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公开(公告)号：US5845647A
公开(公告)日：1998-12-08
申请号：US671718
申请日：1996-06-28
摘要： Tobacco products improved by the use of uncured, green tobacco and propolis for use in smoking tobacco, chewing tobacco, tobacco chewing gum, beverages and foods. In one preferred embodiment green tobacco provides reduced carcinogenic nitrosamines. In another preferred embodiment, the addition of propolis reduces bitterness, prolongs flavor and shelf life, and reduces tar and particulate content. The tobacco products can be used to reduce smoking withdrawal symptoms such as irritability and weight gain by providing nicotine and monoamine oxidase B inhibitor. Further, the invention can be used to treat Alzheimer's disease and to manage weight control in non-smokers.
摘要翻译： 通过使用未固化，绿色烟草和蜂胶吸烟烟草，咀嚼烟草，烟草口香糖，饮料和食品来改善烟草制品。 在一个优选实施方案中，绿色烟草提供减少的致癌亚硝胺。 在另一个优选的实施方案中，蜂胶的添加减少了苦味，延长了风味和保质期，并降低了焦油和颗粒物含量。 烟草制品可用于通过提供尼古丁和单胺氧化酶B抑制剂来减少戒烟症状，例如易怒和体重增加。 此外，本发明可用于治疗阿尔茨海默病并且控制非吸烟者的体重控制。
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公开(公告)号：US5803081A
公开(公告)日：1998-09-08
申请号：US757104
申请日：1996-12-02
摘要： Tobacco products improved by the use of uncured, yellow tobacco low in tar and carcinogenic nitrosamines, treated by microwaving, or convection heating, or freeze drying to kill microbes responsible for curing, for use in smoking tobacco, chewing tobacco, tobacco chewing gum, beverages and foods. In one preferred embodiment tobacco, uncured or cured, is microwaved to reduce further tar and carcinogenic nitrosamines.
摘要翻译： 通过使用低温焦油和致癌亚硝胺，通过微波处理或对流加热或冷冻干燥以杀死负责固化的微生物，用于吸烟烟草，咀嚼烟草，烟草口香糖，饮料的烟草制品，改善了烟草制品 和食物。 在一个优选实施方案中，将未固化或固化的烟草微波炉以减少进一步的焦油和致癌亚硝胺。
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3.发明授权Method of identifying patients not suitable for high-dose cyclophosphamide treatment 有权鉴定不适合高剂量环磷酰胺治疗的患者的方法公开(公告)号：US09279803B2
公开(公告)日：2016-03-08
申请号：US13240443
申请日：2011-09-22
申请人： Robert A. Brodsky , Richard J. Jones , Francis E. O'Donnell, Jr. , Susan Bonitz , Adam Kaplin , Carlos Santos
发明人： Robert A. Brodsky , Richard J. Jones , Francis E. O'Donnell, Jr. , Susan Bonitz , Adam Kaplin , Carlos Santos
CPC分类号： G01N33/5047 , C12Q1/32 , G01N33/94 , G01N33/9493 , Y02A50/57
摘要： The present invention provides methods of identifying subjects that are suitable and not suitable for high-dose cyclophosphamide treatment.
摘要翻译： 本发明提供了鉴定适合于并不适合高剂量环磷酰胺治疗的受试者的方法。
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4.发明授权Combined writing instrument and digital documentor apparatus and method of use 有权组合式书写工具和数字记录仪的使用方法公开(公告)号：US06686910B2
公开(公告)日：2004-02-03
申请号：US10142414
申请日：2002-05-10
IPC分类号： G09G500
CPC分类号： G06K9/222 , G06F3/03545
摘要： A device and method is disclosed for the contemporaneous creation of a digital copy of a written document using a self-contained, hand-held communications device. The self-contained device functions as a writing device and as a digital documenter. It allows for maintenance of position sense within a document thus enabling the user to write cursive, print, draw, write mathematical formulas, draw symbols, punctuate, edit and the like. The invention discloses a self-contained apparatus and method for determining position sense without reliance on special paper, pads, or attachments to the document. The system provides position sense during writing by quantitative comparative analysis of serial images of the surface imperfections of the document. Character generation is discriminated from noncharacter-generating positional changes such as spacing between words. Encryption of data output from the device provides privacy. Encryption and attachment of the device's unique identifying code to a digital copy of a document created by the device provides for confirmation of the source. Uses of the device include short text messaging for cell phones, email composition, note taking in business and education, medical records, and electronic commerce. The imaging system can also be used to read barcodes on documents, allowing for applications to inventory control. Transmission of the digital copy of the document can be through a wired or wireless connection to external digital devices such as cellular phone, personal digital assistant, netpliance, or computer.
摘要翻译： 公开了一种用于使用独立的手持通信设备同时创建书面文档的数字副本的装置和方法。 独立装置用作书写装置和数字记录器。 它允许在文档内保持位置感觉，从而使用户能够书写草图，打印，绘制，写数学公式，绘制符号，标点符号，编辑等。 本发明公开了一种独立的装置和方法，用于在不依赖于专用纸，垫或附件的情况下确定位置感。 该系统通过对文档表面缺陷的串行图像进行定量比较分析，在写入期间提供位置感。 字符产生被区分为不产生字符的位置变化，例如字之间的间距。 从设备加密数据输出提供隐私。 将设备的唯一识别码加密和附加到由设备创建的文档的数字副本中，用于确认源。 设备的使用包括手机短信，电子邮件组合，商业和教育笔记，医疗记录和电子商务。 成像系统还可用于读取文档上的条形码，从而允许应用程序进行库存控制。 文件的数字副本的传输可以通过有线或无线连接到诸如蜂窝电话，个人数字助理，网络或计算机之类的外部数字设备。
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公开(公告)号：US06569174B1
公开(公告)日：2003-05-27
申请号：US09715443
申请日：2000-11-20
IPC分类号： A61B1732
CPC分类号： A61F9/0133 , A61F9/013
摘要： A microkeratome for improved corneal flap production for corneal surgery. The microkeratome, having a first aperture and a cutting blade, includes a second aperture located just below the plane of the cutting blade and through which a corneal plug protrudes in preparation for the lamellar cut of the microkeratome to create a uniformly thick lamellar flap of predetermined diameter and depth. The second aperture can include a second cutting blade. The microkeratome also includes a transparent applanation plate positioned at a predetermined distance above the plane of the cutting blade and an adjustable stop to prevent complete transection of the corneal flap.
摘要翻译： 一种用于改善角膜瓣手术生产角膜瓣的微角膜刀。 具有第一孔和切割刀片的微型角膜刀包括位于切割刀片平面正下方的第二孔，角膜塞通过其突出以准备微型角膜刀的层状切口，以形成均匀厚度的预定 直径和深度。 第二孔可包括第二切割刀片。 微型角膜刀还包括位于切割刀片平面上方预定距离的透明压平板和可调节止挡件，以防止角膜瓣的完全横切。
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6.发明授权Wireless computer peripheral that functions as a mouse and pen with ink processor memory power display and speaker all in one 失效作为鼠标和笔的无线电脑外围设备，配有墨水处理器内存电源显示器和扬声器公开(公告)号：US06486875B1
公开(公告)日：2002-11-26
申请号：US09071086
申请日：1998-05-01
IPC分类号： G09G500
CPC分类号： G06K9/222 , G06F3/03545
摘要： A writing instrument that also functions as a computer peripheral. The writing instrument has the general configuration of a ball-point pen. The pen includes a ball for ink writing that is operatively associated with internal sensors that precisely detect the distance and direction of ball movement and relay that directional and distance data to a microprocessor which records a series of vectors similar to a computer mouse. The pen also includes interchangeable memory cartridge for the storage of the data and a wireless computer connect, for example infrared, that can communicate generated or stored data to an associated computer. The pen also includes an external LED data display, a speaker/microphone and an ink reservoir.
摘要翻译： 也可作为计算机外设的书写工具。 书写工具具有圆珠笔的一般结构。 笔包括用于墨水书写的球，其与内部传感器可操作地相关联，内部传感器精确地检测球运动的距离和方向，并将该方向和距离数据中继到记录与计算机鼠标类似的一系列向量的微处理器。 笔还包括用于存储数据的可互换存储盒，以及无线计算机连接（例如红外），其可以将生成或存储的数据传送到相关联的计算机。 笔还包括外部LED数据显示器，扬声器/麦克风和墨水储存器。
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公开(公告)号：US5507740A
公开(公告)日：1996-04-16
申请号：US287407
申请日：1994-08-08
CPC分类号： A61F9/00814 , B23K26/702 , A61B2017/00725 , A61B3/107 , A61F2009/00855 , A61F2009/00872 , A61F2009/00882 , A61F9/00819
摘要： A thin, pliable mat to enhance visualization of corneal topography during rastostereography or videokeratoscopy. The mat is approximately 20 microns or less in thickness and constructed from hydrophobic material. In one preferred embodiment, the mat has a pattern etched thereon. In an alternative embodiment, a pattern is projected onto the mat. For rastostereography the pattern is a grid. For videokeratoscopy the pattern is concentric circles. The mat conforms to the surface of the cornea and the pattern is analyzed using conventional technology to determine corneal topography.
摘要翻译： 一种薄而柔软的垫，用于增强角膜造影术或视频角膜镜检查中角膜形态的可视化。 该垫的厚度约为20微米或更小，并由疏水材料构成。 在一个优选实施例中，垫具有在其上蚀刻的图案。 在替代实施例中，将图案投影到垫上。 对于胃肠造口术，模式是一个网格。 对于视力角膜镜检查，图案是同心圆。 垫符合角膜表面，并使用常规技术分析图案以确定角膜形貌。
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公开(公告)号：US5460627A
公开(公告)日：1995-10-24
申请号：US269139
申请日：1994-06-30
CPC分类号： A61F9/00814 , B23K26/702 , A61B2017/00725 , A61B3/107 , A61F2009/00855 , A61F2009/00872 , A61F2009/00882 , A61F9/00819
摘要： A method of using rastophotogrammetry and Placido-disc videokeratoscopy in ophthalmological surgery to calibrate a surgical laser wherein the effect of laser ablation on various substrates is measured by performing rastophotogrammetry or Placido-disc videokeratoscopy on the substrate before and after laser ablation to determine whether there is a uniform ablation and no unwanted effects created by the laser. The substrate can be calibration block, an intraoccular lens implant, a contact lens, an artificial cornea, or cornea.
摘要翻译： 一种在眼科手术中使用rastophotogrammetry和Placido-disc视力镜检查来校准手术激光的方法，其中激光消融对各种底物的影响是通过在激光消融之前和之后在衬底上执行纵向摄影测量法或Placido-disc视觉摄影术来测量的，以确定是否存在 均匀的消融并且没有不必要的激光产生的影响。 衬底可以是校准块，眼内透镜植入物，隐形眼镜，人造角膜或角膜。
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公开(公告)号：US07452330B2
公开(公告)日：2008-11-18
申请号：US10234294
申请日：2002-09-03
IPC分类号： A61B3/16
CPC分类号： A61B3/16
摘要： An improved apparatus and method of intraocular pressure determination is disclosed in which applanation tonometry is done with an ultrasonic transducer. The method allows for increased accuracy of intraocular pressure determination based upon adjustment of applanation tonometry for subjacent corneal thickness. The device allows for the operator to view the corneal surface and the pattern of dye to determine the precise endpoint of applanation.
摘要翻译： 公开了一种改进的眼内压测定装置和方法，其中用超音波换能器进行压平眼压测量。 该方法允许基于针对下面的角膜厚度的压平眼压测量来提高眼内压测定的准确度。 该装置允许操作者观察角膜表面和染料的图案以确定压平的精确终点。
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公开(公告)号：US06562027B2
公开(公告)日：2003-05-13
申请号：US09741132
申请日：2000-12-19
IPC分类号： A61F9007
CPC分类号： A61F9/008 , A61F9/00804 , A61F2009/00855 , A61F2009/00872 , A61F2009/00882
摘要： A method for enhancing the accuracy of PRK wherein a UV power meter is placed in the optical path of the laser beam. In one preferred embodiment, the power meter is placed distal to the last optical element so that any optical degradation that affects laser performance is taken into account. The meter consists of a UV-B cube and a pulnix camera with a software package. The meter is used to monitor the fluence of each laser pulse. The power meter is used to size each pulse and to quantify the energy in each pulse. Sensing means is employed to measure intraoperative pulse-to-pulse energy during photorefractive keratectomy (PRK), using said data in conjunction with the location of the pulse within the ablation zone to determine the cumulative energy thus being achieved, and adjusting said laser to treat more or less at each point based upon the difference between the ideal cumulative energy map and the observed cumulative energy map derived from intraoperative power determination.
摘要翻译： 一种提高PRK精度的方法，其中将UV功率计置于激光束的光路中。 在一个优选实施例中，功率计位于最后一个光学元件的远侧，以便考虑影响激光器性能的任何光学劣化。 该仪表由一个UV-B立方体和一个带软件包的pulnix摄像机组成。 该仪表用于监测每个激光脉冲的能量密度。 功率计用于对每个脉冲进行定标，并对每个脉冲中的能量进行量化。 使用感测手段来测量光折射角膜切除术（PRK）期间的术中脉冲 - 脉冲能量，使用所述数据结合消融区域内的脉冲位置来确定由此实现的累积能量，并且调整所述激光治疗 基于理想累积能量图与从术中功率确定导出的观察到的累积能量图之间的差异，在每个点上或多或少地。
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