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公开(公告)号：US10350245B2
公开(公告)日：2019-07-16
申请号：US15545555
申请日：2016-01-21
发明人： Jennifer E. Adair , Hans-Peter Kiem
IPC分类号： A61K35/28 , A61P35/00 , C12M1/42 , C12N15/867 , C12Q1/68
摘要： A platform for ex vivo isolation, production, and formulation of genetically-modified cells is described. The platform utilizes a software-enabled point-of-care and/or portable device making gene therapy more widely available.
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公开(公告)号：US10828333B2
公开(公告)日：2020-11-10
申请号：US16422876
申请日：2019-05-24
发明人： Jennifer E. Adair , Hans-Peter Kiem
摘要： A platform for ex vivo isolation, production, and formulation of genetically-modified cells is described. The platform utilizes a software-enabled point-of-care and/or portable device making gene therapy more widely available.
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公开(公告)号：US20200009266A1
公开(公告)日：2020-01-09
申请号：US16486442
申请日：2018-02-15
申请人： Fred Hutchinson Cancer Research Center , Seattle Children's Hospital d/b/a Seattle Children's Research Institute
发明人： Frieda Chan , Olivier Humbert , Hans-Peter Kiem , Jennifer E. Adair , David Rawlings , Andrew Scharenberg , Troy Torgerson
IPC分类号： A61K48/00 , A61K38/19 , A61K31/395 , A61P37/00
摘要： In vivo gene therapies for immune deficiencies are described. The in vivo gene therapies utilize a foamy viral vector including a PGK promoter with a therapeutic gene. The foamy viral vector can be beneficially administered with cell mobilization into the peripheral blood.
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公开(公告)号：US20220025403A1
公开(公告)日：2022-01-27
申请号：US17311211
申请日：2019-12-05
发明人： Jennifer E. Adair , Reza Shahbazi
摘要： Nanoparticles to genetically modify selected cell types within a biological sample that has been subjected to reduced or minimal manipulation are described. The nanoparticles deliver all components required for precise genome engineering and overcome numerous drawbacks associated with current clinical practices to genetically engineer cells for therapeutic purposes.
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公开(公告)号：US20190365817A1
公开(公告)日：2019-12-05
申请号：US16422876
申请日：2019-05-24
发明人： Jennifer E. Adair , Hans-Peter Kiem
IPC分类号： A61K35/28 , A61P35/00 , C12M1/42 , C12N15/867 , C12Q1/68
摘要： A platform for ex vivo isolation, production, and formulation of genetically-modified cells is described. The platform utilizes a software-enabled point-of-care and/or portable device making gene therapy more widely available.
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公开(公告)号：US20210052658A1
公开(公告)日：2021-02-25
申请号：US16922981
申请日：2020-07-07
发明人： Jennifer E. Adair , Hans-Peter Kiem
摘要： A platform for ex vivo isolation, production, and formulation of genetically-modified cells is described. The platform utilizes a software-enabled point-of-care and/or portable device making gene therapy more widely available.
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公开(公告)号：US20210171983A1
公开(公告)日：2021-06-10
申请号：US16619211
申请日：2018-06-05
发明人： Jennifer E. Adair , Reza Shahbazi
IPC分类号： C12N15/90 , C12N15/113 , C12N9/22 , C12N5/078 , A61K47/69
摘要： Genomic safe harbors (GSH) for genetic therapies in human stem cells and engineered nanoparticles to provide targeted genetic therapies are described. The GSH and/or associated nanoparticles can be used to safely and efficiently treat a variety of genetic, infectious, and malignant diseases.
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公开(公告)号：US20180169148A1
公开(公告)日：2018-06-21
申请号：US15545555
申请日：2016-01-21
发明人： Jennifer E. Adair , Hans-Peter Kiem
IPC分类号： A61K35/28 , A61P35/00 , C12N15/867 , C12Q1/68 , C12M1/42
CPC分类号： A61K35/28 , A61P35/00 , C12M35/02 , C12M47/04 , C12N15/8673 , C12N2740/16043 , C12Q1/68
摘要： A platform for ex vivo isolation, production, and formulation of genetically-modified cells is described. The platform utilizes a software-enabled point-of-care and/or portable device making gene therapy more widely available.
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