公开(公告)号：US20180303393A1

公开(公告)日：2018-10-25

申请号：US15763265

申请日：2016-09-22

Applicant: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH

Inventor： Andreas MAIERHOFER

IPC: A61B5/1455 ,  A61M1/36 ,  G01N33/49

CPC classification number: A61B5/14557 ,  A61B5/14542 ,  A61M1/3609 ,  A61M1/3627 ,  A61M2205/18 ,  A61M2205/3368 ,  A61M2230/20 ,  A61M2230/202 ,  G01N33/4925

Abstract: The invention relates to a blood treatment device with an extracorporeal blood circulation, which uses a gas sensor to measure the concentration of a gas in the gas supernatant of the drip chamber of the extracorporeal blood circulation. The blood treatment device has an evaluation unit, which calculates the corresponding partial pressure of the gas in the blood from the values measured in the gas supernatant in the drip chamber.

公开(公告)号：US20220096720A1

公开(公告)日：2022-03-31

申请号：US17425380

申请日：2020-01-24

Applicant: Fresenius Medical Care Deutschland GmbH

Inventor： Reinder SPICKERMANN ,  Carsten MUELLER ,  Pascal KOPPERSCHMIDT ,  Andreas MAIERHOFER ,  Alfred GAGEL ,  Gerhard WIESEN ,  Liubov SMYSLOVA

IPC: A61M1/16 ,  A61M1/34

Abstract: The present invention relates to an apparatus for an extracorporeal blood treatment having an extracorporeal blood circuit in which a dialyzer is arranged and having a dialyzate circuit, wherein the blood circuit is in fluid communication with a first chamber and the dialyzate circuit is in fluid communication with a second chamber of the dialyzer, and wherein the two chambers are separated from one another by a semipermeable membrane, with a dialyzate pump for a conveying of the dialysis solution being present in the dialyzate circuit, wherein the apparatus has a control unit that is configured to operate the apparatus in a first phase and in a second phase following the first phase, wherein the dialyzate pump is operated with a smaller flow rate in the first phase than in the second phase and/or wherein the dialyzate pump conveys a dialysis solution in the first phase that is of a higher concentration with respect to at least one component than in the second phase.

公开(公告)号：US20170265793A1

公开(公告)日：2017-09-21

申请号：US15504918

申请日：2015-08-17

Applicant: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH

Inventor： Andreas MAIERHOFER

IPC: A61B5/145 ,  A61B5/00

CPC classification number: A61B5/14546 ,  A61B5/1468 ,  A61B5/7221 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/1613 ,  A61M2205/3317 ,  A61M2205/52 ,  A61M2230/20

Abstract: The invention relates to a dialysis machine having the capability of determining a predialytic property in the blood of a dialysis patient which has an extracorporeal blood circuit, a dialyzate circuit, a dialyzer and a processing unit, wherein at least one sensor for determining a property of the dialyzate is arranged in the dialyzate circuit. The processing unit is configured such that temporal evaluation ranges are fixed during an initial phase of the dialysis treatment, in which temporal evaluation ranges all stability criteria from a predefined group are satisfied; and in that only measured values determined by the at least one sensor within these temporal evaluation ranges are used for determining a predialytic property of the patient's blood.

公开(公告)号：US20230173154A1

公开(公告)日：2023-06-08

申请号：US17920045

申请日：2021-04-21

Applicant: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH

Inventor： Andreas MAIERHOFER

IPC: A61M1/16

CPC classification number: A61M1/1617

Abstract: The invention relates to a dialysis device comprising a device for determining at least one first and second haemodialysis parameter, and a method for determining at least one first and second haemodialysis parameter during a dialysis treatment with a dialysis device. The device 20 for determining at least one first and second haemodialysis parameter comprises a device 21 for generating a change in a physical or chemical parameter of the dialysis fluid in the dialysis fluid system 6 in the form of a bolus, and a device 22 for detecting a change over time in the physical or chemical parameter of the dialysis fluid in the dialysis fluid system 6. Furthermore, the dialysis device has a computing and evaluating unit 23 that is configured such that, on the basis of the change in the physical or chemical parameter in the form of a bolus, for at least one dialysis condition at least one value for the clearance of the dialysis treatment is determined, and, on the basis of at least one value for the clearance, a first and second haemodialysis parameter is determined. The dialysis device according to the invention and the method according to the invention are characterised in that boluses of different sizes, in particular boluses having different area contents, are administered to determine the haemodialysis parameter.

公开(公告)号：US20200276380A1

公开(公告)日：2020-09-03

申请号：US15998566

申请日：2017-02-15

Applicant: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH

Inventor： Andreas MAIERHOFER ,  Wei ZHANG

IPC: A61M1/36

Abstract: The invention relates to a blood treatment device having an extracorporeal blood circuit which comprises an arterial line, a blood pump, a blood treatment unit and a venous line, wherein the arterial and venous lines can be connected to a blood vessel of a patient, and wherein the blood treatment device has an evaluation and control unit, wherein the evaluation and control unit is configured to carry out the following steps: (a1) determining the blood recirculation in a blood vessel of the patient connected to the extracorporeal blood circuit; and (b) calculating the blood flow in the blood vessel using the blood recirculation determined in accordance with (a1) and using a provided value or a value likewise previously determined for the cardiac output of the patient.

公开(公告)号：US20170312411A1

公开(公告)日：2017-11-02

申请号：US15521571

申请日：2015-10-22

Applicant: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH

Inventor： Andreas MAIERHOFER

IPC: A61M1/16 ,  G06F1/28 ,  G06F19/00

Abstract: The invention relates to a system comprising a plurality of medical devices, preferably dialysis devices, which are connected to a common supply system, wherein the system has an evaluation unit which is connected to all devices of the system and which is configured such that values set in the different devices and/or predefined values and/or measured values, which are determined by means of at least one sensor and which relate to corresponding parameters, are compared with at least one expected value for recognizing errors of the supply system and/or of an individual device.

公开(公告)号：US20240399036A1

公开(公告)日：2024-12-05

申请号：US18700276

申请日：2022-10-11

Applicant: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH

Inventor： Andreas MAIERHOFER

IPC: A61M1/16 ,  A61M1/34 ,  G01N27/06 ,  G01N33/487

Abstract: The invention relates to a method and a device for monitoring blood purification with an extracorporeal blood purification device which is designed such that a blood purification unit 1 is used to perform blood purification with predetermined treatment parameters Qb in an extracorporeal blood circuit 9. The concentration of a substance is measured during the blood purification with at least one sensor 31, 32, 33, 34 and a parameter K which is characteristic of the purifying performance of the blood purification unit 1 is determined with a computing and/or evaluation unit 25 on the basis of the measured concentration of a substance. The parameter K which is characteristic of the purifying performance of the blood purification unit 1 is compared with an expected value Kref. To this end, a tolerance range is determined for the expected value using the computing and/or evaluation unit 25, wherein actions that are predetermined by the computing and/or evaluation unit 25 are triggered depending on whether the parameter which is characteristic of the purifying performance of the blood purification unit lies within or outside the tolerance range for the expected value.

公开(公告)号：US20190223805A1

公开(公告)日：2019-07-25

申请号：US16330229

申请日：2017-09-04

Applicant: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH

Inventor： Andreas MAIERHOFER

IPC: A61B5/00 ,  A61M1/36 ,  A61M1/16 ,  A61B5/01

Abstract: The present invention relates to a method of determining the body temperature or a temperature correlated therewith of a patient connected to an extracorporeal blood circuit, wherein the extracorporeal blood circuit has a heat exchanger which is flowed through by blood at one side and by a heat carrier medium at the other side, wherein the temperature (Tdi) of the heat carrier medium at the inlet side is measured at the inlet of the heat exchanger and the temperature (Tdo) of the heat carrier medium at the outlet side is measured at the outlet of the heat exchanger and the volume flow of the heat carrier medium (Qd) is measured; and in that the temperature (Tbi) of the blood at the inlet side is determined at the inlet of the heat exchanger in accordance with the relationship Tbi=Tdi (Qd/D) (Tdo−Tdi), where the value D is a value characteristic of the heat transfer by the heat exchanger.

公开(公告)号：US20150136702A1

公开(公告)日：2015-05-21

申请号：US14542947

申请日：2014-11-17

Applicant: Fresenius Medical Care Deutschland GmbH

Inventor： Andreas MAIERHOFER ,  Alfred GAGEL ,  Malte GROSS ,  Michael KOCH

IPC: A61M1/16

CPC classification number: A61M1/1605 ,  A61M1/16 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/165 ,  A61M1/169 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3327 ,  A61M2205/702 ,  A61M2205/707 ,  A61M2205/7554

Abstract: A dialysis machine has at least one filter for the filtration of dialysis liquid and a device for determining calcification of the dialysis machine. The device has one or more sensors configured and arranged to detect either downstream, or upstream and downstream, of the at least one filter an ion concentration or a parameter representative of the ion concentration or of its change of the dialysis liquid, of a solution serving the decalcification or of another measuring solution. The device doe determining the calcification of the dialysis machine has an evaluation or calcification unit configured to determine the calcification of the dialysis machine based on the ion concentration or parameter value detected by the sensor or sensors.For the Examiner's convenience, a clean text version of the replacement abstract (117 words) is presented below:A dialysis machine has at least one filter for the filtration of dialysis liquid and a device for determining calcification of the dialysis machine. The device has one or more sensors configured and arranged to detect either downstream, or upstream and downstream, of the at least one filter an ion concentration or a parameter representative of the ion concentration or of its change of the dialysis liquid, of a solution serving the decalcification or of another measuring solution. The device for determining the calcification of the dialysis machine has an evaluation or calcification unit configured to determine the calcification of the dialysis machine based on the ion concentration or parameter value detected by the sensor or sensors.

Abstract translation: 透析机具有用于透析液体的过滤的至少一个过滤器和用于确定透析机的钙化的装置。 该装置具有一个或多个传感器，其配置和布置成检测所述至少一个过滤器的下游或上游和下游，所述离子浓度或代表所述溶液液体的离子浓度或其透析液体的变化的参数 脱钙或另一种测量溶液。 确定透析机钙化的装置具有评估或钙化单元，其被配置为基于由传感器或传感器检测的离子浓度或参数值来确定透析机的钙化。 对于考官的方便，更换摘要的干净文本版本（117字）如下：透析机至少有一个过滤透析液的过滤器和用于确定透析机钙化的装置。 该装置具有一个或多个传感器，其配置和布置成检测所述至少一个过滤器的下游或上游和下游，所述离子浓度或代表所述溶液液体的离子浓度或其透析液体的变化的参数 脱钙或另一种测量溶液。 用于确定透析机钙化的装置具有评估或钙化单元，其被配置为基于由传感器或传感器检测的离子浓度或参数值来确定透析机的钙化。

公开(公告)号：US20140046150A1

公开(公告)日：2014-02-13

申请号：US13917944

申请日：2013-06-14

Applicant: Fresenius Medical Care Deutschland GmbH

Inventor： Alfred GAGEL ,  Andreas MAIERHOFER

IPC: A61B5/00 ,  A61B5/05 ,  A61B5/145 ,  A61B5/1455 ,  A61M1/28

CPC classification number: A61B5/4848 ,  A61B5/0071 ,  A61B5/05 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14558 ,  A61B5/4836 ,  A61B5/6866 ,  A61B5/7225 ,  A61M1/16 ,  A61M1/1609 ,  A61M1/1619 ,  A61M1/28 ,  A61M1/3406 ,  A61M2205/3306

Abstract: The present invention pertains to Method for monitoring a dialysis treatment of a patient, preferably for monitoring a haemodialysis, haemodiafiltration and/or peritoneal dialysis treatment of a patient, the method including the steps of: irradiating a sample of a dialysis fluid used in the dialysis treatment with linearly polarized irradiation light; detecting the intensity of the fluorescence light emitted by the dialysis fluid in a first polarization plane; detecting the intensity of the fluorescence light emitted by the dialysis fluid in a second polarization plane which is different from the first polarization plane; determining the anisotropy of the fluorescence light emitted by the dialysis fluid; and determining the concentration of at least one fluorophore in the dialysis fluid on the basis of both, the determined anisotropy and the intensity of the fluorescence light emitted by the dialysis fluid.

Abstract translation: 本发明涉及用于监测患者的透析治疗的方法，优选用于监测患者的血液透析，血液透析过滤和/或腹膜透析治疗，所述方法包括以下步骤：照射用于透析的透析液样品 线性偏振照射光处理; 检测透析液在第一偏振面中发出的荧光的强度; 检测在与第一偏振面不同的第二偏振面中由透析液发出的荧光的强度; 确定由透析液发射的荧光的各向异性; 并且基于透析液发射的荧光的确定的各向异性和强度，确定透析液中的至少一种荧光团的浓度。