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公开(公告)号:US08106236B2
公开(公告)日:2012-01-31
申请号:US11737475
申请日:2007-04-19
申请人: Francis Wilson , Alison Reid , Valerie Reader , Richard John Harrison , Mihiro Sunose , Remedios Hernandez-Perni , Jeremy Major , Cyrille Boussard , Kathryn Smelt , Jess Taylor , Adeline LeFormal , Andrew Cansfield , Svenja Burckhardt , Yan Zhang , Chih Yung Ho
发明人: Francis Wilson , Alison Reid , Valerie Reader , Richard John Harrison , Mihiro Sunose , Remedios Hernandez-Perni , Jeremy Major , Cyrille Boussard , Kathryn Smelt , Jess Taylor , Adeline LeFormal , Andrew Cansfield , Svenja Burckhardt , Yan Zhang , Chih Yung Ho
IPC分类号: C07C63/00
CPC分类号: C07D257/04 , C07C51/09 , C07C57/38 , C07C57/58 , C07C59/56 , C07C59/64 , C07C63/331 , C07C69/65
摘要: The present invention relates to compounds having the general formula (I) with the definitions of X, Y, R1, R2, R3, R4, R9, R10 given below, and solvates, hydrates, esters, and pharmaceutically acceptable salts thereof.Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of γ-secretase activity.
摘要翻译: 本发明涉及具有以下给出的X,Y,R 1,R 2,R 3,R 4,R 9,R 10的定义的通式(I)的化合物及其溶剂化物,水合物,酯和药学上可接受的盐。 此外,本发明涉及所述化合物用于治疗阿尔茨海默氏病及其用于调节γ-分泌酶活性的用途。
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公开(公告)号:US07825160B2
公开(公告)日:2010-11-02
申请号:US11665760
申请日:2005-10-21
申请人: Francis Wilson , Alison Reid , Valerie Reader , Richard John Harrison , Mihiro Sunose , Remedios Hernandez-Perni , Jeremy Major , Cyrille Boussard , Kathryn Smelt , Jess Taylor , Adeline Leformal , Andrew Cansfield , Svenja Burckhardt
发明人: Francis Wilson , Alison Reid , Valerie Reader , Richard John Harrison , Mihiro Sunose , Remedios Hernandez-Perni , Jeremy Major , Cyrille Boussard , Kathryn Smelt , Jess Taylor , Adeline Leformal , Andrew Cansfield , Svenja Burckhardt
IPC分类号: A01N37/10 , A61K31/19 , A01N37/08 , A01N53/00 , A61K31/557 , C07C63/00 , C07C65/00 , C07C63/33 , C07C63/333 , C07C61/04 , C07C61/16 , C07C62/00
CPC分类号: C07C59/68 , C07C59/72 , C07C233/54 , C07C235/42 , C07C311/29 , C07C317/22 , C07C317/46 , C07C2601/02 , C07C2601/14 , C07D261/08 , C07D295/192 , C07D295/26 , C07D309/06
摘要: The present invention relates to compounds having the general formula (I) with the definitions of A, X, R1-R6 given below, and/or a salt or ester thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of γ-secretase activity.
摘要翻译: 本发明涉及具有通式(I)的具有下述A,X,R 1 -R 6的定义的化合物和/或其盐或酯。 此外,本发明涉及所述化合物用于治疗阿尔茨海默氏病及其用于调节γ-分泌酶活性的用途。
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公开(公告)号:US20090118289A1
公开(公告)日:2009-05-07
申请号:US11665760
申请日:2005-10-21
申请人: Francis Wilson , Alison Reid , Valerie Reader , Richard John Harrison , Mihiro Sunose , Remedios Hernandez-Perni , Jeremy Major , Cyrille Boussard , Kathryn Smelt , Jess Taylor , Adeline Leformal , Andrew Cansfield , Svenja Burckhardt
发明人: Francis Wilson , Alison Reid , Valerie Reader , Richard John Harrison , Mihiro Sunose , Remedios Hernandez-Perni , Jeremy Major , Cyrille Boussard , Kathryn Smelt , Jess Taylor , Adeline Leformal , Andrew Cansfield , Svenja Burckhardt
IPC分类号: A61K31/19 , C07C59/68 , C07D207/12 , C07D261/06 , C07D265/30 , A61P25/28 , A61K31/5375 , A61K31/40 , A61K31/42
CPC分类号: C07C59/68 , C07C59/72 , C07C233/54 , C07C235/42 , C07C311/29 , C07C317/22 , C07C317/46 , C07C2601/02 , C07C2601/14 , C07D261/08 , C07D295/192 , C07D295/26 , C07D309/06
摘要: The present invention relates to compounds having the general formula (I) with the definitions of A, X, R1-R6 given below, and/or a salt or ester thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of γ-secretase activity.
摘要翻译: 本发明涉及具有通式(I)的具有下述A,X,R 1 -R 6的定义的化合物和/或其盐或酯。 此外,本发明涉及所述化合物用于治疗阿尔茨海默氏病及其用于调节γ-分泌酶活性的用途。
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公开(公告)号:US07557244B2
公开(公告)日:2009-07-07
申请号:US11737938
申请日:2007-04-20
申请人: Francis Wilson , Alison Reid , Valerie Reader , Richard John Harrison , Mihiro Sunose , Remedios Hernadez-Perni , Jeremy Major , Cyrille Boussard , Kathryn Smelt , Jess Taylor , Adeline LeFormal , Andrew Cansfield , Svenja Burckhardt , Chih Yung Ho , Yan Zhang
发明人: Francis Wilson , Alison Reid , Valerie Reader , Richard John Harrison , Mihiro Sunose , Remedios Hernadez-Perni , Jeremy Major , Cyrille Boussard , Kathryn Smelt , Jess Taylor , Adeline LeFormal , Andrew Cansfield , Svenja Burckhardt , Chih Yung Ho , Yan Zhang
IPC分类号: C07C321/00 , C07C229/00 , C07C59/00 , C07D249/08 , A01N43/64 , A01N37/10
CPC分类号: C07C229/42 , C07C59/68
摘要: The present invention relates to compounds having the general Formula (I) with the definitions of X, Y, R1, R2, R3, R4, R9, and R10 given below, and/or a salt or ester thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of γ-secretase activity.
摘要翻译: 本发明涉及具有以下给出的X,Y,R 1,R 2,R 3,R 4,R 9和R 10的定义的通式(I)的化合物和/或其盐或酯。 此外,本发明涉及所述化合物用于治疗阿尔茨海默氏病及其用于调节γ-分泌酶活性的用途。
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公开(公告)号:US20100227800A1
公开(公告)日:2010-09-09
申请号:US12438662
申请日:2007-08-30
申请人: Francis Wilson , Nigel Ramsden , Kathryn Bell , Andrew Cansfield , Svenja Burckhardt , Jess Taylor , Mihiro Sunose , David Middlemiss
发明人: Francis Wilson , Nigel Ramsden , Kathryn Bell , Andrew Cansfield , Svenja Burckhardt , Jess Taylor , Mihiro Sunose , David Middlemiss
IPC分类号: A61K38/13 , C07D471/04 , A61K31/437 , A61P11/02 , A61P3/10 , A61P17/06 , A61P37/06 , A61P29/00 , A61P19/02 , A61P1/04 , A61K31/506 , A61K31/56 , A61K31/436
CPC分类号: C07D471/04
摘要: The invention relates to compounds of formula (I); wherein X and R1 to R5 have the meaning as cited in the description and the claims. Said compounds are useful as protein kinase inhibitors, especially inhibitors of Itk or PI3K, for the treatment or prophylaxis of immunological, inflammatory or allergic disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the production of and use as medicaments.
摘要翻译: 本发明涉及式(I)化合物; 其中X和R 1至R 5具有在说明书和权利要求书中引用的含义。 所述化合物可用作蛋白激酶抑制剂,特别是Itk或PI3K的抑制剂,用于治疗或预防免疫学,炎症或过敏性疾病。 本发明还涉及药物组合物,包括所述化合物,这些化合物的制备以及生产和用作药物。
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公开(公告)号:US08883820B2
公开(公告)日:2014-11-11
申请号:US12438662
申请日:2007-08-30
申请人: Francis Wilson , Nigel Ramsden , Kathryn Bell , Andrew Cansfield , Svenja Burckhardt , Jess Taylor , Mihiro Sunose , David Middlemiss
发明人: Francis Wilson , Nigel Ramsden , Kathryn Bell , Andrew Cansfield , Svenja Burckhardt , Jess Taylor , Mihiro Sunose , David Middlemiss
IPC分类号: A61K31/437 , C07D471/04
CPC分类号: C07D471/04
摘要: The invention relates to compounds of formula (I); wherein X and R1 to R5 have the meaning as cited in the description and the claims. Said compounds are useful as protein kinase inhibitors, especially inhibitors of Itk or PI3K, for the treatment or prophylaxis of immunological, inflammatory or allergic disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the production of and use as medicaments.
摘要翻译: 本发明涉及式(I)化合物; 其中X和R 1至R 5具有在说明书和权利要求书中引用的含义。 所述化合物可用作蛋白激酶抑制剂,特别是Itk或PI3K的抑制剂,用于治疗或预防免疫学,炎症或过敏性疾病。 本发明还涉及药物组合物,包括所述化合物,这些化合物的制备以及生产和用作药物。
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公开(公告)号:US20070108215A1
公开(公告)日:2007-05-17
申请号:US11601369
申请日:2006-11-16
申请人: Francis Wilson
发明人: Francis Wilson
IPC分类号: A47G19/22
CPC分类号: A47G19/2205
摘要: A glass according for holding a liquid comprising a base at the bottom of a stem and a reservoir at the top of the stem for holding a liquid. The stem runs between the base and reservoir. Vertical baffles are included within the reservoir, each of the baffles extending from an inside surface of said reservoir and intersecting with the others of said baffles within the reservoir. The baffles reduce spillage of liquid from the reservoir when the reservoir is moved.
摘要翻译: 用于保持液体的玻璃,该液体包括在杆的底部的基部和在杆的顶部处的用于保持液体的储存器。 阀杆在底座和油箱之间运行。 垂直挡板包括在储存器中,每个挡板从所述储存器的内表面延伸并且与储存器内的所述挡板的其他挡板相交。 当储存器移动时,挡板减少来自储存器的液体的溢出。
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公开(公告)号:US5322453A
公开(公告)日:1994-06-21
申请号:US981265
申请日:1992-11-25
申请人: Paul Resnick , Francis Wilson
发明人: Paul Resnick , Francis Wilson
IPC分类号: H01R13/6592 , H01R24/50 , H01R24/54 , H01R17/04
CPC分类号: H01R24/50 , H01R13/6592 , H01R2103/00 , H01R24/545
摘要: An RF jack and plug assembly provides 360.degree. of contact with a strong mechanical bond between the two parts. The jack has molded and stamped interrelated parts that predeterminedly position the parts for simple and accurate assembly. The construction provides positive electrical contact and long life for the contact elements with complete RF shielding.
摘要翻译: RF插孔和插头组件提供360°的接触,在两个部分之间具有强大的机械键。 千斤顶具有模制和冲压的相互关联的部件,其预定位置的部件用于简单和准确的组装。 该结构为具有完整RF屏蔽的接触元件提供正电接触和长寿命。
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