公开(公告)号：US4764370A

公开(公告)日：1988-08-16

申请号：US650282

申请日：1984-09-12

申请人： Patricia I. Fields ,  Constantine G. Haidaris ,  Frederick L. Heffron

发明人： Patricia I. Fields ,  Constantine G. Haidaris ,  Frederick L. Heffron

IPC分类号： C12N15/00 ,  A61K39/00 ,  A61K39/002 ,  A61K39/02 ,  A61K39/112 ,  C12N1/10 ,  C12N1/14 ,  C12N1/16 ,  C12N1/19 ,  C12N1/20 ,  C12N15/09 ,  C12N15/90 ,  C12R1/01 ,  C12R1/07 ,  C12R1/145 ,  C12R1/185 ,  C12R1/21 ,  C12R1/22 ,  C12R1/32 ,  C12R1/38 ,  C12R1/42 ,  C12R1/44 ,  C12R1/46 ,  C12R1/645 ,  C12R1/66 ,  C12R1/90 ,  C12N1/00 ,  A61K37/00

CPC分类号： A61K39/0002 ,  A61K39/002 ,  A61K39/02 ,  C12N15/90 ,  A61K2039/522 ,  Y10S435/879

摘要： A vaccine against a microbial pathogen comprised of a live, immunogenic but prototrophic and avirulent mutant strain of the selected microbial pathogen in an amount effective to confer immunity. A method of obtaining a vaccine that induces a heightened cellular and humoral immune response to one of a variety of microbial pathogens in a warm blooded animal. A method for isolation of an avirulent strain of a selected pathogenic microorganism.

摘要翻译： 一种针对微生物病原体的疫苗，其包含有效赋予免疫力的选定微生物病原体的活的，免疫原性的，营养不良的和无毒力的突变菌株。 一种获得在温血动物中诱导对各种微生物病原体之一的细胞和体液免疫应答增强的疫苗的方法。 一种分离所选病原微生物的无毒菌株的方法。

公开(公告)号：US09512189B2

公开(公告)日：2016-12-06

申请号：US14237133

申请日：2012-08-06

申请人： Francis Gigliotti ,  Terry W Wright ,  Constantine G. Haidaris ,  Patricia J. Simpson-Haidaris

发明人： Francis Gigliotti ,  Terry W Wright ,  Constantine G. Haidaris ,  Patricia J. Simpson-Haidaris

IPC分类号： C07K14/44 ,  A61K39/00 ,  C07K16/20 ,  C12N9/02

CPC分类号： C07K14/44 ,  A61K39/00 ,  A61K39/0002 ,  A61K2039/55566 ,  C07K16/20 ,  C12N9/0051

摘要： Immunologically active agents are described, including isolated Pneumocystis A 12 protein or polypeptides; immunogenic conjugates containing Pneumocystis A 12 protein or polypeptide of the present invention; antibodies recognizing the Pneumocystis A 12 protein or polypeptide or the immunogenic conjugates of the present invention; and nucleic acid molecules that encode the Pneumocystis A 12 protein or polypeptide of the present invention, as well as DNA constructs, expression vectors, and host cells that contain the nucleic acid molecules. Disclosed uses of the antibodies, immunogenic conjugates, and DNA constructs include inducing passive or active immunity to treat or prevent pathogen infections, particularly by a Pneumocystis organism, in a subject.

摘要翻译： 描述了免疫活性剂，包括分离的肺孢子虫A12蛋白或多肽; 含有本发明的肺囊虫A12蛋白或多肽的免疫原性缀合物; 识别本发明的肺孢子虫A12蛋白或多肽或免疫原性缀合物的抗体; 和编码本发明的肺囊虫A12蛋白或多肽的核酸分子，以及含有核酸分子的DNA构建体，表达载体和宿主细胞。 抗体，免疫原性缀合物和DNA构建体的公开用途包括在受试者中诱导被动或主动免疫以治疗或预防病原体感染，特别是肺囊虫生​​物体的感染。

公开(公告)号：US07815918B2

公开(公告)日：2010-10-19

申请号：US10584871

申请日：2004-12-31

申请人： Francis Gigliotti ,  Terry W. Wright ,  Constantine G. Haidaris ,  Patricia J. Simpsonhaidaris ,  Jesse Wells

发明人： Francis Gigliotti ,  Terry W. Wright ,  Constantine G. Haidaris ,  Patricia J. Simpsonhaidaris ,  Jesse Wells

IPC分类号： A61K39/00 ,  A61K39/38 ,  A61K38/00 ,  C07K14/00

CPC分类号： C07K14/37 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/3156 ,  Y10S530/823

摘要： A number of immunologically active agents are described, including an isolated protein or polypeptide that includes the amino acid sequence of SEQ ID NO: 1, immunogenic conjugates containing either the protein or polypeptide, a full-length Pneumocystis kexin, or a full length Streptococcus pneumoniae pneumococcal surface protein A (PspA), antibodies recognizing the protein or polypeptide or the immunogenic conjugates (particularly the epitope of SEQ ID NO: 1), and nucleic acid molecules that encode the protein or polypeptide, as well as DNA constructs, expression vectors, and host cells that contain the nucleic acid molecules. Disclosed uses of the antibodies, immunogenic conjugates, and DNA constructs include inducing passive or active immunity to treat or prevent pathogen infections, particularly by a Pneumocystis organism, in a patient.

摘要翻译： 描述了许多免疫活性剂，包括分离的蛋白质或多肽，其包括SEQ ID NO：1的氨基酸序列，含有蛋白质或多肽的免疫原性缀合物，全长肺孢子虫Kexin或全长肺炎链球菌 肺炎球菌表面蛋白A（PspA），识别蛋白质或多肽或免疫原性缀合物（特别是SEQ ID NO：1的表位）的抗体，以及编码蛋白质或多肽的核酸分子，以及DNA构建体，表达载体， 和含有核酸分子的宿主细胞。 抗体，免疫原性缀合物和DNA构建体的公开用途包括诱导被动或主动免疫以治疗或预防患者中特别是肺孢子虫生物体的病原体感染。

公开(公告)号：US20140271656A1

公开(公告)日：2014-09-18

申请号：US14237133

申请日：2012-08-06

申请人： Francis Gigliotti ,  Terry W. Wright ,  Constantine G. Haidaris ,  Patricia J. Simpson-Haidaris

发明人： Francis Gigliotti ,  Terry W. Wright ,  Constantine G. Haidaris ,  Patricia J. Simpson-Haidaris

IPC分类号： C07K14/44 ,  A61K39/00 ,  C12N9/02 ,  C07K16/20

CPC分类号： C07K14/44 ,  A61K39/00 ,  A61K39/0002 ,  A61K2039/55566 ,  C07K16/20 ,  C12N9/0051

摘要： Immunologically active agents are described, including isolated Pneumocystis A 12 protein or polypeptides; immunogenic conjugates containing Pneumocystis A 12 protein or polypeptide of the present invention; antibodies recognizing the Pneumocystis A 12 protein or polypeptide or the immunogenic conjugates of the present invention; and nucleic acid molecules that encode the Pneumocystis A 12 protein or polypeptide of the present invention, as well as DNA constructs, expression vectors, and host cells that contain the nucleic acid molecules. Disclosed uses of the antibodies, immunogenic conjugates, and DNA constructs include inducing passive or active immunity to treat or prevent pathogen infections, particularly by a Pneumocystis organism, in a subject.

摘要翻译： 描述了免疫活性剂，包括分离的肺孢子虫A12蛋白或多肽; 含有本发明的肺囊虫A12蛋白或多肽的免疫原性缀合物; 识别本发明的肺孢子虫A12蛋白或多肽或免疫原性缀合物的抗体; 和编码本发明的肺囊虫A12蛋白或多肽的核酸分子，以及含有核酸分子的DNA构建体，表达载体和宿主细胞。 抗体，免疫原性缀合物和DNA构建体的公开用途包括在受试者中诱导被动或主动免疫以治疗或预防病原体感染，特别是肺囊虫生​​物体的感染。

公开(公告)号：US20080171053A1

公开(公告)日：2008-07-17

申请号：US10584871

申请日：2004-12-31

申请人： Francis Gigliotti ,  Terry W. Wright ,  Constantine G. Haidaris ,  Patricia J. Simpson-Haidaris ,  Jesse Wells

发明人： Francis Gigliotti ,  Terry W. Wright ,  Constantine G. Haidaris ,  Patricia J. Simpson-Haidaris ,  Jesse Wells

IPC分类号： A61K39/40 ,  A61K39/02 ,  C07K14/315

CPC分类号： C07K14/37 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/3156 ,  Y10S530/823

摘要： A number of immunologically active agents are described, including an isolated protein or polypeptide that includes the amino acid sequence of SEQ ID NO: 1, immunogenic conjugates containing either the protein or polypeptide, a full-length Pneumocystis kexin, or a full length Streptococcus pneumoniae pneumococcal surface protein A (PspA), antibodies recognizing the protein or polypeptide or the immunogenic conjugates (particularly the epitope of SEQ ID NO: 1), and nucleic acid molecules that encode the protein or polypeptide, as well as DNA constructs, expression vectors, and host cells that contain the nucleic acid molecules. Disclosed uses of the antibodies, immunogenic conjugates, and DNA constructs include inducing passive or active immunity to treat or prevent pathogen infections, particularly by a Pneumocystis organism, in a patient.

摘要翻译： 描述了许多免疫活性剂，包括分离的蛋白质或多肽，其包括SEQ ID NO：1的氨基酸序列，含有蛋白质或多肽的免疫原性缀合物，全长肺孢子虫Kexin或全长肺炎链球菌 肺炎球菌表面蛋白A（PspA），识别蛋白质或多肽或免疫原性缀合物（特别是SEQ ID NO：1的表位）的抗体，以及编码蛋白质或多肽的核酸分子，以及DNA构建体，表达载体， 和含有核酸分子的宿主细胞。 抗体，免疫原性缀合物和DNA构建体的公开用途包括诱导被动或主动免疫以治疗或预防患者中特别是肺孢子虫生物体的病原体感染。