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公开(公告)号：US20250027155A1
公开(公告)日：2025-01-23
申请号：US18281068
申请日：2022-03-07
Applicant: FUJIFILM CELLULAR DYNAMICS, INC.
Inventor： Thomas BURKE , Steven SMITH , Anne STROUSE
IPC: C12Q1/6881 , C12Q1/06 , C12Q1/6874 , G01N33/68
Abstract: The present disclosure provides markers specific for pluripotent stem cells. In particular, the present disclosure relates to nucleic acid and polypeptide markers that are selectively expressed by pluripotent stem cells; and to methods for detecting the presence and/or absence of one or a plurality of pluripotent stem cells, by detecting such markers.
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公开(公告)号：US20240139256A1
公开(公告)日：2024-05-02
申请号：US18479774
申请日：2023-10-02
Inventor： Sarah HIMMERICH , Nathaniel BEARDSLEY , Annie ARMSTRONG SMELTER , Nathan MEYER , Ravi VAIDYANATHAN , Cara RIEGER
CPC classification number: A61K35/33 , A61P9/04 , C12N5/0657 , C12N5/0697 , C12N2501/115 , C12N2501/155 , C12N2501/16 , C12N2501/415 , C12N2506/45
Abstract: Provided herein are methods for producing quiescent cardiac fibroblast cells from pluripotent stem cells. Further provided herein are microtissue compositions comprising the cardiac fibroblast cells with endothelial cells and cardiomyocytes.
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公开(公告)号：US20230212509A1
公开(公告)日：2023-07-06
申请号：US18000008
申请日：2021-05-28
Applicant: FUJIFILM Cellular Dynamics, Inc. , The United States of America, as represented by the Secretary, Department of Health and Human Servic
Inventor： Andrew DIAS , Erich BERNDT , Lucas CHASE , Juan AMARAL , Arvydas MAMINISHKIS , Kapil BHARTI
IPC: C12N5/0793 , C12N5/079 , A61L27/36 , C12N5/00 , A61L27/18 , A61L27/56 , A61L27/58 , A61L27/20 , A61L27/22 , A61L27/54
CPC classification number: C12N5/062 , A61L27/18 , A61L27/20 , A61L27/54 , A61L27/56 , A61L27/58 , A61L27/227 , A61L27/3641 , C12N5/0056 , C12N5/0621 , A61L2430/16 , C12N2533/40 , C12N2533/50 , C12N2533/90
Abstract: Provided herein are methods of producing a distinct bilayer culture of retinal epithelial cells (RPE) with photoreceptor cells and/or photoreceptor precursor cells (PR/PRP). Further provided herein is a therapy comprising transplantation of the RPE and PR/PRP bilayer as well as methods for testing candidate drugs using the bilayer.
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公开(公告)号：US10947502B2
公开(公告)日：2021-03-16
申请号：US15769386
申请日：2016-10-20
Applicant: FUJIFILM Cellular Dynamics, Inc.
Inventor： Maksym A. Vodyanyk , Xin Zhang , Andrew J. Brandl , Deepika Rajesh , Bradley Swanson , Christie Munn , Sarah A. Burton , Wen Bo Wang
IPC: C12N5/0783 , C12N5/0784 , C12N5/0789 , C12N5/0781 , C12N15/85 , C12N15/86
Abstract: Provided herein are methods for the efficient in vitro differentiation of somatic cell-derived pluripotent stem cells to hematopoietic precursor cells, and the further differentiation of the hematopoietic precursor cells into immune cells of various myeloid or lymphoid lineages, particularly T cells, NK cells, and dendritic cells. The pluripotent cells may be maintained and differentiated under defined conditions; thus, the use of mouse feeder cells or serum is not required in certain embodiments for the differentiation of the hematopoietic precursor cells.
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公开(公告)号：US20250011714A1
公开(公告)日：2025-01-09
申请号：US18886115
申请日：2024-09-16
Applicant: FUJIFILM Cellular Dynamics, Inc.
Inventor： Nathan MEYER , Lucas CHASE , Casey STANKEWICZ
Abstract: Provided herein are methods of enriching a retinal pigment epithelium (RPE) cell population derived from stem cells. Such a method may comprise removing contaminating cells through the depletion of CD24 positive cells, CD56 positive cells, and/or CD90 positive cells from a starting population of RPE cells.
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Patent Agency Ranking
公开(公告)号：US12129486B2
公开(公告)日：2024-10-29
申请号：US17063204
申请日：2020-10-05
Applicant: FUJIFILM Cellular Dynamics, Inc.
Inventor： Maksym A. Vodyanyk , Xin Zhang , Andrew J. Brandl , Deepika Rajesh , Bradley Swanson , Christie Munn , Sarah A. Burton , Wen Bo Wang
IPC: C12N5/0783 , C12N5/0781 , C12N5/0784 , C12N5/0789 , C12N15/85 , C12N15/86
CPC classification number: C12N5/0636 , C12N5/0635 , C12N5/0637 , C12N5/0638 , C12N5/0639 , C12N5/0646 , C12N5/0647 , C12N15/85 , C12N15/86 , C12N2500/38 , C12N2500/90 , C12N2501/115 , C12N2501/125 , C12N2501/145 , C12N2501/155 , C12N2501/165 , C12N2501/22 , C12N2501/2303 , C12N2501/2306 , C12N2501/2307 , C12N2501/25 , C12N2501/26 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2501/727 , C12N2501/998 , C12N2501/999 , C12N2506/025 , C12N2506/03 , C12N2506/09 , C12N2506/11 , C12N2506/45 , C12N2510/00 , C12N2533/50 , C12N2840/20
Abstract: Provided herein are methods for the efficient in vitro differentiation of somatic cell-derived pluripotent stem cells to hematopoietic precursor cells, and the further differentiation of the hematopoietic precursor cells into immune cells of various myeloid or lymphoid lineages, particularly T cells, NK cells, and dendritic cells. The pluripotent cells may be maintained and differentiated under defined conditions; thus, the use of mouse feeder cells or serum is not required in certain embodiments for the differentiation of the hematopoietic precursor cells.
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公开(公告)号：US12110503B2
公开(公告)日：2024-10-08
申请号：US17049018
申请日：2019-04-22
Applicant: FUJIFILM Cellular Dynamics, Inc.
Inventor： Lucas Chase , Kyle Wallace , Benjamin Meline , Andrew Dias , Brandon Shelley , Marisa Fenn , Debjani Phillips , Matthew Sternfeld , Nathan Meyer
IPC: C12N5/079 , A61K35/30 , C12N5/0793 , G01N33/68
CPC classification number: C12N5/0621 , A61K35/30 , C12N5/062 , G01N33/68 , C12N2500/38 , C12N2501/105 , C12N2501/115 , C12N2501/15 , C12N2501/155 , C12N2501/415 , C12N2501/727 , C12N2501/734 , C12N2506/45
Abstract: Provided herein are methods of producing a photoreceptor precursor (PRP) cell population derived from stem cells. Further provided herein are methods of using the PRP cell populations, such as for therapeutics.
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公开(公告)号：US20240191186A1
公开(公告)日：2024-06-13
申请号：US17760446
申请日：2022-05-05
Inventor： Deepika RAJESH , Kiranmayee BAKSHY , Christie SAVIC , Sarah BURTON , Wayne POON , Simon HILCOVE
CPC classification number: C12N5/0622 , G01N33/5058 , G01N33/6863 , C12N2506/45 , G01N2333/535 , G01N2333/5406 , G01N2333/5437 , G01N2333/57 , G01N2400/50
Abstract: The present disclosure provides iPSC-derived microglia comprising a protective CD33 allele. Further provided herein are assays for screening analytes and genes associated with the protective CD33 allele.
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公开(公告)号：US20230343118A1
公开(公告)日：2023-10-26
申请号：US18305021
申请日：2023-04-21
Applicant: FUJIFILM Cellular Dynamics, Inc.
Inventor： Steven Smith , Takashi Wakui
CPC classification number: G06V20/698 , G06V20/695 , G06V10/25 , G06V10/54 , G06V10/98 , G06T7/0012 , G06V10/776 , G06T7/11 , G06V10/56
Abstract: Examples herein include methods, systems, and computer program products for utilizing neural networks in ultrasound systems. The methods include processor(s) of a computing device obtaining an image that depicts cells. The processor(s) applies one or more nuclei detection algorithms to detect nuclear aspects in the image. The processor(s) generates a nuclear segmentation map. The processor(s) utilizes the nuclear segmentation map to identify one or more regions of interest in the image. The processor(s) generates a classification result by automatically determining a cell type for each cell in a region of interest of the regions of interest.
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公开(公告)号：US20230071939A1
公开(公告)日：2023-03-09
申请号：US17760228
申请日：2021-02-02
Applicant: FUJIFILM Cellular Dynamics, Inc.
Inventor： Randall D. LEARISH , Nathaniel A. BEARDSLEY , Sho SATO , Christopher W. McMAHON
IPC: A61M5/145
Abstract: Apparatus and methods for monitoring and delivering a cell suspension. In certain examples, the apparatus comprises a reservoir containing the cell suspension, a cannula, and a liquid transfer mechanism configured to transfer the cell suspension from the reservoir to the cannula. The apparatus can also comprise an agitation mechanism to agitate the cell suspension, and a monitoring device to quantify a concentration of cells transferred from the reservoir to the cannula.
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