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21 条记录 (耗时 0.181 秒)

    Process of separation and purification of a propargyl alcohols
    1.
    发明授权
    Process of separation and purification of a propargyl alcohols 失效
    炔丙醇的分离和纯化方法

    公开(公告)号：US5043495A

    公开(公告)日：1991-08-27

    申请号：US475892

    申请日：1990-01-30

    申请人： Fumio Toda ,  Koichi Tanaka ,  Kikuo Ataka

    发明人： Fumio Toda ,  Koichi Tanaka ,  Kikuo Ataka

    IPC分类号： C07C29/88 ,  C07B57/00 ,  C07C27/00 ,  C07C29/76 ,  C07C33/30 ,  C07C33/48 ,  C07C67/00 ,  C07D295/02 ,  C07D295/03 ,  C07D487/04

    CPC分类号： C07D295/03 ,  C07C29/76 ,  C07C33/48 ,  C07D487/04 ,  C07B2200/07

    摘要： A process of separation and purification of a propargyl alcohol which comprises treating a propargyl alcohol represented by Formula (I): ##STR1## wherein each of R.sub.1 and R.sub.2 represents a substituent which is different from each other, and is selected from the group consisting of a C.sub.1 -C.sub.8 alkyl group, a phenyl group; a halophenyl group, a phenyl group having at least one methyl substituent, an aralkyl group and a cycloalkyl group,which is chemically or optically impure,with a tertiary diamine represented by Formula (II): ##STR2## wherein each of R.sub.3, R.sub.4, R.sub.5 and R.sub.6 may be the same or different and represents an aralkyl group or an alkyl group having 1 to 6 carbon atoms; and R.sub.3, R.sub.4, R.sub.5 and R.sub.6 may be bonded to each other,to form a crystalline complex compound of the propargyl alcohol represented by Formula (I) and the tertiary diamine represented by Formula (II), separating and purifying the resulting compound, and treating the resultant compound with an acid to isolate the propargyl alcohol represented by Formula (I).

    Optically active propargyl alcohol derivative and a method for preparation of the same
    3.
    发明授权
    Optically active propargyl alcohol derivative and a method for preparation of the same 失效
    光学活性炔丙醇衍生物及其制备方法

    公开(公告)号：US4467102A

    公开(公告)日：1984-08-21

    申请号：US553644

    申请日：1983-11-21

    申请人： Fumio Toda ,  Koichi Tanaka

    发明人： Fumio Toda ,  Koichi Tanaka

    IPC分类号： C07B31/00 ,  C07B57/00 ,  C07C27/00 ,  C07C29/44 ,  C07C29/88 ,  C07C33/28 ,  C07C33/48 ,  C07C67/00 ,  C07D333/16 ,  C07D333/00

    CPC分类号： C07D333/16 ,  C07C29/44 ,  C07C33/28 ,  C07C33/48

    摘要： An optically active propargyl alcohol derivative of the formula (I) ##STR1## wherein X=phenyl or thienyl and R=lower alkyl, halogenated methyl, phenyl or substituted phenyl having at least one lower alkyl radical and or halogen atom, is prepared by contacting a racemic modification of l- and d-isomers of the formula (I) with l-brucine in an organic solvent, by separating the resultant deposited diastereomer from a solution containing the resultant other diastereomer in the organic solvent, by decomposing each diastereomer with an aqueous mineral acid solution in the presence of an organic solvent capable of dissolving the corresponding optically active isomer dissociated from the diastereomer and incompatible with water so as to allow the optically active isomer to be dissolved in the water-incompatible organic solvent, and by recovering the optically active isomer from the solution thereof.

    摘要翻译： 式（I）的光学活性炔丙醇衍生物其中X =苯基或噻吩基，R =低级烷基，卤代甲基，苯基或具有至少一个低级烷基和/或卤素原子的取代苯基是 通过在有机溶剂中使式 - （I）的1-和D-异构体的外消旋改性物与1-羧酸接触，通过将所得到的沉积的非对映异构体与含有所得的其它非对映异构体的溶液在有机溶剂中分离， 在无机酸溶液存在下，在有机溶剂的存在下，能够溶解与非对映异构体解离的相应的光学活性异构体并且与水不相容，以使光学活性异构体溶解在与水不相容的有机溶剂中，以及 通过从其溶液中回收旋光异构体。

    Alkynol type compounds and alcohol-separating process
    5.
    发明授权
    Alkynol type compounds and alcohol-separating process 失效
    炔醇类化合物和醇分离过程

    公开(公告)号：US4769502A

    公开(公告)日：1988-09-06

    申请号：US48495

    申请日：1987-05-08

    申请人： Fumio Toda ,  Koichi Tanaka

    发明人： Fumio Toda ,  Koichi Tanaka

    IPC分类号： C07C33/28 ,  C07C27/26 ,  C07C29/74

    CPC分类号： C07C33/28

    摘要： Alkynol type compounds of the following formula (I): ##STR1## [wherein R.sub.1 -R.sub.5 and R.sub.6 -R.sub.10 each represent hydrogen atoms or lower alkyl group and R.sub.11 represents a lower alkyl group or a group of the formula: ##STR2## (wherein R.sub.1 -R.sub.5 and R.sub.6 -R.sub.10 are as hereinbefore defined); at least one of R.sub.1 -R.sub.5 and at least one of R.sub.6 -R.sub.10 being lower alkyl grops.] These compounds are capable of forming and precipitating crystalline complexes with alcohols when added to an aqueous solution of alcohol. Thus, these compounds are useful for separating alcohols from aqueous solutions of alcohols.

    摘要翻译： 下式（I）的炔醇型化合物：其中R 1 -R 5和R 6 -R 10各自表示氢原子或低级烷基，R 11表示低级烷基或下式的基团：其中 R1-R5和R6-R10如上文所定义）; R 1 -R 5中的至少一个和R 6 -R 10中的至少一个为低级烷基。]这些化合物当加入到醇的水溶液中时能够与醇形成和沉淀结晶配合物。 因此，这些化合物可用于从醇的水溶液中分离醇。

    Method of optically resolving a racemate or a diastereomeric mixture of glycidyl compound
    6.
    发明授权
    Method of optically resolving a racemate or a diastereomeric mixture of glycidyl compound 失效
    光学拆分缩水甘油基化合物的外消旋物或非对映体混合物的方法

    公开(公告)号：US4841081A

    公开(公告)日：1989-06-20

    申请号：US918724

    申请日：1986-10-14

    申请人： Fumio Toda ,  Koichi Tanaka ,  Tetsuya Nakata

    发明人： Fumio Toda ,  Koichi Tanaka ,  Tetsuya Nakata

    IPC分类号： C07D303/16 ,  C07D303/28

    CPC分类号： C07D303/28 ,  C07D303/16

    摘要： A method of optically resolving a racemate, or a diastereomeric mixture, of a substituted or unsubstituted glycidyl ester or ether compound having at least one glycidylic structure represented by the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3, independently from each other, represent H or CH.sub.3, and 1 to 3 asymmetric carbon atoms in the molecule, or a racemate of a beta-dihalohydrin ester compound, which comprises contacting said racemate or diastereomeric mixture with an optically active form of a compound having the following formula (I) ##STR2## wherein X represents a halogen atom, to form an inclusion complex compound having the optically active compound of formula (I) as a host, and separating the resulting complex compound.

    摘要翻译： 光学拆分取代或未取代的缩水甘油酯或醚化合物的外消旋物或非对映异构体混合物的方法，所述取代或未取代的缩水甘油酯或醚化合物具有由下式表示的至少一个缩水甘油基结构：其中R 1，R 2和R 3彼此独立地表示H 或分子中的1至3个不对称碳原子或β-二卤代醇酯化合物的外消旋体，其包括使所述外消旋体或非对映异构体混合物与光学活性形式的具有下式（I）的化合物接触

    Optically active biphenyl derivative and process for optical resolution
    7.
    发明授权
    Optically active biphenyl derivative and process for optical resolution 失效
    光学活性联苯衍生物和光学拆分方法

    公开(公告)号：US5202504A

    公开(公告)日：1993-04-13

    申请号：US646096

    申请日：1991-01-25

    申请人： Fumio Toda

    发明人： Fumio Toda

    IPC分类号： C07D207/267 ,  C07B57/00 ,  C07C33/46 ,  C07C39/15 ,  C07C43/23 ,  C07C205/00 ,  C07C209/88 ,  C07C211/00 ,  C07C211/27 ,  C07C231/20 ,  C07C255/12 ,  C07C311/00 ,  C07C317/00

    CPC分类号： C07B57/00 ,  C07C33/46

    摘要： A biphenyl compound having the formula (I) is newly separated into its optical active compound and useful as an optically separating agent: ##STR1## wherein W, X and Y are each an atom or atomic group selected from among H, F, Cl, Br, I, CH.sub.3, CF.sub.3, OH, OCH.sub.3, NH.sub.2 and N(CH.sub.3).sub.2 and Z is an atom or atomic group selected from among Cl, Br, I, CH.sub.3 and OCH.sub.3, R is an atomic group having 1 to 20 carbon atoms and containing a polar functional group selected from among ##STR2##

    摘要翻译： 将具有式（I）的联苯化合物新分离成其光学活性化合物，并用作光学分离剂：其中W，X和Y各自为选自H，F ，Cl，Br，I，CH3，CF3，OH，OCH3，NH2和N（CH3）2，Z是选自Cl，Br，I，CH3和OCH3的原子或原子团，R是具有1 至20个碳原子并含有选自 中的极性官能团

    Process for separating alkyl-substituted naphthalene derivatives using clathrate complexes
    8.
    发明授权
    Process for separating alkyl-substituted naphthalene derivatives using clathrate complexes 失效
    使用包合络合物分离烷基取代的萘衍生物的方法

    公开(公告)号：US4962274A

    公开(公告)日：1990-10-09

    申请号：US403961

    申请日：1989-09-07

    申请人： Fumio Toda

    发明人： Fumio Toda

    IPC分类号： C07C7/152 ,  C07C15/24 ,  C07C15/28

    CPC分类号： C07C15/28 ,  C07C15/24 ,  C07C7/152 ,  C07C2103/24

    摘要： A process for the separation of an alkyl-substituted naphthalene from a mixture containing the desired alkyl-substituted naphthalene and at least one isomer thereof comprises placing 9,9'-bianthracene in contact with the mixture to form a clathrate complex of the formula ##STR1## wherein A represents 2-methylnaphthalene, 2-isopropyl-naphthalene of 2,6-diisopropylnaphthalene, collecting the clathrate complex by filtration, subjecting the clathrate complex to thermal decomposition, and then recovering the alkyl-substituted naphthalene derivative.

    摘要翻译： 从含有所需烷基取代萘和至少一种异构体的混合物中分离烷基取代的萘的方法包括使9,9'-双蒽与该混合物接触以形成下式的包合物络合物：IMA IMA >（I）其中A表示2-甲基萘，2,6-二异丙基萘的2-异丙基萘，通过过滤收集包合络合物，使包合物络合物热分解，然后回收烷基取代的萘衍生物。

    Compound and separating agent
    9.
    发明授权
    Compound and separating agent 失效
    复合分离剂

    公开(公告)号：US5395985A

    公开(公告)日：1995-03-07

    申请号：US206449

    申请日：1994-03-04

    申请人： Fumio Toda

    发明人： Fumio Toda

    IPC分类号： C07B57/00 ,  C07B63/02 ,  C07C33/28 ,  C07C33/48 ,  C07C45/78 ,  C07C49/643 ,  C07D307/33

    CPC分类号： C07D307/33 ,  C07B57/00 ,  C07C33/28 ,  C07C33/48 ,  C07C33/486 ,  C07C45/78 ,  C07C49/643

    摘要： A compound represented by the general formula (I) and a separating agent comprising the same: ##STR1## wherein Ar and Ar' are each an aromatic group; and the positional relationship of the two substituents on the central benzene ring may be any of ortho, meta and para.The above compound is effective in the separation and purification of many compounds to and enables the provision of various compounds (such as intermediates of drugs) which are useful in the field of fine chemicals, particularly optically active substances, at high purities and in large amounts.

    摘要翻译： 由通式（I）表示的化合物和包含其的分离剂：其中Ar和Ar'各自为芳族基团; 并且中心苯环上的两个取代基的位置关系可以是邻位，间位和对位中的任何一个。 上述化合物在许多化合物的分离和纯化中是有效的，并且能够提供在高纯度和大量的精细化学品，特别是光学活性物质领域中有用的各种化合物（例如药物的中间体） 。