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公开(公告)号：US09289509B2
公开(公告)日：2016-03-22
申请号：US12774705
申请日：2010-05-05
申请人： Frank Osterroth , Christoph Uherek , Christoph Bruecher , Benjamin Daelken , Andre Engling , Thomas Haeder , Andrea Wartenberg-Demand , Gabriele Niemann , Chantal Zuber , Niklas Czeloth , Silke Aigner , Steffen Zeng , Gregor Schulz
发明人： Frank Osterroth , Christoph Uherek , Christoph Bruecher , Benjamin Daelken , Andre Engling , Thomas Haeder , Andrea Wartenberg-Demand , Gabriele Niemann , Chantal Zuber , Niklas Czeloth , Silke Aigner , Steffen Zeng , Gregor Schulz
IPC分类号： A61K39/395 , A61K47/48 , B82Y5/00
CPC分类号： A61K47/48276 , A61K47/6425 , A61K47/66 , A61K47/6851 , B82Y5/00
摘要： Disclosed are methods and treatment regimes that include the administration of immunconjugates targeting CD138 to combat diseases. The immunoconjugate is either used as the sole active ingredient, as part of a treatment regime or as part of an anticancer combination.
摘要翻译： 公开的方法和治疗方案包括施用靶向CD138的免疫接种物来对抗疾病。 免疫缀合物既可用作单一活性成分，也可用作治疗方案的一部分或作为抗癌组合的一部分。
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公开(公告)号：US20110123554A1
公开(公告)日：2011-05-26
申请号：US12774705
申请日：2010-05-05
申请人： Frank Osterroth , Christoph Uherek , Christoph Bruecher , Benjamin Daelken , Andre Engling , Thomas Haeder , Andrea Wartenberg-Demand , Gabriele Niemann , Chantal Zuber , Niklas Czeloth , Silke Aigner , Steffen Zeng
发明人： Frank Osterroth , Christoph Uherek , Christoph Bruecher , Benjamin Daelken , Andre Engling , Thomas Haeder , Andrea Wartenberg-Demand , Gabriele Niemann , Chantal Zuber , Niklas Czeloth , Silke Aigner , Steffen Zeng
IPC分类号： A61K39/395 , A61P35/00 , A61P29/00 , A61P19/08
CPC分类号： A61K47/48276 , A61K47/6425 , A61K47/66 , A61K47/6851 , B82Y5/00
摘要： Disclosed are methods and treatment regimes that include the administration of immunconjugates targeting CD138 to combat diseases. The immunoconjugate is either used as the sole active ingredient, as part of a treatment regime or as part of an anticancer combination.
摘要翻译： 公开的方法和治疗方案包括施用靶向CD138的免疫接种物来对抗疾病。 免疫缀合物既可用作单一活性成分，也可用作治疗方案的一部分或作为抗癌组合的一部分。
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公开(公告)号：US20110229465A1
公开(公告)日：2011-09-22
申请号：US13074357
申请日：2011-03-29
申请人： Frank Osterroth , Silke Aigner , Christoph Uherek , Andrea Wartenberg-Demand , Anatoly Rudnev , Michael Soldan , Christoph Bruecher , Benjamin Daelken , Chantal Zuber , Gregor Schulz , Niklas Czeloth
发明人： Frank Osterroth , Silke Aigner , Christoph Uherek , Andrea Wartenberg-Demand , Anatoly Rudnev , Michael Soldan , Christoph Bruecher , Benjamin Daelken , Chantal Zuber , Gregor Schulz , Niklas Czeloth
IPC分类号： A61K39/395 , A61K31/519 , A61K38/13 , A61K31/675 , A61K31/65 , A61K31/575 , A61P19/02 , A61P29/00
CPC分类号： C07K16/2812 , A61K39/39541 , C07K2317/24 , C07K2317/56 , A61K2300/00
摘要： The present invention provides pharmaceutical compositions and kits comprising an agent capable of activating CD4+CD25+ regulatory T cells and methotrexate, and methods of treatment and medical uses utilising the same.
摘要翻译： 本发明提供了包含能够激活CD4 + CD25 +调节性T细胞和甲氨蝶呤的药剂的药物组合物和试剂盒，以及利用其的治疗方法和医疗用途。
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4.发明申请HUMANIZED ANTI-IL 10 ANTIBODIES FOR THE TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) 有权用于治疗系统性红斑狼疮（SLE）的人类抗IL10抗体公开(公告)号：US20120321618A1
公开(公告)日：2012-12-20
申请号：US13512780
申请日：2010-11-30
申请人： Frank Osterroth , Christoph Uherek , Christoph Bruecher , Peter Röttgen , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth , Andrea Wartenberg-Demand , Marcus Gutscher , Judith Wessels-Kranz
发明人： Frank Osterroth , Christoph Uherek , Christoph Bruecher , Peter Röttgen , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth , Andrea Wartenberg-Demand , Marcus Gutscher , Judith Wessels-Kranz
IPC分类号： A61K39/395 , C12N15/62 , C12N15/85 , A61P19/00 , C12N5/071 , G01N33/566 , C12N5/10 , C07K16/46 , C12P21/00
CPC分类号： C07K16/244 , A61K2039/505 , C07K2299/00 , C07K2317/14 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2317/92 , G01N33/6869
摘要： Provided is a humanized or chimeric antibody or fragment thereof capable of binding to interleukin-10 (Th-10), wherein said antibody or fragment thereof is capable of being administered to a subject in the absence of an intolerable increase in the level of pro-inflammatory cytokines. Further provided are methods of treatment involving the use of the antibody or fragment thereof.
摘要翻译： 本发明提供了能够结合白细胞介素-10（Th-10）的人源化或嵌合抗体或其片段，其中所述抗体或其片段能够在不存在不能耐受的增加的细胞因子的情况下施用于受试者 炎性细胞因子。 还提供了涉及使用抗体或其片段的治疗方法。
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5.发明授权Humanized anti-IL-10 antibodies for the treatment of systemic lupus erythematosus (SLE) 有权用于治疗系统性红斑狼疮（SLE）的人源化抗IL-10抗体公开(公告)号：US08852871B2
公开(公告)日：2014-10-07
申请号：US13512780
申请日：2010-11-30
申请人： Frank Osterroth , Christoph Uherek , Christoph Bruecher , Peter Röttgen , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth , Andrea Wartenberg-Demand , Marcus Gutscher , Judith Wessels-Kranz
发明人： Frank Osterroth , Christoph Uherek , Christoph Bruecher , Peter Röttgen , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth , Andrea Wartenberg-Demand , Marcus Gutscher , Judith Wessels-Kranz
CPC分类号： C07K16/244 , A61K2039/505 , C07K2299/00 , C07K2317/14 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2317/92 , G01N33/6869
摘要： Provided is a humanized or chimeric antibody or fragment thereof capable of binding to interleukin-10 (Th-10), wherein said antibody or fragment thereof is capable of being administered to a subject in the absence of an intolerable increase in the level of pro-inflammatory cytokines. Further provided are methods of treatment involving the use of the antibody or fragment thereof.
摘要翻译： 本发明提供了能够结合白细胞介素-10（Th-10）的人源化或嵌合抗体或其片段，其中所述抗体或其片段能够在不存在不能耐受的增加的细胞因子的情况下施用于受试者 炎性细胞因子。 还提供了涉及使用抗体或其片段的治疗方法。
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6.发明授权Humanized anti-IL 10 antibodies for the treatment of systemic lupus erythematosus (SLE) 有权用于治疗系统性红斑狼疮（SLE）的人源化抗IL 10抗体公开(公告)号：US08956607B2
公开(公告)日：2015-02-17
申请号：US13512712
申请日：2010-11-30
申请人： Frank Osterroth , Christoph Uherek , Christoph Bruecher , Peter Röttgen , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth
发明人： Frank Osterroth , Christoph Uherek , Christoph Bruecher , Peter Röttgen , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth
CPC分类号： C07K16/244 , A61K2039/505 , C07K2299/00 , C07K2317/14 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2317/92 , G01N33/6869
摘要： Provided is a humanized or chimeric antibody or fragment thereof capable of binding to interleukin-10 (IL-10), wherein said antibody or fragment thereof: (i) binds to the same region of IL-10 as the IL-10 receptor α(IL-I10Ra) and is not capable of binding IL-10 when the IL-10 is bound to the IL- 10 receptor; and (ii) binds to IL-10 in homodimeric form by binding a discontinuous epitope comprising residues of both monomers. Further provided are related products and methods involving the use of the antibody or fragment thereof.
摘要翻译： 提供能够结合白细胞介素-10（IL-10）的人源化或嵌合抗体或其片段，其中所述抗体或其片段：（i）结合与IL-10受体α相同的IL-10区域（ IL-10Ra），并且当IL-10与IL-10受体结合时不能结合IL-10; 和（ii）通过结合包含两个单体的残基的不连续表位与同型二聚体形式的IL-10结合。 进一步提供涉及使用抗体或其片段的相关产物和方法。
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公开(公告)号：US20130004513A1
公开(公告)日：2013-01-03
申请号：US13483280
申请日：2012-05-30
申请人： Frank Osterroth , Christoph Uherek , Christoph Bruecher , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth , Holger Wallmeier , Kirsten Völp , Gregor Schulz
发明人： Frank Osterroth , Christoph Uherek , Christoph Bruecher , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth , Holger Wallmeier , Kirsten Völp , Gregor Schulz
IPC分类号： A61K39/395 , C07K16/28 , C40B30/04 , C07K19/00 , C07K9/00 , C07K14/73 , C12N15/13 , C12N15/63 , C12P21/00 , C12N5/0783 , A61P37/06 , C12N1/19 , C12N5/10 , C12N5/12 , H01F1/42 , G06F19/10 , A61M37/00 , G01N23/207 , G01R33/46 , G01N33/53
CPC分类号： G01N33/505 , C07K16/2812 , C07K2299/00 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/75 , G01N2333/70514
摘要： Provided are methods of screening to identify molecules capable of binding to CD4 and capable of activating CD4+CD25+ regulatory T cells. Further provided are antibodies and antibody fragments capable of activating CD4+CD25+ regulatory T cells and methods and uses involving the antibodies and fragments thereof.
摘要翻译： 提供了筛选以鉴定能够结合CD4并能够激活CD4 + CD25 +调节性T细胞的分子的方法。 进一步提供能够激活CD4 + CD25 +调节性T细胞的抗体和抗体片段以及涉及抗体及其片段的方法和用途。
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公开(公告)号：US09995733B2
公开(公告)日：2018-06-12
申请号：US13483280
申请日：2012-05-30
申请人： Frank Osterroth , Christoph Uherek , Christoph Bruecher , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth , Holger Wallmeier , Kirsten Völp , Gregor Schulz
发明人： Frank Osterroth , Christoph Uherek , Christoph Bruecher , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth , Holger Wallmeier , Kirsten Völp , Gregor Schulz
CPC分类号： G01N33/505 , C07K16/2812 , C07K2299/00 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/75 , G01N2333/70514
摘要： Provided are methods of screening to identify molecules capable of binding to CD4 and capable of activating CD4+CD25+ regulatory T cells. Further provided are antibodies and antibody fragments capable of activating CD4+CD25+ regulatory T cells and methods and uses involving the antibodies and fragments thereof.
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9.发明申请HUMANIZED ANTI-IL 10 ANTIBODIES FOR THE TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) 有权用于治疗系统性红斑狼疮（SLE）的人类抗IL10抗体公开(公告)号：US20120321617A1
公开(公告)日：2012-12-20
申请号：US13512712
申请日：2010-11-30
申请人： Frank Osterroth , Christoph Uherek , Christoph Bruecher , Peter Röttgen , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth
发明人： Frank Osterroth , Christoph Uherek , Christoph Bruecher , Peter Röttgen , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth
IPC分类号： A61K39/395 , C12N15/13 , A61P19/04 , C07K17/00 , G01N33/566 , C12N1/21 , C12N5/10 , C12P21/02 , C12N5/078 , C07K16/24 , C12N15/63
CPC分类号： C07K16/244 , A61K2039/505 , C07K2299/00 , C07K2317/14 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2317/92 , G01N33/6869
摘要： Provided is a humanized or chimeric antibody or fragment thereof capable of binding to interleukin-10 (IL-10), wherein said antibody or fragment thereof: (i) binds to the same region of IL-10 as the 1L-10 receptor α (IL-I10Ra) and is not capable of binding IL-10 when the IL-10 is bound to the IL-10 receptor; and (ii) binds to IL-10 in homodimeric form by binding a discontinuous epitope comprising residues of both monomers. Further provided are related products and methods involving the use of the antibody or fragment thereof.
摘要翻译： 提供能够结合白细胞介素-10（IL-10）的人源化或嵌合抗体或其片段，其中所述抗体或其片段：（i）结合与1L-10受体α相同的IL-10区域（ IL-10Ra），并且当IL-10与IL-10受体结合时不能结合IL-10; 和（ii）通过结合包含两个单体的残基的不连续表位与同型二聚体形式的IL-10结合。 进一步提供涉及使用抗体或其片段的相关产物和方法。
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