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    SILICA PARTICLES HAVING REACTIVE FUNCTIONAL GROUP ON SURFACE, AND METHOD OF PRODUCING THE SAME
    1.
    发明申请
    SILICA PARTICLES HAVING REACTIVE FUNCTIONAL GROUP ON SURFACE, AND METHOD OF PRODUCING THE SAME 审中-公开
    具有表面反应性官能团的二氧化硅颗粒及其生产方法

    公开(公告)号：US20160153981A1

    公开(公告)日：2016-06-02

    申请号：US15016028

    申请日：2016-02-04

    Applicant: FURUKAWA ELECTRIC CO., LTD.

    Inventor： Masataka NISHIDA ,  Nobumitsu YAMANAKA ,  Kazutomi MIYOSHI ,  Michio OHKUBO

    IPC: G01N33/552 ,  G01N33/58

    Abstract: Silica particles having a thiol group on a surface thereof, and satisfying the following conditions (a) to (c): (a) a particle diameter is 20 to 1,000 nm; (b) a density of the thiol group on the surface of the silica particles is 0.002 to 0.2 piece/nm2; and (c) a ratio (B/A) in terms of an amount B (piece/particle) of the thiol group existing on the surface of the silica particles to an amount A of sulfur elements in the silica particles (the number of sulfur elements derived from thiol per silica particle) is 0.10 to 0.60.

    Abstract translation: 表面具有硫醇基的二氧化硅粒子，满足以下条件（a）〜（c）：（a）粒径为20〜1000nm; （b）二氧化硅粒子表面的硫醇基的密度为0.002〜0.2片/ nm 2， 和（c）二氧化硅颗粒表面上存在的硫醇基的量B（片/颗粒）与二氧化硅颗粒中硫元素的量A（硫数）之比（B / A） 源自硫醇/二氧化硅颗粒的元素）为0.10〜0.60。

    IMMUNOCHROMATOGRAPHY, AND DETECTION DEVICE AND REAGENT FOR THE SAME
    4.
    发明申请
    IMMUNOCHROMATOGRAPHY, AND DETECTION DEVICE AND REAGENT FOR THE SAME 审中-公开
    免疫印迹，检测装置和试剂

    公开(公告)号：US20150268239A1

    公开(公告)日：2015-09-24

    申请号：US14674825

    申请日：2015-03-31

    Applicant: FURUKAWA ELECTRIC CO., LTD.

    Inventor： Hideki AIZAWA ,  Michio OHKUBO ,  Kazutomi MIYOSHI

    IPC: G01N33/569

    CPC classification number: G01N33/56983 ,  B82Y30/00 ,  G01N21/59 ,  G01N21/6428 ,  G01N21/6489 ,  G01N21/8483 ,  G01N33/558 ,  G01N33/582 ,  G01N2021/6439 ,  G01N2021/8488 ,  G01N2333/08 ,  G01N2333/11 ,  G01N2469/10

    Abstract: An immunochromatography for multi-item detection is provided which contains detecting and measuring fluorescence and light absorption respectively at once with a detection device. The immunochromatography contains using fluorescent particles and light absorbing particles, wherein the fluorescence excitation wavelength of the fluorescent particles and the absorption wavelength of the light absorbing particles are in the same wavelength region; and detecting and measuring, at once, the intensity of reflected light from a test area, the intensity of reflected light from another test area, and the intensity of reflected light from a non-test area other than the test areas.

    Abstract translation: 提供了一种用于多项目检测的免疫层析法，其中检测和测量一次检测和测量荧光和光吸收。 免疫色谱法包含使用荧光颗粒和光吸收颗粒，其中荧光颗粒的荧光激发波长和吸光颗粒的吸收波长处于相同的波长区域; 并且一次检测并测量来自测试区域的反射光的强度，来自另一测试区域的反射光的强度以及来自测试区域以外的非测试区域的反射光的强度。

    METHOD OF PRODUCING LABELED ANTIBODY
    6.
    发明申请
    METHOD OF PRODUCING LABELED ANTIBODY 审中-公开
    生产标签抗体的方法

    公开(公告)号：US20150338395A1

    公开(公告)日：2015-11-26

    申请号：US14816836

    申请日：2015-08-03

    Applicant: FURUKAWA ELECTRIC CO., LTD.

    Inventor： Nobumitsu YAMANAKA ,  Hideki AIZAWA ,  Michio OHKUBO ,  Kazutomi MIYOSHI

    IPC: G01N33/533

    CPC classification number: G01N33/533 ,  G01N33/532 ,  G01N33/54346 ,  G01N33/54353 ,  G01N33/552 ,  Y10T428/2982

    Abstract: A method of producing a labeled antibody, including the steps of: a) allowing silica nanoparticles containing a functional molecule and having a thiol group on a surface thereof, and a linker molecule containing a maleimido group and an amino group, to coexist in a solvent to form a thioether bond between the thiol group and the maleimido group, thereby obtaining functional molecule-containing silica nanoparticles on which the linker molecule is bonded; and b) allowing the functional molecule-containing silica nanoparticles on which the linker molecule is bonded, carbodiimide and an antibody to coexist in an aqueous solvent to form an amide bond between the amino group of the linker molecule and a carboxyl group of the antibody.

    Abstract translation: 一种制备标记抗体的方法，包括以下步骤：a）使含有功能性分子的二氧化硅纳米粒子和表面上具有硫醇基的二氧化硅纳米粒子和含有马来酰亚胺基和氨基的连接体共存于溶剂中 在硫醇基和马来酰亚胺基之间形成硫醚键，从而得到其上键合有连接分子的含功能分子的二氧化硅纳米粒子; b）使含有连接子分子键合的功能性分子的二氧化硅纳米粒子，碳二亚胺和抗体在水性溶剂中共存，从而在连接分子的氨基与抗体的羧基之间形成酰胺键。

    METHOD OF PRODUCING FUNCTIONAL MOLECULE-CONTAINING SILICA NANOPARTICLES ON WHICH BIOMOLECULES ARE BONDED
    7.
    发明申请
    METHOD OF PRODUCING FUNCTIONAL MOLECULE-CONTAINING SILICA NANOPARTICLES ON WHICH BIOMOLECULES ARE BONDED 有权
    生产生物分子结合的功能性分子二氧化硅纳米粒子的方法

    公开(公告)号：US20140051186A1

    公开(公告)日：2014-02-20

    申请号：US14063666

    申请日：2013-10-25

    Applicant: FURUKAWA ELECTRIC CO., LTD.

    Inventor： Hideki AIZAWA ,  Michio OHKUBO ,  Masataka NISHIDA

    IPC: C07K17/14 ,  G01N33/552

    CPC classification number: C07K17/14 ,  G01N33/54346 ,  G01N33/54353 ,  G01N33/552 ,  G01N33/558 ,  Y10T436/143333

    Abstract: A method of producing functional molecule-containing silica nanoparticles on which a biomolecule is bonded, containing the steps of: allowing silica nanoparticles containing a functional molecule and having a thiol group on a surface thereof to coexist with a linker molecule having a maleimido group and a carboxyl group in an aprotic solvent, thereby allowing formation of a thioether bond between the thiol group and the maleimido group, and obtaining functional molecule-containing silica nanoparticles on which the linker molecule is bonded; and allowing the functional molecule-containing silica nanoparticles on which the linker molecule is bonded to coexist with carbodiimide and a biomolecule having an amino group in an aqueous solvent, thereby allowing formation of an amide bond between the carboxyl group active esterified by the carbodiimide, and the amino group of the biomolecule.

    Abstract translation: 一种制备其上结合有生物分子的含有功能分子的二氧化硅纳米颗粒的方法，包括以下步骤：使含有功能分子的二氧化硅纳米粒子与其表面上的硫醇基团共存于具有马来酰亚胺基和 羧基在非质子溶剂中，从而在硫醇基和马来酰亚胺基之间形成硫醚键，并获得其上键合有连接分子的含功能分子的二氧化硅纳米颗粒; 并且使含有连接体分子的功能性分子的二氧化硅纳米粒子与碳二亚胺和在水性溶剂中具有氨基的生物分子共存，由此可以在由碳二亚胺酯化的羧基之间形成酰胺键，和 生物分子的氨基。

    PARTICULATE MIXTURE, CATHODE ACTIVE MATERIAL, CATHODE, SECONDARY BATTERY, AND PRODUCTION METHOD THEREOF
    9.
    发明申请
    PARTICULATE MIXTURE, CATHODE ACTIVE MATERIAL, CATHODE, SECONDARY BATTERY, AND PRODUCTION METHOD THEREOF 审中-公开
    颗粒混合物，阴极活性材料，阴极，二次电池及其制备方法

    公开(公告)号：US20130316233A1

    公开(公告)日：2013-11-28

    申请号：US13957031

    申请日：2013-08-01

    Applicant: FURUKAWA ELECTRIC CO., LTD

    Inventor： Yosuke HIRAYAMA ,  Michio OHKUBO

    IPC: H01M4/58

    CPC classification number: H01M4/5825 ,  H01M4/02 ,  H01M4/131 ,  H01M4/136 ,  H01M4/1391 ,  H01M4/1397 ,  H01M4/364 ,  H01M2004/021

    Abstract: The object of the present invention is to provide a method for producing lithium transition metal phosphate with a small particle size and uniform element spatial distribution, which enables continuous and large-scale synthesis. Its solution is as follows: A particulate mixture is synthesized by the spray-combustion method, wherein a mixed solution containing a lithium source, a transition metal source, and a phosphorus source is supplied into a flame along with a combustion-supporting gas and a flammable gas, as a mist-like droplet. It is a method for producing lithium transition metal phosphate-type cathode active material, which further comprises a process of mixing the synthesized particulate mixture with a carbon source, a process of calcining the particulate mixture under inert gas atmosphere to produce an active material aggregate, and a process of pulverizing the active material aggregate.

    Abstract translation: 本发明的目的是提供一种粒径小，元素空间分布均匀的锂过渡金属磷酸盐的制造方法，能够连续进行大规模的合成。 其解决方案如下：通过喷雾燃烧法合成颗粒状混合物，其中将包含锂源，过渡金属源和磷源的混合溶液与燃烧载气一起供入火焰中， 易燃气体，如雾状液滴。 它是制造锂过渡金属磷酸盐型正极活性物质的方法，其还包括将合成的颗粒混合物与碳源混合的方法，在惰性气体气氛下煅烧颗粒混合物以制备活性物质聚集体的方法， 以及粉碎活性物质聚集体的方法。

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