公开(公告)号：US08425424B2

公开(公告)日：2013-04-23

申请号：US12620235

申请日：2009-11-17

申请人： Eyal Zadicario ,  Arik Hananel ,  Gilat Schiff ,  Javier Grinfeld

发明人： Eyal Zadicario ,  Arik Hananel ,  Gilat Schiff ,  Javier Grinfeld

IPC分类号： A61B8/00

CPC分类号： A61N7/02 ,  A61B5/0263 ,  A61B90/37 ,  A61N7/022

摘要： The present invention provides procedures and systems that use a closed-loop approach for directing ultrasound energy at a clot while monitoring blood flow and/or liquification of the clot tissue so as to allow automated and/or manual adjustments to various treatment parameters.

摘要翻译： 本发明提供了使用闭环方法在凝块上引导超声能量同时监测凝块组织的血流和/或液化以便允许对各种治疗参数进行自动和/或手动调整的程序和系统。

公开(公告)号：US11857807B2

公开(公告)日：2024-01-02

申请号：US16622050

申请日：2018-06-29

申请人： Yoav Levy ,  Rafi De Picciotto ,  Javier Grinfeld ,  Eyal Zadicario

发明人： Yoav Levy ,  Rafi De Picciotto ,  Javier Grinfeld ,  Eyal Zadicario

IPC分类号： A61M37/00 ,  A61N7/00 ,  A61N5/10 ,  A61B5/00 ,  A61N7/02 ,  A61B34/10 ,  A61B6/12 ,  A61B6/03 ,  A61B6/00

CPC分类号： A61N5/1049 ,  A61B5/489 ,  A61B34/10 ,  A61M37/0092 ,  A61N5/103 ,  A61N5/1039 ,  A61N5/1048 ,  A61N5/1064 ,  A61N7/02 ,  A61B5/4836 ,  A61B6/03 ,  A61B6/12 ,  A61B6/504 ,  A61N2005/1052 ,  A61N2005/1055 ,  A61N2005/1058 ,  A61N2005/1061 ,  A61N2005/1087 ,  A61N2005/1092 ,  A61N2005/1098 ,  A61N2007/0004 ,  A61N2007/0039 ,  A61N2007/0052 ,  A61N2007/0082 ,  A61N2007/027

摘要： Various approaches for computationally generating a protocol for treatment of one or more target BBB regions within a tissue region of interest using a source of focused ultrasound include specifying (i) settings of sonication parameters for applying one or more sequence of sonications to the target BBB region using the source of focused ultrasound and (ii) a characteristic of microbubbles selected to be administered into the target BBB region; electronically simulating treatment in accordance with the protocol at least in part by computationally executing the sequence(s) of sonications and computationally administering the microbubbles having the characteristic; and computationally predicting a tissue disruption effect of the target BBB region resulting from the treatment.

公开(公告)号：US11291866B2

公开(公告)日：2022-04-05

申请号：US15837365

申请日：2017-12-11

申请人： Yoav Levy ,  Eyal Zadicario ,  Shuki Vitek ,  Javier Grinfeld ,  Ohad Silbiger

发明人： Yoav Levy ,  Eyal Zadicario ,  Shuki Vitek ,  Javier Grinfeld ,  Ohad Silbiger

IPC分类号： A61B8/00 ,  A61B8/08 ,  G01S15/89 ,  G01S7/52 ,  A61B5/01 ,  A61B5/055 ,  A61N7/02 ,  A61N7/00 ,  A61B17/22 ,  A61B34/10

摘要： Various approaches to generating and maintaining an ultrasound focus at a target region include configuring a controller to cause transmission of treatment ultrasound pulses from a transducer having multiple transducer elements; cause the transducer to transmit focusing ultrasound pulses to the target region and generate an acoustic reflector therein; measure reflections of the focusing ultrasound pulses from the acoustic reflector; based at least in part on the measured reflections, adjust a parameter value associated with one or more transducer elements so as to maintain and/or improve the ultrasound focus at the target region.

公开(公告)号：US11527001B2

公开(公告)日：2022-12-13

申请号：US17104450

申请日：2020-11-25

申请人： Omer Brokman ,  Oleg Prus ,  Eyal Zadicario

发明人： Omer Brokman ,  Oleg Prus ,  Eyal Zadicario

IPC分类号： G06T7/30 ,  A61B6/03 ,  A61B5/055 ,  A61B6/12 ,  A61B8/00 ,  A61B8/08 ,  A61B6/00 ,  A61B5/00 ,  G06T7/70 ,  A61N7/02 ,  G06T7/00 ,  G06T7/32 ,  G06T3/00 ,  G06T7/20 ,  G06T11/00 ,  G06T15/50 ,  G01R33/56 ,  A61B17/00 ,  G01R33/48 ,  A61B90/00

摘要： Embodiments of the present invention provide systems and methods to detect a moving anatomic feature during a treatment sequence based on a computed and/or a measured shortest distance between the anatomic feature and at least a portion of an imaging system.

公开(公告)号：US20170103533A1

公开(公告)日：2017-04-13

申请号：US14879235

申请日：2015-10-09

申请人： Omer Brokman ,  Oleg Prus ,  Eyal Zadicario

发明人： Omer Brokman ,  Oleg Prus ,  Eyal Zadicario

IPC分类号： G06T7/00

CPC分类号： G06T7/30 ,  A61B5/0035 ,  A61B5/055 ,  A61B6/032 ,  A61B6/12 ,  A61B6/488 ,  A61B6/5247 ,  A61B8/4209 ,  A61B8/4416 ,  A61B8/4483 ,  A61B8/5261 ,  A61B8/5276 ,  A61B2017/0011 ,  A61B2090/364 ,  A61B2090/374 ,  A61B2090/3762 ,  A61N7/02 ,  G01R33/4814 ,  G01R33/5608 ,  G06T3/0068 ,  G06T7/0014 ,  G06T7/20 ,  G06T7/32 ,  G06T7/70 ,  G06T11/006 ,  G06T15/503 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10132 ,  G06T2207/20221

摘要： Embodiments of the present invention provide systems and methods to verify and/or obtain a registration of images obtained two image systems (such as a CT system and an MRI system) via the use of a third imaging modality (such as an ultrasound system).

公开(公告)号：US10589129B2

公开(公告)日：2020-03-17

申请号：US15265204

申请日：2016-09-14

申请人： Kobi Vortman ,  Shuki Vitek ,  Eyal Zadicario ,  Yoav Levy

发明人： Kobi Vortman ,  Shuki Vitek ,  Eyal Zadicario ,  Yoav Levy

IPC分类号： A61N7/00 ,  A61N7/02 ,  A61B5/055 ,  A61B34/10 ,  A61B17/22 ,  A61B8/08 ,  A61B90/00

摘要： Various approaches for reducing microbubble interference with ultrasound waves transmitted from multiple transducer elements and traversing tissue onto a target region include measuring microbubbles in high-throughput areas of ultrasound exposure and reducing the amount of microbubbles using the ultrasound waves.

公开(公告)号：US20120029396A1

公开(公告)日：2012-02-02

申请号：US13194286

申请日：2011-07-29

申请人： Kobi Vortman ,  Eyal Zadicario ,  Shuki Vitek

发明人： Kobi Vortman ,  Eyal Zadicario ,  Shuki Vitek

IPC分类号： A61N7/00

CPC分类号： A61N7/02 ,  A61B8/0808 ,  A61B2090/364 ,  A61B2090/374 ,  A61B2090/3762 ,  A61B2090/378

摘要： Treatment of moving tissue may be facilitated by identifying voxels within a volume of the tissue, associating treatment-related attributes with the voxels, and shifting positions of the voxels based on the tissue movement. One or more treatment parameters may then be altered based on the treatment-related attributes of the shifted voxels.

摘要翻译： 可以通过识别组织体积内的体素，将治疗相关属性与体素相关联，以及基于组织移动来移位体素的位置来促进移动组织的治疗。 然后可以基于移位体素的治疗相关属性来改变一个或多个治疗参数。

公开(公告)号：US11872412B2

公开(公告)日：2024-01-16

申请号：US16112150

申请日：2018-08-24

申请人： Kobi Vortman ,  Shuki Vitek ,  Eyal Zadicario

发明人： Kobi Vortman ,  Shuki Vitek ,  Eyal Zadicario

IPC分类号： A61N7/00 ,  A61N7/02 ,  A61B90/00

CPC分类号： A61N7/00 ,  A61N7/02 ,  A61B2090/374 ,  A61N2007/0073 ,  A61N2007/0078

摘要： A system and method for selecting a patient-specific frequency for ultrasound therapy of a target within the patient are provided. The method includes: (a) for at least one segment of an ultrasound transducer and for each of a plurality of ultrasound frequencies within a test range, sonicating the target and measuring a parameter correlated with an amount of ultrasound energy absorbed in the target; and (b) for each said at least one segment, selecting for subsequent ultrasound therapy, among the frequencies within the test range, a frequency corresponding to a value of the measured parameter that itself corresponds to a maximum amount of ultrasound energy absorbed in the target.

公开(公告)号：US20190009109A1

公开(公告)日：2019-01-10

申请号：US16112150

申请日：2018-08-24

申请人： Kobi Vortman ,  Shuki Vitek ,  Eyal Zadicario

发明人： Kobi Vortman ,  Shuki Vitek ,  Eyal Zadicario

IPC分类号： A61N7/00

摘要： In ultrasound therapy, the frequency of sonications can be optimized, within a certain frequency range, to maximize the absorption or the acoustic intensity at the target in a manner specific to the patient.

公开(公告)号：US20100179425A1

公开(公告)日：2010-07-15

申请号：US12352932

申请日：2009-01-13

申请人： Eyal Zadicario

发明人： Eyal Zadicario

IPC分类号： A61B8/00

CPC分类号： A61N7/02 ,  A61B8/0816 ,  A61B8/585 ,  A61B2018/00023 ,  A61B2090/374 ,  A61B2090/3762 ,  A61N2007/0078

摘要： The emission intensities of transducer elements of an ultrasound transducer array are controlled based on anatomical characteristics of non-uniform tissue regions, e.g., regions of a skull, and a pre-determined threshold.

摘要翻译： 超声换能器阵列的换能器元件的发射强度基于非均匀组织区域（例如颅骨的区域）和预定阈值的解剖特征来控制。