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1.发明授权Method for the rapid diagnosis of targets in human body fluids using undiluted samples 有权使用未稀释样品快速诊断人体液中靶标的方法公开(公告)号：US08647890B2
公开(公告)日：2014-02-11
申请号：US12701799
申请日：2010-02-08
申请人： Franz Aberl , Marcus Scheibenzuber , Robert P. Sambursky , Robert W. VanDine , Jose S. Sambursky
发明人： Franz Aberl , Marcus Scheibenzuber , Robert P. Sambursky , Robert W. VanDine , Jose S. Sambursky
IPC分类号： G01N33/558 , G01N33/53
CPC分类号： G01N33/56983 , G01N33/487 , G01N33/558 , G01N33/6893 , G01N2333/07 , Y10S436/811 , Y10T436/25375 , Y10T436/255
摘要： More particularly, the present invention relates to a method for the detection of a target, e.g. pathogen in a human body fluid wherein a body fluid sample is collected with a swab member.
摘要翻译： 更具体地，本发明涉及用于检测靶的方法。 人体液中的病原体，其中用拭子构件收集体液样品。
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2.发明申请METHOD TO INCREASE SPECIFICITY AND/OR ACCURACY OF LATERAL FLOW IMMUNOASSAYS 有权增加侧流量免疫球蛋白特异性和/或准确度的方法公开(公告)号：US20100112725A1
公开(公告)日：2010-05-06
申请号：US12568970
申请日：2009-09-29
申请人： Uma Mahesh Babu , Franz Aberl , Marcus Scheibenzuber , Robert P. Sambursky , Robert W. VanDine , Jose S. Sambursky
发明人： Uma Mahesh Babu , Franz Aberl , Marcus Scheibenzuber , Robert P. Sambursky , Robert W. VanDine , Jose S. Sambursky
IPC分类号： G01N33/543 , G01N30/02 , G01N33/52 , G01N33/53
CPC分类号： G01N33/54393 , G01N33/54386 , G01N33/558 , G01N33/6893 , Y10T436/142222 , Y10T436/173845 , Y10T436/25 , Y10T436/25125 , Y10T436/25375
摘要： The present invention includes methods and devices for preventing interfering substances from affecting the accuracy of a lateral flow immunoassay. In preferred embodiments, a test strip includes a capturing zone that includes at least one mobile capturing reagent that separates at least one interfering substance from the analyte. The capturing zone is preferably located upstream of the sample application zone. In some embodiments, the reagent/conjugate zone is also located upstream of the sample application zone. The capturing zone may be located upstream, downstream, or overlapping with the reagent/conjugate zone in these embodiments. In other preferred embodiments, one or more mobile capturing reagents are included in the elution medium/running buffer. In yet other embodiments, the capturing reagent is incorporated into a sample collection device of a sample collection system, preferably separate from the chromatographic test strip. A lysis zone is also included in some preferred embodiments.
摘要翻译： 本发明包括用于防止干扰物质影响侧流免疫测定精度的方法和装置。 在优选的实施方案中，测试条包括捕获区，其包含至少一种从分析物分离至少一种干扰物质的移动捕获试剂。 捕获区优选位于样品施加区域的上游。 在一些实施方案中，试剂/共轭区也位于样品施加区的上游。 在这些实施例中，捕获区可以位于上游，下游或与试剂/共轭区重叠。 在其它优选实施方案中，一种或多种移动捕获试剂包括在洗脱介质/运行缓冲液中。 在其他实施方案中，将捕获试剂并入样品收集系统的样品收集装置中，优选与色谱测试条分离。 裂解区也包括在一些优选的实施方案中。
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3.发明授权Method to increase specificity and/or accuracy of lateral flow immunoassays 有权增加侧流免疫测定的特异性和/或准确性的方法公开(公告)号：US08445293B2
公开(公告)日：2013-05-21
申请号：US12568970
申请日：2009-09-29
申请人： Uma Mahesh Babu , Franz Aberl , Marcus Scheibenzuber , Robert P. Sambursky , Robert W. VanDine , Jose S. Sambursky
发明人： Uma Mahesh Babu , Franz Aberl , Marcus Scheibenzuber , Robert P. Sambursky , Robert W. VanDine , Jose S. Sambursky
IPC分类号： G01N33/558
CPC分类号： G01N33/54393 , G01N33/54386 , G01N33/558 , G01N33/6893 , Y10T436/142222 , Y10T436/173845 , Y10T436/25 , Y10T436/25125 , Y10T436/25375
摘要： The present invention includes methods and devices for preventing interfering substances from affecting the accuracy of a lateral flow immunoassay. In preferred embodiments, a test strip includes a capturing zone that includes at least one mobile capturing reagent that separates at least one interfering substance from the analyte. The capturing zone is preferably located upstream of the sample application zone. In some embodiments, the reagent/conjugate zone is also located upstream of the sample application zone. The capturing zone may be located upstream, downstream, or overlapping with the reagent/conjugate zone in these embodiments. In other preferred embodiments, one or more mobile capturing reagents are included in the elution medium/running buffer. In yet other embodiments, the capturing reagent is incorporated into a sample collection device of a sample collection system, preferably separate from the chromatographic test strip. A lysis zone is also included in some preferred embodiments.
摘要翻译： 本发明包括用于防止干扰物质影响侧流免疫测定精度的方法和装置。 在优选的实施方案中，测试条包括捕获区，其包含至少一种从分析物分离至少一种干扰物质的移动捕获试剂。 捕获区优选位于样品施加区域的上游。 在一些实施方案中，试剂/共轭区也位于样品施加区的上游。 在这些实施例中，捕获区可以位于上游，下游或与试剂/共轭区重叠。 在其它优选实施方案中，一种或多种移动捕获试剂包括在洗脱介质/运行缓冲液中。 在其他实施方案中，将捕获试剂并入样品收集系统的样品收集装置中，优选与色谱测试条分离。 裂解区也包括在一些优选的实施方案中。
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公开(公告)号：US20100143891A1
公开(公告)日：2010-06-10
申请号：US12701799
申请日：2010-02-08
申请人： Franz Aberl , Marcus Scheibenzuber , Robert P. Sambursky , Robert W. VanDine , Jose S. Sambursky
发明人： Franz Aberl , Marcus Scheibenzuber , Robert P. Sambursky , Robert W. VanDine , Jose S. Sambursky
CPC分类号： G01N33/56983 , G01N33/487 , G01N33/558 , G01N33/6893 , G01N2333/07 , Y10S436/811 , Y10T436/25375 , Y10T436/255
摘要： More particularly, the present invention relates to a method for the detection of a target, e.g. pathogen in a human body fluid wherein a body fluid sample is collected with a swab member.
摘要翻译： 更具体地，本发明涉及用于检测靶的方法。 人体液中的病原体，其中用拭子构件收集体液样品。
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公开(公告)号：US20110086359A1
公开(公告)日：2011-04-14
申请号：US12957683
申请日：2010-12-01
CPC分类号： G01N33/5308 , C12Q1/6834 , Y10T436/143333 , C12Q2565/625 , C12Q2565/519 , C12Q2525/161
摘要： Assays and methods including mobile tagged single stranded nucleic acid reagents pre-loaded on an analysis device, which are preferably tagged, but not labeled and are complementary to a strand (preferably the anti-sense strand in double stranded DNA targets) of the target nucleic acid. The assay also includes a running buffer that includes a dye or other detectable label that nonspecifically binds only to double stranded nucleic acids. In addition, the analysis device includes a detection zone including one or more test zones that have an immobilized tag that binds to the tag on the mobile nucleic acid reagent.
摘要翻译： 测定和方法，包括预先加载在分析装置上的移动标记单链核酸试剂，其优选地被标记但未标记并与靶核酸的链（优选双链DNA靶的反义链）互补 酸。 该测定还包括运行缓冲液，其包括仅与双链核酸非特异性结合的染料或其它可检测标记。 此外，分析装置包括检测区域，该检测区域包括具有与移动核酸试剂上的标签结合的固定化标签的一个或多个测试区域。
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公开(公告)号：US08609433B2
公开(公告)日：2013-12-17
申请号：US12958454
申请日：2010-12-02
IPC分类号： G01N33/563 , G01N33/558 , G01N33/553
CPC分类号： G01N33/54306 , B01L3/5023 , B01L3/502715 , B01L3/502738 , B01L2200/027 , B01L2400/0633 , G01N33/5302 , G01N33/543 , G01N33/558 , Y02A50/51 , Y02A50/53 , Y02A50/54 , Y02A50/60 , Y10T436/25
摘要： A sample compressor applies pressure to a sample collector and a sample application zone of a test strip to transfer a sample from the sample collector and a binding partner of an analyte to the sample application zone in a lateral flow device. At least one of the binding partners of the analyte is not located on the test strip prior to use of the lateral flow device. The test strip may be a universal test strip with no molecule that specifically binds the analyte is located on the test strip. The sample compressor may be a universal sample compressor also with no molecule that specifically binds the analyte on the sample compressor. The lateral flow device may also include one or more enhancement elements, where the enhancement elements bind to the analyte sandwich to increase a detection signal in the test zone.
摘要翻译： 样品压缩机向样品收集器和测试条的样品施加区域施加压力，以将样品从样品收集器和分析物的结合配对物转移到侧向流动装置中的样品施加区域。 在使用侧流装置之前，分析物的至少一个结合配偶体不位于测试条上。 测试条可以是通用测试条，没有特异性结合分析物位于测试条上的分子。 样品压缩机可以是通用样品压缩机，也不具有特异性结合样品压缩机上的分析物的分子。 侧向流动装置还可以包括一个或多个增强元件，其中增强元件结合到分析物夹心物以增加测试区域中的检测信号。
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公开(公告)号：US20120264133A1
公开(公告)日：2012-10-18
申请号：US13531993
申请日：2012-06-25
CPC分类号： G01N33/526 , C12Q1/6834 , Y10S436/81 , C12Q2565/625 , C12Q2565/519 , C12Q2525/161
摘要： Point-of-care binding assays include at least one target nucleic acid binding in a multiplex structure with at least one sequence in a partner nucleic acid associated with a label, due to complementary base pairings between at least one sequence in the target nucleic acid and at least one sequence in the partner nucleic acid. The assays overcome the inherent deficiencies of antibody-protein antigen assays. In a preferred embodiment, color tagged nucleic acid sequences are used to bind a complementary target nucleic acid. The tagged nucleic acid sequences are preferably made from deoxyribonucleotides, ribonucleotides, or peptide nucleotides.
摘要翻译： 点护理结合测定法包括至少一种多核结构中的靶核酸与靶标核酸中的至少一个序列之间的互补碱基配对与靶核酸中的至少一个序列之间的互补碱基配对和 伴侣核酸中的至少一个序列。 该测定克服了抗体 - 蛋白质抗原测定的固有缺陷。 在优选的实施方案中，使用彩色标记的核酸序列结合互补靶核酸。 标记的核酸序列优选由脱氧核糖核苷酸，核糖核苷酸或肽核苷酸制成。
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公开(公告)号：US20110136258A1
公开(公告)日：2011-06-09
申请号：US12958454
申请日：2010-12-02
IPC分类号： G01N33/566 , C12M1/34 , G01N1/28 , G01N33/543
CPC分类号： G01N33/54306 , B01L3/5023 , B01L3/502715 , B01L3/502738 , B01L2200/027 , B01L2400/0633 , G01N33/5302 , G01N33/543 , G01N33/558 , Y02A50/51 , Y02A50/53 , Y02A50/54 , Y02A50/60 , Y10T436/25
摘要： A sample compressor applies pressure to a sample collector and a sample application zone of a test strip to transfer a sample from the sample collector and a binding partner of an analyte to the sample application zone in a lateral flow device. At least one of the binding partners of the analyte is not located on the test strip prior to use of the lateral flow device. The test strip may be a universal test strip with no molecule that specifically binds the analyte is located on the test strip. The sample compressor may be a universal sample compressor also with no molecule that specifically binds the analyte on the sample compressor. The lateral flow device may also include one or more enhancement elements, where the enhancement elements bind to the analyte sandwich to increase a detection signal in the test zone.
摘要翻译： 样品压缩机向样品收集器和测试条的样品施加区域施加压力，以将样品从样品收集器和分析物的结合配对物转移到侧向流动装置中的样品施加区域。 在使用侧流装置之前，分析物的至少一个结合配偶体不位于测试条上。 测试条可以是通用测试条，没有特异性结合分析物位于测试条上的分子。 样品压缩机可以是通用样品压缩机，也不具有特异性结合样品压缩机上的分析物的分子。 侧向流动装置还可以包括一个或多个增强元件，其中增强元件结合到分析物夹心物以增加测试区域中的检测信号。
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公开(公告)号：US20090291508A1
公开(公告)日：2009-11-26
申请号：US12469207
申请日：2009-05-20
IPC分类号： G01N33/543 , B01J19/00
CPC分类号： G01N33/54346 , B01J2219/00576 , B01J2219/00648 , B01J2219/00725 , B01J2219/0074 , B01J2219/00743 , B82Y30/00
摘要： The present invention includes methods and devices that detect target molecules in a biological sample. The sample analysis device of the present invention includes nanoparticles. In one embodiment, the nanoparticles are directly immobilized on the surface of the sample analysis device. In another embodiment, the nanoparticles are indirectly immobilized on the surface of the sample analysis device by incorporating them in appropriate media and immobilizing the nanoparticles within a matrix.
摘要翻译： 本发明包括检测生物样品中的靶分子的方法和装置。 本发明的样品分析装置包括纳米颗粒。 在一个实施方案中，纳米颗粒直接固定在样品分析装置的表面上。 在另一个实施方案中，纳米颗粒通过将它们并入合适的介质并将纳米颗粒固定在基质内而间接地固定在样品分析装置的表面上。
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公开(公告)号：US09910036B2
公开(公告)日：2018-03-06
申请号：US12782162
申请日：2010-05-18
IPC分类号： G01N33/558 , G01N33/543 , B82Y30/00 , G01N33/569
CPC分类号： G01N33/54386 , B01J2219/00576 , B01J2219/00648 , B01J2219/00725 , B01J2219/0074 , B01J2219/00743 , B82Y30/00 , G01N33/54346 , G01N33/56911 , G01N33/56983 , G01N2333/47 , G01N2333/4737 , G01N2333/914
摘要： A lateral flow assay detects and differentiates between viral and bacterial infections. A combined point of care diagnostic device tests markers for viral infection and markers for bacterial infection, to effectively assist in the rapid differentiation of viral and bacterial infections. In one preferred embodiment, the bacterial marker is CRP. In another preferred embodiment, the viral marker is MxA. In some embodiments, it is unnecessary to lyse the cells in the sample prior to applying it to the device.
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