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公开(公告)号：US08348310B2
公开(公告)日：2013-01-08
申请号：US12851212
申请日：2010-08-05
CPC分类号： E05B85/26 , E05B81/15 , E05B83/16 , Y10T292/1047 , Y10T292/1048
摘要： A compartment latch is shown. It includes a fork bolt that moves between an open position and a closed position and a first detent lever that that cooperates with the fork bolt and that moves between a latched position and a released position. A support for holding the fork bolt and the detent lever is also provided. A second detent lever for biasing against the first detent lever when the first detent lever is in the released position is provided. The second detent lever is connected to the support at a hinge.
摘要翻译： 显示一个隔间闩锁。 它包括在打开位置和关闭位置之间移动的叉形螺栓和与叉形螺栓配合并且在锁定位置和释放位置之间移动的第一棘爪杆。 还提供了用于保持叉形螺栓和止动杆的支撑件。 提供了当第一制动杆处于释放位置时用于偏压抵靠第一制动杆的第二制动杆。 第二定位杆在铰链处连接到支撑件。
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公开(公告)号：US20110031765A1
公开(公告)日：2011-02-10
申请号：US12851212
申请日：2010-08-05
IPC分类号： E05C3/06
CPC分类号： E05B85/26 , E05B81/15 , E05B83/16 , Y10T292/1047 , Y10T292/1048
摘要： A compartment latch is shown. It includes a fork bolt that moves between an open position and a closed position and a first detent lever that that cooperates with the fork bolt and that moves between a latched position and a released position. A support for holding the fork bolt and the detent lever is also provided. A second detent lever for biasing against the first detent lever when the first detent lever is in the released position is provided. The second detent lever is connected to the support at a hinge.
摘要翻译： 显示一个隔间闩锁。 它包括在打开位置和关闭位置之间移动的叉形螺栓和与叉形螺栓配合并且在锁定位置和释放位置之间移动的第一棘爪杆。 还提供了用于保持叉形螺栓和止动杆的支撑件。 提供了当第一制动杆处于释放位置时用于偏压抵靠第一制动杆的第二制动杆。 第二定位杆在铰链处连接到支撑件。
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公开(公告)号：US20150233452A1
公开(公告)日：2015-08-20
申请号：US14623451
申请日：2015-02-16
申请人： Alfredo Martinez , Eduardo Estrada , Ian Dow , Francisco Vazquez
发明人： Alfredo Martinez , Eduardo Estrada , Ian Dow , Francisco Vazquez
摘要： An actuator for a latch is provided, the actuator having: a motor operatively coupled to a gear train; and a rack moveably mounted to the actuator for linear movement with respect to a housing of the actuator, wherein the gear train comprises: a worm; a worm gear and a pinion gear, wherein the pinion gear is rotatably mounted to the worm gear and the pinion gear has a plurality of teeth configured to engage a portion of the rack, wherein the axis of rotation of the worm is perpendicular to the axis of rotation of the worm gear and the pinion gear.
摘要翻译： 提供了一种用于闩锁的致动器，所述致动器具有：可操作地联接到齿轮系的马达; 以及可移动地安装到所述致动器以相对于所述致动器的壳体线性运动的齿条，其中所述齿轮系包括：蜗杆; 蜗轮和小齿轮，其中小齿轮可旋转地安装到蜗轮上，小齿轮具有构造成接合齿条的一部分的多个齿，其中蜗杆的旋转轴线垂直于轴线 蜗轮和小齿轮的旋转。
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公开(公告)号：US20150233152A1
公开(公告)日：2015-08-20
申请号：US14623380
申请日：2015-02-16
IPC分类号： E05B85/02
CPC分类号： E05B85/02 , Y10T292/08
摘要： A latch, having: an actuator housing configured to be “snap fit” or coupled to a latch housing of the latch.
摘要翻译： 一种闩锁，具有：构造成“卡扣配合”或联接到闩锁的闩锁壳体的致动器壳体。
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5.发明申请ACTUATOR FOR VEHICLE LATCH AND MULTI-FUNCTION RACK FOR USE WITH THE ACTUATOR 审中-公开用于执行机构的车辆锁扣和多功能机架的执行器公开(公告)号：US20150233147A1
公开(公告)日：2015-08-20
申请号：US14623449
申请日：2015-02-16
CPC分类号： F16H19/04 , E05B81/06 , E05B81/16 , E05B81/25 , E05B81/34 , E05B81/64 , F16D43/26 , F16H1/16 , F16H37/124 , Y10T74/18792 , Y10T292/1018
摘要： An actuator for a latch is provided, the actuator having: a motor operatively coupled to a gear train; and a rack moveably mounted to the actuator for linear movement with respect to a housing of the actuator, wherein the gear train comprises: a worm; a worm gear and a pinion gear, wherein the pinion gear is rotatably mounted to the worm gear and the pinion gear has a plurality of teeth configured to engage a portion of the rack, wherein the axis of rotation of the worm is perpendicular to the axis of rotation of the worm gear and the pinion gear and wherein the rack is configured to operatively couple the gear train to a locking lever of the latch and the rack also has a cam surface configured to actuate a switch as the rack is moved by the gear train.
摘要翻译： 提供了一种用于闩锁的致动器，所述致动器具有：可操作地联接到齿轮系的马达; 以及可移动地安装到所述致动器以相对于所述致动器的壳体线性运动的齿条，其中所述齿轮系包括：蜗杆; 蜗轮和小齿轮，其中小齿轮可旋转地安装到蜗轮上，小齿轮具有构造成接合齿条的一部分的多个齿，其中蜗杆的旋转轴线垂直于轴线 蜗轮和小齿轮的旋转，并且其中齿条构造成将齿轮系可操作地联接到闩锁的锁定杆，并且齿条还具有凸轮表面，凸轮表面被配置为当齿条由齿轮移动时致动开关 培养。
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6.发明授权Methods for inhibiting angiogenesis with inhibitors of proadrenomedullin N-terminal 20 peptide (PAMP) 有权用肾上腺髓质素N末端20肽（PAMP）抑制剂抑制血管生成的方法公开(公告)号：US07862815B2
公开(公告)日：2011-01-04
申请号：US12240656
申请日：2008-09-29
IPC分类号： A61K39/395 , A61K38/08 , C07K4/12 , C07K7/06 , C07K16/18
CPC分类号： G01N33/74 , A61K38/00 , A61K38/1825 , A61K38/1866 , C07K14/575 , G01N2333/515 , G01N2500/00 , G01N2500/02 , A61K2300/00
摘要： The present disclosure concerns the use of peptides and compositions, such as pharmaceutical compositions, to influence angiogenesis. Particular methods are useful for promoting angiogenesis, while others are particularly useful for inhibiting angiogenesis.
摘要翻译： 本公开涉及使用肽和组合物，例如药物组合物来影响血管发生。 特别的方法可用于促进血管生成，而其它方法对于抑制血管发生特别有用。
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公开(公告)号：US20100127512A1
公开(公告)日：2010-05-27
申请号：US12324103
申请日：2008-11-26
IPC分类号： E05C3/00
CPC分类号： E05B85/26 , E05B2015/0431 , Y10T292/1047
摘要： A door latch comprising a forkbolt that has a movement between a latched position and an unlatched position is provided. A detent is included that has movement on a travel path between a first position and a second position, the detent engaging and holding the forkbolt in the latched position when the detent is in the first position. The detent releases the forkbolt for movement to the unlatched position when the detent moves to the second position. A detent spring eccentrically engages the detent relative to the detent travel path and biases the detent toward the first position. A release mechanism is also included for moving the detent against the bias of the detent spring to the second position, thus releasing the forkbolt and producing a non-linear torque on the detent.
摘要翻译： 提供了一种门锁，其包括具有在闩锁位置和解锁位置之间的运动的叉形件。 包括在第一位置和第二位置之间的行进路径上具有运动的制动器，当止动器处于第一位置时，制动器接合并保持锁止位置处于锁定位置。 当制动器移动到第二位置时，制动器释放用于移动到解锁位置的叉簧。 制动弹簧相对于制动器行进路径偏心地接合制动器，并将制动器朝向第一位置偏压。 还包括释放机构，用于将制动器抵抗制动弹簧的偏压移动到第二位置，从而释放推杆并在制动器上产生非线性扭矩。
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公开(公告)号：US20100127511A1
公开(公告)日：2010-05-27
申请号：US12572842
申请日：2009-10-02
IPC分类号： E05C3/06
CPC分类号： E05B81/06 , E05B81/16 , E05B81/34 , Y10T292/1082
摘要： A door latch having a forkbolt that moves between a latched position and an unlatched position is provided. It includes a detent for holding the forkbolt in the latched position, and a power operated lock mechanism for moving the door latch to an unlock or lock position. It further comprises a first rotatable locking lever moveable between an unlocked and locked position and in operable communication with the detent through an intermittent lever; a second rotatable locking lever in operable communication with the first rotatable locking lever; a motor driven actuator engaging the second rotatable locking lever; and an actuator pin disposed between the motor driven actuator and the second rotatable locking lever for rotating the second rotatable locking lever.
摘要翻译： 提供具有在闩锁位置和解锁位置之间移动的卡扣的门闩。 它包括用于将卡扣保持在锁定位置的制动器，以及用于将门闩移动到解锁或锁定位置的动力操作的锁定机构。 其还包括可在解锁和锁定位置之间移动并通过间歇杆与制动器可操作地连通的第一可旋转锁定杆; 与第一可旋转锁定杆可操作地连通的第二可旋转锁定杆; 接合所述第二可旋转锁定杆的马达驱动致动器; 以及致动销，设置在电动机驱动致动器和第二可旋转锁定杆之间，用于旋转第二可旋转锁定杆。
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9.发明申请DETERMINATION OF AM-BINDING PROTEINS AND THE ASSOCIATION OF ADRENOMEDULLIN (AM) THEREWITH 有权AM结合蛋白的测定和ADRENOMEDULLIN（AM）的关联公开(公告)号：US20100098703A1
公开(公告)日：2010-04-22
申请号：US12638747
申请日：2009-12-15
申请人： Frank Cuttitta , Ted H. Elsasser , Alfredo Martinez , Rubén Pío
发明人： Frank Cuttitta , Ted H. Elsasser , Alfredo Martinez , Rubén Pío
IPC分类号： A61K39/395 , C07K14/00 , A61K38/16 , C07K16/00 , A61P43/00 , G01N33/543 , G01N33/53
CPC分类号： C07K16/18 , A61K38/1709 , A61K2039/505 , G01N33/74 , G01N2500/00
摘要： The present invention provides methods for the isolation, identification, and purification of adrenomedullin (AM)-binding proteins. Also, provided are methods for utilizing the purified AM-binding proteins, or functional portions thereof, to diagnose, treat, and monitor AM-related diseases, for example, diseases or disorders associated with abnormally elevated AM levels. In addition, the present invention provides a newly identified complex between AM and a specific AM-binding protein 1 (AMBP-1); which has been isolated and identified herein as factor H (fH). The invention also provides AM/AMBP complexes, particularly AM/FH complexes, and antibodies specifically reactive with this complexes. Further provided are methods for identifying and purifying complexes of AM and an AM binding protein using anti-AM/fH antibodies, and methods for treating conditions such as cancer or diabetes utilizing compositions comprising these antibodies. The present invention additionally provides methods for identifying antagonists agents that inhibit the function of AM, factor H, or the AM/factor H complex. The invention also provides methods for treating conditions such as cancer or diabetes using these antagonist agents.
摘要翻译： 本发明提供了分离，鉴定和纯化肾上腺髓质素（AM）结合蛋白的方法。 此外，提供了利用纯化的AM结合蛋白或其功能部分来诊断，治疗和监测AM相关疾病的方法，例如与异常升高的AM水平相关的疾病或病症。 此外，本发明提供了AM和特异性AM结合蛋白1（AMBP-1）之间新鉴定的复合物; 其在本文中被分离和鉴定为因子H（fH）。 本发明还提供AM / AMBP复合物，特别是AM / FH复合物和与该复合物特异性反应的抗体。 进一步提供了使用抗AM / fH抗体鉴定和纯化AM和AM结合蛋白的复合物的方法，以及使用包含这些抗体的组合物治疗诸如癌症或糖尿病的病症的方法。 本发明另外提供用于鉴定抑制AM，因子H或AM /因子H复合物的功能的拮抗剂的方法。 本发明还提供了使用这些拮抗剂治疗诸如癌症或糖尿病的病症的方法。
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10.发明申请FUNCTIONAL ROLE OF ADRENOMEDULLIN (AM) AND THE GENE RELATED PRODUCT (PAMP) IN HUMAN PATHOLOGY AND PHYSIOLOGY 有权ADRENOMEDULLIN（AM）和基因相关产品（PAMP）在人类病理学和生理学中的功能作用公开(公告)号：US20100021469A1
公开(公告)日：2010-01-28
申请号：US12569821
申请日：2009-09-29
申请人： Frank Cuttitta , Alfredo Martinez , Mae Jean Miller , Edward J. Unsworth , William A. Hook , Thomas Walsh , Karen Gray , Charles Macri
发明人： Frank Cuttitta , Alfredo Martinez , Mae Jean Miller , Edward J. Unsworth , William A. Hook , Thomas Walsh , Karen Gray , Charles Macri
IPC分类号： A61K39/395 , C07K16/00 , G01N33/53 , A61P7/12 , A61P37/00
CPC分类号： C07K16/26 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/51 , C07K14/575 , C07K2317/34 , C07K2317/73
摘要： The methods of the present invention demonstrate that adrenomedullin (AM) is expressed in human cancer cell lines of diverse origin and functions as a universal autocrine growth factor driving neoplastic proliferation. The present invention provides for AM peptides and AM antibodies useful in therapeutic, pharmacologic and physiologic compositions. The present invention additionally provides for methods of diagnosis, treatment and prevention of disease utilizing compositions comprising the AM peptides and antibodies of the present invention. The methods of the present invention also provide for experimental models for use in identifying the role of AM in pancreatic physiology. The methods pertaining to rat isolated islets have show that AM inhibits insulin secretion in a dose-dependent manner. The monoclonal antibody MoAb-G6, which neutralizes AM bioactivity, was show by the methods of the present invention to increase insulin release fivefold, an effect that was reversed by the addition of synthetic AM.
摘要翻译： 本发明的方法证明，肾上腺髓质素（AM）在不同来源的人类癌细胞系中表达，并且作为驱动肿瘤增殖的通用自分泌生长因子起作用。 本发明提供可用于治疗，药理和生理组合物的AM肽和AM抗体。 本发明另外提供了使用包含本发明的AM肽和抗体的组合物来诊断，治疗和预防疾病的方法。 本发明的方法还提供了用于鉴定AM在胰腺生理学中的作用的实验模型。 与大鼠分离的胰岛有关的方法表明，AM以剂量依赖的方式抑制胰岛素分泌。 通过本发明的方法显示了中和AM生物活性的单克隆抗体MoAb-G6，以增加胰岛素释放的五倍，这是通过加入合成AM而逆转的作用。
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