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1.发明授权Method for treating muscular dystrophy using antagonist antibodies against GDF-8 有权使用针对GDF-8的拮抗剂抗体治疗肌营养不良的方法公开(公告)号：US08349327B2
公开(公告)日：2013-01-08
申请号：US13030978
申请日：2011-02-18
申请人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , William Kelley, legal representative , Xiang-Yang Tan , Seung Poon Kwak , Menelas N. Pangalos
发明人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , Xiang-Yang Tan , Seung Poon Kwak , Menelas N. Pangalos
IPC分类号： A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N33/74 , G01N2333/475 , G01N2800/2835 , G01N2800/50 , G01N2800/52
摘要： The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
摘要翻译： 本公开提供了与生长和分化因子-8（GDF-8）特别是小鼠和人源化抗体以及抗体片段相关的新分子，包括在体外和/或体内抑制GDF-8活性和信号传导的抗体片段。 本公开还提供了用于诊断，治疗，改善，预防，预后或监测肌肉，骨骼和胰岛素代谢等的退行性顺序，特别是肌萎缩性侧索硬化（ALS）的方法。 此外，本公开提供了通过使用本发明的抗体，多肽，多核苷酸和载体来治疗这种病症的药物组合物。
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公开(公告)号：US07888486B2
公开(公告)日：2011-02-15
申请号：US11503062
申请日：2006-08-14
申请人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , William Kelley, legal representative , Xiang-Yang Tan , Seung Poon Kwak , Menelas N. Pangalos
发明人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , Xiang-Yang Tan , Seung Poon Kwak , Menelas N. Pangalos
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N33/74 , G01N2333/475 , G01N2800/2835 , G01N2800/50 , G01N2800/52
摘要： The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
摘要翻译： 本公开提供了与生长和分化因子-8（GDF-8）特别是小鼠和人源化抗体以及抗体片段相关的新分子，包括在体外和/或体内抑制GDF-8活性和信号传导的抗体片段。 本公开还提供了用于诊断，治疗，改善，预防，预后或监测肌肉，骨骼和胰岛素代谢等的退行性顺序，特别是肌萎缩性侧索硬化（ALS）的方法。 此外，本公开提供了通过使用本发明的抗体，多肽，多核苷酸和载体来治疗这种病症的药物组合物。
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3.发明授权Antagonist antibodies against GDF-8 and uses in treatment of ALS and other GDF-8 associated disorders 有权抗GDF-8抗体抗体，用于治疗ALS和其他GDF-8相关疾病公开(公告)号：US07910107B2
公开(公告)日：2011-03-22
申请号：US12508618
申请日：2009-07-24
申请人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Erika L. F. Holzbaur-Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , William Kelley, legal representative , Xiang-Yang Tan , Seung Poon Kwak , Karen Wallace , Nicholas Weber , Menelas N. Pangalos
发明人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Erika L. F. Holzbaur-Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , Xiang-Yang Tan , Seung Poon Kwak , Karen Wallace , Nicholas Weber , Menelas N. Pangalos
IPC分类号： A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N33/74 , G01N2333/475 , G01N2800/2835 , G01N2800/50 , G01N2800/52
摘要： The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
摘要翻译： 本公开提供了与生长和分化因子-8（GDF-8）特别是小鼠和人源化抗体以及抗体片段相关的新分子，包括在体外和/或体内抑制GDF-8活性和信号传导的抗体片段。 本公开还提供了用于诊断，治疗，改善，预防，预后或监测肌肉，骨骼和胰岛素代谢等的退行性顺序，特别是肌萎缩性侧索硬化（ALS）的方法。 此外，本公开提供了通过使用本发明的抗体，多肽，多核苷酸和载体来治疗这种病症的药物组合物。
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4.发明申请ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES IN TREATMENT OF ALS AND OTHER GDF-8 ASSOCIATED DISORDERS 有权针对GDF-8的拮抗剂抗体和用于治疗ALS和其他GDF-8相关疾病的用途公开(公告)号：US20120016106A1
公开(公告)日：2012-01-19
申请号：US13038954
申请日：2011-03-02
申请人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Erika L.F. Holzbaur-Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , William Kelley , Xiang-Yang Tan , Seung Poon Kwak , Karen Wallace , Nicholas Weber , Menelas N. Pangalos
发明人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Erika L.F. Holzbaur-Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , William Kelley , Xiang-Yang Tan , Seung Poon Kwak , Karen Wallace , Nicholas Weber , Menelas N. Pangalos
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N33/74 , G01N2333/475 , G01N2800/2835 , G01N2800/50 , G01N2800/52
摘要： The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
摘要翻译： 本公开提供了与生长和分化因子-8（GDF-8）特别是小鼠和人源化抗体以及抗体片段相关的新分子，包括在体外和/或体内抑制GDF-8活性和信号传导的抗体片段。 本公开还提供了用于诊断，治疗，改善，预防，预后或监测肌肉，骨骼和胰岛素代谢等的退行性顺序，特别是肌萎缩性侧索硬化（ALS）的方法。 此外，本公开提供了通过使用本发明的抗体，多肽，多核苷酸和载体来治疗这种病症的药物组合物。
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5.发明申请ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES IN TREATMENT OF ALS AND OTHER GDF-8 ASSOCIATED DISORDERS 有权针对GDF-8的拮抗剂抗体和用于治疗ALS和其他GDF-8相关疾病的用途公开(公告)号：US20090285827A1
公开(公告)日：2009-11-19
申请号：US12508618
申请日：2009-07-24
申请人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Erika L. F. Holzbaur-Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , William Kelley , Xiang-Yang Tan , Seung Poon Kwak , Karen Wallace , Nicholas Weber , Menelas N. Pangalos
发明人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Erika L. F. Holzbaur-Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , William Kelley , Xiang-Yang Tan , Seung Poon Kwak , Karen Wallace , Nicholas Weber , Menelas N. Pangalos
IPC分类号： A61K39/395 , G01N33/53
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N33/74 , G01N2333/475 , G01N2800/2835 , G01N2800/50 , G01N2800/52
摘要： The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
摘要翻译： 本公开提供了与生长和分化因子-8（GDF-8）特别是小鼠和人源化抗体以及抗体片段相关的新分子，包括在体外和/或体内抑制GDF-8活性和信号传导的抗体片段。 本公开还提供了用于诊断，治疗，改善，预防，预后或监测肌肉，骨骼和胰岛素代谢等的退行性顺序，特别是肌萎缩性侧索硬化（ALS）的方法。 此外，本公开提供了通过使用本发明的抗体，多肽，多核苷酸和载体来治疗这种病症的药物组合物。
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公开(公告)号：US08372625B2
公开(公告)日：2013-02-12
申请号：US13038954
申请日：2011-03-02
申请人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Lioudmila Tchistiakova , Riyez Karim , Xiang-Yang Tan , Seung Poon Kwak , Menelas N. Pangalos , William Kelley
发明人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , Xiang-Yang Tan , Seung Poon Kwak , Menelas N. Pangalos
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N33/74 , G01N2333/475 , G01N2800/2835 , G01N2800/50 , G01N2800/52
摘要： The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
摘要翻译： 本公开提供了与生长和分化因子-8（GDF-8）特别是小鼠和人源化抗体以及抗体片段相关的新分子，包括在体外和/或体内抑制GDF-8活性和信号传导的抗体片段。 本公开还提供了用于诊断，治疗，改善，预防，预后或监测肌肉，骨骼和胰岛素代谢等的退行性顺序，特别是肌萎缩性侧索硬化（ALS）的方法。 此外，本公开提供了通过使用本发明的抗体，多肽，多核苷酸和载体来治疗这种病症的药物组合物。
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