公开(公告)号：US08334510B2

公开(公告)日：2012-12-18

申请号：US13002448

申请日：2009-07-02

申请人： Dov Shachal ,  Rafi De Picciotto

发明人： Dov Shachal ,  Rafi De Picciotto

IPC分类号： H01J37/28 ,  H01J37/20 ,  G01N23/00

CPC分类号： G01N23/22 ,  G01N2223/079 ,  G01N2223/08 ,  H01J37/228 ,  H01J37/256 ,  H01J37/28 ,  H01J2237/164 ,  H01J2237/208 ,  H01J2237/244 ,  H01J2237/2608 ,  H01J2237/2808

摘要： An interface, a scanning electron microscope and a method for observing an object that is positioned in a non-vacuum environment. The method includes: generating an electron beam in the vacuum environment; scanning a region of the object with the electron beam while the object is located below an object holder; wherein the scanning comprises allowing the electron beam to pass through an aperture of an aperture array, pass through an ultra thin membrane that seals the aperture, and pass through the object holder; wherein the ultra thin membrane withstands a pressure difference between the vacuum environment and the non-vacuum environment; and detecting particles generated in response to an interaction between the electron beam and the object.

摘要翻译： 接口，扫描电子显微镜和用于观察位于非真空环境中的物体的方法。 该方法包括：在真空环境中产生电子束; 当物体位于物体保持器下方时用电子束扫描物体的区域; 其中所述扫描包括允许所述电子束穿过孔阵列的孔，穿过密封所述孔的超薄膜并穿过所述物体保持器; 其中所述超薄膜承受所述真空环境和所述非真空环境之间的压力差; 以及检测响应于电子束和物体之间的相互作用而产生的微粒。

公开(公告)号：US20110210247A1

公开(公告)日：2011-09-01

申请号：US13120344

申请日：2009-09-24

申请人： Dov Shachal ,  Rafi De picciotto

发明人： Dov Shachal ,  Rafi De picciotto

IPC分类号： H01J37/28 ,  H01J3/14 ,  H01J3/26 ,  B23P6/00

CPC分类号： H01J37/28 ,  H01J37/16 ,  H01J37/18 ,  H01J2237/0245 ,  H01J2237/164 ,  Y10T29/4973

摘要： A vacuumed device that includes: a sealed housing, an electron beam source, an electron optic component, a thin membrane, and a detector. The thin membrane seals an aperture of the sealed housing. The sealed housing defines a vacuumed space in which vacuum is maintained. The electron beam source is configured to generate an electron beam that propagates within the vacuumed space, interacts with the electron optic component and passes through the thin membrane. A first portion of the sealed housing is shaped to fit a space defined by non-vacuumed scanning electron microscope components that are maintained in a non-vacuum environment.

摘要翻译： 一种真空装置，包括：密封壳体，电子束源，电子光学部件，薄膜和检测器。 薄膜密封密封外壳的孔。 密封的壳体限定了真空保持的真空空间。 电子束源被配置为产生在真空空间内传播的电子束，与电子光学部件相互作用并通过薄膜。 密封壳体的第一部分被成形为适合保持在非真空环境中的非真空扫描电子显微镜部件限定的空间。

公开(公告)号：US20200171327A1

公开(公告)日：2020-06-04

申请号：US16622050

申请日：2018-06-29

申请人： Yoav LEVY ,  Rafi DE PICCIOTTO ,  Javier GRINFELD ,  Eyal ZADICARIO

发明人： Yoav LEVY ,  Rafi DE PICCIOTTO ,  Javier GRINFELD ,  Eyal ZADICARIO

IPC分类号： A61N5/10 ,  A61B34/10 ,  A61N7/02 ,  A61B5/00

摘要： Various approaches for computationally generating a protocol for treatment of one or more target BBB regions within a tissue region of interest using a source of focused ultrasound include specifying (i) settings of sonication parameters for applying one or more sequence of sonications to the target BBB region using the source of focused ultrasound and (ii) a characteristic of microbubbles selected to be administered into the target BBB region; electronically simulating treatment in accordance with the protocol at least in part by computationally executing the sequence(s) of sonications and computationally administering the microbubbles having the characteristic; and computationally predicting a tissue disruption effect of the target BBB region resulting from the treatment.

公开(公告)号：US20110168889A1

公开(公告)日：2011-07-14

申请号：US13002448

申请日：2009-07-02

申请人： Dov Shachal ,  Rafi De Picciotto

发明人： Dov Shachal ,  Rafi De Picciotto

IPC分类号： G01N23/04 ,  G01N23/00

CPC分类号： G01N23/22 ,  G01N2223/079 ,  G01N2223/08 ,  H01J37/228 ,  H01J37/256 ,  H01J37/28 ,  H01J2237/164 ,  H01J2237/208 ,  H01J2237/244 ,  H01J2237/2608 ,  H01J2237/2808

摘要： An interface, a scanning electron microscope and a method for observing an object that is positioned in a non-vacuum environment. The method includes: generating an electron beam in the vacuum environment; scanning a region of the object with the electron beam while the object is located below an object holder; wherein the scanning comprises allowing the electron beam to pass through an aperture of an aperture array, pass through an ultra thin membrane that seals the aperture, and pass through the object holder; wherein the ultra thin membrane withstands a pressure difference between the vacuum environment and the non-vacuum environment; and detecting particles generated in response to an interaction between the electron beam and the object.

摘要翻译： 接口，扫描电子显微镜和用于观察位于非真空环境中的物体的方法。 该方法包括：在真空环境中产生电子束; 当物体位于物体保持器下方时用电子束扫描物体的区域; 其中所述扫描包括允许所述电子束穿过孔阵列的孔，穿过密封所述孔的超薄膜并穿过所述物体保持器; 其中所述超薄膜承受所述真空环境和所述非真空环境之间的压力差; 以及检测响应于电子束和物体之间的相互作用而产生的微粒。

公开(公告)号：US11857807B2

公开(公告)日：2024-01-02

申请号：US16622050

申请日：2018-06-29

申请人： Yoav Levy ,  Rafi De Picciotto ,  Javier Grinfeld ,  Eyal Zadicario

发明人： Yoav Levy ,  Rafi De Picciotto ,  Javier Grinfeld ,  Eyal Zadicario

IPC分类号： A61M37/00 ,  A61N7/00 ,  A61N5/10 ,  A61B5/00 ,  A61N7/02 ,  A61B34/10 ,  A61B6/12 ,  A61B6/03 ,  A61B6/00

CPC分类号： A61N5/1049 ,  A61B5/489 ,  A61B34/10 ,  A61M37/0092 ,  A61N5/103 ,  A61N5/1039 ,  A61N5/1048 ,  A61N5/1064 ,  A61N7/02 ,  A61B5/4836 ,  A61B6/03 ,  A61B6/12 ,  A61B6/504 ,  A61N2005/1052 ,  A61N2005/1055 ,  A61N2005/1058 ,  A61N2005/1061 ,  A61N2005/1087 ,  A61N2005/1092 ,  A61N2005/1098 ,  A61N2007/0004 ,  A61N2007/0039 ,  A61N2007/0052 ,  A61N2007/0082 ,  A61N2007/027

摘要： Various approaches for computationally generating a protocol for treatment of one or more target BBB regions within a tissue region of interest using a source of focused ultrasound include specifying (i) settings of sonication parameters for applying one or more sequence of sonications to the target BBB region using the source of focused ultrasound and (ii) a characteristic of microbubbles selected to be administered into the target BBB region; electronically simulating treatment in accordance with the protocol at least in part by computationally executing the sequence(s) of sonications and computationally administering the microbubbles having the characteristic; and computationally predicting a tissue disruption effect of the target BBB region resulting from the treatment.

公开(公告)号：US08492716B2

公开(公告)日：2013-07-23

申请号：US13120344

申请日：2009-09-24

申请人： Dov Shachal ,  Rafi De Picciotto

发明人： Dov Shachal ,  Rafi De Picciotto

IPC分类号： G01N23/00

CPC分类号： H01J37/28 ,  H01J37/16 ,  H01J37/18 ,  H01J2237/0245 ,  H01J2237/164 ,  Y10T29/4973

摘要： A vacuumed device that includes: a sealed housing, an electron beam source, an electron optic component, a thin membrane, and a detector. The thin membrane seals an aperture of the sealed housing. The sealed housing defines a vacuumed space in which vacuum is maintained. The electron beam source is configured to generate an electron beam that propagates within the vacuumed space, interacts with the electron optic component and passes through the thin membrane. A first portion of the sealed housing is shaped to fit a space defined by non-vacuumed scanning electron microscope components that are maintained in a non-vacuum environment.

摘要翻译： 一种真空装置，包括：密封壳体，电子束源，电子光学部件，薄膜和检测器。 薄膜密封密封外壳的孔。 密封的壳体限定了真空保持的真空空间。 电子束源被配置为产生在真空空间内传播的电子束，与电子光学部件相互作用并通过薄膜。 密封壳体的第一部分被成形为适合保持在非真空环境中的非真空扫描电子显微镜部件限定的空间。