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公开(公告)号：US20050130143A1
公开(公告)日：2005-06-16
申请号：US10486057
申请日：2002-08-09
申请人： Fady Malik , Christophe Beraud , Richard Freedman , Andrew Craven , Roman Sakowicz , James Hartman
发明人： Fady Malik , Christophe Beraud , Richard Freedman , Andrew Craven , Roman Sakowicz , James Hartman
IPC分类号： G01N33/50 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12Q1/34 , G01N33/15 , C12Q1/68 , C07H21/04 , C07K16/40 , C12N9/22
CPC分类号： C07K14/4716
摘要： The invention provides novel compositions, methods, and uses of hSMMyHC polypeptides and polynucleotides.
摘要翻译： 本发明提供hSMMyHC多肽和多核苷酸的新型组合物，方法和用途。
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公开(公告)号：US07462482B2
公开(公告)日：2008-12-09
申请号：US10486057
申请日：2002-08-09
申请人： Fady Malik , Christophe Beraud , Richard Freedman , Andrew Craven , Roman Sakowicz , James Hartman
发明人： Fady Malik , Christophe Beraud , Richard Freedman , Andrew Craven , Roman Sakowicz , James Hartman
CPC分类号： C07K14/4716
摘要： The invention provides novel compositions, methods, and uses of hSMMyHC polypeptides and polynucleotides.
摘要翻译： 本发明提供hSMMyHC多肽和多核苷酸的新型组合物，方法和用途。
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公开(公告)号：US06974688B2
公开(公告)日：2005-12-13
申请号：US09927597
申请日：2001-08-10
申请人： Fady Malik , Christophe Beraud , Richard Freedman , Andrew Craven , Roman Sakowicz , James Hartman
发明人： Fady Malik , Christophe Beraud , Richard Freedman , Andrew Craven , Roman Sakowicz , James Hartman
IPC分类号： G01N33/50 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12Q1/34 , G01N33/15 , C12N9/16
CPC分类号： C07K14/4716
摘要： The invention provides novel compositions, methods, and uses of hSMMyHC polypeptides and polynucleotides.
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公开(公告)号：US20070259390A1
公开(公告)日：2007-11-08
申请号：US11789457
申请日：2007-04-23
申请人： James Hartman , Fady Malik , Roman Sakowicz , Jeffrey Finer
发明人： James Hartman , Fady Malik , Roman Sakowicz , Jeffrey Finer
IPC分类号： C12Q1/48
CPC分类号： C12Q1/34 , A61K38/00 , C12Q1/37 , C12Q1/42 , G01N33/6887 , G01N33/6893 , G01N2333/914 , G01N2500/00
摘要： The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
摘要翻译： 本发明提供用于鉴定调节生物化学功能性肌节的生物活性的化合物的高通量筛选系统。 该方法可以多次同时进行荧光或吸光度读数。
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公开(公告)号：US20050266511A1
公开(公告)日：2005-12-01
申请号：US11102237
申请日：2005-04-07
申请人： James Hartman , Fady Malik , Roman Sakowicz , Jeffrey Finer
发明人： James Hartman , Fady Malik , Roman Sakowicz , Jeffrey Finer
CPC分类号： C12Q1/34 , A61K38/00 , C12Q1/37 , C12Q1/42 , G01N33/6887 , G01N33/6893 , G01N2333/914 , G01N2500/00
摘要： The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
摘要翻译： 本发明提供用于鉴定调节生物化学功能性肌节的生物活性的化合物的高通量筛选系统。 该方法可以多次同时进行荧光或吸光度读数。
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6.发明授权Compositions and assays utilizing ADP or phosphate for detecting protein modulators 有权使用ADP或磷酸盐检测蛋白质调节剂的组合物和测定法公开(公告)号：US07378254B2
公开(公告)日：2008-05-27
申请号：US11655733
申请日：2007-01-18
CPC分类号： C12Q1/34 , C12Q1/42 , C12Q1/485 , G01N33/573
摘要： Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.
摘要翻译： 本文描述了鉴定候选试剂与蛋白质结合或作为蛋白质的结合特征或生物活性的调节剂的方法。 通常，该方法涉及使用ADP或磷酸盐。 该测定法可用于高通量系统以避免使用凝胶或放射性物质的繁琐步骤。
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公开(公告)号：US07202051B1
公开(公告)日：2007-04-10
申请号：US11270193
申请日：2005-11-08
CPC分类号： C12Q1/34 , C12Q1/42 , C12Q1/485 , G01N33/573
摘要： Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.
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8.发明授权Compositions and assays utilizing ADP or phosphate for detecting protein modulators 有权使用ADP或磷酸盐检测蛋白质调节剂的组合物和测定法公开(公告)号：US06743599B1
公开(公告)日：2004-06-01
申请号：US10106665
申请日：2002-03-25
IPC分类号： C12Q142
摘要： Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.
摘要翻译： 本文描述了鉴定候选试剂与蛋白质结合或作为蛋白质的结合特征或生物活性的调节剂的方法。 通常，该方法涉及使用ADP或磷酸盐。 该测定法可用于高通量系统以避免使用凝胶或放射性物质的繁琐步骤。
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公开(公告)号：US06495337B1
公开(公告)日：2002-12-17
申请号：US09539164
申请日：2000-03-29
申请人： James J. Hartman , Fady Malik , Roman Sakowicz , Jeffrey T. Finer
发明人： James J. Hartman , Fady Malik , Roman Sakowicz , Jeffrey T. Finer
IPC分类号： C12Q144
CPC分类号： C12Q1/34 , A61K38/00 , C12Q1/37 , C12Q1/42 , G01N33/6887 , G01N33/6893 , G01N2333/914 , G01N2500/00
摘要： The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
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10.发明授权Compositions and assays utilizing ADP or phosphate for detecting protein modulators 有权使用ADP或磷酸盐检测蛋白质调节剂的组合物和测定法公开(公告)号：US06410254B1
公开(公告)日：2002-06-25
申请号：US09314464
申请日：1999-05-18
IPC分类号： C12Q142
摘要： Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.
摘要翻译： 本文描述了鉴定候选试剂与蛋白质结合或作为蛋白质的结合特征或生物活性的调节剂的方法。 通常，该方法涉及使用ADP或磷酸盐。 该测定法可用于高通量系统以避免使用凝胶或放射性物质的繁琐步骤。
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