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公开(公告)号：US06874699B2
公开(公告)日：2005-04-05
申请号：US10271250
申请日：2002-10-15
申请人： Bradley James Larson , Chung Hoon Lee , Amit Lal , Max G. Lagally
发明人： Bradley James Larson , Chung Hoon Lee , Amit Lal , Max G. Lagally
CPC分类号： B01L3/0268 , B01J2219/00367 , B01J2219/00378 , B01J2219/00527 , B01J2219/00533 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00659 , B01J2219/00689 , B01J2219/00722 , B01L99/00 , B01L2300/0819 , B01L2300/0867 , B01L2400/0439 , C40B40/06 , C40B60/14 , G01N2035/1041
摘要： Devices and methods for depositing fluids on substrates in patterns of spots, lines, or other features use a nozzle, which is preferably configured similarly to a micropipette, having a piezoelectric crystal or other ultrasonic actuator coupled to one of its sides. The nozzle may be charged via capillary action by dipping it into a well containing the fluid to be deposited, and may then be positioned over a desired area of a substrate, at which point activation of the ultrasonic actuator at ultrasonic frequencies will eject the fluid onto the substrate. The needle may subsequently be dipped into a well of rinsing fluid for cleaning. Spots or lines on the order of 5 micrometers width may be generated, making the invention particularly suitable for use in biological applications such as microarray production and in microelectronics applications such as the printing of organic circuitry.
摘要翻译： 用于以斑点，线或其它特征的图案在基底上沉积流体的装置和方法使用喷嘴，其优选地被配置为类似于具有耦合到其一侧的压电晶体或其它超声致动器的微量移液管。 喷嘴可以通过将毛细管作用浸入含有要沉积的流体的孔中而被充电，然后可以将其定位在衬底的期望区域上，此时超声波致动器在超声频率下的激活将喷射流体到 底物。 随后将针浸入冲洗液的孔中进行清洗。 可能产生5微米宽度的斑点或线，使得本发明特别适用于生物应用，如微阵列生产和微电子应用，如有机电路的印刷。
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公开(公告)号：US20110095651A1
公开(公告)日：2011-04-28
申请号：US12913470
申请日：2010-10-27
IPC分类号： G01H11/08
CPC分类号： B01L3/0268 , B01L2200/143 , G01N35/1011
摘要： A device and method for the detection of the interaction between two or more objects is disclosed. The device utilizes electrical impedance spectra measured from a piezoelectric element attached to one such object. Comparison of such spectra along a range of traverse allows precise estimates of distance to be made. One useful application is the topographical mapping of a surface.
摘要翻译： 公开了一种用于检测两个或多个物体之间的相互作用的装置和方法。 该器件利用从连接到一个这样的对象的压电元件测量的电阻抗谱。 沿着横越范围的这种光谱的比较允许精确估计距离。 一个有用的应用是表面的地形图。
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公开(公告)号：US07723126B2
公开(公告)日：2010-05-25
申请号：US10809318
申请日：2004-03-24
申请人： Ferencz S. Denes , Sorin Odisei Manolache , Jason M. Helgren , Max G. Lagally , Bradley James Larson
发明人： Ferencz S. Denes , Sorin Odisei Manolache , Jason M. Helgren , Max G. Lagally , Bradley James Larson
IPC分类号： G01N33/545 , G01N33/552 , G01N33/553 , G01N33/554 , C07C217/50
CPC分类号： H01J37/32825 , H01J37/32091
摘要： Methods for producing plasma-treated, functionalized inorganic oxide surfaces are provided. The methods include the steps of subjecting an oxide surface to a plasma to create hydroxyl functionalities on the surface and reacting the hydroxyl functionalities with epoxy group-containing molecules in situ in the absence of plasma. Biomolecules may be immobilized on the resulting functionalized surfaces. The methods may be used to treat a variety of oxide surfaces, including glass, quartz, silica and metal oxides.
摘要翻译： 提供了制备等离子体处理的官能化无机氧化物表面的方法。 所述方法包括以下步骤：使氧化物表面经受等离子体在表面上产生羟基官能团，并且在不存在等离子体的情况下将羟基官能团与含环氧基的分子原位反应。 生物分子可以固定在所得官能化表面上。 该方法可用于处理各种氧化物表面，包括玻璃，石英，二氧化硅和金属氧化物。
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公开(公告)号：US07806137B2
公开(公告)日：2010-10-05
申请号：US11847997
申请日：2007-08-30
IPC分类号： F16K11/24
CPC分类号： F16K99/0001 , B01D15/1842 , B01D15/3804 , F16K99/0015 , F16K2099/008 , Y10T137/87249
摘要： The present invention provides devices and methods for micro-scale simulated moving bed chromatography (SMB) for continuous preparation of analytic quantities of highly pure fractions of target molecules. The present apparatus and method of the invention is adapted in a preferred embodiment to separations by affinity chromatography involving three discontinuous liquid flow loops. An alternative embodiment of affinity chromatography utilizes standard SMB operating under isocratic conditions.
摘要翻译： 本发明提供用于连续制备分析量高的目标分子的高纯度级分的微尺度模拟移动床层析（SMB）的装置和方法。 本发明的本发明的装置和方法在优选实施方案中适用于通过亲和层析分离，涉及三个不连续的液体流动循环。 亲和层析的另一个实施方案利用在等度条件下操作的标准SMB。
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公开(公告)号：US20100021654A1
公开(公告)日：2010-01-28
申请号：US10809318
申请日：2004-03-24
申请人： Ferencz S. Denes , Sorin Odisei Manolache , Jason M. Helgren , Max G. Lagally , Bradley James Larson
发明人： Ferencz S. Denes , Sorin Odisei Manolache , Jason M. Helgren , Max G. Lagally , Bradley James Larson
IPC分类号： B01J19/08
CPC分类号： H01J37/32825 , H01J37/32091
摘要： Methods for producing plasma-treated, functionalized inorganic oxide surfaces are provided. The methods include the steps of subjecting an oxide surface to a plasma to create hydroxyl functionalities on the surface and reacting the hydroxyl functionalities with epoxy group-containing molecules in situ in the absence of plasma. Biomolecules may be immobilized on the resulting functionalized surfaces. The methods may be used to treat a variety of oxide surfaces, including glass, quartz, silica and metal oxides.
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公开(公告)号：US07467751B2
公开(公告)日：2008-12-23
申请号：US11064226
申请日：2005-02-22
申请人： Bradley James Larson , Chung Hoon Lee , Amit Lal , Max G. Lagally
发明人： Bradley James Larson , Chung Hoon Lee , Amit Lal , Max G. Lagally
IPC分类号： B05B1/08
CPC分类号： B01L3/0268 , B01J2219/00367 , B01J2219/00378 , B01J2219/00527 , B01J2219/00533 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00659 , B01J2219/00689 , B01J2219/00722 , B01L99/00 , B01L2300/0819 , B01L2300/0867 , B01L2400/0439 , C40B40/06 , C40B60/14 , G01N2035/1041
摘要： Devices and methods for depositing fluids on substrates in patterns of spots, lines, or other features use a nozzle, which is preferably configured similarly to a micropipette, having a piezoelectric crystal or other ultrasonic actuator coupled to one of its sides. The nozzle may be charged via capillary action by dipping it into a well containing the fluid to be deposited, and may then be positioned over a desired area of a substrate, at which point activation of the ultrasonic actuator at ultrasonic frequencies will eject the fluid onto the substrate. The needle may subsequently be dipped into a well of rinsing fluid for cleaning. Spots or lines on the order of 5 micrometers width may be generated, making the invention particularly suitable for use in biological applications such as microarray production and in microelectronics applications such as the printing of organic circuitry.
摘要翻译： 用于以斑点，线或其它特征的图案在基底上沉积流体的装置和方法使用喷嘴，其优选地被配置为类似于具有耦合到其一侧的压电晶体或其它超声致动器的微量移液管。 喷嘴可以通过将毛细管作用浸入含有要沉积的流体的孔中而被充电，然后可以将其定位在衬底的期望区域上，此时超声波致动器在超声频率下的激活将喷射流体到 底物。 随后将针浸入冲洗液的孔中进行清洗。 可能产生5微米宽度的斑点或线，使得本发明特别适用于生物应用，如微阵列生产和微电子应用，如有机电路的印刷。
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公开(公告)号：US07849738B2
公开(公告)日：2010-12-14
申请号：US11716097
申请日：2007-03-09
IPC分类号： G01F23/28
CPC分类号： B01L3/0268 , B01L2200/143 , G01N35/1011
摘要： A device and method for the detection of the interaction between two or more objects is disclosed. The device utilizes electrical impedance spectra measured from a piezoelectric element attached to one such object. Comparison of such spectra along a range of traverse allows precise estimates of distance to be made. One useful application is the topographical mapping of a surface.
摘要翻译： 公开了一种用于检测两个或多个物体之间的相互作用的装置和方法。 该器件利用从连接到一个这样的对象的压电元件测量的电阻抗谱。 沿着横越范围的这种光谱的比较允许精确估计距离。 一个有用的应用是表面的地形图。
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公开(公告)号：US07276283B2
公开(公告)日：2007-10-02
申请号：US10807914
申请日：2004-03-24
申请人： Ferencz S. Denes , Sorin Odisei Manolache , Luis Emilio Cruz-Barba , Max G. Lagally , Bradley James Larson
发明人： Ferencz S. Denes , Sorin Odisei Manolache , Luis Emilio Cruz-Barba , Max G. Lagally , Bradley James Larson
CPC分类号： A61K48/00 , B31B2100/00 , B31B2120/30 , B82Y30/00 , C08J7/18 , Y10S977/847 , Y10S977/89 , Y10T428/2991
摘要： Methods for producing plasma-treated, functionalized carbon-containing surfaces are provided. The methods include the steps of subjecting a carbon-containing substrate to a plasma to create surface active sites on the surface of the substrate and reacting the surface active sites with stable spacer molecules in the absence of plasma. Biomolecules may be immobilized on the resulting functionalized surfaces. The methods may be used to treat a variety of carbon-containing substrates, including polymeric surfaces, diamond-like carbon films and carbon nanotubes and nanoparticles.
摘要翻译： 提供了等离子体处理的官能化含碳表面的制造方法。 所述方法包括以下步骤：使含碳衬底经受等离子体在衬底表面上产生表面活性位点，并且在不存在等离子体的情况下使表面活性位点与稳定的间隔分子反应。 生物分子可以固定在所得官能化表面上。 该方法可用于处理各种含碳基底，包括聚合物表面，类金刚石碳膜和碳纳米管和纳米颗粒。
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公开(公告)号：US20070210677A1
公开(公告)日：2007-09-13
申请号：US11716097
申请日：2007-03-09
IPC分类号： H01L41/113
CPC分类号： B01L3/0268 , B01L2200/143 , G01N35/1011
摘要： A device and method for the detection of the interaction between two or more objects is disclosed. The device utilizes electrical impedance spectra measured from a piezoelectric element attached to one such object. Comparison of such spectra along a range of traverse allows precise estimates of distance to be made. One useful application is the topographical mapping of a surface.
摘要翻译： 公开了一种用于检测两个或多个物体之间的相互作用的装置和方法。 该器件利用从连接到一个这样的对象的压电元件测量的电阻抗谱。 沿着横越范围的这种光谱的比较允许精确估计距离。 一个有用的应用是表面的地形图。
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