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1.发明申请IMMUNOADSORPTION OF ANTI-VON WILLEBRAND FACTOR CLEAVING PROTEASE ANTIBODIES 有权免疫抵抗抗体抗体的抗体WILLEBRAND因子公开(公告)号：US20090264631A1
公开(公告)日：2009-10-22
申请号：US12388450
申请日：2009-02-18
CPC分类号： C12N9/6416 , A61K2039/505 , C07K14/755 , C07K16/40 , C12Q1/56 , G01N33/86
摘要： This invention relates to adsorbents and methods for highly selective removal of anti-von Willebrand Factor-cleaving protease antibodies (“anti-vWF-cp-abs”) from human plasma using human von Willebrand Factor-cleaving protease (“hvWF-cp”) or fragments thereof as affinity ligands. The adsorbents can be used for treating disorders associated with the occurrence of anti-vWF-cp-abs in patients, such as thromboembolic diseases.
摘要翻译： 本发明涉及使用人血管性血友病因子切割蛋白酶（“hvWF-cp”）从人血浆中高度选择性除去抗血管性血友病因子切割蛋白酶抗体（“anti-vWF-cp-abs”）的吸附剂和方法。 或其片段作为亲和配体。 吸附剂可用于治疗与患者中抗vWF-cp-abs的发生相关的疾病，例如血栓栓塞性疾病。
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2.发明授权Immunoadsorption of anti-von Willebrand factor cleaving protease antibodies 有权抗von Willebrand因子切割蛋白酶抗体的免疫吸附公开(公告)号：US08795999B2
公开(公告)日：2014-08-05
申请号：US12388450
申请日：2009-02-18
CPC分类号： C12N9/6416 , A61K2039/505 , C07K14/755 , C07K16/40 , C12Q1/56 , G01N33/86
摘要： This invention relates to adsorbents and methods for highly selective removal of anti-von Willebrand Factor-cleaving protease antibodies (“anti-vWF-cp-abs”) from human plasma using human von Willebrand Factor-cleaving protease (“hvWF-cp”) or fragments thereof as affinity ligands. The adsorbents can be used for treating disorders associated with the occurrence of anti-vWF-cp-abs in patients, such as thromboembolic diseases.
摘要翻译： 本发明涉及使用人血管性血友病因子切割蛋白酶（“hvWF-cp”）从人血浆中高度选择性除去抗血管性血友病因子切割蛋白酶抗体（“anti-vWF-cp-abs”）的吸附剂和方法。 或其片段作为亲和配体。 吸附剂可用于治疗与患者中抗vWF-cp-abs的发生相关的疾病，例如血栓栓塞性疾病。
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3.发明授权Diagnostic assay for anti-von Willebrand Factor cleaving protease (ADAMTS13) antibodies 有权抗Von Willebrand因子切割蛋白酶（ADAMTS13）抗体的诊断测定公开(公告)号：US07943326B2
公开(公告)日：2011-05-17
申请号：US12829872
申请日：2010-07-02
IPC分类号： G01N33/53
摘要： This invention relates to a kit to be used in an assay system for determination of an anti-von Willebrand Factor-cleaving protease (“anti-vWF-cp”) antibody in a sample. The kit comprises vWF-cp and/or vWF-fragment(s) immobilized on a solid phase. The kit can be used in a method for determination of anti-vWF-cp antibodies from a patient, for the diagnosis of disorders associated with the occurrence of anti-vWF-cp-antibodies, and the differentiation of various forms of thrombotic microangiopathy.
摘要翻译： 本发明涉及一种用于测定样品中抗血管性血友病因子切割蛋白酶（“vWF-cp”）抗体的测定系统的试剂盒。 该试剂盒包含固定在固相上的vWF-cp和/或vWF-片段。 该试剂盒可用于测定来自患者的抗vWF-cp抗体的方法，用于诊断与抗vWF-cp抗体发生相关的病症，以及各种形式的血栓性微血管病变的分化。
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4.发明授权Diagnostic assay for anti-von Willebrand Factor cleaving protease (ADAMTS13) antibodies 有权抗Von Willebrand因子切割蛋白酶（ADAMTS13）抗体的诊断测定公开(公告)号：US07763430B2
公开(公告)日：2010-07-27
申请号：US10422052
申请日：2003-04-22
IPC分类号： G01N33/53
摘要： This invention relates to a kit to be used in an assay system for determination of an anti-von Willebrand Factor-cleaving protease (“anti-vWF-cp”) antibody in a sample. The kit comprises vWF-cp and/or vWF-fragment(s) immobilized on a solid phase. The kit can be used in a method for determination of anti-vWF-cp antibodies from a patient, for the diagnosis of disorders associated with the occurrence of anti-vWF-cp-antibodies, and the differentiation of various forms of thrombotic microangiopathy.
摘要翻译： 本发明涉及一种用于测定样品中抗血管性血友病因子切割蛋白酶（“vWF-cp”）抗体的测定系统的试剂盒。 该试剂盒包含固定在固相上的vWF-cp和/或vWF-片段。 该试剂盒可用于测定来自患者的抗vWF-cp抗体的方法，用于诊断与抗vWF-cp抗体发生相关的病症，以及各种形式的血栓性微血管病变的分化。
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公开(公告)号：US20120315650A1
公开(公告)日：2012-12-13
申请号：US13475166
申请日：2012-05-18
申请人： Silvia Ferrari , Bernadette Gruber , Barbara Plaimauer , Hanspeter Rottensteiner , Friedrich Scheiflinger
发明人： Silvia Ferrari , Bernadette Gruber , Barbara Plaimauer , Hanspeter Rottensteiner , Friedrich Scheiflinger
IPC分类号： G01N33/573
CPC分类号： G01N33/564
摘要： The present invention relates to methods and means for detecting ADAMTS13 immune complexes in a sample. The methods include the steps of capturing and labelling immune complexes of anti-ADAMTS13 antibodies. Capturing and labelling may be achieved by two different binding units targeting the immune complexes. The invention further relates to diagnosing diseases associated with immunologic ADAMTS13 dysfunction like TTP (thrombotic thrombocytopenic purpura).
摘要翻译： 本发明涉及检测样品中ADAMTS13免疫复合物的方法和手段。 所述方法包括捕获和标记抗ADAMTS13抗体的免疫复合物的步骤。 捕获和标记可以通过靶向免疫复合物的两种不同的结合单元实现。 本发明还涉及诊断与免疫学ADAMTS13功能障碍（如TTP）（血栓性血小板减少性紫癜）相关的疾病。
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公开(公告)号：US20070015703A1
公开(公告)日：2007-01-18
申请号：US11454615
申请日：2006-06-16
IPC分类号： A61K38/17
CPC分类号： C12N9/6489 , A61K38/17 , A61K38/4886
摘要： This invention relates to a pharmaceutical composition having thrombolytic activity comprising ADAMTS13, and to methods for treating or preventing a disorder associated with the formation and/or the presence of one or more thrombus and to methods of disintegrating one or more thrombus in a patient in need thereof. Furthermore, the invention relates to the use of a pharmaceutically effective amount of ADAMTS13 for the preparation of a pharmaceutical composition for treating or preventing a disorder associated with the formation or the presence of one or more thrombus and for disintegrating one or more thrombus in a patient in need thereof.
摘要翻译： 本发明涉及具有包含ADAMTS13的溶栓活性的药物组合物，以及用于治疗或预防与一种或多种血栓的形成和/或存在相关的病症的方法以及在需要的患者中分解一种或多种血栓的方法 其中。 此外，本发明涉及药物有效量的ADAMTS13用于制备用于治疗或预防与形成或存在一种或多种血栓并且在患者中分解一种或多种血栓有关的病症的药物组合物的用途 需要它。
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7.发明申请DIAGNOSTIC ASSAY FOR ANTI-VON WILLEBRAND FACTOR CLEAVING PROTEASE (ADAMTS13) ANTIBODIES 有权用于抗血栓威因因子（ADAMTS13）抗体的诊断测定公开(公告)号：US20100273183A1
公开(公告)日：2010-10-28
申请号：US12829872
申请日：2010-07-02
IPC分类号： G01N33/53
摘要： This invention relates to a kit to be used in an assay system for determination of an anti-von Willebrand Factor-cleaving protease (“anti-vWF-cp”) antibody in a sample. The kit comprises vWF-cp and/or vWF-fragment(s) immobilized on a solid phase. The kit can be used in a method for determination of anti-vWF-cp antibodies from a patient, for the diagnosis of disorders associated with the occurrence of anti-vWF-cp-antibodies, and the differentiation of various forms of thrombotic microangiopathy.
摘要翻译： 本发明涉及一种用于测定样品中抗血管性血友病因子切割蛋白酶（“vWF-cp”）抗体的测定系统的试剂盒。 该试剂盒包含固定在固相上的vWF-cp和/或vWF-片段。 该试剂盒可用于测定来自患者的抗vWF-cp抗体的方法，用于诊断与抗vWF-cp抗体发生相关的病症，以及各种形式的血栓性微血管病变的分化。
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公开(公告)号：US20090203110A1
公开(公告)日：2009-08-13
申请号：US12370129
申请日：2009-02-12
申请人： Bernhard Laemmle , Helena Elisabeth Schaller-Gerritsen , Miha Furlan , Peter Turecek , Hans-Peter Schwarz , Friedrich Scheiflinger , Gerhard Antoine , Randolf Kerschbaumer , Luigina Tagliavacca , Klaus Zimmermann
发明人： Bernhard Laemmle , Helena Elisabeth Schaller-Gerritsen , Miha Furlan , Peter Turecek , Hans-Peter Schwarz , Friedrich Scheiflinger , Gerhard Antoine , Randolf Kerschbaumer , Luigina Tagliavacca , Klaus Zimmermann
IPC分类号： C12N9/50
CPC分类号： A61K38/4886 , A61K38/00 , C07K14/755 , C07K16/36 , C12N9/6416 , C12N9/6489 , C12Y304/24087
摘要： The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV, vWF cleaving complexes and methods for their production.
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9.发明授权Composition exhibiting a von Willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV 有权表现出von Willebrand因子（vWF）蛋白酶活性的组合物，其包含具有氨基酸序列AAGGILHLELLV的多肽链公开(公告)号：US07501117B2
公开(公告)日：2009-03-10
申请号：US11166288
申请日：2005-06-23
申请人： Bernhard Laemmle , Helena Elisabeth Schaller-Gerritsen , Miha Furlan , Peter Turecek , Hans-Peter Schwarz , Friedrich Scheiflinger , Gerhard Antoine , Randolf Kerschbaumer , Luigina Tagliavacca , Klaus Zimmermann
发明人： Bernhard Laemmle , Helena Elisabeth Schaller-Gerritsen , Miha Furlan , Peter Turecek , Hans-Peter Schwarz , Friedrich Scheiflinger , Gerhard Antoine , Randolf Kerschbaumer , Luigina Tagliavacca , Klaus Zimmermann
CPC分类号： A61K38/4886 , A61K38/00 , C07K14/755 , C07K16/36 , C12N9/6416 , C12N9/6489 , C12Y304/24087
摘要： The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV, vWF cleaving complexes and methods for their production.
摘要翻译： 本发明涉及分子量为180kD，170kD，160kD，120kD或110kD的VWF切割实体以及AAGGILHLELLV的N-末端氨基酸序列，vWF切割复合物及其生产方法。
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10.发明申请Composition Exhibiting a von Willebrand Factor (vWF) Protease Activity Comprising a Polypeptide Chain with the Amino Acid Sequence AAGGILHLELLV 有权组成展示von Willebrand因子（vWF）包含氨基酸序列的多肽链的蛋白酶活性AAGGILHLELLV公开(公告)号：US20080176312A1
公开(公告)日：2008-07-24
申请号：US12032553
申请日：2008-02-15
申请人： Bernhard Laemmle , Helena Elisabeth Gerritsen , Miha Furlan , Peter Turecek , Hans-Peter Schwarz , Friedrich Scheiflinger , Gerhard Antoine , Randolf Kerschbaumer , Luigina Tagliavacca , Klaus Zimmermann
发明人： Bernhard Laemmle , Helena Elisabeth Gerritsen , Miha Furlan , Peter Turecek , Hans-Peter Schwarz , Friedrich Scheiflinger , Gerhard Antoine , Randolf Kerschbaumer , Luigina Tagliavacca , Klaus Zimmermann
IPC分类号： C12N9/50
CPC分类号： A61K38/4886 , A61K38/00 , C07K14/755 , C07K16/36 , C12N9/6416 , C12N9/6489 , C12Y304/24087
摘要： The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV, vWF cleaving complexes and methods for their production.
摘要翻译： 本发明涉及分子量为180kD，170kD，160kD，120kD或110kD的VWF切割实体以及AAGGILHLELLV的N-末端氨基酸序列，vWF切割复合物及其生产方法。
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