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    METHOD TO INCREASE SPECIFICITY AND/OR ACCURACY OF LATERAL FLOW IMMUNOASSAYS
    1.
    发明申请
    METHOD TO INCREASE SPECIFICITY AND/OR ACCURACY OF LATERAL FLOW IMMUNOASSAYS 有权
    增加侧流量免疫球蛋白特异性和/或准确度的方法

    公开(公告)号：US20100112725A1

    公开(公告)日：2010-05-06

    申请号：US12568970

    申请日：2009-09-29

    申请人： Uma Mahesh Babu ,  Franz Aberl ,  Marcus Scheibenzuber ,  Robert P. Sambursky ,  Robert W. VanDine ,  Jose S. Sambursky

    发明人： Uma Mahesh Babu ,  Franz Aberl ,  Marcus Scheibenzuber ,  Robert P. Sambursky ,  Robert W. VanDine ,  Jose S. Sambursky

    IPC分类号： G01N33/543 ,  G01N30/02 ,  G01N33/52 ,  G01N33/53

    CPC分类号： G01N33/54393 ,  G01N33/54386 ,  G01N33/558 ,  G01N33/6893 ,  Y10T436/142222 ,  Y10T436/173845 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/25375

    摘要： The present invention includes methods and devices for preventing interfering substances from affecting the accuracy of a lateral flow immunoassay. In preferred embodiments, a test strip includes a capturing zone that includes at least one mobile capturing reagent that separates at least one interfering substance from the analyte. The capturing zone is preferably located upstream of the sample application zone. In some embodiments, the reagent/conjugate zone is also located upstream of the sample application zone. The capturing zone may be located upstream, downstream, or overlapping with the reagent/conjugate zone in these embodiments. In other preferred embodiments, one or more mobile capturing reagents are included in the elution medium/running buffer. In yet other embodiments, the capturing reagent is incorporated into a sample collection device of a sample collection system, preferably separate from the chromatographic test strip. A lysis zone is also included in some preferred embodiments.

    摘要翻译： 本发明包括用于防止干扰物质影响侧流免疫测定精度的方法和装置。 在优选的实施方案中，测试条包括捕获区，其包含至少一种从分析物分离至少一种干扰物质的移动捕获试剂。 捕获区优选位于样品施加区域的上游。 在一些实施方案中，试剂/共轭区也位于样品施加区的上游。 在这些实施例中，捕获区可以位于上游，下游或与试剂/共轭区重叠。 在其它优选实施方案中，一种或多种移动捕获试剂包括在洗脱介质/运行缓冲液中。 在其他实施方案中，将捕获试剂并入样品收集系统的样品收集装置中，优选与色谱测试条分离。 裂解区也包括在一些优选的实施方案中。

    Method to increase specificity and/or accuracy of lateral flow immunoassays
    3.
    发明授权
    Method to increase specificity and/or accuracy of lateral flow immunoassays 有权
    增加侧流免疫测定的特异性和/或准确性的方法

    公开(公告)号：US08445293B2

    公开(公告)日：2013-05-21

    申请号：US12568970

    申请日：2009-09-29

    申请人： Uma Mahesh Babu ,  Franz Aberl ,  Marcus Scheibenzuber ,  Robert P. Sambursky ,  Robert W. VanDine ,  Jose S. Sambursky

    发明人： Uma Mahesh Babu ,  Franz Aberl ,  Marcus Scheibenzuber ,  Robert P. Sambursky ,  Robert W. VanDine ,  Jose S. Sambursky

    IPC分类号： G01N33/558

    CPC分类号： G01N33/54393 ,  G01N33/54386 ,  G01N33/558 ,  G01N33/6893 ,  Y10T436/142222 ,  Y10T436/173845 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/25375

    摘要： The present invention includes methods and devices for preventing interfering substances from affecting the accuracy of a lateral flow immunoassay. In preferred embodiments, a test strip includes a capturing zone that includes at least one mobile capturing reagent that separates at least one interfering substance from the analyte. The capturing zone is preferably located upstream of the sample application zone. In some embodiments, the reagent/conjugate zone is also located upstream of the sample application zone. The capturing zone may be located upstream, downstream, or overlapping with the reagent/conjugate zone in these embodiments. In other preferred embodiments, one or more mobile capturing reagents are included in the elution medium/running buffer. In yet other embodiments, the capturing reagent is incorporated into a sample collection device of a sample collection system, preferably separate from the chromatographic test strip. A lysis zone is also included in some preferred embodiments.

    摘要翻译： 本发明包括用于防止干扰物质影响侧流免疫测定精度的方法和装置。 在优选的实施方案中，测试条包括捕获区，其包含至少一种从分析物分离至少一种干扰物质的移动捕获试剂。 捕获区优选位于样品施加区域的上游。 在一些实施方案中，试剂/共轭区也位于样品施加区的上游。 在这些实施例中，捕获区可以位于上游，下游或与试剂/共轭区重叠。 在其它优选实施方案中，一种或多种移动捕获试剂包括在洗脱介质/运行缓冲液中。 在其他实施方案中，将捕获试剂并入样品收集系统的样品收集装置中，优选与色谱测试条分离。 裂解区也包括在一些优选的实施方案中。