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    Drimenol synthases I
    1.
    发明授权
    Drimenol synthases I 有权

    公开(公告)号：US10351880B2

    公开(公告)日：2019-07-16

    申请号：US15330813

    申请日：2015-05-06

    Applicant: Firmenich SA

    Inventor： Laurent Daviet ,  Olivier Haefliger ,  Xiu-Feng He ,  Jian Li ,  Yu-Hua Zhang

    IPC: C12P7/02 ,  C12N9/88

    Abstract: The present invention relates to a method of producing drimenol and/or drimenol derivatives by contacting at least one polypeptide with farnesyl diphosphate. The method may be performed in vitro or in vivo. The present invention also provides amino acid sequences of polypeptides useful in the method of the invention and nucleic acid encoding the polypeptides of the invention. The method further provides host cells or organisms genetically modified to express the polypeptides of the invention and useful to produce drimenol and/or drimenol derivatives.

    Method for producing drimanyl acetate compounds
    2.
    发明授权
    Method for producing drimanyl acetate compounds 有权

    公开(公告)号：US12252727B2

    公开(公告)日：2025-03-18

    申请号：US17271474

    申请日：2019-10-14

    Applicant: FIRMENICH SA

    Inventor： Daniel Solis Escalante ,  Christian Görner ,  Laurent Daviet ,  Qi Wang

    IPC: C12P7/62 ,  C12P7/02

    Abstract: Described herein are novel methods for the acetyl transferase-catalyzed production of drimanyl-acetate compounds by the acetylation of the respective drimanyl alcohol sources performed in vitro or in vivo. Also described herein is the identification of enzymes having corresponding acetyl transferase activity from different microbial and plant sources. Also described herein is the provision of enzyme mutants derived from the newly identified enzymes. Further described herein is the provision of corresponding coding sequences of such enzymes and mutants, recombinant vectors, and recombinant host cells suitable for the production of such acetyl transferases and mutants and for performing the novel production methods of drimanyl acetate compounds. Still further described herein is a method of using such drimanyl acetates as intermediates for the production of odorant, flavor or fragrance or insect/pest control ingredients.

    PRODUCTION OF MANOOL
    3.
    发明申请
    PRODUCTION OF MANOOL 有权

    公开(公告)号：US20210010035A1

    公开(公告)日：2021-01-14

    申请号：US16938605

    申请日：2020-07-24

    Applicant: FIRMENICH SA

    Inventor： Michel Schalk ,  Laurent Daviet ,  Letizia Rocci ,  Daniel Solis Escalante

    IPC: C12P7/02 ,  C12N9/88 ,  C12N15/70 ,  C12N15/81 ,  C12N1/16 ,  C12N1/20

    Abstract: Described herein are methods of producing (+)-manool, the methods including: contacting geranylgeranyl diphosphate with a copalyl diphosphate (CPP) synthase to form a (9S, 10S)-copalyl diphosphate and contacting the CPP with a sclareol synthase enzyme to form (+)-manool and derivatives thereof. Also described herein are nucleic acids encoding CPP synthases and sclareol synthases for use in the methods. Further described herein are expression vectors and non-human host organisms and cells including nucleic acids encoding a CPP synthase and a sclareol synthase as described herein.

    Production of manool
    5.
    发明授权
    Production of manool 有权

    公开(公告)号：US10752922B2

    公开(公告)日：2020-08-25

    申请号：US16472120

    申请日：2017-12-18

    Applicant: FIRMENICH SA

    Inventor： Michel Schalk ,  Laurent Daviet ,  Letizia Rocci ,  Daniel Solis Escalante

    IPC: C12N9/88 ,  C12N1/16 ,  C12N1/20 ,  C12N15/70 ,  C12N15/81 ,  C12P7/02

    Abstract: Described herein are methods of producing (+)-manool, the methods including: contacting geranylgeranyl diphosphate with a copalyl diphosphate (CPP) synthase to form a (9S, 10S)-copalyl diphosphate and contacting the CPP with a sclareol synthase enzyme to form (+)-manool and derivatives thereof. Also described herein are nucleic acids encoding CPP synthases and sclareol synthases for use in the methods. Further described herein are expression vectors and non-human host organisms and cells including nucleic acids encoding a CPP synthase and a sclareol synthase as described herein.

    PRODUCTION OF MANOOL
    6.
    发明申请
    PRODUCTION OF MANOOL 审中-公开

    公开(公告)号：US20190352673A1

    公开(公告)日：2019-11-21

    申请号：US16472120

    申请日：2017-12-18

    Applicant: FIRMENICH SA

    Inventor： Michel Schalk ,  Laurent Daviet ,  Letizia Rocci ,  Daniel Solis Escalante

    IPC: C12P7/02 ,  C12N9/88 ,  C12N15/70 ,  C12N15/81

    Abstract: Described herein are methods of producing (+)-manool, the methods including: contacting geranylgeranyl diphosphate with a copalyl diphosphate (CPP) synthase to form a (9S, 10S)-copalyl diphosphate and contacting the CPP with a sclareol synthase enzyme to form (+)-manool and derivatives thereof. Also described herein are nucleic acids encoding CPP synthases and sclareol synthases for use in the methods. Further described herein are expression vectors and non-human host organisms and cells including nucleic acids encoding a CPP synthase and a sclareol synthase as described herein.

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