公开(公告)号：US07723126B2

公开(公告)日：2010-05-25

申请号：US10809318

申请日：2004-03-24

申请人： Ferencz S. Denes ,  Sorin Odisei Manolache ,  Jason M. Helgren ,  Max G. Lagally ,  Bradley James Larson

发明人： Ferencz S. Denes ,  Sorin Odisei Manolache ,  Jason M. Helgren ,  Max G. Lagally ,  Bradley James Larson

IPC分类号： G01N33/545 ,  G01N33/552 ,  G01N33/553 ,  G01N33/554 ,  C07C217/50

CPC分类号： H01J37/32825 ,  H01J37/32091

摘要： Methods for producing plasma-treated, functionalized inorganic oxide surfaces are provided. The methods include the steps of subjecting an oxide surface to a plasma to create hydroxyl functionalities on the surface and reacting the hydroxyl functionalities with epoxy group-containing molecules in situ in the absence of plasma. Biomolecules may be immobilized on the resulting functionalized surfaces. The methods may be used to treat a variety of oxide surfaces, including glass, quartz, silica and metal oxides.

摘要翻译： 提供了制备等离子体处理的官能化无机氧化物表面的方法。 所述方法包括以下步骤：使氧化物表面经受等离子体在表面上产生羟基官能团，并且在不存在等离子体的情况下将羟基官能团与含环氧基的分子原位反应。 生物分子可以固定在所得官能化表面上。 该方法可用于处理各种氧化物表面，包括玻璃，石英，二氧化硅和金属氧化物。

公开(公告)号：US20100021654A1

公开(公告)日：2010-01-28

申请号：US10809318

申请日：2004-03-24

申请人： Ferencz S. Denes ,  Sorin Odisei Manolache ,  Jason M. Helgren ,  Max G. Lagally ,  Bradley James Larson

发明人： Ferencz S. Denes ,  Sorin Odisei Manolache ,  Jason M. Helgren ,  Max G. Lagally ,  Bradley James Larson

IPC分类号： B01J19/08

CPC分类号： H01J37/32825 ,  H01J37/32091

摘要： Methods for producing plasma-treated, functionalized inorganic oxide surfaces are provided. The methods include the steps of subjecting an oxide surface to a plasma to create hydroxyl functionalities on the surface and reacting the hydroxyl functionalities with epoxy group-containing molecules in situ in the absence of plasma. Biomolecules may be immobilized on the resulting functionalized surfaces. The methods may be used to treat a variety of oxide surfaces, including glass, quartz, silica and metal oxides.

公开(公告)号：US07276283B2

公开(公告)日：2007-10-02

申请号：US10807914

申请日：2004-03-24

申请人： Ferencz S. Denes ,  Sorin Odisei Manolache ,  Luis Emilio Cruz-Barba ,  Max G. Lagally ,  Bradley James Larson

发明人： Ferencz S. Denes ,  Sorin Odisei Manolache ,  Luis Emilio Cruz-Barba ,  Max G. Lagally ,  Bradley James Larson

IPC分类号： B32B5/16 ,  C12N11/14

CPC分类号： A61K48/00 ,  B31B2100/00 ,  B31B2120/30 ,  B82Y30/00 ,  C08J7/18 ,  Y10S977/847 ,  Y10S977/89 ,  Y10T428/2991

摘要： Methods for producing plasma-treated, functionalized carbon-containing surfaces are provided. The methods include the steps of subjecting a carbon-containing substrate to a plasma to create surface active sites on the surface of the substrate and reacting the surface active sites with stable spacer molecules in the absence of plasma. Biomolecules may be immobilized on the resulting functionalized surfaces. The methods may be used to treat a variety of carbon-containing substrates, including polymeric surfaces, diamond-like carbon films and carbon nanotubes and nanoparticles.

摘要翻译： 提供了等离子体处理的官能化含碳表面的制造方法。 所述方法包括以下步骤：使含碳衬底经受等离子体在衬底表面上产生表面活性位点，并且在不存在等离子体的情况下使表面活性位点与稳定的间隔分子反应。 生物分子可以固定在所得官能化表面上。 该方法可用于处理各种含碳基底，包括聚合物表面，类金刚石碳膜和碳纳米管和纳米颗粒。

公开(公告)号：US20080138626A1

公开(公告)日：2008-06-12

申请号：US11609045

申请日：2006-12-11

申请人： Ferencz S. Denes ,  Sorin Odisei Manolache ,  Luis Emilio Cruz-Barba ,  Alvaro de Jesus Martinez-Gomez

发明人： Ferencz S. Denes ,  Sorin Odisei Manolache ,  Luis Emilio Cruz-Barba ,  Alvaro de Jesus Martinez-Gomez

IPC分类号： B32B9/04 ,  B32B13/04 ,  B32B15/04 ,  B32B17/06 ,  C07C223/00 ,  H05H1/24 ,  B32B23/04 ,  B32B27/00 ,  B32B27/36

CPC分类号： C07C215/40 ,  C07F9/54 ,  C08J7/06 ,  C08J7/123 ,  C08J2301/00 ,  Y10T428/31504 ,  Y10T428/31507 ,  Y10T428/3154 ,  Y10T428/31544 ,  Y10T428/31678 ,  Y10T428/31786 ,  Y10T428/31855 ,  Y10T428/31935 ,  Y10T428/31938 ,  Y10T428/31971

摘要： Bactericidal substrates and methods of functionalizing the surface of substrates with quaternary ammonium and quaternary phosphonium groups using non-equilibrium RF plasmas are provided. The methods include the step of treating the surface of a substrate with a plasma to create surface active sites. Some methods include the step of reacting the surface active sites with linker molecules, which are then reacted with quaternary ammonium precursor molecules to provide a substrate surface functionalized with quaternary ammonium precursor groups. Other methods react the surface active sites with polymer precursor molecules under plasma conditions to form a covalently-bound polymer layer having reactive sites. The polymer reactive sites are reacted with quaternary phosphonium precursor molecules to provide a substrate surface functionalized with quaternary phosphonium groups. Also provided are bactericidal substrates having immobilized, covalently-bound quaternary ammonium or quaternary phosphonium groups.

摘要翻译： 提供杀菌底物和使用非平衡RF等离子体使季铵盐和季鏻基团官能化表面的方法。 该方法包括用等离子体处理衬底的表面以产生表面活性位点的步骤。 一些方法包括使表面活性位点与接头分子反应的步骤，然后与季铵前体分子反应以提供用季铵前体基团官能化的底物表面。 其他方法在等离子体条件下使表面活性位点与聚合物前体分子反应形成具有反应性位点的共价结合的聚合物层。 聚合物反应位点与季鏻前体分子反应以提供用季鏻基官能化的底物表面。 还提供了具有固定的，共价结合的季铵或季鏻基团的杀菌底物。

公开(公告)号：US08029902B2

公开(公告)日：2011-10-04

申请号：US11609045

申请日：2006-12-11

申请人： Ferencz S. Denes ,  Sorin Odisei Manolache ,  Luis Emilio Cruz-Barba ,  Alvaro de Jesus Martinez-Gomez

发明人： Ferencz S. Denes ,  Sorin Odisei Manolache ,  Luis Emilio Cruz-Barba ,  Alvaro de Jesus Martinez-Gomez

IPC分类号： B32B27/28

CPC分类号： C07C215/40 ,  C07F9/54 ,  C08J7/06 ,  C08J7/123 ,  C08J2301/00 ,  Y10T428/31504 ,  Y10T428/31507 ,  Y10T428/3154 ,  Y10T428/31544 ,  Y10T428/31678 ,  Y10T428/31786 ,  Y10T428/31855 ,  Y10T428/31935 ,  Y10T428/31938 ,  Y10T428/31971

摘要： Bactericidal substrates and methods of functionalizing the surface of substrates with quaternary ammonium and quaternary phosphonium groups using non-equilibrium RF plasmas are provided. The methods include the step of treating the surface of a substrate with a plasma to create surface active sites. Some methods include the step of reacting the surface active sites with linker molecules, which are then reacted with quaternary ammonium precursor molecules to provide a substrate surface functionalized with quaternary ammonium precursor groups. Other methods react the surface active sites with polymer precursor molecules under plasma conditions to form a covalently-bound polymer layer having reactive sites. The polymer reactive sites are reacted with quaternary phosphonium precursor molecules to provide a substrate surface functionalized with quaternary phosphonium groups. Also provided are bactericidal substrates having immobilized, covalently-bound quaternary ammonium or quaternary phosphonium groups.

摘要翻译： 提供杀菌底物和使用非平衡RF等离子体使季铵盐和季鏻基团官能化表面的方法。 该方法包括用等离子体处理衬底的表面以产生表面活性位点的步骤。 一些方法包括使表面活性位点与接头分子反应的步骤，然后与季铵前体分子反应以提供用季铵前体基团官能化的底物表面。 其他方法在等离子体条件下使表面活性位点与聚合物前体分子反应形成具有反应性位点的共价结合的聚合物层。 聚合物反应位点与季鏻前体分子反应以提供用季鏻基官能化的底物表面。 还提供了具有固定的，共价结合的季铵或季鏻基团的杀菌底物。