公开(公告)号：US20240177967A1

公开(公告)日：2024-05-30

申请号：US18522679

申请日：2023-11-29

申请人： FEI Company

发明人： Matej Dolník ,  Veronika Vrbovská ,  Radim Kríž ,  Jakub Kuba ,  Tilman Franke

IPC分类号： H01J37/305

CPC分类号： H01J37/3056 ,  H01J2237/31749

摘要： The disclosure relates to a method for micromachining a biological sample for creating a lamella for analysis in a Cryo-Charged Particle Microscope (Cryo-CPM). The method comprising the steps of providing a biological sample on a sample carrier; Locating a sample area on the sample carrier, said sample area comprising a region of interest having biological material from which a lamella can be created; and Micromachining at least part of the biological sample so as to remove material in a part of the sample area surrounding the region of interest, in order to increase a visual contrast between the biological material in the region of interest and its surroundings. With the increased visual contrast a location for a potential lamella can be identified.

公开(公告)号：US20240162001A1

公开(公告)日：2024-05-16

申请号：US18360232

申请日：2023-07-27

申请人： FEI Company

发明人： Michal Valík ,  Petr Malek ,  John Mitchels ,  František Vaške ,  Veronika Vrbovská ,  Miloš Hovorka

IPC分类号： H01J37/20 ,  H01J37/28

CPC分类号： H01J37/20 ,  H01J37/28 ,  H01J2237/20207 ,  H01J2237/208 ,  H01J2237/2802 ,  H01J2237/31749

摘要： The present invention provides a method of sample preparation and analysis and a sample holder that may be used in said method.