B2
公开(公告)日：2024-01-02
申请号：US16622050
申请日：2018-06-29
申请人： Yoav Levy , Rafi De Picciotto , Javier Grinfeld , Eyal Zadicario
发明人： Yoav Levy , Rafi De Picciotto , Javier Grinfeld , Eyal Zadicario
IPC分类号： A61M37/00 , A61N7/00 , A61N5/10 , A61B5/00 , A61N7/02 , A61B34/10 , A61B6/12 , A61B6/03 , A61B6/00
CPC分类号： A61N5/1049 , A61B5/489 , A61B34/10 , A61M37/0092 , A61N5/103 , A61N5/1039 , A61N5/1048 , A61N5/1064 , A61N7/02 , A61B5/4836 , A61B6/03 , A61B6/12 , A61B6/504 , A61N2005/1052 , A61N2005/1055 , A61N2005/1058 , A61N2005/1061 , A61N2005/1087 , A61N2005/1092 , A61N2005/1098 , A61N2007/0004 , A61N2007/0039 , A61N2007/0052 , A61N2007/0082 , A61N2007/027
摘要： Various approaches for computationally generating a protocol for treatment of one or more target BBB regions within a tissue region of interest using a source of focused ultrasound include specifying (i) settings of sonication parameters for applying one or more sequence of sonications to the target BBB region using the source of focused ultrasound and (ii) a characteristic of microbubbles selected to be administered into the target BBB region; electronically simulating treatment in accordance with the protocol at least in part by computationally executing the sequence(s) of sonications and computationally administering the microbubbles having the characteristic; and computationally predicting a tissue disruption effect of the target BBB region resulting from the treatment.
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公开(公告)号：US11291866B2
公开(公告)日：2022-04-05
申请号：US15837365
申请日：2017-12-11
申请人： Yoav Levy , Eyal Zadicario , Shuki Vitek , Javier Grinfeld , Ohad Silbiger
发明人： Yoav Levy , Eyal Zadicario , Shuki Vitek , Javier Grinfeld , Ohad Silbiger
IPC分类号： A61B8/00 , A61B8/08 , G01S15/89 , G01S7/52 , A61B5/01 , A61B5/055 , A61N7/02 , A61N7/00 , A61B17/22 , A61B34/10
摘要： Various approaches to generating and maintaining an ultrasound focus at a target region include configuring a controller to cause transmission of treatment ultrasound pulses from a transducer having multiple transducer elements; cause the transducer to transmit focusing ultrasound pulses to the target region and generate an acoustic reflector therein; measure reflections of the focusing ultrasound pulses from the acoustic reflector; based at least in part on the measured reflections, adjust a parameter value associated with one or more transducer elements so as to maintain and/or improve the ultrasound focus at the target region.
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公开(公告)号：US11103731B2
公开(公告)日：2021-08-31
申请号：US15404412
申请日：2017-01-12
申请人： Kobi Vortman , Shuki Vitek , Eyal Zadicario , Yoav Levy
发明人： Kobi Vortman , Shuki Vitek , Eyal Zadicario , Yoav Levy
摘要： Various approaches for heating a target region substantially uniformly include identifying one or more locations of one or more hot spots in the target region and/or surrounding regions of the target region during an ultrasound sonication process; computing a temporal variation to an output parameter of at least one of the transducer elements based at least in part on the identified location(s) of the hot spot(s); and operating the at least one transducer element to achieve the temporal variation of the output parameter so as to minimize the hot spot(s).
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公开(公告)号：US10589129B2
公开(公告)日：2020-03-17
申请号：US15265204
申请日：2016-09-14
申请人： Kobi Vortman , Shuki Vitek , Eyal Zadicario , Yoav Levy
发明人： Kobi Vortman , Shuki Vitek , Eyal Zadicario , Yoav Levy
摘要： Various approaches for reducing microbubble interference with ultrasound waves transmitted from multiple transducer elements and traversing tissue onto a target region include measuring microbubbles in high-throughput areas of ultrasound exposure and reducing the amount of microbubbles using the ultrasound waves.
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公开(公告)号：US10739316B2
公开(公告)日：2020-08-11
申请号：US15837392
申请日：2017-12-11
摘要： Various approaches for calibrating the geometry of an ultrasound transducer having multiple transducer elements include providing an acoustic reflector spanning an area traversing by multiple beam paths of ultrasound waves transmitted from all (or at least some) transducer elements to a focal zone; causing the transducer elements to transmit the ultrasound waves to the focal zone; measuring reflections of the ultrasound waves off the acoustic reflector; and based at least in part on the measured reflections, determining optimal geometric parameters associated with the transducer elements.
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公开(公告)号：US10575816B2
公开(公告)日：2020-03-03
申请号：US15415351
申请日：2017-01-25
摘要： Various approaches for detecting microbubble cavitation resulting from ultrasound waves transmitted from an ultrasound transducer include associating at least one time-domain reference signal with microbubble cavitation; causing the transducer to transmit one or more ultrasound pulse; acquiring, in the time domain, an echo signal from microbubbles in response to the transmitted ultrasound pulse(s); correlating at least a portion of the echo signal to at least a corresponding portion of the time-domain reference signal based on similarity therebetween; and detecting the microbubble cavitation based on the corresponding portion of the reference signal.
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公开(公告)号：US08267576B2
公开(公告)日：2012-09-18
申请号：US11666886
申请日：2005-10-31
申请人： Dietrich Haarer , Yoav Levy
发明人： Dietrich Haarer , Yoav Levy
摘要： The present invention is generally in the field of measuring and indicating techniques and relates to a time-temperature indicating device and methods of manufacturing and reading this device. More specifically, the time-temperature indicator (TTI) device comprises at least one active reactant being at least a part of a component that is configured to be either an electrical component or transformable into an electrical component, said at least one active reactant being selected to be affectable by a chemical and/or physical reaction effecting a change in at least an electrical property of said electrical component at a rate that is time-temperature dependent.
摘要翻译： 本发明通常在测量和指示技术领域中，涉及一种时间温度指示装置及其制造和读取方法。 更具体地，时间 - 温度指示器（TTI）装置包括至少一个活性反应物，其是被配置为电组分或可转化成电组分的组分的至少一部分，所述至少一种活性反应物被选择 通过化学和/或物理反应来影响，所述化学和/或物理反应以时间依赖性的速率影响所述电气部件的至少电性能的变化。
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公开(公告)号：US20120163183A1
公开(公告)日：2012-06-28
申请号：US12979587
申请日：2010-12-28
申请人： Yuri Podlyas , Gil Benamar , Yoav Levy , Doron Tal
发明人： Yuri Podlyas , Gil Benamar , Yoav Levy , Doron Tal
IPC分类号： H04W24/00
CPC分类号： H04W76/12
摘要： A method for acceleration of wireless communication in a residential gateway, the residential gateway enables communication between a plurality of subscriber devices connected in a wireless local area network (WLAN) and a passive optical network (PON). The method comprises pre-configuring a wireless controller to intercept networking functions programmed in a wireless stack of a wireless driver, wherein the wireless controller and the wireless driver are components of a kernel of an operating system executed by a host processor; monitoring system calls initiated by the wireless driver to the kernel; for each monitored system call, checking if a system call is a request for a networking function; and forwarding the system call for a network function to a packet processor.
摘要翻译： 一种用于在住宅网关中加速无线通信的方法，住宅网关实现了连接在无线局域网（WLAN）和无源光网络（PON）之间的多个用户设备之间的通信。 该方法包括预先配置无线控制器以拦截在无线驱动器的无线堆栈中编程的网络功能，其中无线控制器和无线驱动器是由主处理器执行的操作系统的内核的组件; 将无线驱动程序发起的监控系统呼叫发送到内核; 对于每个被监视的系统调用，检查系统调用是否是对联网功能的请求; 并将用于网络功能的系统调用转发到分组处理器。
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公开(公告)号：US11730452B2
公开(公告)日：2023-08-22
申请号：US16378945
申请日：2019-04-09
申请人： Yoav Levy
发明人： Yoav Levy
CPC分类号： A61B8/481 , A61N7/02 , G01S15/895 , A61N2007/0039
摘要： Various approaches for regulating microbubbles in a treatment procedure for a target include generating a tissue-sensitivity map including multiple regions, at least one of the regions being outside the target region, the tissue-sensitivity map assigning, to each of the regions, a sensitivity level indicative of tissue sensitivity to the interaction between the microbubbles and an acoustic beam; select one or more interaction regions based at least in part on the tissue-sensitivity map; and activating the ultrasound transducer so as to generate the acoustic beam for interacting with the microbubbles in the selection interaction region(s) in the tissue-sensitivity map, thereby indirectly changing a characteristic of the microbubbles at the target region.
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公开(公告)号：US11376074B2
公开(公告)日：2022-07-05
申请号：US16929460
申请日：2020-07-15
申请人： Yoav Levy , Benny Assif , Gilad Halevy , Yoni Hertzberg
发明人： Yoav Levy , Benny Assif , Gilad Halevy , Yoni Hertzberg
摘要： A focused-ultrasound or other procedure for treating a target within a tissue region can be planned iteratively by creating a treatment plan specifying a treatment location pattern and stimuli applied thereto, simulating the treatment, computationally predicting an effect of the simulated treatment, comparing the predicted effect against one or more treatment constraints (such as efficacy and/or safety thresholds), and, if a constraint is violated, repeating the simulation for an adjusted treatment plan.
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