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公开(公告)号:US5091382A
公开(公告)日:1992-02-25
申请号:US552058
申请日:1990-07-13
IPC分类号: A61K31/545 , A61K31/546 , A61P31/04 , C07D277/36 , C07D277/56 , C07D501/00 , C07D501/36
CPC分类号: C07D277/56 , C07D277/36 , C07D501/00
摘要: Cephalosporin derivatives of the general formula ##STR1## pharmaceutical preparations active against bacterial infections which contain such cephalosporin derivatives, processes for the preparation of the cephalosporin derivatives, use of the cephalosporin derivatives for the preparation of a pharmaceutical for combating bacterial infections, and starting products for the preparation of cephalosporin derivatives.
摘要翻译: 具有通式
的头孢菌素衍生物,其含有这种头孢菌素衍生物的细菌感染活性的药物制剂,头孢菌素衍生物的制备方法,头孢菌素衍生物用于制备抗菌细菌感染药物,以及起始产品 头孢菌素衍生物的制备。 -
公开(公告)号:US5306717A
公开(公告)日:1994-04-26
申请号:US924598
申请日:1992-07-24
申请人: Friedhelm Adam , Walter Durckheimer , Gerd Fischer , Burkhard Mencke , Gerhard Seibert , Dieter Isert , Norbert Klesel
发明人: Friedhelm Adam , Walter Durckheimer , Gerd Fischer , Burkhard Mencke , Gerhard Seibert , Dieter Isert , Norbert Klesel
IPC分类号: A61K20060101 , A61K31/545 , A61K31/546 , A61P31/04 , C07D20060101 , C07D501/00 , C07D501/04 , C07D501/06 , C07D501/22 , C07D501/34 , C07D501/46
CPC分类号: C07D501/34
摘要: Cephalosporin derivatives of the general formula ##STR1## pharmaceutical preparations which are active against bacterial infections and contain such cephem derivatives, processes for the preparation of the cephem derivatives and the pharmaceutical preparations and the use of the cephem derivatives for combating bacterial infections.
摘要翻译: 具有抗细菌感染和含有此类头孢烯衍生物的通式为“IMAGE”+ TR
的药物制剂的头孢菌素衍生物,头孢烯衍生物和药物制剂的制备方法以及头孢烯衍生物用于对抗细菌 感染。 -
公开(公告)号:USRE34865E
公开(公告)日:1995-02-21
申请号:US978980
申请日:1992-11-19
申请人: Friedhelm Adam , Jurgen Blumbach , Walter Durckheimer , Gerd Fischer , Burghard Mencke , Dieter Isert , Gerhard Seibert
发明人: Friedhelm Adam , Jurgen Blumbach , Walter Durckheimer , Gerd Fischer , Burghard Mencke , Dieter Isert , Gerhard Seibert
IPC分类号: A61K20060101 , A61K31/545 , A61K31/546 , A61P31/04 , C07D20060101 , C07D501/00 , C07D501/32 , C07D501/34
CPC分类号: C07D501/34 , C07D501/00
摘要: Cephemcarboxylic acid esters of the general formula ##STR1## pharmaceutical preparations which are active against bacterial infections, which contain such cephem derivatives, a process for the preparation of the cephem derivatives and the pharmaceutical preparations, and also the use of the cephem derivatives for combating bacterial infections.
摘要翻译: 具有抗细菌感染活性的含有此类头孢烯衍生物的通式
+ TR 药物制剂的头孢霉羧酸酯,制备头孢烯衍生物和药物制剂的方法,以及使用 头孢烯衍生物用于对抗细菌感染。 -
公开(公告)号:US5100887A
公开(公告)日:1992-03-31
申请号:US555807
申请日:1990-07-23
申请人: Friedhelm Adam , Jurgen Blumbach , Walter Durckheimer , Gerd Fischer , Burghard Mencke , Dieter Isert , Gerhard Seibert
发明人: Friedhelm Adam , Jurgen Blumbach , Walter Durckheimer , Gerd Fischer , Burghard Mencke , Dieter Isert , Gerhard Seibert
IPC分类号: A61K20060101 , A61K31/545 , A61K31/546 , A61P31/04 , C07D20060101 , C07D501/00 , C07D501/32 , C07D501/34
CPC分类号: C07D501/34 , C07D501/00
摘要: Cephemcarboxylic acid esters of the general formula ##STR1## pharmaceutical preparations which are active against bacterial infections, which contain such cephem derivatives, a process for the preparation of the cephem derivatives and the pharmaceutical preparations, and also the use of the cephem derivatives for combating bacterial infections.
摘要翻译: 具有抗细菌感染活性的含有此类头孢烯衍生物的通式
+ TR 药物制剂的头孢霉羧酸酯,制备头孢烯衍生物和药物制剂的方法,以及使用 头孢烯衍生物用于对抗细菌感染。 -
5.
公开(公告)号:US5409918A
公开(公告)日:1995-04-25
申请号:US931505
申请日:1992-08-21
IPC分类号: A61K31/545 , A61K31/546 , A61P31/04 , C07D501/00 , C07D501/34 , C07D501/56 , C07D501/32
CPC分类号: C07D501/00
摘要: Crystalline cephem acid addition salts of the general formula II ##STR1## pharmaceutical preparations effective against bacterial infections which contain such cephem derivatives, processes for the preparation of the cephem derivatives and the pharmaceutical preparations, and the use of the cephem derivatives for combating bacterial infections.
摘要翻译: 具有通式II的结晶头孢酸加成盐对于含有此类头孢烯衍生物的细菌感染药物制剂,制备头孢烯衍生物和药物制剂的方法,以及使用头孢烯 防治细菌感染的衍生物。
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公开(公告)号:US4590267A
公开(公告)日:1986-05-20
申请号:US770406
申请日:1985-08-28
申请人: Karl-Heinz Scheunemann , Burkhard Mencke , Jurgen Blumbach , Walter Durckheimer , Klaus Fleischmann
发明人: Karl-Heinz Scheunemann , Burkhard Mencke , Jurgen Blumbach , Walter Durckheimer , Klaus Fleischmann
IPC分类号: C07D501/00 , A61K31/38 , A61K31/545 , A61K31/546 , A61P31/04 , C07D20060101 , C07D501/12 , C07D501/36 , C07D501/46 , C07D501/56
CPC分类号: C07D501/36
摘要: A crystalline water soluble disodium salt of 7-.beta.-[2-(2-aminothiazol-4-yl)-2-syn-methoximinoacetamido]-3-(5-carboxymethyl-4-methyl-1,3-thiazol-2-ylthiomethyl)ceph-3-em-4-carboxylic acid (cefodizim), or an adduct or solvate thereof with water and/or an organic solvent.
摘要翻译: 7β-[2-(2-氨基噻唑-4-基)-2-顺式 - 邻甲酰氨基乙酰氨基] -3-(5-羧甲基-4-甲基-1,3-噻唑-2 - 硫基甲基)头孢-3-烯-4-羧酸(头孢地嗪)或其与水和/或有机溶剂的加合物或溶剂合物。
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公开(公告)号:US4762848A
公开(公告)日:1988-08-09
申请号:US837700
申请日:1986-03-10
申请人: Karl-Heinz Scheunemann , Walter Durckheimer , Jurgen Blumbach , Michael Limbert , Hans-Ulrich Schorlemmer , Gerhard Dickneite , Hans-Harald Sedlacek
发明人: Karl-Heinz Scheunemann , Walter Durckheimer , Jurgen Blumbach , Michael Limbert , Hans-Ulrich Schorlemmer , Gerhard Dickneite , Hans-Harald Sedlacek
IPC分类号: A61K31/33 , A61K31/41 , A61K31/415 , A61K31/4184 , A61K31/425 , A61K31/426 , A61K31/428 , A61K31/433 , A61K31/455 , A61K31/465 , A61K31/53 , A61P31/04 , A61P35/00 , A61P37/00 , A61P37/04 , A61P43/00 , C07D211/54 , C07D211/84 , C07D213/80 , C07D231/18 , C07D235/28 , C07D237/18 , C07D239/38 , C07D241/18 , C07D249/12 , C07D253/06 , C07D253/07 , C07D277/20 , C07D277/32 , C07D277/36 , C07D277/46 , C07D277/56 , C07D277/70 , C07D277/74 , C07D285/12 , C07D285/125 , C07D521/00 , A61K31/38 , C07D213/62 , C07D277/34
CPC分类号: C07D213/80 , C07D235/28 , C07D249/12 , C07D253/07 , C07D277/36 , C07D277/46 , C07D277/56 , C07D277/74 , C07D285/125
摘要: Heterocyclic sulfides of the general formula heterocycle-S-R, a process for their preparation and, in particular, their use for immunostimulation, immunorestoration and cytostatic treatment, and pharmaceutical agents, which contain a sulfide of this type, for these indications.
摘要翻译: 用于这些适应症的通式杂环-S-R的杂环硫化物,其制备方法,特别是其用于免疫刺激,免疫测定和细胞抑制处理的药物和含有这种硫化物的药剂。
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公开(公告)号:US4647556A
公开(公告)日:1987-03-03
申请号:US471649
申请日:1983-03-03
IPC分类号: C07D501/36 , A61K31/545 , A61K31/546 , A61P31/04 , C07D277/20 , C07D501/34 , C07D501/46 , C07D501/38
CPC分类号: C07D277/587
摘要: The invention relates to cephem derivatives of the general formula I ##STR1## and their physiologically acceptable acid addition salts, to pharmaceutical formulations active against bacterial infections, to processes for preparing the compounds and formulations, and to the use of the compounds for combating bacterial infections.
摘要翻译: 本发明涉及通式Ⅰ的头孢烯衍生物及其生理上可接受的酸加成盐,对抗细菌感染的药物制剂,制备化合物和制剂的方法,以及该化合物用于抗菌感染的用途 。
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公开(公告)号:US5036063A
公开(公告)日:1991-07-30
申请号:US440797
申请日:1989-11-24
IPC分类号: A61K31/43 , C07D499/88
CPC分类号: C07D499/88
摘要: Penem derivatives of the formula ##STR1## having R.sup.1 equal to 3-oxocyclobutyl and R.sup.2 equal to H or an ester-forming group, pharmaceutical preparations active against bacterial infections and which contain penem derivatives of this type, processes for the preparation of the penem derivatives and the pharmaceutical preparations, and use of the penem derivatives for the control of bacterial infections are described.
摘要翻译: 具有R1等于3-氧代环丁基和R2等于H或成酯基团的式“IMAGE”的Penem衍生物,对细菌感染有活性的药物制剂,并且含有这种类型的penin衍生物,penem衍生物的制备方法 并描述了药物制剂以及青霉烯衍生物用于控制细菌感染的用途。
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公开(公告)号:US4701452A
公开(公告)日:1987-10-20
申请号:US702319
申请日:1985-02-15
IPC分类号: C07D501/36 , A61K31/545 , A61K31/546 , A61P37/00
CPC分类号: A61K31/545
摘要: The use of cephem compounds of the general formula I ##STR1## to increase the immunological responsiveness of mammals and formulations which contain an effective content of cephem compounds of the general formula I.
摘要翻译: 使用通式I的头孢烯化合物增加哺乳动物和制剂的免疫应答性,其含有通式I的头孢烯化合物的有效含量。
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