公开(公告)号：US11162070B2

公开(公告)日：2021-11-02

申请号：US15258744

申请日：2016-09-07

Applicant: FUJIFILM Cellular Dynamics, Inc.

Inventor： Nathan Meyer ,  Lucas Chase ,  Casey Stankewicz

IPC: C12N5/00 ,  C12N5/079

Abstract: Provided herein are methods of enriching a retinal pigment epithelium (RPE) cell population derived from stem cells. Such a method may comprise removing contaminating cells through the depletion of CD24 positive cells, CD56 positive cells, and/or CD90 positive cells from a starting population of RPE cells.

公开(公告)号：US12110503B2

公开(公告)日：2024-10-08

申请号：US17049018

申请日：2019-04-22

Applicant: FUJIFILM Cellular Dynamics, Inc.

Inventor： Lucas Chase ,  Kyle Wallace ,  Benjamin Meline ,  Andrew Dias ,  Brandon Shelley ,  Marisa Fenn ,  Debjani Phillips ,  Matthew Sternfeld ,  Nathan Meyer

IPC: C12N5/079 ,  A61K35/30 ,  C12N5/0793 ,  G01N33/68

CPC classification number: C12N5/0621 ,  A61K35/30 ,  C12N5/062 ,  G01N33/68 ,  C12N2500/38 ,  C12N2501/105 ,  C12N2501/115 ,  C12N2501/15 ,  C12N2501/155 ,  C12N2501/415 ,  C12N2501/727 ,  C12N2501/734 ,  C12N2506/45

Abstract: Provided herein are methods of producing a photoreceptor precursor (PRP) cell population derived from stem cells. Further provided herein are methods of using the PRP cell populations, such as for therapeutics.

公开(公告)号：US20210139847A1

公开(公告)日：2021-05-13

申请号：US16931003

申请日：2020-07-16

Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services ,  FUJIFILM Cellular Dynamics, Inc.

Inventor： Kapil Bharti ,  Lucas Chase ,  Feng Xuezhu ,  Balendu Shekhar Jha

IPC: C12N5/079

Abstract: Provided herein are methods of producing an RPE cell population from a starting cell suspension, such as a single cell suspension, of pluripotent stem cells (PSCs). Such a method may comprise culturing the starting single cell suspension of PSCs in differentiation media to produce human RPE cells.

公开(公告)号：US10828335B2

公开(公告)日：2020-11-10

申请号：US15614755

申请日：2017-06-06

Applicant: FUJIFILM Cellular Dynamics, Inc.

Inventor： Matt George ,  Carrie Chavez ,  Chris McMahon ,  Wen Bo Wang ,  Lucas Chase ,  Brad Swanson

IPC: A61K35/30 ,  B65D25/20 ,  G01N33/50 ,  C12N9/02 ,  C12Q1/68 ,  A61J1/00 ,  C12N5/0793 ,  C12Q1/6876

Abstract: Methods are provided for efficient production of midbrain dopaminergic (DA) neurons. In some aspects, methods involve differentiation and selection of DA neurons for a transgenic pluripotent cell population (e.g., cells comprising a selectable marker gene). Cell populations produced by the instant methods and methods of their use are likewise provided.

公开(公告)号：US12241083B2

公开(公告)日：2025-03-04

申请号：US17493533

申请日：2021-10-04

Applicant: FUJIFILM Cellular Dynamics, Inc.

Inventor： Nathan Meyer ,  Lucas Chase ,  Casey Stankewicz

IPC: C12N5/00 ,  C12N5/079

Abstract: Provided herein are methods of enriching a retinal pigment epithelium (RPE) cell population derived from stem cells. Such a method may comprise removing contaminating cells through the depletion of CD24 positive cells, CD56 positive cells, and/or CD90 positive cells from a starting population of RPE cells.

公开(公告)号：US12065671B2

公开(公告)日：2024-08-20

申请号：US16931003

申请日：2020-07-16

Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services ,  FUJIFILM Cellular Dynamics, Inc.

Inventor： Kapil Bharti ,  Lucas Chase ,  Feng Xuezhu ,  Balendu Shekhar Jha

IPC: C12N5/079

CPC classification number: C12N5/0621 ,  C12N2500/30 ,  C12N2501/105 ,  C12N2501/15 ,  C12N2501/155 ,  C12N2501/16 ,  C12N2501/415 ,  C12N2506/45 ,  C12N2533/50 ,  C12N2533/52

Abstract: Provided herein are methods of producing an RPE cell population from a starting cell suspension, such as a single cell suspension, of pluripotent stem cells (PSCs). Such a method may comprise culturing the starting single cell suspension of PSCs in differentiation media to produce human RPE cells.