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    Polypeptides And Immunogenic Conjugates Capable of Inducing Antibodies Against Pathogens, and Uses Thereof
    1.
    发明申请
    Polypeptides And Immunogenic Conjugates Capable of Inducing Antibodies Against Pathogens, and Uses Thereof 有权
    能够诱导抗病原体抗体的多肽和免疫原性缀合物及其用途

    公开(公告)号：US20080171053A1

    公开(公告)日：2008-07-17

    申请号：US10584871

    申请日：2004-12-31

    申请人： Francis Gigliotti ,  Terry W. Wright ,  Constantine G. Haidaris ,  Patricia J. Simpson-Haidaris ,  Jesse Wells

    发明人： Francis Gigliotti ,  Terry W. Wright ,  Constantine G. Haidaris ,  Patricia J. Simpson-Haidaris ,  Jesse Wells

    IPC分类号： A61K39/40 ,  A61K39/02 ,  C07K14/315

    CPC分类号： C07K14/37 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/3156 ,  Y10S530/823

    摘要： A number of immunologically active agents are described, including an isolated protein or polypeptide that includes the amino acid sequence of SEQ ID NO: 1, immunogenic conjugates containing either the protein or polypeptide, a full-length Pneumocystis kexin, or a full length Streptococcus pneumoniae pneumococcal surface protein A (PspA), antibodies recognizing the protein or polypeptide or the immunogenic conjugates (particularly the epitope of SEQ ID NO: 1), and nucleic acid molecules that encode the protein or polypeptide, as well as DNA constructs, expression vectors, and host cells that contain the nucleic acid molecules. Disclosed uses of the antibodies, immunogenic conjugates, and DNA constructs include inducing passive or active immunity to treat or prevent pathogen infections, particularly by a Pneumocystis organism, in a patient.

    摘要翻译： 描述了许多免疫活性剂，包括分离的蛋白质或多肽，其包括SEQ ID NO：1的氨基酸序列，含有蛋白质或多肽的免疫原性缀合物，全长肺孢子虫Kexin或全长肺炎链球菌 肺炎球菌表面蛋白A（PspA），识别蛋白质或多肽或免疫原性缀合物（特别是SEQ ID NO：1的表位）的抗体，以及编码蛋白质或多肽的核酸分子，以及DNA构建体，表达载体， 和含有核酸分子的宿主细胞。 抗体，免疫原性缀合物和DNA构建体的公开用途包括诱导被动或主动免疫以治疗或预防患者中特别是肺孢子虫生物体的病原体感染。

    Polypeptides and immunogenic conjugates capable of inducing antibodies against pathogens, and uses thereof
    2.
    发明授权
    Polypeptides and immunogenic conjugates capable of inducing antibodies against pathogens, and uses thereof 有权
    能够诱导针对病原体的抗体的多肽和免疫原性缀合物及其用途

    公开(公告)号：US07815918B2

    公开(公告)日：2010-10-19

    申请号：US10584871

    申请日：2004-12-31

    申请人： Francis Gigliotti ,  Terry W. Wright ,  Constantine G. Haidaris ,  Patricia J. Simpsonhaidaris ,  Jesse Wells

    发明人： Francis Gigliotti ,  Terry W. Wright ,  Constantine G. Haidaris ,  Patricia J. Simpsonhaidaris ,  Jesse Wells

    IPC分类号： A61K39/00 ,  A61K39/38 ,  A61K38/00 ,  C07K14/00

    CPC分类号： C07K14/37 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/3156 ,  Y10S530/823

    摘要： A number of immunologically active agents are described, including an isolated protein or polypeptide that includes the amino acid sequence of SEQ ID NO: 1, immunogenic conjugates containing either the protein or polypeptide, a full-length Pneumocystis kexin, or a full length Streptococcus pneumoniae pneumococcal surface protein A (PspA), antibodies recognizing the protein or polypeptide or the immunogenic conjugates (particularly the epitope of SEQ ID NO: 1), and nucleic acid molecules that encode the protein or polypeptide, as well as DNA constructs, expression vectors, and host cells that contain the nucleic acid molecules. Disclosed uses of the antibodies, immunogenic conjugates, and DNA constructs include inducing passive or active immunity to treat or prevent pathogen infections, particularly by a Pneumocystis organism, in a patient.

    摘要翻译： 描述了许多免疫活性剂，包括分离的蛋白质或多肽，其包括SEQ ID NO：1的氨基酸序列，含有蛋白质或多肽的免疫原性缀合物，全长肺孢子虫Kexin或全长肺炎链球菌 肺炎球菌表面蛋白A（PspA），识别蛋白质或多肽或免疫原性缀合物（特别是SEQ ID NO：1的表位）的抗体，以及编码蛋白质或多肽的核酸分子，以及DNA构建体，表达载体， 和含有核酸分子的宿主细胞。 抗体，免疫原性缀合物和DNA构建体的公开用途包括诱导被动或主动免疫以治疗或预防患者中特别是肺孢子虫生物体的病原体感染。

    Media storage container and two-disc hub
    4.
    发明申请
    Media storage container and two-disc hub 审中-公开
    介质储存容器和双盘毂

    公开(公告)号：US20070138039A1

    公开(公告)日：2007-06-21

    申请号：US11528707

    申请日：2006-09-27

    申请人： Kevin Kirtz ,  Jesse Wells

    发明人： Kevin Kirtz ,  Jesse Wells

    IPC分类号： B65D85/30

    CPC分类号： G11B33/0427 ,  G11B33/045

    摘要： A disc storage container has a container body with a base and a lid. The lid is movable between open and closed positions with respect to the base. The base has a nest and a peripheral wall that cooperate to define a slot disposed between the portion of the nest adjacent to the peripheral wall. A disc-holding page having a rim is pivotably connected to the container body. A portion of the rim is disposed in the slot when the lid is closed with respect to the base to enclose the disc-holding page within the container. The multiple disc hub configuration for the page includes alternating disc retaining fingers projecting from opposite sides of the base wall of the page.

    摘要翻译： 盘存储容器具有带底座和盖子的容器本体。 盖可相对于基座在打开和关闭位置之间移动。 基部具有嵌套和周壁，其协作以限定设置在邻近周壁的巢的部分之间的狭槽。 具有轮辋的盘保持页可枢转地连接到容器主体。 当盖子相对于基座关闭时，边缘的一部分设置在槽中，以将盘保持页封闭在容器内。 用于页面的多个盘毂配置包括从页面的底壁的相对侧突出的交替的盘保持指状物。

    Media storage container with cooperating disc retaining hubs
    5.
    发明申请
    Media storage container with cooperating disc retaining hubs 审中-公开
    介质储存容器带有合作盘片保持毂

    公开(公告)号：US20070193900A1

    公开(公告)日：2007-08-23

    申请号：US11649707

    申请日：2007-01-03

    申请人： Kevin Kirtz ,  Jesse Wells

    发明人： Kevin Kirtz ,  Jesse Wells

    IPC分类号： B65D85/30

    CPC分类号： G11B33/045 ,  G11B33/0427

    摘要： A media storage container has a base and lid with a hub disposed on each of the base and lid. The hubs overlap each other when the lid is closed so that the overall height of the media storage container may be reduced. In one configuration, the hubs engage each other to stabilize the media storage container when the lid is closed. In one configuration, each hub includes a pair of positioning fingers disposed between retaining fingers. The positioning fingers have a height less than the height of the retaining fingers and do not snap over the top of the media disc when the media disc is disposed on the hub. Each positioning finger includes an upper arm that may engage the upper arm of the retaining finger when the lid is closed to help hold the discs on the hubs.

    摘要翻译： 介质储存容器具有底座和盖子，底座和盖子设置在每个基座和盖子上。 当盖子关闭时，轮毂彼此重叠，从而可以减小介质储存容器的整体高度。 在一种构造中，当盖关闭时，毂彼此接合以稳定介质存储容器。 在一种构造中，每个毂包括设置在保持指状件之间的一对定位指状物。 定位指状物的高度小于固定指的高度，当介质盘设置在轮毂上时，定位指不会卡在介质盘的顶部。 每个定位指状物包括上臂，当盖关闭时，上臂可以与保持指的上臂接合，以帮助将盘保持在轮毂上。

    Multi-disc media case
    7.
    发明申请
    Multi-disc media case 有权
    多盘介质盒

    公开(公告)号：US20060191809A1

    公开(公告)日：2006-08-31

    申请号：US11349055

    申请日：2006-02-07

    申请人： Mark Heuser ,  Jesse Wells

    发明人： Mark Heuser ,  Jesse Wells

    IPC分类号： B65D85/30

    CPC分类号： G11B33/0427

    摘要： The present invention provides a media storage case that is configured to resiliently hold up to six media discs on a single hub. In one construction, a first panel and a second panel are joined by a hinge and configured to securely hold up to six media discs on a common hub through transit and distribution, using a cantilevered disc retention finger and/or a spine disc retention fin. The media storage case can hold multiple media discs and accompanying literature, while having a minimized case thickness.

    摘要翻译： 本发明提供了一种媒体存储盒，其配置为在单个集线器上弹性地容纳六个媒体盘。 在一个结构中，第一面板和第二面板通过铰链连接并且构造成通过使用悬臂式盘保持指和/或脊椎盘保持翅片通过运输和分配来牢固地容纳在公共轮毂上的六个介质盘。 媒体存储盒可以容纳多个媒体盘和随附的文献，同时具有最小化的壳体厚度。

    Lockable media storage container
    8.
    发明申请
    Lockable media storage container 有权
    可锁定媒体存储容器

    公开(公告)号：US20050279143A1

    公开(公告)日：2005-12-22

    申请号：US11036774

    申请日：2005-01-14

    申请人： Dennis Belden ,  Ronald Marsilio ,  Aaron McMahan ,  Jesse Wells

    发明人： Dennis Belden ,  Ronald Marsilio ,  Aaron McMahan ,  Jesse Wells

    IPC分类号： E05B73/00 ,  G11B33/04 ,  E05B65/00 ,  B65D85/57

    CPC分类号： E05B73/0023 ,  G11B33/0427 ,  G11B33/045 ,  Y10T70/5004 ,  Y10T70/5031

    摘要： A lockable media storage container includes a lock disposed within the lock reception cavity defined by the container. The lock may be moved from a locked position to an unlocked position while remaining disposed within the lock reception cavity. In one embodiment, the lock that locks itself in the unlocked position so that it cannot accidently move back into the locked position. The lock includes a plurality of lock hooks extending from a common lock frame. A lock finger also extends from the common lock frame. The lock finger holds the lock in the locked position. A magnetic key is used to unlock the lock and move the lock slide to the unlocked position.

    摘要翻译： 可锁定介质存储容器包括设置在由容器限定的锁接收腔内的锁。 锁可以从锁定位置移动到解锁位置，同时保持设置在锁接收腔内。 在一个实施例中，锁定其自身锁定在解锁位置，使得其不会意外地移回到锁定位置。 该锁包括从公共锁定框架延伸的多个锁定钩。 锁定手指也从公共锁定框架延伸。 锁定手指将锁定件锁定在锁定位置。 使用磁性钥匙来解锁锁并将锁定滑块移动到解锁位置。