摘要:
The invention relates to a medicament against tumors and their metastases, which preferentially settle in bone tissue, comprising as active ingredient at least one binding molecule which binds to bone sialoprotein or a fragment thereof in serum or plasma.
摘要:
Described are antisense oligonucleotides targeted to the gene encoding osteopontin, bone sialoprotein II and/or osteonectin, wherein said oligonucleotides inhibit the expression of said gene(s). Moreover, the therapeutic use of said antisense oligonucleotides is described, e.g., for the treatment or prevention of cancer/metastasis, preferably osteolytic metastasis or metastasis of breast cancer cells.
摘要:
The invention relates to an exhaust-gas-driven turbocharger having a hydrodynamic plain bearing having a rotor and a stator, the rotor being rotatable with respect to the stator, the rotor bearing surface being located opposite a counter-surface of the stator in order to generate hydrodynamic pressure in the region of a converging gap. In such a hydrodynamic plain bearing, the application properties can be improved by the fact that the rotor bearing surface and/or the counter-surface constitutes in a section view, in the context of a section along and through the rotation axis, a continuous bearing contour that is constituted from convex or concave curvatures and/or from at least two contour segments that are embodied as straight lines and/or curvatures. The invention also relates to a hydrodynamic plain bearing or bearing arrangement having such a plain bearing.
摘要:
The invention relates to a synchronization piece which, as part of a servo synchronization system comprising a sliding sleeve, a clutch body, a synchronizer ring and an idler gear, can synchronize a transmission having toothed wheel gears. The invention furthermore relates to an entire synchronizing system having a synchronization piece according to the invention. A full-servo synchronization system is also presented.
摘要:
The invention relates to an exhaust gas turbocharger having a fluid dynamic bearing having a rotor (10) and a counter-bearing part (50) assigned to the rotor (10), wherein a rotor bearing surface of the rotor (10) and a counterface of the counter-bearing part (50) face each other, to form a fluid dynamic bearing, wherein the rotor bearing surface and/or the counterface form(s) a continuous bearing contour when cut longitudinally and through the axis of rotation (R) in sectional view, which bearing contour(s) are formed of at least two contour sections (44.1 to 44.3; 53.1 to 53.3) to generate fluid dynamic load capacities in both the radial and the axial directions, wherein the bearing surface of the rotor (10) is formed by a rotor part (40), which is connected to a rotor shaft (11) and is secured on the rotor shaft (11), and wherein the rotor part (40) is supported relative to the rotor shaft (11) in the area of a support section (14) of the rotor shaft (11). In order to be able to provide such an exhaust gas turbocharger with a compact and efficient bearing arrangement having a fluid dynamic bearing, wherein at the same time the fluid dynamic bearing can be easily mounted using few parts, provision is made according to the invention that the support section (14) and at least one of the contour sections (53.1 to 53.3) of the counter-bearing part (50) at least sectionally overlap in the direction of the axis of rotation (R).
摘要:
The invention relates to an exhaust gas turbocharger having a fluid dynamic bearing having a rotor (10) and a counter-bearing part (50) assigned to the rotor (10), wherein a rotor bearing surface of the rotor (10) and a counterface of the counter-bearing part (50) face each other, to form a fluid dynamic bearing, wherein the rotor bearing surface and/or the counterface form(s) a continuous bearing contour when cut longitudinally and through the axis of rotation (R) in sectional view, which bearing contour(s) are formed of at least two contour sections (44.1 to 44.3; 53.1 to 53.3) to generate fluid dynamic load capacities in both the radial and the axial directions, wherein the bearing surface of the rotor (10) is formed by a rotor part (40), which is connected to a rotor shaft (11) and is secured on the rotor shaft (11), and wherein the rotor part (40) is supported relative to the rotor shaft (11) in the area of a support section (14) of the rotor shaft (11). In order to be able to provide such an exhaust gas turbocharger with a compact and efficient bearing arrangement having a fluid dynamic bearing, wherein at the same time the fluid dynamic bearing can be easily mounted using few parts, provision is made according to the invention that the support section (14) and at least one of the contour sections (53.1 to 53.3) of the counter-bearing part (50) at least sectionally overlap in the direction of the axis of rotation (R).
摘要:
Systems and methods are provided for evaluating the complexity of a stenosis or a section of a vessel. At least one image of the stenosis or the section of the vessel is provided. A geometrical feature value of the stenosis and/or or the section of the vessel is identified from the at least one image. At least one intensity feature value is determined based on a grey level intensity of the stenosis or the section of the vessel from the at least one image. A complexity value relating to the geometrical complexity of the stenosis or the section of the vessel is calculated as a function of the at least one geometrical feature value and the at least one intensity feature value of the stenosis or the section of the vessel.
摘要:
An interferometric measuring device includes a reference arm having a reference surface and a measuring arm having lighting optics for deflecting measuring light onto a measuring surface of an object to be measured, and having an image recorder connected to an analyzing device. A rapid, simple measurement with a rugged design of the measuring device may be achieved by configuring the lighting optics as a light guide body insertable into a cavity in the object to be measured, having a peripheral, radially symmetrical effective reflex surface directed radially or obliquely outward, and also including at least one deflector surface deflecting the measuring light onto same.
摘要:
Systems and methods are provided for evaluating the complexity of a stenosis or a section of a vessel. At least one image of the stenosis or the section of the vessel is provided. A geometrical feature value of the stenosis and/or or the section of the vessel is identified from the at least one image. At least one intensity feature value is determined based on a grey level intensity of the stenosis or the section of the vessel from the at least one image. A complexity value relating to the geometrical complexity of the stenosis or the section of the vessel is calculated as a function of the at least one geometrical feature value and the at least one intensity feature value of the stenosis or the section of the vessel.
摘要:
In a method and magnetic resonance apparatus for automating the analysis of MR raw data representing a spectrum, at least one post-processing procedure is applied to the raw data, so as to obtain a processed spectrum. The number of numerical values depicted by the processed spectrum is lowered to a feature vector. The feature vector is allocated to one of numerous groups of known feature vectors.