Abstract:
A method of producing a labeled antibody, including the steps of: a) allowing silica nanoparticles containing a functional molecule and having a thiol group on a surface thereof, and a linker molecule containing a maleimido group and an amino group, to coexist in a solvent to form a thioether bond between the thiol group and the maleimido group, thereby obtaining functional molecule-containing silica nanoparticles on which the linker molecule is bonded; and b) allowing the functional molecule-containing silica nanoparticles on which the linker molecule is bonded, carbodiimide and an antibody to coexist in an aqueous solvent to form an amide bond between the amino group of the linker molecule and a carboxyl group of the antibody.
Abstract:
Silica particles having a thiol group on a surface thereof, and satisfying the following conditions (a) to (c): (a) a particle diameter is 20 to 1,000 nm; (b) a density of the thiol group on the surface of the silica particles is 0.002 to 0.2 piece/nm2; and (c) a ratio (B/A) in terms of an amount B (piece/particle) of the thiol group existing on the surface of the silica particles to an amount A of sulfur elements in the silica particles (the number of sulfur elements derived from thiol per silica particle) is 0.10 to 0.60.
Abstract:
A test piece for immunochromatography, containing an aggregation inhibiting pad, a conjugate pad, and a membrane, in which the membrane contains a test area for capturing a target substance, the aggregation inhibiting pad contains a desalting agent, and the conjugate pad contains a labeling agent.
Abstract:
A coreless motor includes a rotating shaft, a rotor plate attached to the rotating shaft, and a coil supported by the rotor plate. The coil includes a carbon nanotube electric wire, the carbon nanotube electric wire including a carbon nanotube wire and a coating layer, the carbon nanotube wire including a plurality of carbon nanotubes, the coating layer including an insulating layer that covers the carbon nanotube wire so as to insulate the carbon nanotube wire.
Abstract:
A coated carbon nanotube wire for a coil includes: a carbon nanotube wire, the carbon nanotube wire being composed of a plurality of carbon nanotube aggregates each constituted of a plurality of carbon nanotubes, or being composed of a plurality of carbon nanotube element wires each constituted of a plurality of carbon nanotubes; and a coating layer coating the carbon nanotube wire, wherein each of the carbon nanotube aggregates contacts one or more other adjacent carbon nanotube aggregates, or each of the carbon nanotube element wires contacts one or more other adjacent carbon nanotube element wires.
Abstract:
A method of detecting a target substance, containing the steps of: incorporating labeling particles into a test liquid containing an analyte; heating the test liquid; irradiating the test liquid with excitation light, and detecting the target substance contained in the test liquid depending on a state of light emission of the labeling particles; wherein an aggregation state of the labeling particles is changed by the heating step; and wherein the labeling particles have a thermoresponsive polymer on a surface of a composite particle containing a magnetic material and a fluorescent material, and further have a biomolecule having properties of binding with the target substance.
Abstract:
An immunochromatography for multi-item detection is provided which contains detecting and measuring fluorescence and light absorption respectively at once with a detection device. The immunochromatography contains using fluorescent particles and light absorbing particles, wherein the fluorescence excitation wavelength of the fluorescent particles and the absorption wavelength of the light absorbing particles are in the same wavelength region; and detecting and measuring, at once, the intensity of reflected light from a test area, the intensity of reflected light from another test area, and the intensity of reflected light from a non-test area other than the test areas.
Abstract:
A metal nanonetwork includes metal nanostructures that are joined by metallic bond. The joined part between the metal nanostructures includes a fillet part. In the joined part between the metal nanostructures, the distance between the central axis of one metal nanostructure and the central axis of another metal nanostructure is smaller than the sum of the radii of both metal nanostructures. The metal nanostructure is a metal nanowire. A first method for producing the metal nanonetwork includes a process of forming an oxide film on the outermost surface of the metal nanostructure, and a process of reducing the oxide film at the joined parts of a plurality of the metal nanostructures to thereby join the metal nanostructures.
Abstract:
There is provided a CNTs wire capable of materializing a low resistivity and improving the electroconductivity. The CNT wire is formed from a single CNT aggregate constituted of a plurality of CNTs . . . having a single- or multi-walled structure, or formed by bundling a plurality of the CNT aggregates. The proportion of the total number of the CNTs having a double-walled or triple-walled structure based on the number of the plurality of CNTs constituting the CNT wire is 75% or higher; the proportion of the total number of the CNTs having an average diameter of the innermost wall of 1.7 nm or smaller based on the number of the CNTs constituting the CNT wire is 75% or higher; and the full-width at half maximum Δθ in azimuth angle in azimuth intensity distribution by SAXS indicating orientation of the plurality of CNT aggregates is 60° or smaller.
Abstract:
A fluorescent labeling particle for detecting a target substance, containing a composite particle having a phase containing a magnetic material and a phase containing a fluorescent material, and a thermoresponsive polymer on a surface of the composite particle.