利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

14 条记录 (耗时 0.019 秒)

    Human monoclonal antibodies against bacterial toxins
    3.
    发明授权
    Human monoclonal antibodies against bacterial toxins 失效
    针对细菌毒素的人单克隆抗体

    公开(公告)号：US4689299A

    公开(公告)日：1987-08-25

    申请号：US534658

    申请日：1983-09-22

    申请人： Richard A. Insel ,  Francis Gigliotti

    发明人： Richard A. Insel ,  Francis Gigliotti

    IPC分类号： C07K16/12 ,  C12N5/00 ,  C12N15/00

    CPC分类号： C07K16/1282 ,  C07K16/1285

    摘要： The production of stable hybrid cell lines that secrete human monoclonal antibodies against bacterial toxins by fusing post-immunization human peripheral blood lymphocytes with nonsecretor mouse myeloma cells is described. Using the method, protective monoclonal antibodies against tetanus toxin and diphtheria toxin were produced that bind tetanus toxin and diphtheria toxin in vitro, respectively, and prevent tetanus and diphtheria in vivo in animals, respectively.

    摘要翻译： 描述了通过将免疫后外周血淋巴细胞与未分离的小鼠骨髓瘤细胞融合来分泌针对细菌毒素的人单克隆抗体的稳定杂交细胞系的产生。 使用该方法，分别在体外分别结合破伤风毒素和白喉毒素的破伤风毒素和白喉毒素的保护性单克隆抗体，并分别在动物体内预防破伤风和白喉。

    Optimized antigens of pneumocystis and use thereof
    4.
    发明授权
    Optimized antigens of pneumocystis and use thereof 有权
    优化的肺囊虫抗原及其用途

    公开(公告)号：US09512189B2

    公开(公告)日：2016-12-06

    申请号：US14237133

    申请日：2012-08-06

    申请人： Francis Gigliotti ,  Terry W Wright ,  Constantine G. Haidaris ,  Patricia J. Simpson-Haidaris

    发明人： Francis Gigliotti ,  Terry W Wright ,  Constantine G. Haidaris ,  Patricia J. Simpson-Haidaris

    IPC分类号： C07K14/44 ,  A61K39/00 ,  C07K16/20 ,  C12N9/02

    CPC分类号： C07K14/44 ,  A61K39/00 ,  A61K39/0002 ,  A61K2039/55566 ,  C07K16/20 ,  C12N9/0051

    摘要： Immunologically active agents are described, including isolated Pneumocystis A 12 protein or polypeptides; immunogenic conjugates containing Pneumocystis A 12 protein or polypeptide of the present invention; antibodies recognizing the Pneumocystis A 12 protein or polypeptide or the immunogenic conjugates of the present invention; and nucleic acid molecules that encode the Pneumocystis A 12 protein or polypeptide of the present invention, as well as DNA constructs, expression vectors, and host cells that contain the nucleic acid molecules. Disclosed uses of the antibodies, immunogenic conjugates, and DNA constructs include inducing passive or active immunity to treat or prevent pathogen infections, particularly by a Pneumocystis organism, in a subject.

    摘要翻译： 描述了免疫活性剂，包括分离的肺孢子虫A12蛋白或多肽; 含有本发明的肺囊虫A12蛋白或多肽的免疫原性缀合物; 识别本发明的肺孢子虫A12蛋白或多肽或免疫原性缀合物的抗体; 和编码本发明的肺囊虫A12蛋白或多肽的核酸分子，以及含有核酸分子的DNA构建体，表达载体和宿主细胞。 抗体，免疫原性缀合物和DNA构建体的公开用途包括在受试者中诱导被动或主动免疫以治疗或预防病原体感染，特别是肺囊虫生​​物体的感染。

    Polypeptides and immunogenic conjugates capable of inducing antibodies against pathogens, and uses thereof
    5.
    发明授权
    Polypeptides and immunogenic conjugates capable of inducing antibodies against pathogens, and uses thereof 有权
    能够诱导针对病原体的抗体的多肽和免疫原性缀合物及其用途

    公开(公告)号：US07815918B2

    公开(公告)日：2010-10-19

    申请号：US10584871

    申请日：2004-12-31

    申请人： Francis Gigliotti ,  Terry W. Wright ,  Constantine G. Haidaris ,  Patricia J. Simpsonhaidaris ,  Jesse Wells

    发明人： Francis Gigliotti ,  Terry W. Wright ,  Constantine G. Haidaris ,  Patricia J. Simpsonhaidaris ,  Jesse Wells

    IPC分类号： A61K39/00 ,  A61K39/38 ,  A61K38/00 ,  C07K14/00

    CPC分类号： C07K14/37 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/3156 ,  Y10S530/823

    摘要： A number of immunologically active agents are described, including an isolated protein or polypeptide that includes the amino acid sequence of SEQ ID NO: 1, immunogenic conjugates containing either the protein or polypeptide, a full-length Pneumocystis kexin, or a full length Streptococcus pneumoniae pneumococcal surface protein A (PspA), antibodies recognizing the protein or polypeptide or the immunogenic conjugates (particularly the epitope of SEQ ID NO: 1), and nucleic acid molecules that encode the protein or polypeptide, as well as DNA constructs, expression vectors, and host cells that contain the nucleic acid molecules. Disclosed uses of the antibodies, immunogenic conjugates, and DNA constructs include inducing passive or active immunity to treat or prevent pathogen infections, particularly by a Pneumocystis organism, in a patient.

    摘要翻译： 描述了许多免疫活性剂，包括分离的蛋白质或多肽，其包括SEQ ID NO：1的氨基酸序列，含有蛋白质或多肽的免疫原性缀合物，全长肺孢子虫Kexin或全长肺炎链球菌 肺炎球菌表面蛋白A（PspA），识别蛋白质或多肽或免疫原性缀合物（特别是SEQ ID NO：1的表位）的抗体，以及编码蛋白质或多肽的核酸分子，以及DNA构建体，表达载体， 和含有核酸分子的宿主细胞。 抗体，免疫原性缀合物和DNA构建体的公开用途包括诱导被动或主动免疫以治疗或预防患者中特别是肺孢子虫生物体的病原体感染。

    LIQUID METAL DIRECTIONAL CASTING APPARATUS
    7.
    发明申请
    LIQUID METAL DIRECTIONAL CASTING APPARATUS 审中-公开
    液体金属定向铸造设备

    公开(公告)号：US20090126894A1

    公开(公告)日：2009-05-21

    申请号：US11942198

    申请日：2007-11-19

    申请人： Andrew John Elliott ,  Michael Francis Gigliotti ,  Shyh-Chin Huang ,  Adegboyega Masud Makinde ,  Roger J. Petterson ,  Stephen Francis Rutkowski

    发明人： Andrew John Elliott ,  Michael Francis Gigliotti ,  Shyh-Chin Huang ,  Adegboyega Masud Makinde ,  Roger J. Petterson ,  Stephen Francis Rutkowski

    IPC分类号： B22D15/04

    CPC分类号： B22D27/045

    摘要： An apparatus for directionally casting articles generally includes a seal between a mold assembly and chill plate. In one embodiment, the mold assembly includes a skirt laterally extending from at least one shell mold, wherein the skirt includes a channel disposed in a bottom surface that is configured to surround the at least one shell mold. A chill plate fastened to a bottom of the mold assembly and includes a boss having a shape complementary to the channel, wherein the boss of the chill plate is seated within the channel of the mold assembly to define the seal about the at least one shell mold.

    摘要翻译： 用于定向铸造制品的装置通常包括在模具组件和冷却板之间的密封件。 在一个实施例中，模具组件包括从至少一个外壳模具横向延伸的裙部，其中裙部包括设置在底部表面中的通道，该通道被配置为围绕至少一个壳模具。 固定到模具组件的底部的冷却板包括具有与通道互补的形状的凸台，其中冷却板的凸台位于模具组件的通道内以限定围绕至少一个壳模具的密封 。

    Directionally solidified eutectic superalloys for elevated temperature applications
    8.
    发明申请
    Directionally solidified eutectic superalloys for elevated temperature applications 审中-公开
    定向凝固的共晶超级合金用于高温应用

    公开(公告)号：US20050135962A1

    公开(公告)日：2005-06-23

    申请号：US10743604

    申请日：2003-12-22

    申请人： Michael Henry ,  Melvin Jackson ,  Ji-Cheng Zhao ,  Michael Francis Gigliotti

    发明人： Michael Henry ,  Melvin Jackson ,  Ji-Cheng Zhao ,  Michael Francis Gigliotti

    IPC分类号： C22C19/05

    CPC分类号： C22C19/057

    摘要： A measurement device for measuring and displaying a physical quantity such as a heartbeat, an atmospheric pressure or temperature, or the like, includes a clock for counting time, a physical quantity measuring device for measuring the physical quantity to be displayed, a processor for determining a plurality of values based on the measured physical quantity and the counted time, a first display for simultaneously displaying the plurality of values and a second display for magnifying at least one of the values and displaying the magnified value.

    摘要翻译： 用于测量和显示诸如心跳，大气压或温度等的物理量的测量装置包括用于计算时间的时钟，用于测量要显示的物理量的物理量测量装置，用于确定 基于测量的物理量和计数时间的多个值，用于同时显示多个值的第一显示器和用于放大至少一个值并显示放大值的第二显示器。

    OPTIMIZED ANTIGENS OF PNEUMOCYSTIS AND USE THEREOF
    9.
    发明申请
    OPTIMIZED ANTIGENS OF PNEUMOCYSTIS AND USE THEREOF 有权
    优化的肺结核抗原及其用途

    公开(公告)号：US20140271656A1

    公开(公告)日：2014-09-18

    申请号：US14237133

    申请日：2012-08-06

    申请人： Francis Gigliotti ,  Terry W. Wright ,  Constantine G. Haidaris ,  Patricia J. Simpson-Haidaris

    发明人： Francis Gigliotti ,  Terry W. Wright ,  Constantine G. Haidaris ,  Patricia J. Simpson-Haidaris

    IPC分类号： C07K14/44 ,  A61K39/00 ,  C12N9/02 ,  C07K16/20

    CPC分类号： C07K14/44 ,  A61K39/00 ,  A61K39/0002 ,  A61K2039/55566 ,  C07K16/20 ,  C12N9/0051

    摘要： Immunologically active agents are described, including isolated Pneumocystis A 12 protein or polypeptides; immunogenic conjugates containing Pneumocystis A 12 protein or polypeptide of the present invention; antibodies recognizing the Pneumocystis A 12 protein or polypeptide or the immunogenic conjugates of the present invention; and nucleic acid molecules that encode the Pneumocystis A 12 protein or polypeptide of the present invention, as well as DNA constructs, expression vectors, and host cells that contain the nucleic acid molecules. Disclosed uses of the antibodies, immunogenic conjugates, and DNA constructs include inducing passive or active immunity to treat or prevent pathogen infections, particularly by a Pneumocystis organism, in a subject.

    摘要翻译： 描述了免疫活性剂，包括分离的肺孢子虫A12蛋白或多肽; 含有本发明的肺囊虫A12蛋白或多肽的免疫原性缀合物; 识别本发明的肺孢子虫A12蛋白或多肽或免疫原性缀合物的抗体; 和编码本发明的肺囊虫A12蛋白或多肽的核酸分子，以及含有核酸分子的DNA构建体，表达载体和宿主细胞。 抗体，免疫原性缀合物和DNA构建体的公开用途包括在受试者中诱导被动或主动免疫以治疗或预防病原体感染，特别是肺囊虫生​​物体的感染。