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    Use of DL-(+/-)-.alpha.-lipoic acid, D-(+)-.alpha.-lipoic acid, .alpha.-lipoic acid in reduced or oxidized form or salts for treating circulatory disorders
    2.
    发明授权
    Use of DL-(+/-)-.alpha.-lipoic acid, D-(+)-.alpha.-lipoic acid, .alpha.-lipoic acid in reduced or oxidized form or salts for treating circulatory disorders 失效
    使用DL-（+/-） - α-硫辛酸，D - （+） - α-硫辛酸，还原或氧化形式的α-硫辛酸或用于治疗循环障碍的盐

    公开(公告)号：US5650429A

    公开(公告)日：1997-07-22

    申请号：US554418

    申请日：1995-11-08

    申请人： Frank Conrad ,  Hermann-August Henrich ,  Wolfgang Geise ,  Heinz Ulrich

    发明人： Frank Conrad ,  Hermann-August Henrich ,  Wolfgang Geise ,  Heinz Ulrich

    IPC分类号： A61K31/20 ,  A61K31/385 ,  A61P7/00 ,  A61P9/00 ,  A61P27/16 ,  A61P43/00

    CPC分类号： A61K31/385

    摘要： The invention relates to the use of DL-(+/-)-.alpha. lipoic acid, D-(+)-.alpha.-lipoic acid, L-(-)-.alpha.-lipoic acid in reduced or oxidized form or of the metabolites and salts, esters, amides thereof for the preparation of medicines for the treatment of disorders caused by changes or disturbances in the rheological properties of the blood such as blood viscosity, erythrocyte flexibility and the aggregation of erythrocytes, in particular for the treatment of microangiopathy with disturbed microcirculation. It can also be used in the treatment of diabetics and of dialysis patients for protection of the erythrocytes, in central and peripheral circulatory disturbances and in tinnitus and hearing loss.

    摘要翻译： 本发明涉及DL-（+/-） - α硫辛酸，D - （+） - α-硫辛酸，L - （ - ） - α-硫辛酸的还原或氧化形式或代谢物， 盐，酯，酰胺，用于制备用于治疗由血液流变性质变化或紊乱引起的疾病的药物，例如血液粘度，红细胞柔性和红细胞聚集，特别是用于治疗受干扰的微血管病变 微循环。 它还可用于治疗糖尿病患者和透析患者，以保护红细胞，中枢和外周循环障碍以及耳鸣和听力损失。

    Combination medications containing alpha-lipoic acid and related
    3.
    发明授权
    Combination medications containing alpha-lipoic acid and related 失效
    含有α-硫辛酸和相关的组合药物

    公开(公告)号：US5569670A

    公开(公告)日：1996-10-29

    申请号：US404153

    申请日：1995-03-14

    申请人： Carl-Heinrich Weischer ,  Heinz Ulrich ,  Klaus Wessel

    发明人： Carl-Heinrich Weischer ,  Heinz Ulrich ,  Klaus Wessel

    IPC分类号： A61K31/385 ,  A61K31/44 ,  A61K31/51 ,  A61K31/525

    CPC分类号： A61K31/714 ,  A61K31/385 ,  A61K31/44 ,  A61K31/51 ,  A61K31/525 ,  Y10S514/866

    摘要： A pharmaceutical composition containing alpha-lipoic acid, dihydrolipoic acid, metabolites of alpha-lipoic acid (inter alia bisnortetralipoic acid and tetranorlipoic acid), optical isomers R- and S- forms of alpha-lipoic acid in oxidized and reduced form together with a vitamin, especially vitamins A, B1, B2, B6, B12, C and E and their pharmaceutically acceptable salts. The compositions are useful for producing analgesic, anti-inflammatory, antidiabetic, cytoprotective, anti-ulcer, antinecrotic, neuroprotective, detoxifying, anti-ischemic, liver function regulating, anti-allergic, immune-stimulating and antioncogenic effects.

    摘要翻译： 含有α-硫辛酸，二氢硫辛酸，α-硫辛酸（特别是二肉桂酸和四肉桂酸）的代谢物的药物组合物，氧化还原形式的α-硫辛酸的旋光异构体R-和S-形式以及维生素 特别是维生素A，B1，B2，B6，B12，C和E及其药学上可接受的盐。 该组合物可用于产生镇痛，抗炎，抗糖尿病，细胞保护，抗溃疡，抗坏死，神经保护，解毒，抗缺血，肝功能调节，抗过敏，免疫刺激和抗阴离子作用。

    Sliding wall
    8.
    发明授权
    Sliding wall 失效
    滑墙

    公开(公告)号：US06233878B1

    公开(公告)日：2001-05-22

    申请号：US09299146

    申请日：1999-04-26

    申请人： Hans Krähenbühl ,  Jürg Nyffenegger ,  Heinz Ulrich

    发明人： Hans Krähenbühl ,  Jürg Nyffenegger ,  Heinz Ulrich

    IPC分类号： E05F1514

    CPC分类号： E05F15/632 ,  E05F15/638 ,  E05Y2201/434 ,  E05Y2201/722 ,  E05Y2400/40 ,  E05Y2400/415 ,  E05Y2400/44 ,  E05Y2400/652 ,  E05Y2400/658 ,  E05Y2400/66 ,  E05Y2600/46 ,  E05Y2800/00 ,  E05Y2800/205 ,  E05Y2800/21 ,  E05Y2800/232 ,  E05Y2900/142

    摘要： In a sliding wall (10) comprising a plural number of individually slidable wall elements (13), with each of the wall elements (13) at its upper edge near the ceiling being delimited by a horizontally aligned support profile (12), and being laterally slidable along a common track (11) arranged above the support profile (12) by means of at least one running gear (14, 30) attached to the support profile; with each wall element (13) comprising its own drive (17) with an electrically operated drive motor (27), said drive (17) being attached to the wall element (13) and interacting with the track (11) by way of drive means (24, 25), a compact construction and at the same time flexible application are achieved in that the drive motor (27) is arranged within the support profile (12).

    摘要翻译： 在包括多个单独可滑动的壁元件（13）的滑动壁（10）中，其顶部附近的上边缘处的每个壁元件（13）由水平对准的支撑轮廓（12）限定，并且是 通过连接到支撑轮廓的至少一个行走齿轮（14,30）沿着布置在支撑轮廓（12）上方的公共轨道（11）可横向滑动; 每个壁元件（13）包括其自身的驱动器（17），其具有电动驱动电动机（27），所述驱动器（17）附接到壁元件（13）并且通过驱动与轨道（11）相互作用 装置（24,25），紧凑的构造并且同时灵活地实现了驱动马达（27）布置在支撑轮廓（12）内。

    Use of R-(+)-&agr;-lipoic acid, R-(−)-dihydrolipoic acid and metabolites in the form of the free acid or as salts or esters or amides for the preparation of drugs for the treatment of diabetes mellitus as well as of its sequelae
    10.
    发明授权
    Use of R-(+)-&agr;-lipoic acid, R-(−)-dihydrolipoic acid and metabolites in the form of the free acid or as salts or esters or amides for the preparation of drugs for the treatment of diabetes mellitus as well as of its sequelae 失效
    R - （+） - α-硫辛酸，R - （ - ） - 二氢硫辛酸和游离酸形式的代谢物或盐或酯或酰胺用于制备治疗糖尿病的药物 作为其后遗症

    公开(公告)号：US06284787B1

    公开(公告)日：2001-09-04

    申请号：US09628295

    申请日：2000-07-28

    申请人： Klaus Wessel ,  Harald Borbe ,  Heinz Ulrich ,  Helmut Hettche ,  Hans Bisswanger ,  Lester Packer ,  Amira Klip

    发明人： Klaus Wessel ,  Harald Borbe ,  Heinz Ulrich ,  Helmut Hettche ,  Hans Bisswanger ,  Lester Packer ,  Amira Klip

    IPC分类号： A61K31385

    CPC分类号： A61K31/385 ,  A61K31/19 ,  A61K31/22 ,  A61K31/355 ,  Y10S514/866

    摘要： The invention relates to the use of R-(+)-&agr;-lipoic acid, R-(−)-dihydrolipoic acid or their metabolites, salts, esters and amides for the synthesis of drugs for the treatment of diabetes mellitus of types I and II, compensated and decompensated insulin resistance and sequelae or late complications of diabetes mellitus, such as cataracts, polyneuropathy, nephropathy, as well as sequelae or late complications of insulin resistance. These drugs mentioned can also be used advantageously in combination with other antidiabetic drugs, particularly with insulin, and/or other additives or stabilizers or adjuvants, such as vitamin B, vitamin C, NADH, NADPH and ubiquinone. The invention furthermore relates to the use of R-(+)-&agr;-lipoic acid, R-(−)-dihydrolipoic acid or their metabolites, as well as their salts, esters and amides for the preparation of drugs for the treatment of diseases with limited function of or a lowered content of the glucose transporters.

    摘要翻译： 本发明涉及R - （+） - α-硫辛酸，R - （ - ） - 二氢硫辛酸或其代谢物，盐，酯和酰胺在合成药物治疗I型糖尿病和 II，补偿和代偿失调的胰岛素抵抗和后遗症或糖尿病晚期并发症，如白内障，多发性神经病，肾病，以及胰岛素抵抗的后遗症或晚期并发症。 所提及的这些药物也可有利地与其它抗糖尿病药物，特别是与胰岛素和/或其它添加剂或稳定剂或佐剂，如维生素B，维生素C，NADH，NADPH和泛醌一起使用。本发明还涉及使用 的R - （+） - α-硫辛酸，R - （ - ） - 二氢硫辛酸或其代谢物，以及它们的盐，酯和酰胺，用于制备治疗有限功能或降低的疾病的药物 葡萄糖转运蛋白的含量。